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# Portal-reproducibility
Codes for reproducing the experiments of the paper "Adversarial domain translation networks enable fast and accurate large-scale atlas-level single-cell data integration".
Codes for reproducing the experiments of the paper "Adversarial domain translation networks for fast and accurate integration of large-scale atlas-level single-cell datasets". [Portal package](https://github.com/YangLabHKUST/Portal).

+ [Integration of mouse spleen datasets](https://htmlpreview.github.io/?https://github.com/jiazhao97/Portal-reproducibility/blob/main/Reproduce-Spleen.html) (we reproduce the result of performance metrics in this notebook as an example). [Benchmarking](https://htmlpreview.github.io/?https://github.com/jiazhao97/Portal-reproducibility/blob/main/Benchmarking-Spleen.html).
+ [Integration of mouse marrow datasets](https://htmlpreview.github.io/?https://github.com/jiazhao97/Portal-reproducibility/blob/main/Reproduce-Marrow.html).
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+ [Integration of scRNA-seq and scATAC-seq datasets](https://htmlpreview.github.io/?https://github.com/jiazhao97/Portal-reproducibility/blob/main/Reproduce-PBMC-ATACseq.html).
+ [Integration of developmental trajectories](https://htmlpreview.github.io/?https://github.com/jiazhao97/Portal-reproducibility/blob/main/Reproduce-trajectory.html).
+ [Integration of spermatogenesis differentiation process across multiple species](https://htmlpreview.github.io/?https://github.com/jiazhao97/Portal-reproducibility/blob/main/Reproduce-Spermatogenesis.html). Gene lists from Ensembl Biomart (we only use genes that are assigned with the type "ortholog_one2one" in the lists): [orthologues (human vs mouse)](https://github.com/jiazhao97/Portal-reproducibility/raw/main/orthologues_human_mouse.txt), [orthologues (human vs macaque)](https://github.com/jiazhao97/Portal-reproducibility/raw/main/orthologues_human_macaque.txt).

## Portal Package
Jia Zhao, Gefei Wang, Jingsi Ming, Zhixiang Lin, Yang Wang, The Tabula Microcebus Consortium, Angela Ruohao Wu, Can Yang. Adversarial domain translation networks for fast and accurate integration of large-scale atlas-level single-cell datasets. bioRxiv 2021.11.16.468892; doi: [https://doi.org/10.1101/2021.11.16.468892](https://doi.org/10.1101/2021.11.16.468892).


## Citation
Jia Zhao, Gefei Wang, Jingsi Ming, Zhixiang Lin, Yang Wang, The Tabula Microcebus Consortium, Angela Ruohao Wu, Can Yang. Adversarial domain translation networks for fast and accurate integration of large-scale atlas-level single-cell datasets. bioRxiv 2021.11.16.468892; doi: [https://doi.org/10.1101/2021.11.16.468892](https://doi.org/10.1101/2021.11.16.468892).

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