Multi-Omics Characterization of Developing Forebrain Organoids Unravels the Dynamic Molecular Events of Rett Syndrome Pathogenesis
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This repository contains the scripts of the project "Multi-Omics Characterization of Developing Forebrain Organoids Unravels the Dynamic Molecular Events of Rett Syndrome Pathogenesis".
Although MECP2 mutations are a well-known cause of Rett Syndrome (RTT), the molecular events contributing to its pathogenesis are still not fully elucidated.
We analyzed the spatiotemporal gene and protein expression patterns in MeCP2-mutant (RTT) and isogenic control (IC) forebrain organoids. HiPSC-derived dorsal and ventral forebrain organoids were cultured and transcriptomics and proteomics profiles were characterized at days 0, 13, 40, and 75.
R version 4.3.1.RStudio version 2024.04.0+735
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