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A nextflow pipeline for the evaluation de novo transcriptome assemblies: TranscRiptome EvaluATion (TREAT).

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License: GPL v3 Nextflow Twitter URL

Authors: Lasse Faber, Martin Hölzer

TREAT: TranscRiptome EvaluATion

Treat your assemblies well!

A pipeline combining docker containers or conda environments and nextflow for the evaluation of (de novo) transcriptome assembly results.

Execution

To see all options:

nextflow run main.nf --help

Simple example execution:

nextflow run main.nf --assemblies 'test_data/*.fasta' --reads test_data/eco.fastq --reference test_data/eco_genome.fa --annotation test_data/eco_annotation.gff3 --threads 8 --busco bacteria_odb9 -profile standard

Example output for test command

heatmap

Profiles

The workflow can be deployed in different environments.

  • standard: uses docker containers and can be run locally
  • conda: uses conda environments and can be run locally
  • googlegenomics: uses the google cloud and needs to configured manually to run with your gcloud environment

Overview

dag

Motivation

This workflow implementation was motivated by our study comparing various de novo transcriptome assembly tools:

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A nextflow pipeline for the evaluation de novo transcriptome assemblies: TranscRiptome EvaluATion (TREAT).

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