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r-trimbour authored Mar 25, 2024
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Expand Up @@ -18,7 +18,7 @@ The current outputs available from HuMMuS are
* TF - DNA binding regions
* TF - target genes.

#### [Read our preprint](https://www.biorxiv.org/content/10.1101/2023.06.09.543828v1) for more details !
#### [Read our publication](https://academic.oup.com/bioinformatics/advance-article/doi/10.1093/bioinformatics/btae143/7625061) for more details !
<img src="man/figures/Fig_0001.jpg" align="center" width="1000"/>

### **scRNA + scATAC**
Expand All @@ -31,7 +31,7 @@ It is then possible to add any additional network to an already **existing modal

## Tutorials/Vignettes

* [**Infer a gene regulatory network and other outputs from unpaired/paired scRNA+scATAC data**](https://cantinilab.github.io/HuMMuS/articles/chen_vignette.html) shows the application of HuMMuS to the Chen dataset, used in the benchmark of [HuMMuS publication](https://www.biorxiv.org/content/10.1101/2023.06.09.543828v1).
* [**Infer a gene regulatory network and other outputs from unpaired/paired scRNA+scATAC data**](https://cantinilab.github.io/HuMMuS/articles/chen_vignette.html) shows the application of HuMMuS to the Chen dataset, used in the benchmark of [HuMMuS publication](https://academic.oup.com/bioinformatics/advance-article/doi/10.1093/bioinformatics/btae143/7625061).

## Installation
HuMMuS is for now ready only in R but requires some python dependencies (hummuspy).
Expand Down Expand Up @@ -82,4 +82,4 @@ To reproduce HuMMuS results presented in the manuscript, preprocessed data [are
<br> For quick tests, the Chen dataset preprocessed is accessible directly through the package as a Seurat object: `load(chen_data)`.

## Cite us
Trimbour R., Deutschmann I. M., Cantini L. Molecular mechanisms reconstruction from single-cell multi-omics data with HuMMuS. bioXriv (2023). doi: https://doi.org/10.1101/2023.06.09.543828
Trimbour R., Deutschmann I. M., Cantini L. Molecular mechanisms reconstruction from single-cell multi-omics data with HuMMuS. Bioinformatics (2024), btae143. doi: https://doi.org/10.1093/bioinformatics/btae143

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