EpiFocus provides scientific consulting in pharmacoepidemiology.
Central to our ethos is quality. Hence, we take the necessary time, using the best methods applied to the most appropriate data, to provide unbiased and useful results.
We ensure that the data will meet your research needs prior to undertaking. We also believe that effective communication and friendly collaboration mean that the final results meet the research requirements.
We are based in London and have a European focus.
- Epidemiological & statistical consulting services
- Database studies; methodological expertise
- Evidence synthesis
- Evidence strategy: pre-clinical to post-marketing
- Data resource evaluation
- Design and analysis of registries
- Benefit-risk modelling
- Drug uptake monitoring
- Chart review: design, collection (UK) and analysis
- Prospective: design, collection (UK) and analysis
Using pre-collected data
The analysis of pre-collected medical is an efficient way to undertake bespoke drug & epidemiological research
Care and experience are needed as the data are normally for clinical management and hence understanding data quality is vital
Andrew Maguire developed the main data quality parameter for the THIN database:
Maguire A, Blak B, Thompson M. The importance of defining periods of complete mortality reporting for research using automated data from primary care. Pharmacoepidemiology and Drug Safety 2009; 18: 76–83
Early evidence to support decision making. Includes disease areas and quantification of unmet medical needs, potential indication(s), rates of likely safety outcomes, how to efficiently measure efficacy and effectiveness. Later needs include studies of drug safety and effectiveness, assessment of accrual of evidence (meta-analysis) and benefit risk assessment
- NEW: Deslee G, Fabry-Vendrand C, Poccardi N, Thabut G, Eteve PitsaerC, CoriatA, Renaudat C, Maguire A, Pinto T. Use and persistence of single and multiple inhaler triple therapy prescribed for patients with COPD in France. BMJ Open Resp Res 2023;10:e001585. doi:10.1136/bmjresp-2022-00158
- Maguire A, Puelles J, Raboisson P et al. Early-stage Mycosis Fungoides: Epidemiology and Prognosis. Acta Dermato-Venereologica 2019 https://www.medicaljournals.se/acta/content/abstract/10.2340/00015555-3367
- Collings SL, Lefèvre C, Johnson ME, Evans D, Hack G, Stynes G, Maguire A. Oral anticoagulant persistence in patients with non-valvular atrial fibrillation: A cohort study using primary care data in Germany. PLoS One. 2017 Oct 10;12(10)
- Maguire A, Johnson ME, Denning DW, Ferreira GLC, Cassidy A. Identifying rare diseases using electronic medical records: the example of allergic bronchopulmonary aspergillosis. Pharmacoepidemiol Drug Saf. 2017 Mar 3
- Lamy FX, Saragoussi D, Johnson ME, Guiraud-Diawara A, Jørgensen KT, Loze JY, Maguire A. The use of adjunctive antipsychotics to treat depression in UK primary care. Curr Med Res Opin. 2017 May;33(5):891-898
- Gordon JP, McEwan PC, Maguire A, Sugrue DM, Puelles J. Characterizing unmet medical need and the potential role of new biologic treatment options in patients with ulcerative colitis and Crohn's disease: a systematic review and clinician surveys. Eur J Gastroenterol Hepatol. 2015 Jul;27(7):804-12
- Maguire A, Mitchell B, Cid-Ruzafa J. Antihyperglycaemic treatment patterns, observed glycaemic control and determinants of treatment change among patients with type 2 diabetes in the United Kingdom primary care: a retrospective cohort study. BMC Endocrine Disorders 2014, 14:73
- Khalid JM, Fox KM, Globe G, Maguire A, Chau D. Treatment patterns and therapy effectiveness in psoriasis patients initiating biologic therapy in England. Journal of Dermatological Treatment. 2014 Feb;25(1):67-72
- Blak, B, Wilson K, Metcalfe M, Maguire A, Hards M. Evaluation of varenicline as an aid to smoking cessation in UK general practice – a THIN database study. Current Medical Research & Opinion, 2010; 26(4): 861-70
- Maguire A, Blak B, Thompson M. the importance of defining periods of complete mortality reporting for research using automated data from primary care. Pharmacoepidemiology and Drug Safety 2009; 18: 76–83
- Varas-Lorenzo C, Maguire A, Castellsague J, Perez-Gutthann S. Quantitative assessment of the gastrointestinal and cardiovascular risk-benefit of celecoxib compared to individual NSAIDs at the population level. Pharmacoepidemiol & Drug Safety 2007; 16(4): 366-376
- Varas-Lorenzo C, Garcia-Rodriguez LA, Maguire A, Gonzalez-Perez A. Non-steroidal anti-inflammatory drugs and the risk of myocardial infarction in the general population. Circulation. 2004;109:3000-3006
- Maguire A, Porta M, Sanz-Anquela JM, Ruano I, Malats N, Piñol JL. Sex as a prognostic factor in gastric cancer. Eur J Cancer 1996;32A:1303-9
- Kalache A, Maguire A, Thompson S. Age at Last Full Term Pregnancy and Breast Cancer Risk. The Lancet 1993;341:32-35
