You can compile Toxygen using PyInstaller
Install PyInstaller:
pip3 install pyinstaller
Compile Toxygen:
pyinstaller --windowed --icon images/icon.ico main.py
Don't forget to copy /images/, /sounds/, /translations/, /styles/, /smileys/, /stickers/, /plugins/ (and /libs/libtox.dll, /libs/libsodium.a on Windows) to /dist/main/