diff --git a/index.d.ts b/index.d.ts
index bdd1a54..7129549 100644
--- a/index.d.ts
+++ b/index.d.ts
@@ -16,6 +16,29 @@ export type Options = {
 	`/Users/sindresorhus/dev/clean-stack/unicorn.js:2:15` → `unicorn.js:2:15`
 	*/
 	readonly basePath?: string;
+
+	/**
+	Remove the stack lines where the given function returns `false`. The function receives the path part of the stack line.
+
+	@example
+	```
+	import cleanStack from 'clean-stack';
+
+	const error = new Error('Missing unicorn');
+
+	console.log(cleanStack(error.stack));
+	// Error: Missing unicorn
+	//     at Object.<anonymous> (/Users/sindresorhus/dev/clean-stack/unicorn.js:2:15)
+	//     at Object.<anonymous> (/Users/sindresorhus/dev/clean-stack/omit-me.js:1:16)
+
+	const pathFilter = path => !/omit-me/.test(path);
+
+	console.log(cleanStack(error.stack, {pathFilter}));
+	// Error: Missing unicorn
+	//     at Object.<anonymous> (/Users/sindresorhus/dev/clean-stack/unicorn.js:2:15)
+	```
+	*/
+	readonly pathFilter?: (path: string) => boolean;
 };
 
 /**
diff --git a/index.js b/index.js
index 649da79..3aa7409 100644
--- a/index.js
+++ b/index.js
@@ -4,7 +4,7 @@ import getHomeDirectory from '#home-directory';
 const extractPathRegex = /\s+at.*[(\s](.*)\)?/;
 const pathRegex = /^(?:(?:(?:node|node:[\w/]+|(?:(?:node:)?internal\/[\w/]*|.*node_modules\/(?:babel-polyfill|pirates)\/.*)?\w+)(?:\.js)?:\d+:\d+)|native)/;
 
-export default function cleanStack(stack, {pretty = false, basePath} = {}) {
+export default function cleanStack(stack, {pretty = false, basePath, pathFilter} = {}) {
 	const basePathRegex = basePath && new RegExp(`(file://)?${escapeStringRegexp(basePath.replace(/\\/g, '/'))}/?`, 'g');
 	const homeDirectory = pretty ? getHomeDirectory() : '';
 
@@ -32,7 +32,9 @@ export default function cleanStack(stack, {pretty = false, basePath} = {}) {
 				return false;
 			}
 
-			return !pathRegex.test(match);
+			return pathFilter
+				? !pathRegex.test(match) && pathFilter(match)
+				: !pathRegex.test(match);
 		})
 		.filter(line => line.trim() !== '')
 		.map(line => {
diff --git a/readme.md b/readme.md
index 3aa45a9..8c72ddc 100644
--- a/readme.md
+++ b/readme.md
@@ -73,6 +73,29 @@ Example with `'/Users/sindresorhus/dev/clean-stack'` as `basePath`:
 
 `/Users/sindresorhus/dev/clean-stack/unicorn.js:2:15` → `unicorn.js:2:15`
 
+##### pathFilter
+
+Type: `(path: string) => boolean`
+
+Remove the stack lines where the given function returns `false`. The function receives the path part of the stack line.
+
+```js
+import cleanStack from 'clean-stack';
+
+const error = new Error('Missing unicorn');
+
+console.log(cleanStack(error.stack));
+// Error: Missing unicorn
+//     at Object.<anonymous> (/Users/sindresorhus/dev/clean-stack/unicorn.js:2:15)
+//     at Object.<anonymous> (/Users/sindresorhus/dev/clean-stack/omit-me.js:1:16)
+
+const pathFilter = path => !/omit-me/.test(path);
+
+console.log(cleanStack(error.stack, {pathFilter}));
+// Error: Missing unicorn
+//     at Object.<anonymous> (/Users/sindresorhus/dev/clean-stack/unicorn.js:2:15)
+```
+
 ## Related
 
 - [extract-stack](https://github.com/sindresorhus/extract-stack) - Extract the actual stack of an error
diff --git a/test.js b/test.js
index a91cff4..3a75169 100644
--- a/test.js
+++ b/test.js
@@ -218,6 +218,40 @@ test('`basePath` option should support file URLs', t => {
 	t.is(cleanStack(stack, {basePath, pretty: true}), expected);
 });
 
+test('`pathFilter` option allows for excluding custom lines if the callback returns true', t => {
+	const pathFilter = path => !/home-directory/.test(path);
+
+	const pre = `Error: foo
+    at Test.fn (/Users/sindresorhus/dev/clean-stack/test.js:6:15)`;
+
+	const stack = `${pre}\n
+		at getHomeDirectory (/Users/sindresorhus/dev/clean-stack/home-directory.js:3:32)
+    at MySocket.emit (node:events:365:28)
+    at MySocket.emit (node:fs/promises:363:28)
+    at handleMessage (internal/child_process.js:695:10)
+    at Pipe.channel.onread (internal/child_process.js:440:11)
+    at process.emit (events.js:172:7)`;
+
+	t.is(cleanStack(stack, {pathFilter}), pre);
+});
+
+test('`pathFilter` option keeps custom lines if the callback returns false', t => {
+	const pathFilterCallback = () => true;
+
+	const pre = `Error: foo
+    at Test.fn (/Users/sindresorhus/dev/clean-stack/test.js:6:15)
+    at getHomeDirectory (/Users/sindresorhus/dev/clean-stack/home-directory.js:3:32)`;
+
+	const stack = `${pre}\n
+    at MySocket.emit (node:events:365:28)
+    at MySocket.emit (node:fs/promises:363:28)
+    at handleMessage (internal/child_process.js:695:10)
+    at Pipe.channel.onread (internal/child_process.js:440:11)
+    at process.emit (events.js:172:7)`;
+
+	t.is(cleanStack(stack, {pathFilterCallback}), pre);
+});
+
 test('new stack format on Node.js 15 and later', t => {
 	const stack = `Error
     at B (/home/fengkx/projects/test/stack.js:5:19)