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DESCRIPTION
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DESCRIPTION
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Package: GxEprs
Title: Genotype-by-Environment Interaction in Polygenic Score Models
Version: 1.2
Authors@R: c(person("Dovini", "Jayasinghe", role = c("aut", "cre","cph"), email = "[email protected]"),
person("Hong", "Lee", role = c("aut","cph"),email = "[email protected]"),
person("Moksedul", "Momin", role = c("aut","cph"), email = "[email protected]"))
Description: A novel PRS model is introduced to enhance the prediction accuracy by utilising GxE effects. This package performs Genome Wide Association Studies (GWAS) and Genome Wide Environment Interaction Studies (GWEIS) using a discovery dataset. The package has the ability to obtain polygenic risk scores (PRSs) for a target sample. Finally it predicts the risk values of each individual in the target sample. Users have the choice of using existing models (Li et al., 2015) <doi:10.1093/annonc/mdu565>, (Pandis et al., 2013) <doi:10.1093/ejo/cjt054>, (Peyrot et al., 2018) <doi:10.1016/j.biopsych.2017.09.009> and (Song et al., 2022) <doi:10.1038/s41467-022-32407-9>, as well as newly proposed models for genomic risk prediction (refer to the URL for more details).
URL: https://github.com/DoviniJ/GxEprs
License: GPL (>=3)
Encoding: UTF-8
Roxygen: list(markdown = TRUE)
RoxygenNote: 7.2.3
Depends:
R (>= 2.10)
LazyData: true