Machine learning-assisted viral quasispecies analysis: a novel approach for apprasing the immune tolerant phase of chronic hepatitis B
First Authors
Dr. Mingjie Wang
Prof. Li Chen
Corespoding Authors
- Prof. Xinxin Zhang
- Prof. Fabien Zoulim
- Prof. Jiming Zhang
All the scripts used in the manuscript were deposited here for several purposes and aims.
- To demenstrate the reliability and reproducibility of the results.
- Making the codes fully accessible to researcher doing relavant researches
- Looking forward to valuable suggestions and useful upgrades
- Finding someone who has interests in similar studies (ngs, viral QS, viral hepatitis).
Basically three folders corespond to three parts of the whole data manipulation and calculation procedure.
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NGS raw data pre-processing
From fastq reads to viral haplotype quantification view
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Machine learning model construction and evaluation
From viral quantification to clinical diagnostic models view
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Hierarchical clustering, principle components analysis and K-means classification
From viral quantification to clinical phenotypes view
If you have found any errors or encountered any bugs when running the scripts, please feel no hesitation to report it here or directly email me [email protected].