diff --git a/UPGRADE.md b/UPGRADE.md
index 2a383739bc7..32d5945e257 100644
--- a/UPGRADE.md
+++ b/UPGRADE.md
@@ -8,6 +8,14 @@ awareness about deprecated code.
 
 # Upgrade to 4.2
 
+## Support for new PDO subclasses on PHP 8.4
+
+On PHP 8.4, if you call `getNativeConnection()` on a connection established through one of the PDO drivers,
+you will get an instance of the new PDO subclasses, e.g. `Pdo\Mysql` or `Pdo\Ppgsql` instead of just `PDO`.
+
+However, this currently does not apply to persistent connections.
+See https://github.com/php/php-src/issues/16314 for details.
+
 ## Minor BC break: incompatible query cache format
 
 The query cache format has been changed to address the issue where a cached result with no rows would miss the metadata.
diff --git a/phpstan.neon.dist b/phpstan.neon.dist
index 2a04d32d39c..8ff5ab63b79 100644
--- a/phpstan.neon.dist
+++ b/phpstan.neon.dist
@@ -115,6 +115,10 @@ parameters:
         # Type check for legacy implementations of the Result interface
         # TODO: remove in 5.0.0
         - '~^Call to function method_exists\(\) with Doctrine\\DBAL\\Driver\\Result and ''getColumnName'' will always evaluate to true\.$~'
+
+        # PHPStan does not know the new PDO classes yet.
+        - '~^Class Pdo\\\w+ not found\.$~'
+        - '~^Call to an undefined static method PDO\:\:connect\(\)\.$~'
 includes:
     - vendor/phpstan/phpstan-phpunit/extension.neon
     - vendor/phpstan/phpstan-phpunit/rules.neon
diff --git a/psalm.xml.dist b/psalm.xml.dist
index af28777385c..08cff97ebf8 100644
--- a/psalm.xml.dist
+++ b/psalm.xml.dist
@@ -293,6 +293,14 @@
                 <file name="src/Driver/PgSQL/Statement.php"/>
             </errorLevel>
         </TypeDoesNotContainType>
+        <UndefinedClass>
+            <errorLevel type="suppress">
+                <!-- New PDO classes introduced in PHP 8.4 -->
+                <referencedClass name="Pdo\Mysql"/>
+                <referencedClass name="Pdo\Pgsql"/>
+                <referencedClass name="Pdo\Sqlite"/>
+            </errorLevel>
+        </UndefinedClass>
         <UndefinedDocblockClass>
             <errorLevel type="suppress">
                 <!-- See https://github.com/vimeo/psalm/issues/5472 -->
@@ -304,6 +312,12 @@
                 <referencedClass name="OCILob"/>
             </errorLevel>
         </UndefinedDocblockClass>
+        <UndefinedMethod>
+            <errorLevel type="suppress">
+                <!-- New PDO static constructor introduced in PHP 8.4 -->
+                <referencedMethod name="PDO::connect"/>
+            </errorLevel>
+        </UndefinedMethod>
         <UnsupportedPropertyReferenceUsage>
             <errorLevel type="suppress">
                 <!-- This code is valid -->
diff --git a/src/Driver/PDO/MySQL/Driver.php b/src/Driver/PDO/MySQL/Driver.php
index fad4b55954c..919f8475583 100644
--- a/src/Driver/PDO/MySQL/Driver.php
+++ b/src/Driver/PDO/MySQL/Driver.php
@@ -8,6 +8,7 @@
 use Doctrine\DBAL\Driver\PDO\Connection;
 use Doctrine\DBAL\Driver\PDO\Exception;
 use Doctrine\DBAL\Driver\PDO\Exception\InvalidConfiguration;
+use Doctrine\DBAL\Driver\PDO\PDOConnect;
 use PDO;
 use PDOException;
 use SensitiveParameter;
@@ -16,6 +17,8 @@
 
 final class Driver extends AbstractMySQLDriver
 {
+    use PDOConnect;
+
     /**
      * {@inheritDoc}
      */
@@ -39,7 +42,7 @@ public function connect(
         unset($safeParams['password']);
 
         try {
-            $pdo = new PDO(
+            $pdo = $this->doConnect(
                 $this->constructPdoDsn($safeParams),
                 $params['user'] ?? '',
                 $params['password'] ?? '',
diff --git a/src/Driver/PDO/OCI/Driver.php b/src/Driver/PDO/OCI/Driver.php
index 45f3ea25b01..49882b0d6cb 100644
--- a/src/Driver/PDO/OCI/Driver.php
+++ b/src/Driver/PDO/OCI/Driver.php
@@ -8,6 +8,7 @@
 use Doctrine\DBAL\Driver\PDO\Connection;
 use Doctrine\DBAL\Driver\PDO\Exception;
 use Doctrine\DBAL\Driver\PDO\Exception\InvalidConfiguration;
+use Doctrine\DBAL\Driver\PDO\PDOConnect;
 use PDO;
 use PDOException;
 use SensitiveParameter;
@@ -16,6 +17,8 @@
 
 final class Driver extends AbstractOracleDriver
 {
+    use PDOConnect;
+
     /**
      * {@inheritDoc}
      */
@@ -39,7 +42,7 @@ public function connect(
         unset($safeParams['password']);
 
         try {
-            $pdo = new PDO(
+            $pdo = $this->doConnect(
                 $this->constructPdoDsn($params),
                 $params['user'] ?? '',
                 $params['password'] ?? '',
diff --git a/src/Driver/PDO/PDOConnect.php b/src/Driver/PDO/PDOConnect.php
new file mode 100644
index 00000000000..f14a97c07aa
--- /dev/null
+++ b/src/Driver/PDO/PDOConnect.php
@@ -0,0 +1,28 @@
+<?php
+
+declare(strict_types=1);
+
+namespace Doctrine\DBAL\Driver\PDO;
+
+use PDO;
+
+use const PHP_VERSION_ID;
+
+/** @internal */
+trait PDOConnect
+{
+    /** @param array<int, mixed> $options */
+    private function doConnect(
+        string $dsn,
+        string $username,
+        string $password,
+        array $options,
+    ): PDO {
+        // see https://github.com/php/php-src/issues/16314
+        if (PHP_VERSION_ID < 80400 || ($options[PDO::ATTR_PERSISTENT] ?? false) === true) {
+            return new PDO($dsn, $username, $password, $options);
+        }
+
+        return PDO::connect($dsn, $username, $password, $options);
+    }
+}
diff --git a/src/Driver/PDO/PgSQL/Driver.php b/src/Driver/PDO/PgSQL/Driver.php
index 39e8a9452f1..cdf411aff54 100644
--- a/src/Driver/PDO/PgSQL/Driver.php
+++ b/src/Driver/PDO/PgSQL/Driver.php
@@ -8,6 +8,7 @@
 use Doctrine\DBAL\Driver\PDO\Connection;
 use Doctrine\DBAL\Driver\PDO\Exception;
 use Doctrine\DBAL\Driver\PDO\Exception\InvalidConfiguration;
+use Doctrine\DBAL\Driver\PDO\PDOConnect;
 use PDO;
 use PDOException;
 use SensitiveParameter;
@@ -16,6 +17,8 @@
 
 final class Driver extends AbstractPostgreSQLDriver
 {
+    use PDOConnect;
+
     /**
      * {@inheritDoc}
      */
@@ -39,7 +42,7 @@ public function connect(
         unset($safeParams['password']);
 
         try {
-            $pdo = new PDO(
+            $pdo = $this->doConnect(
                 $this->constructPdoDsn($safeParams),
                 $params['user'] ?? '',
                 $params['password'] ?? '',
diff --git a/src/Driver/PDO/SQLSrv/Driver.php b/src/Driver/PDO/SQLSrv/Driver.php
index 7950c41a5e5..2d7490b8ae3 100644
--- a/src/Driver/PDO/SQLSrv/Driver.php
+++ b/src/Driver/PDO/SQLSrv/Driver.php
@@ -10,6 +10,7 @@
 use Doctrine\DBAL\Driver\PDO\Connection as PDOConnection;
 use Doctrine\DBAL\Driver\PDO\Exception as PDOException;
 use Doctrine\DBAL\Driver\PDO\Exception\InvalidConfiguration;
+use Doctrine\DBAL\Driver\PDO\PDOConnect;
 use PDO;
 use SensitiveParameter;
 
@@ -19,6 +20,8 @@
 
 final class Driver extends AbstractSQLServerDriver
 {
+    use PDOConnect;
+
     /**
      * {@inheritDoc}
      */
@@ -52,7 +55,7 @@ public function connect(
         unset($safeParams['password']);
 
         try {
-            $pdo = new PDO(
+            $pdo = $this->doConnect(
                 $this->constructDsn($safeParams, $dsnOptions),
                 $params['user'] ?? '',
                 $params['password'] ?? '',
diff --git a/src/Driver/PDO/SQLite/Driver.php b/src/Driver/PDO/SQLite/Driver.php
index 4bef08bf997..fbd4187532d 100644
--- a/src/Driver/PDO/SQLite/Driver.php
+++ b/src/Driver/PDO/SQLite/Driver.php
@@ -8,7 +8,7 @@
 use Doctrine\DBAL\Driver\PDO\Connection;
 use Doctrine\DBAL\Driver\PDO\Exception;
 use Doctrine\DBAL\Driver\PDO\Exception\InvalidConfiguration;
-use PDO;
+use Doctrine\DBAL\Driver\PDO\PDOConnect;
 use PDOException;
 use SensitiveParameter;
 
@@ -17,6 +17,8 @@
 
 final class Driver extends AbstractSQLiteDriver
 {
+    use PDOConnect;
+
     /**
      * {@inheritDoc}
      */
@@ -31,7 +33,7 @@ public function connect(
         }
 
         try {
-            $pdo = new PDO(
+            $pdo = $this->doConnect(
                 $this->constructPdoDsn(array_intersect_key($params, ['path' => true, 'memory' => true])),
                 $params['user'] ?? '',
                 $params['password'] ?? '',
diff --git a/tests/Functional/Driver/PDO/PDOSubclassTest.php b/tests/Functional/Driver/PDO/PDOSubclassTest.php
new file mode 100644
index 00000000000..5a9180ae383
--- /dev/null
+++ b/tests/Functional/Driver/PDO/PDOSubclassTest.php
@@ -0,0 +1,43 @@
+<?php
+
+declare(strict_types=1);
+
+namespace Doctrine\DBAL\Tests\Functional\Driver\PDO;
+
+use Doctrine\DBAL\Tests\FunctionalTestCase;
+use Doctrine\DBAL\Tests\TestUtil;
+use Pdo\Mysql;
+use Pdo\Pgsql;
+use Pdo\Sqlite;
+use PHPUnit\Framework\Attributes\RequiresPhp;
+
+#[RequiresPhp('8.4')]
+final class PDOSubclassTest extends FunctionalTestCase
+{
+    public function testMySQLSubclass(): void
+    {
+        if (! TestUtil::isDriverOneOf('pdo_mysql')) {
+            self::markTestSkipped('This test requires the pdo_mysql driver.');
+        }
+
+        self::assertInstanceOf(Mysql::class, $this->connection->getNativeConnection());
+    }
+
+    public function testPgSQLSubclass(): void
+    {
+        if (! TestUtil::isDriverOneOf('pdo_pgsql')) {
+            self::markTestSkipped('This test requires the pdo_pgsql driver.');
+        }
+
+        self::assertInstanceOf(Pgsql::class, $this->connection->getNativeConnection());
+    }
+
+    public function testSQLiteSubclass(): void
+    {
+        if (! TestUtil::isDriverOneOf('pdo_sqlite')) {
+            self::markTestSkipped('This test requires the pdo_sqlite driver.');
+        }
+
+        self::assertInstanceOf(Sqlite::class, $this->connection->getNativeConnection());
+    }
+}