Traits_MR-APSS.ipynb

{
 "cells": [
  {
   "cell_type": "markdown",
   "metadata": {},
   "source": [
    "# The function for calling MRAPSS() from MRAPSS package"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 2,
   "metadata": {},
   "outputs": [],
   "source": [
    "run_APSS_func <- function(clumped=NULL,\n",
    "                          exposure=NULL,\n",
    "                          outcome=NULL,\n",
    "                          C = diag(2),\n",
    "                          Omega = matrix(0, 2, 2),\n",
    "                          IV.Threshold = 5e-08, # IV selection threshold\n",
    "                          Threshold = 5e-08,    # threshold for correcting for selection bias\n",
    "                          Cor.SelectionBias=T){\n",
    "  \n",
    " \n",
    "  res=NULL\n",
    "  \n",
    "  for(i in 1:length(Threshold)){\n",
    "    \n",
    "    if(!is.null(clumped)){\n",
    "      \n",
    "      test = subset(clumped, pval.exp <= IV.Threshold[i])\n",
    "      if(nrow(test) < 4 ) next\n",
    "      test$Threshold = Threshold[i]\n",
    "      cat(\"IV selection threshold:\", IV.Threshold[i] ,\"\\n\")\n",
    "      \n",
    "      \n",
    "      MRres = try(MRAPSS::MRAPSS(test,\n",
    "                                 exposure=exposure,\n",
    "                                 outcome=outcome,\n",
    "                                 C= C,\n",
    "                                 Omega= Omega,\n",
    "                                 Cor.SelectionBias = Cor.SelectionBias))\n",
    "      \n",
    "      if(inherits(MRres, 'try-error')) {\n",
    "        MRres=NULL\n",
    "      }\n",
    "    }\n",
    "    \n",
    "    \n",
    "    res0 = data.frame(exposure = MRres$exposure,\n",
    "                      outcome = MRres$outcome,\n",
    "                      nSNP = nrow(MRres$MRdat),\n",
    "                      pi0 = MRres$pi0,\n",
    "                      nvalid = nrow(MRres$MRdat)*MRres$pi0,\n",
    "                      sigma.sq= MRres$sigma.sq,\n",
    "                      tau.sq= MRres$tau.sq,\n",
    "                      beta = MRres$beta,\n",
    "                      se = MRres$beta.se,\n",
    "                      pval= MRres$pvalue,\n",
    "                      method = MRres$method,\n",
    "                      Threshold = Threshold[i],\n",
    "                      IVstrength = MRres$IVsignal.sum\n",
    "    )\n",
    "    \n",
    "    if(nrow(res0)!=0){\n",
    "      res0$IV.Threshold = IV.Threshold[i]\n",
    "    }\n",
    "    \n",
    "    res = rbind(res, res0)\n",
    "    \n",
    "  }\n",
    "  \n",
    "  return(res)\n",
    "  \n",
    "}"
   ]
  },
  {
   "cell_type": "markdown",
   "metadata": {},
   "source": [
    "# Run MR-APSS at IV threshold 5e-05 (default)"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 3,
   "metadata": {},
   "outputs": [
    {
     "name": "stdout",
     "output_type": "stream",
     "text": [
      "Pair:  AD ~ ASD \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  AD  on  ASD : \n",
      "MR-APSS: beta =  0.011 , beta.se =  0.0739 , p-value =  8.8180e-01 . \n",
      "Total NO. of IVs=  72 , NO. of valid IVs with foreground signals:  18.70112 . \n",
      "***********************************************************\n",
      "Pair:  AD ~ Daytime_Sleepiness \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  AD  on  Daytime_Sleepiness : \n",
      "MR-APSS: beta =  0.01 , beta.se =  0.0154 , p-value =  5.1838e-01 . \n",
      "Total NO. of IVs=  70 , NO. of valid IVs with foreground signals:  18.81116 . \n",
      "***********************************************************\n",
      "Pair:  AD ~ Height_UKB \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  AD  on  Height_UKB : \n",
      "MR-APSS: beta =  0.0424 , beta.se =  0.0298 , p-value =  1.5543e-01 . \n",
      "Total NO. of IVs=  69 , NO. of valid IVs with foreground signals:  16.97834 . \n",
      "***********************************************************\n",
      "Pair:  AD ~ Intelligence \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  AD  on  Intelligence : \n",
      "MR-APSS: beta =  0.0186 , beta.se =  0.0488 , p-value =  7.0273e-01 . \n",
      "Total NO. of IVs=  69 , NO. of valid IVs with foreground signals:  19.3063 . \n",
      "***********************************************************\n",
      "Pair:  AD ~ RA \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  AD  on  RA : \n",
      "MR-APSS: beta =  -0.0264 , beta.se =  0.0404 , p-value =  5.1399e-01 . \n",
      "Total NO. of IVs=  69 , NO. of valid IVs with foreground signals:  16.78603 . \n",
      "***********************************************************\n",
      "Pair:  AD ~ T2D \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  AD  on  T2D : \n",
      "MR-APSS: beta =  -0.0586 , beta.se =  0.0333 , p-value =  7.8928e-02 . \n",
      "Total NO. of IVs=  71 , NO. of valid IVs with foreground signals:  19.50717 . \n",
      "***********************************************************\n",
      "Pair:  AD ~ Alcohol \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  AD  on  Alcohol : \n",
      "MR-APSS: beta =  -0.014 , beta.se =  0.0202 , p-value =  4.8908e-01 . \n",
      "Total NO. of IVs=  74 , NO. of valid IVs with foreground signals:  18.75627 . \n",
      "***********************************************************\n",
      "Pair:  AD ~ BMI \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  AD  on  BMI : \n",
      "MR-APSS: beta =  -0.016 , beta.se =  0.0293 , p-value =  5.8346e-01 . \n",
      "Total NO. of IVs=  69 , NO. of valid IVs with foreground signals:  18.26211 . \n",
      "***********************************************************\n",
      "Pair:  AD ~ Depression \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  AD  on  Depression : \n",
      "MR-APSS: beta =  -3e-04 , beta.se =  0.0162 , p-value =  9.8694e-01 . \n",
      "Total NO. of IVs=  68 , NO. of valid IVs with foreground signals:  17.27834 . \n",
      "***********************************************************\n",
      "Pair:  AD ~ IBD \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  AD  on  IBD : \n",
      "MR-APSS: beta =  0.0607 , beta.se =  0.0643 , p-value =  3.4474e-01 . \n",
      "Total NO. of IVs=  69 , NO. of valid IVs with foreground signals:  17.47261 . \n",
      "***********************************************************\n",
      "Pair:  AD ~ MDD \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  AD  on  MDD : \n",
      "MR-APSS: beta =  -0.0115 , beta.se =  0.0195 , p-value =  5.5477e-01 . \n",
      "Total NO. of IVs=  69 , NO. of valid IVs with foreground signals:  17.18142 . \n",
      "***********************************************************\n",
      "Pair:  AD ~ SCZ \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  AD  on  SCZ : \n",
      "MR-APSS: beta =  -0.0802 , beta.se =  0.0422 , p-value =  5.7303e-02 . \n",
      "Total NO. of IVs=  67 , NO. of valid IVs with foreground signals:  19.97172 . \n",
      "***********************************************************\n",
      "Pair:  AD ~ Angina \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  AD  on  Angina : \n",
      "MR-APSS: beta =  -0.0165 , beta.se =  0.0184 , p-value =  3.6917e-01 . \n",
      "Total NO. of IVs=  69 , NO. of valid IVs with foreground signals:  17.16725 . \n",
      "***********************************************************\n",
      "Pair:  AD ~ CAD \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  AD  on  CAD : \n",
      "MR-APSS: beta =  -0.0116 , beta.se =  0.023 , p-value =  6.1460e-01 . \n",
      "Total NO. of IVs=  75 , NO. of valid IVs with foreground signals:  19.23792 . \n",
      "***********************************************************\n",
      "Pair:  AD ~ HBP \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  AD  on  HBP : \n",
      "MR-APSS: beta =  0.0073 , beta.se =  0.0236 , p-value =  7.5662e-01 . \n",
      "Total NO. of IVs=  69 , NO. of valid IVs with foreground signals:  18.49143 . \n",
      "***********************************************************\n",
      "Pair:  AD ~ Income \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  AD  on  Income : \n",
      "MR-APSS: beta =  0.0065 , beta.se =  0.0192 , p-value =  7.3589e-01 . \n",
      "Total NO. of IVs=  79 , NO. of valid IVs with foreground signals:  19.73371 . \n",
      "***********************************************************\n",
      "Pair:  AD ~ NEB \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  AD  on  NEB : \n",
      "MR-APSS: beta =  -0.0226 , beta.se =  0.0199 , p-value =  2.5604e-01 . \n",
      "Total NO. of IVs=  65 , NO. of valid IVs with foreground signals:  17.79819 . \n",
      "***********************************************************\n",
      "Pair:  AD ~ Smoking \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  AD  on  Smoking : \n",
      "MR-APSS: beta =  7e-04 , beta.se =  0.0207 , p-value =  9.7198e-01 . \n",
      "Total NO. of IVs=  72 , NO. of valid IVs with foreground signals:  18.57148 . \n",
      "***********************************************************\n",
      "Pair:  AD ~ Urate \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  AD  on  Urate : \n",
      "MR-APSS: beta =  -0.0575 , beta.se =  0.0283 , p-value =  4.1664e-02 . \n",
      "Total NO. of IVs=  75 , NO. of valid IVs with foreground signals:  19.33699 . \n",
      "***********************************************************\n",
      "Pair:  AD ~ Anorexia \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  AD  on  Anorexia : \n",
      "MR-APSS: beta =  0.0088 , beta.se =  0.0401 , p-value =  8.2709e-01 . \n",
      "Total NO. of IVs=  72 , NO. of valid IVs with foreground signals:  20.14084 . \n",
      "***********************************************************\n",
      "Pair:  AD ~ CD \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  AD  on  CD : \n",
      "MR-APSS: beta =  0.0222 , beta.se =  0.0636 , p-value =  7.2690e-01 . \n",
      "Total NO. of IVs=  69 , NO. of valid IVs with foreground signals:  16.6697 . \n",
      "***********************************************************\n",
      "Pair:  AD ~ Height_GIANT \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  AD  on  Height_GIANT : \n",
      "MR-APSS: beta =  3e-04 , beta.se =  0.026 , p-value =  9.9058e-01 . \n",
      "Total NO. of IVs=  65 , NO. of valid IVs with foreground signals:  17.81756 . \n",
      "***********************************************************\n",
      "Pair:  AD ~ Insomnia \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  AD  on  Insomnia : \n",
      "MR-APSS: beta =  -0.0054 , beta.se =  0.0166 , p-value =  7.4466e-01 . \n",
      "Total NO. of IVs=  70 , NO. of valid IVs with foreground signals:  18.68998 . \n",
      "***********************************************************\n",
      "Pair:  AD ~ Neuroticism \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  AD  on  Neuroticism : \n",
      "MR-APSS: beta =  -0.0155 , beta.se =  0.0229 , p-value =  4.9980e-01 . \n",
      "Total NO. of IVs=  69 , NO. of valid IVs with foreground signals:  17.6841 . \n",
      "***********************************************************\n",
      "Pair:  AD ~ SWB \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  AD  on  SWB : \n",
      "MR-APSS: beta =  0.0157 , beta.se =  0.0209 , p-value =  4.5208e-01 . \n",
      "Total NO. of IVs=  68 , NO. of valid IVs with foreground signals:  17.75021 . \n",
      "***********************************************************\n",
      "Pair:  ASD ~ AD \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  ASD  on  AD : \n",
      "MR-APSS: beta =  -0.0098 , beta.se =  0.0841 , p-value =  9.0721e-01 . \n",
      "Total NO. of IVs=  40 , NO. of valid IVs with foreground signals:  39.99333 . \n",
      "***********************************************************\n",
      "Pair:  ASD ~ Daytime_Sleepiness \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  ASD  on  Daytime_Sleepiness : \n",
      "MR-APSS: beta =  -0.0734 , beta.se =  0.0323 , p-value =  2.2888e-02 . \n",
      "Total NO. of IVs=  40 , NO. of valid IVs with foreground signals:  39.98983 . \n",
      "***********************************************************\n",
      "Pair:  ASD ~ Height_UKB \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  ASD  on  Height_UKB : \n",
      "MR-APSS: beta =  0.0857 , beta.se =  0.0624 , p-value =  1.7009e-01 . \n",
      "Total NO. of IVs=  39 , NO. of valid IVs with foreground signals:  38.9945 . \n",
      "***********************************************************\n",
      "Pair:  ASD ~ Intelligence \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  ASD  on  Intelligence : \n",
      "MR-APSS: beta =  0.0162 , beta.se =  0.0813 , p-value =  8.4222e-01 . \n",
      "Total NO. of IVs=  39 , NO. of valid IVs with foreground signals:  38.9644 . \n",
      "***********************************************************\n",
      "Pair:  ASD ~ RA \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  ASD  on  RA : \n",
      "MR-APSS: beta =  0.1033 , beta.se =  0.104 , p-value =  3.2072e-01 . \n",
      "Total NO. of IVs=  37 , NO. of valid IVs with foreground signals:  20.87723 . \n",
      "***********************************************************\n",
      "Pair:  ASD ~ T2D \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  ASD  on  T2D : \n",
      "MR-APSS: beta =  -0.0536 , beta.se =  0.0596 , p-value =  3.6772e-01 . \n",
      "Total NO. of IVs=  41 , NO. of valid IVs with foreground signals:  40.98521 . \n",
      "***********************************************************\n",
      "Pair:  ASD ~ Alcohol \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  ASD  on  Alcohol : \n",
      "MR-APSS: beta =  0.0038 , beta.se =  0.0333 , p-value =  9.0987e-01 . \n",
      "Total NO. of IVs=  41 , NO. of valid IVs with foreground signals:  40.99235 . \n",
      "***********************************************************\n",
      "Pair:  ASD ~ BMI \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  ASD  on  BMI : \n",
      "MR-APSS: beta =  -0.0077 , beta.se =  0.0527 , p-value =  8.8415e-01 . \n",
      "Total NO. of IVs=  39 , NO. of valid IVs with foreground signals:  38.97725 . \n",
      "***********************************************************\n",
      "Pair:  ASD ~ Depression \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  ASD  on  Depression : \n",
      "MR-APSS: beta =  0.0502 , beta.se =  0.0434 , p-value =  2.4656e-01 . \n",
      "Total NO. of IVs=  39 , NO. of valid IVs with foreground signals:  30.08095 . \n",
      "***********************************************************\n",
      "Pair:  ASD ~ IBD \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  ASD  on  IBD : \n",
      "MR-APSS: beta =  -0.0541 , beta.se =  0.0909 , p-value =  5.5179e-01 . \n",
      "Total NO. of IVs=  38 , NO. of valid IVs with foreground signals:  37.97736 . \n",
      "***********************************************************\n",
      "Pair:  ASD ~ MDD \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  ASD  on  MDD : \n",
      "MR-APSS: beta =  0.0144 , beta.se =  0.0364 , p-value =  6.9288e-01 . \n",
      "Total NO. of IVs=  39 , NO. of valid IVs with foreground signals:  38.99395 . \n",
      "***********************************************************\n",
      "Pair:  ASD ~ SCZ \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  ASD  on  SCZ : \n",
      "MR-APSS: beta =  0.0725 , beta.se =  0.0784 , p-value =  3.5518e-01 . \n",
      "Total NO. of IVs=  41 , NO. of valid IVs with foreground signals:  40.9919 . \n",
      "***********************************************************\n",
      "Pair:  ASD ~ Angina \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  ASD  on  Angina : \n",
      "MR-APSS: beta =  -0.023 , beta.se =  0.0372 , p-value =  5.3620e-01 . \n",
      "Total NO. of IVs=  39 , NO. of valid IVs with foreground signals:  38.99038 . \n",
      "***********************************************************\n",
      "Pair:  ASD ~ CAD \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  ASD  on  CAD : \n",
      "MR-APSS: beta =  -0.0218 , beta.se =  0.042 , p-value =  6.0288e-01 . \n",
      "Total NO. of IVs=  41 , NO. of valid IVs with foreground signals:  40.98869 . \n",
      "***********************************************************\n",
      "Pair:  ASD ~ HBP \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  ASD  on  HBP : \n",
      "MR-APSS: beta =  -0.0558 , beta.se =  0.0451 , p-value =  2.1612e-01 . \n",
      "Total NO. of IVs=  39 , NO. of valid IVs with foreground signals:  38.99269 . \n",
      "***********************************************************\n",
      "Pair:  ASD ~ Income \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  ASD  on  Income : \n",
      "MR-APSS: beta =  -0.0395 , beta.se =  0.0381 , p-value =  3.0005e-01 . \n",
      "Total NO. of IVs=  41 , NO. of valid IVs with foreground signals:  40.9869 . \n",
      "***********************************************************\n",
      "Pair:  ASD ~ NEB \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  ASD  on  NEB : \n",
      "MR-APSS: beta =  0.0045 , beta.se =  0.0281 , p-value =  8.7166e-01 . \n",
      "Total NO. of IVs=  35 , NO. of valid IVs with foreground signals:  34.99334 . \n",
      "***********************************************************\n",
      "Pair:  ASD ~ Smoking \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  ASD  on  Smoking : \n",
      "MR-APSS: beta =  0.0775 , beta.se =  0.0545 , p-value =  1.5511e-01 . \n",
      "Total NO. of IVs=  39 , NO. of valid IVs with foreground signals:  38.98693 . \n",
      "***********************************************************\n",
      "Pair:  ASD ~ Urate \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  ASD  on  Urate : \n",
      "MR-APSS: beta =  0.0482 , beta.se =  0.0469 , p-value =  3.0374e-01 . \n",
      "Total NO. of IVs=  35 , NO. of valid IVs with foreground signals:  34.99342 . \n",
      "***********************************************************\n",
      "Pair:  ASD ~ Anorexia \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  ASD  on  Anorexia : \n",
      "MR-APSS: beta =  -0.275 , beta.se =  0.186 , p-value =  1.3932e-01 . \n",
      "Total NO. of IVs=  35 , NO. of valid IVs with foreground signals:  4.564259 . \n",
      "***********************************************************\n",
      "Pair:  ASD ~ CD \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  ASD  on  CD : \n",
      "MR-APSS: beta =  0.0595 , beta.se =  0.1164 , p-value =  6.0964e-01 . \n",
      "Total NO. of IVs=  38 , NO. of valid IVs with foreground signals:  37.98361 . \n",
      "***********************************************************\n",
      "Pair:  ASD ~ Height_GIANT \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  ASD  on  Height_GIANT : \n",
      "MR-APSS: beta =  0.089 , beta.se =  0.0537 , p-value =  9.7069e-02 . \n",
      "Total NO. of IVs=  35 , NO. of valid IVs with foreground signals:  34.99446 . \n",
      "***********************************************************\n",
      "Pair:  ASD ~ Insomnia \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  ASD  on  Insomnia : \n",
      "MR-APSS: beta =  -0.0272 , beta.se =  0.041 , p-value =  5.0793e-01 . \n",
      "Total NO. of IVs=  40 , NO. of valid IVs with foreground signals:  39.98651 . \n",
      "***********************************************************\n",
      "Pair:  ASD ~ Neuroticism \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  ASD  on  Neuroticism : \n",
      "MR-APSS: beta =  0.0525 , beta.se =  0.0902 , p-value =  5.6047e-01 . \n",
      "Total NO. of IVs=  39 , NO. of valid IVs with foreground signals:  14.29352 . \n",
      "***********************************************************\n",
      "Pair:  ASD ~ SWB \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  ASD  on  SWB : \n",
      "MR-APSS: beta =  -0.0751 , beta.se =  0.0383 , p-value =  5.0194e-02 . \n",
      "Total NO. of IVs=  35 , NO. of valid IVs with foreground signals:  34.99272 . \n",
      "***********************************************************\n",
      "Pair:  Daytime_Sleepiness ~ AD \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  Daytime_Sleepiness  on  AD : \n",
      "MR-APSS: beta =  -0.0176 , beta.se =  0.0999 , p-value =  8.5979e-01 . \n",
      "Total NO. of IVs=  248 , NO. of valid IVs with foreground signals:  72.26229 . \n",
      "***********************************************************\n",
      "Pair:  Daytime_Sleepiness ~ ASD \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  Daytime_Sleepiness  on  ASD : \n",
      "MR-APSS: beta =  -0.3362 , beta.se =  0.2281 , p-value =  1.4045e-01 . \n",
      "Total NO. of IVs=  248 , NO. of valid IVs with foreground signals:  75.04896 . \n",
      "***********************************************************\n",
      "Pair:  Daytime_Sleepiness ~ Height_UKB \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  Daytime_Sleepiness  on  Height_UKB : \n",
      "MR-APSS: beta =  0.2132 , beta.se =  0.1532 , p-value =  1.6405e-01 . \n",
      "Total NO. of IVs=  243 , NO. of valid IVs with foreground signals:  63.64524 . \n",
      "***********************************************************\n",
      "Pair:  Daytime_Sleepiness ~ Intelligence \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  Daytime_Sleepiness  on  Intelligence : \n",
      "MR-APSS: beta =  0.0852 , beta.se =  0.1186 , p-value =  4.7254e-01 . \n",
      "Total NO. of IVs=  243 , NO. of valid IVs with foreground signals:  77.1203 . \n",
      "***********************************************************\n",
      "Pair:  Daytime_Sleepiness ~ RA \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  Daytime_Sleepiness  on  RA : \n",
      "MR-APSS: beta =  0.0939 , beta.se =  0.0967 , p-value =  3.3120e-01 . \n",
      "Total NO. of IVs=  243 , NO. of valid IVs with foreground signals:  69.05547 . \n",
      "***********************************************************\n",
      "Pair:  Daytime_Sleepiness ~ T2D \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  Daytime_Sleepiness  on  T2D : \n",
      "MR-APSS: beta =  0.0663 , beta.se =  0.1036 , p-value =  5.2196e-01 . \n",
      "Total NO. of IVs=  248 , NO. of valid IVs with foreground signals:  65.08714 . \n",
      "***********************************************************\n",
      "Pair:  Daytime_Sleepiness ~ Alcohol \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  Daytime_Sleepiness  on  Alcohol : \n",
      "MR-APSS: beta =  -0.1066 , beta.se =  0.0938 , p-value =  2.5576e-01 . \n",
      "Total NO. of IVs=  249 , NO. of valid IVs with foreground signals:  62.92195 . \n",
      "***********************************************************\n",
      "Pair:  Daytime_Sleepiness ~ BMI \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  Daytime_Sleepiness  on  BMI : \n",
      "MR-APSS: beta =  0.288 , beta.se =  0.1261 , p-value =  2.2359e-02 . \n",
      "Total NO. of IVs=  243 , NO. of valid IVs with foreground signals:  62.60258 . \n",
      "***********************************************************\n",
      "Pair:  Daytime_Sleepiness ~ Depression \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  Daytime_Sleepiness  on  Depression : \n",
      "MR-APSS: beta =  0.0509 , beta.se =  0.0582 , p-value =  3.8108e-01 . \n",
      "Total NO. of IVs=  243 , NO. of valid IVs with foreground signals:  69.10102 . \n",
      "***********************************************************\n",
      "Pair:  Daytime_Sleepiness ~ IBD \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  Daytime_Sleepiness  on  IBD : \n",
      "MR-APSS: beta =  -0.0386 , beta.se =  0.1517 , p-value =  7.9921e-01 . \n",
      "Total NO. of IVs=  241 , NO. of valid IVs with foreground signals:  59.66146 . \n",
      "***********************************************************\n",
      "Pair:  Daytime_Sleepiness ~ MDD \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  Daytime_Sleepiness  on  MDD : \n",
      "MR-APSS: beta =  -0.0199 , beta.se =  0.056 , p-value =  7.2228e-01 . \n",
      "Total NO. of IVs=  243 , NO. of valid IVs with foreground signals:  78.81413 . \n",
      "***********************************************************\n",
      "Pair:  Daytime_Sleepiness ~ SCZ \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  Daytime_Sleepiness  on  SCZ : \n",
      "MR-APSS: beta =  0.2204 , beta.se =  0.1489 , p-value =  1.3872e-01 . \n",
      "Total NO. of IVs=  245 , NO. of valid IVs with foreground signals:  94.52319 . \n",
      "***********************************************************\n",
      "Pair:  Daytime_Sleepiness ~ Angina \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  Daytime_Sleepiness  on  Angina : \n",
      "MR-APSS: beta =  0.0807 , beta.se =  0.0464 , p-value =  8.1910e-02 . \n",
      "Total NO. of IVs=  243 , NO. of valid IVs with foreground signals:  69.71017 . \n",
      "***********************************************************\n",
      "Pair:  Daytime_Sleepiness ~ CAD \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  Daytime_Sleepiness  on  CAD : \n",
      "MR-APSS: beta =  0.1193 , beta.se =  0.0631 , p-value =  5.8511e-02 . \n",
      "Total NO. of IVs=  249 , NO. of valid IVs with foreground signals:  68.12798 . \n",
      "***********************************************************\n",
      "Pair:  Daytime_Sleepiness ~ HBP \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  Daytime_Sleepiness  on  HBP : \n",
      "MR-APSS: beta =  0.0909 , beta.se =  0.0689 , p-value =  1.8711e-01 . \n",
      "Total NO. of IVs=  243 , NO. of valid IVs with foreground signals:  71.86232 . \n",
      "***********************************************************\n",
      "Pair:  Daytime_Sleepiness ~ Income \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  Daytime_Sleepiness  on  Income : \n",
      "MR-APSS: beta =  0.0391 , beta.se =  0.0749 , p-value =  6.0159e-01 . \n",
      "Total NO. of IVs=  249 , NO. of valid IVs with foreground signals:  71.31906 . \n",
      "***********************************************************\n",
      "Pair:  Daytime_Sleepiness ~ NEB \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  Daytime_Sleepiness  on  NEB : \n",
      "MR-APSS: beta =  0.0201 , beta.se =  0.0537 , p-value =  7.0804e-01 . \n",
      "Total NO. of IVs=  241 , NO. of valid IVs with foreground signals:  69.02537 . \n",
      "***********************************************************\n",
      "Pair:  Daytime_Sleepiness ~ Smoking \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  Daytime_Sleepiness  on  Smoking : \n",
      "MR-APSS: beta =  0.018 , beta.se =  0.0741 , p-value =  8.0833e-01 . \n",
      "Total NO. of IVs=  248 , NO. of valid IVs with foreground signals:  74.93388 . \n",
      "***********************************************************\n",
      "Pair:  Daytime_Sleepiness ~ Urate \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  Daytime_Sleepiness  on  Urate : \n",
      "MR-APSS: beta =  0.2507 , beta.se =  0.1134 , p-value =  2.6986e-02 . \n",
      "Total NO. of IVs=  242 , NO. of valid IVs with foreground signals:  62.02157 . \n",
      "***********************************************************\n",
      "Pair:  Daytime_Sleepiness ~ Anorexia \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  Daytime_Sleepiness  on  Anorexia : \n",
      "MR-APSS: beta =  0.0384 , beta.se =  0.1163 , p-value =  7.4115e-01 . \n",
      "Total NO. of IVs=  221 , NO. of valid IVs with foreground signals:  62.68828 . \n",
      "***********************************************************\n",
      "Pair:  Daytime_Sleepiness ~ CD \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  Daytime_Sleepiness  on  CD : \n",
      "MR-APSS: beta =  -0.1457 , beta.se =  0.2024 , p-value =  4.7137e-01 . \n",
      "Total NO. of IVs=  241 , NO. of valid IVs with foreground signals:  57.28221 . \n",
      "***********************************************************\n",
      "Pair:  Daytime_Sleepiness ~ Height_GIANT \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  Daytime_Sleepiness  on  Height_GIANT : \n",
      "MR-APSS: beta =  0.2123 , beta.se =  0.1314 , p-value =  1.0614e-01 . \n",
      "Total NO. of IVs=  240 , NO. of valid IVs with foreground signals:  59.03651 . \n",
      "***********************************************************\n",
      "Pair:  Daytime_Sleepiness ~ Insomnia \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  Daytime_Sleepiness  on  Insomnia : \n",
      "MR-APSS: beta =  0.1932 , beta.se =  0.0734 , p-value =  8.4763e-03 . \n",
      "Total NO. of IVs=  249 , NO. of valid IVs with foreground signals:  73.27844 . \n",
      "***********************************************************\n",
      "Pair:  Daytime_Sleepiness ~ Neuroticism \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  Daytime_Sleepiness  on  Neuroticism : \n",
      "MR-APSS: beta =  0.0748 , beta.se =  0.0869 , p-value =  3.8942e-01 . \n",
      "Total NO. of IVs=  243 , NO. of valid IVs with foreground signals:  71.60473 . \n",
      "***********************************************************\n",
      "Pair:  Daytime_Sleepiness ~ SWB \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  Daytime_Sleepiness  on  SWB : \n",
      "MR-APSS: beta =  -0.0222 , beta.se =  0.0508 , p-value =  6.6207e-01 . \n",
      "Total NO. of IVs=  242 , NO. of valid IVs with foreground signals:  69.17492 . \n",
      "***********************************************************\n",
      "Pair:  Height_UKB ~ AD \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  Height_UKB  on  AD : \n",
      "MR-APSS: beta =  -0.0423 , beta.se =  0.0149 , p-value =  4.4081e-03 . \n",
      "Total NO. of IVs=  2217 , NO. of valid IVs with foreground signals:  394.3933 . \n",
      "***********************************************************\n",
      "Pair:  Height_UKB ~ ASD \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  Height_UKB  on  ASD : \n",
      "MR-APSS: beta =  0.0124 , beta.se =  0.0238 , p-value =  6.0224e-01 . \n",
      "Total NO. of IVs=  2220 , NO. of valid IVs with foreground signals:  387.8746 . \n",
      "***********************************************************\n",
      "Pair:  Height_UKB ~ Daytime_Sleepiness \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  Height_UKB  on  Daytime_Sleepiness : \n",
      "MR-APSS: beta =  -0.0031 , beta.se =  0.0058 , p-value =  5.9422e-01 . \n",
      "Total NO. of IVs=  2226 , NO. of valid IVs with foreground signals:  395.3283 . \n",
      "***********************************************************\n",
      "Pair:  Height_UKB ~ Intelligence \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  Height_UKB  on  Intelligence : \n",
      "MR-APSS: beta =  0.0741 , beta.se =  0.013 , p-value =  1.3414e-08 . \n",
      "Total NO. of IVs=  2227 , NO. of valid IVs with foreground signals:  393.1643 . \n",
      "***********************************************************\n",
      "Pair:  Height_UKB ~ RA \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  Height_UKB  on  RA : \n",
      "MR-APSS: beta =  0.0434 , beta.se =  0.0156 , p-value =  5.4557e-03 . \n",
      "Total NO. of IVs=  2224 , NO. of valid IVs with foreground signals:  397.4994 . \n",
      "***********************************************************\n",
      "Pair:  Height_UKB ~ T2D \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  Height_UKB  on  T2D : \n",
      "MR-APSS: beta =  -0.0083 , beta.se =  0.0143 , p-value =  5.6033e-01 . \n",
      "Total NO. of IVs=  2218 , NO. of valid IVs with foreground signals:  403.5913 . \n",
      "***********************************************************\n",
      "Pair:  Height_UKB ~ Alcohol \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  Height_UKB  on  Alcohol : \n",
      "MR-APSS: beta =  0.0159 , beta.se =  0.0078 , p-value =  4.1325e-02 . \n",
      "Total NO. of IVs=  2225 , NO. of valid IVs with foreground signals:  390.1198 . \n",
      "***********************************************************\n",
      "Pair:  Height_UKB ~ BMI \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  Height_UKB  on  BMI : \n",
      "MR-APSS: beta =  -0.0637 , beta.se =  0.0135 , p-value =  2.4801e-06 . \n",
      "Total NO. of IVs=  2226 , NO. of valid IVs with foreground signals:  405.4622 . \n",
      "***********************************************************\n",
      "Pair:  Height_UKB ~ Depression \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  Height_UKB  on  Depression : \n",
      "MR-APSS: beta =  -0.0122 , beta.se =  0.0056 , p-value =  2.9436e-02 . \n",
      "Total NO. of IVs=  2223 , NO. of valid IVs with foreground signals:  394.3694 . \n",
      "***********************************************************\n",
      "Pair:  Height_UKB ~ IBD \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  Height_UKB  on  IBD : \n",
      "MR-APSS: beta =  0.0319 , beta.se =  0.0197 , p-value =  1.0478e-01 . \n",
      "Total NO. of IVs=  2224 , NO. of valid IVs with foreground signals:  399.6071 . \n",
      "***********************************************************\n",
      "Pair:  Height_UKB ~ MDD \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  Height_UKB  on  MDD : \n",
      "MR-APSS: beta =  7e-04 , beta.se =  0.0059 , p-value =  9.0627e-01 . \n",
      "Total NO. of IVs=  2227 , NO. of valid IVs with foreground signals:  393.867 . \n",
      "***********************************************************\n",
      "Pair:  Height_UKB ~ SCZ \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  Height_UKB  on  SCZ : \n",
      "MR-APSS: beta =  -0.0147 , beta.se =  0.0144 , p-value =  3.0679e-01 . \n",
      "Total NO. of IVs=  2185 , NO. of valid IVs with foreground signals:  387.4595 . \n",
      "***********************************************************\n",
      "Pair:  Height_UKB ~ Angina \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  Height_UKB  on  Angina : \n",
      "MR-APSS: beta =  -0.0301 , beta.se =  0.0073 , p-value =  3.9853e-05 . \n",
      "Total NO. of IVs=  2227 , NO. of valid IVs with foreground signals:  400.5705 . \n",
      "***********************************************************\n",
      "Pair:  Height_UKB ~ CAD \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  Height_UKB  on  CAD : \n",
      "MR-APSS: beta =  -0.057 , beta.se =  0.0106 , p-value =  7.3636e-08 . \n",
      "Total NO. of IVs=  2224 , NO. of valid IVs with foreground signals:  396.5718 . \n",
      "***********************************************************\n",
      "Pair:  Height_UKB ~ HBP \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  Height_UKB  on  HBP : \n",
      "MR-APSS: beta =  -0.031 , beta.se =  0.011 , p-value =  4.8120e-03 . \n",
      "Total NO. of IVs=  2227 , NO. of valid IVs with foreground signals:  413.7424 . \n",
      "***********************************************************\n",
      "Pair:  Height_UKB ~ Income \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  Height_UKB  on  Income : \n",
      "MR-APSS: beta =  0.0543 , beta.se =  0.0077 , p-value =  1.6180e-12 . \n",
      "Total NO. of IVs=  2226 , NO. of valid IVs with foreground signals:  395.2777 . \n",
      "***********************************************************\n",
      "Pair:  Height_UKB ~ NEB \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  Height_UKB  on  NEB : \n",
      "MR-APSS: beta =  0.001 , beta.se =  0.0056 , p-value =  8.5618e-01 . \n",
      "Total NO. of IVs=  2187 , NO. of valid IVs with foreground signals:  385.1921 . \n",
      "***********************************************************\n",
      "Pair:  Height_UKB ~ Smoking \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  Height_UKB  on  Smoking : \n",
      "MR-APSS: beta =  -0.0037 , beta.se =  0.0068 , p-value =  5.8862e-01 . \n",
      "Total NO. of IVs=  2208 , NO. of valid IVs with foreground signals:  382.5819 . \n",
      "***********************************************************\n",
      "Pair:  Height_UKB ~ Urate \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  Height_UKB  on  Urate : \n",
      "MR-APSS: beta =  0 , beta.se =  0.002 , p-value =  9.8785e-01 . \n",
      "Total NO. of IVs=  2199 , NO. of valid IVs with foreground signals:  386.6527 . \n",
      "***********************************************************\n",
      "Pair:  Height_UKB ~ Anorexia \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  Height_UKB  on  Anorexia : \n",
      "MR-APSS: beta =  0.0123 , beta.se =  0.0129 , p-value =  3.3995e-01 . \n",
      "Total NO. of IVs=  2077 , NO. of valid IVs with foreground signals:  347.0775 . \n",
      "***********************************************************\n",
      "Pair:  Height_UKB ~ CD \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  Height_UKB  on  CD : \n",
      "MR-APSS: beta =  0.0203 , beta.se =  0.024 , p-value =  3.9864e-01 . \n",
      "Total NO. of IVs=  2224 , NO. of valid IVs with foreground signals:  398.9499 . \n",
      "***********************************************************\n",
      "Pair:  Height_UKB ~ Height_GIANT \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  Height_UKB  on  Height_GIANT : \n",
      "MR-APSS: beta =  0.8087 , beta.se =  0.0233 , p-value =  3.8481e-264 . \n",
      "Total NO. of IVs=  2176 , NO. of valid IVs with foreground signals:  396.9522 . \n",
      "***********************************************************\n",
      "Pair:  Height_UKB ~ Insomnia \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  Height_UKB  on  Insomnia : \n",
      "MR-APSS: beta =  -0.0148 , beta.se =  0.0066 , p-value =  2.4493e-02 . \n",
      "Total NO. of IVs=  2226 , NO. of valid IVs with foreground signals:  394.8063 . \n",
      "***********************************************************\n",
      "Pair:  Height_UKB ~ Neuroticism \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  Height_UKB  on  Neuroticism : \n",
      "MR-APSS: beta =  -0.0114 , beta.se =  0.0078 , p-value =  1.4150e-01 . \n",
      "Total NO. of IVs=  2227 , NO. of valid IVs with foreground signals:  396.4799 . \n",
      "***********************************************************\n",
      "Pair:  Height_UKB ~ SWB \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  Height_UKB  on  SWB : \n",
      "MR-APSS: beta =  -0.0045 , beta.se =  0.006 , p-value =  4.5485e-01 . \n",
      "Total NO. of IVs=  2188 , NO. of valid IVs with foreground signals:  381.1223 . \n",
      "***********************************************************\n",
      "Pair:  Intelligence ~ AD \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  Intelligence  on  AD : \n",
      "MR-APSS: beta =  -0.132 , beta.se =  0.0781 , p-value =  9.1069e-02 . \n",
      "Total NO. of IVs=  402 , NO. of valid IVs with foreground signals:  68.47134 . \n",
      "***********************************************************\n",
      "Pair:  Intelligence ~ ASD \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  Intelligence  on  ASD : \n",
      "MR-APSS: beta =  0.2629 , beta.se =  0.1392 , p-value =  5.8973e-02 . \n",
      "Total NO. of IVs=  400 , NO. of valid IVs with foreground signals:  64.49809 . \n",
      "***********************************************************\n",
      "Pair:  Intelligence ~ Daytime_Sleepiness \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  Intelligence  on  Daytime_Sleepiness : \n",
      "MR-APSS: beta =  -0.0476 , beta.se =  0.0377 , p-value =  2.0658e-01 . \n",
      "Total NO. of IVs=  400 , NO. of valid IVs with foreground signals:  73.16991 . \n",
      "***********************************************************\n",
      "Pair:  Intelligence ~ Height_UKB \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  Intelligence  on  Height_UKB : \n",
      "MR-APSS: beta =  0.3158 , beta.se =  0.1162 , p-value =  6.5739e-03 . \n",
      "Total NO. of IVs=  403 , NO. of valid IVs with foreground signals:  55.59181 . \n",
      "***********************************************************\n",
      "Pair:  Intelligence ~ RA \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  Intelligence  on  RA : \n",
      "MR-APSS: beta =  -0.2003 , beta.se =  0.0745 , p-value =  7.1698e-03 . \n",
      "Total NO. of IVs=  401 , NO. of valid IVs with foreground signals:  74.34622 . \n",
      "***********************************************************\n",
      "Pair:  Intelligence ~ T2D \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  Intelligence  on  T2D : \n",
      "MR-APSS: beta =  -0.0388 , beta.se =  0.0751 , p-value =  6.0590e-01 . \n",
      "Total NO. of IVs=  398 , NO. of valid IVs with foreground signals:  67.5893 . \n",
      "***********************************************************\n",
      "Pair:  Intelligence ~ Alcohol \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  Intelligence  on  Alcohol : \n",
      "MR-APSS: beta =  0.0738 , beta.se =  0.0497 , p-value =  1.3745e-01 . \n",
      "Total NO. of IVs=  403 , NO. of valid IVs with foreground signals:  68.69851 . \n",
      "***********************************************************\n",
      "Pair:  Intelligence ~ BMI \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  Intelligence  on  BMI : \n",
      "MR-APSS: beta =  -0.1521 , beta.se =  0.0813 , p-value =  6.1363e-02 . \n",
      "Total NO. of IVs=  403 , NO. of valid IVs with foreground signals:  73.14071 . \n",
      "***********************************************************\n",
      "Pair:  Intelligence ~ Depression \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  Intelligence  on  Depression : \n",
      "MR-APSS: beta =  -0.1037 , beta.se =  0.0332 , p-value =  1.7773e-03 . \n",
      "Total NO. of IVs=  400 , NO. of valid IVs with foreground signals:  78.37219 . \n",
      "***********************************************************\n",
      "Pair:  Intelligence ~ IBD \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  Intelligence  on  IBD : \n",
      "MR-APSS: beta =  0.0408 , beta.se =  0.1023 , p-value =  6.9012e-01 . \n",
      "Total NO. of IVs=  402 , NO. of valid IVs with foreground signals:  56.01873 . \n",
      "***********************************************************\n",
      "Pair:  Intelligence ~ MDD \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  Intelligence  on  MDD : \n",
      "MR-APSS: beta =  0.0225 , beta.se =  0.0351 , p-value =  5.2168e-01 . \n",
      "Total NO. of IVs=  403 , NO. of valid IVs with foreground signals:  76.48664 . \n",
      "***********************************************************\n",
      "Pair:  Intelligence ~ SCZ \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  Intelligence  on  SCZ : \n",
      "MR-APSS: beta =  -0.3238 , beta.se =  0.1043 , p-value =  1.9152e-03 . \n",
      "Total NO. of IVs=  391 , NO. of valid IVs with foreground signals:  78.86244 . \n",
      "***********************************************************\n",
      "Pair:  Intelligence ~ Angina \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  Intelligence  on  Angina : \n",
      "MR-APSS: beta =  -0.0538 , beta.se =  0.0279 , p-value =  5.3997e-02 . \n",
      "Total NO. of IVs=  403 , NO. of valid IVs with foreground signals:  70.3657 . \n",
      "***********************************************************\n",
      "Pair:  Intelligence ~ CAD \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  Intelligence  on  CAD : \n",
      "MR-APSS: beta =  -0.0966 , beta.se =  0.0384 , p-value =  1.1915e-02 . \n",
      "Total NO. of IVs=  403 , NO. of valid IVs with foreground signals:  70.0773 . \n",
      "***********************************************************\n",
      "Pair:  Intelligence ~ HBP \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  Intelligence  on  HBP : \n",
      "MR-APSS: beta =  -0.0261 , beta.se =  0.0476 , p-value =  5.8362e-01 . \n",
      "Total NO. of IVs=  403 , NO. of valid IVs with foreground signals:  65.09508 . \n",
      "***********************************************************\n",
      "Pair:  Intelligence ~ Income \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  Intelligence  on  Income : \n",
      "MR-APSS: beta =  0.3553 , beta.se =  0.0594 , p-value =  2.2285e-09 . \n",
      "Total NO. of IVs=  403 , NO. of valid IVs with foreground signals:  62.32222 . \n",
      "***********************************************************\n",
      "Pair:  Intelligence ~ NEB \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  Intelligence  on  NEB : \n",
      "MR-APSS: beta =  -0.0579 , beta.se =  0.0332 , p-value =  8.0849e-02 . \n",
      "Total NO. of IVs=  385 , NO. of valid IVs with foreground signals:  71.57483 . \n",
      "***********************************************************\n",
      "Pair:  Intelligence ~ Smoking \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  Intelligence  on  Smoking : \n",
      "MR-APSS: beta =  -0.0762 , beta.se =  0.0435 , p-value =  7.9629e-02 . \n",
      "Total NO. of IVs=  398 , NO. of valid IVs with foreground signals:  79.91094 . \n",
      "***********************************************************\n",
      "Pair:  Intelligence ~ Urate \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  Intelligence  on  Urate : \n",
      "MR-APSS: beta =  -0.0049 , beta.se =  0.0527 , p-value =  9.2658e-01 . \n",
      "Total NO. of IVs=  386 , NO. of valid IVs with foreground signals:  65.97606 . \n",
      "***********************************************************\n",
      "Pair:  Intelligence ~ Anorexia \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  Intelligence  on  Anorexia : \n",
      "MR-APSS: beta =  0.1965 , beta.se =  0.0895 , p-value =  2.8216e-02 . \n",
      "Total NO. of IVs=  365 , NO. of valid IVs with foreground signals:  68.22473 . \n",
      "***********************************************************\n",
      "Pair:  Intelligence ~ CD \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  Intelligence  on  CD : \n",
      "MR-APSS: beta =  0.0725 , beta.se =  0.1304 , p-value =  5.7858e-01 . \n",
      "Total NO. of IVs=  402 , NO. of valid IVs with foreground signals:  53.93816 . \n",
      "***********************************************************\n",
      "Pair:  Intelligence ~ Height_GIANT \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  Intelligence  on  Height_GIANT : \n",
      "MR-APSS: beta =  0.161 , beta.se =  0.1052 , p-value =  1.2577e-01 . \n",
      "Total NO. of IVs=  383 , NO. of valid IVs with foreground signals:  47.06809 . \n",
      "***********************************************************\n",
      "Pair:  Intelligence ~ Insomnia \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  Intelligence  on  Insomnia : \n",
      "MR-APSS: beta =  -0.0492 , beta.se =  0.0393 , p-value =  2.1088e-01 . \n",
      "Total NO. of IVs=  400 , NO. of valid IVs with foreground signals:  87.20293 . \n",
      "***********************************************************\n",
      "Pair:  Intelligence ~ Neuroticism \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  Intelligence  on  Neuroticism : \n",
      "MR-APSS: beta =  -0.123 , beta.se =  0.0471 , p-value =  9.1101e-03 . \n",
      "Total NO. of IVs=  403 , NO. of valid IVs with foreground signals:  85.26204 . \n",
      "***********************************************************\n",
      "Pair:  Intelligence ~ SWB \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  Intelligence  on  SWB : \n",
      "MR-APSS: beta =  -0.005 , beta.se =  0.0294 , p-value =  8.6445e-01 . \n",
      "Total NO. of IVs=  384 , NO. of valid IVs with foreground signals:  67.21424 . \n",
      "***********************************************************\n",
      "Pair:  RA ~ AD \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  RA  on  AD : \n",
      "MR-APSS: beta =  -0.0192 , beta.se =  0.0247 , p-value =  4.3571e-01 . \n",
      "Total NO. of IVs=  134 , NO. of valid IVs with foreground signals:  95.80056 . \n",
      "***********************************************************\n",
      "Pair:  RA ~ ASD \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  RA  on  ASD : \n",
      "MR-APSS: beta =  -0.0234 , beta.se =  0.042 , p-value =  5.7718e-01 . \n",
      "Total NO. of IVs=  135 , NO. of valid IVs with foreground signals:  96.04267 . \n",
      "***********************************************************\n",
      "Pair:  RA ~ Daytime_Sleepiness \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  RA  on  Daytime_Sleepiness : \n",
      "MR-APSS: beta =  0.0172 , beta.se =  0.0091 , p-value =  5.7553e-02 . \n",
      "Total NO. of IVs=  134 , NO. of valid IVs with foreground signals:  95.43812 . \n",
      "***********************************************************\n",
      "Pair:  RA ~ Height_UKB \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  RA  on  Height_UKB : \n",
      "MR-APSS: beta =  0.0058 , beta.se =  0.021 , p-value =  7.8239e-01 . \n",
      "Total NO. of IVs=  134 , NO. of valid IVs with foreground signals:  93.60023 . \n",
      "***********************************************************\n",
      "Pair:  RA ~ Intelligence \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  RA  on  Intelligence : \n",
      "MR-APSS: beta =  -0.0198 , beta.se =  0.0228 , p-value =  3.8493e-01 . \n",
      "Total NO. of IVs=  135 , NO. of valid IVs with foreground signals:  91.9647 . \n",
      "***********************************************************\n",
      "Pair:  RA ~ T2D \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  RA  on  T2D : \n",
      "MR-APSS: beta =  0.029 , beta.se =  0.0186 , p-value =  1.1921e-01 . \n",
      "Total NO. of IVs=  134 , NO. of valid IVs with foreground signals:  94.35637 . \n",
      "***********************************************************\n",
      "Pair:  RA ~ Alcohol \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  RA  on  Alcohol : \n",
      "MR-APSS: beta =  -0.0107 , beta.se =  0.0102 , p-value =  2.9199e-01 . \n",
      "Total NO. of IVs=  135 , NO. of valid IVs with foreground signals:  95.60043 . \n",
      "***********************************************************\n",
      "Pair:  RA ~ BMI \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  RA  on  BMI : \n",
      "MR-APSS: beta =  -0.0151 , beta.se =  0.0169 , p-value =  3.7019e-01 . \n",
      "Total NO. of IVs=  135 , NO. of valid IVs with foreground signals:  97.71269 . \n",
      "***********************************************************\n",
      "Pair:  RA ~ Depression \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  RA  on  Depression : \n",
      "MR-APSS: beta =  -0.0062 , beta.se =  0.0103 , p-value =  5.4359e-01 . \n",
      "Total NO. of IVs=  134 , NO. of valid IVs with foreground signals:  95.49594 . \n",
      "***********************************************************\n",
      "Pair:  RA ~ IBD \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  RA  on  IBD : \n",
      "MR-APSS: beta =  -0.1586 , beta.se =  0.0604 , p-value =  8.6919e-03 . \n",
      "Total NO. of IVs=  134 , NO. of valid IVs with foreground signals:  94.22109 . \n",
      "***********************************************************\n",
      "Pair:  RA ~ MDD \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  RA  on  MDD : \n",
      "MR-APSS: beta =  0.0118 , beta.se =  0.0114 , p-value =  3.0059e-01 . \n",
      "Total NO. of IVs=  135 , NO. of valid IVs with foreground signals:  95.28819 . \n",
      "***********************************************************\n",
      "Pair:  RA ~ SCZ \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  RA  on  SCZ : \n",
      "MR-APSS: beta =  -0.0376 , beta.se =  0.023 , p-value =  1.0160e-01 . \n",
      "Total NO. of IVs=  131 , NO. of valid IVs with foreground signals:  95.05736 . \n",
      "***********************************************************\n",
      "Pair:  RA ~ Angina \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  RA  on  Angina : \n",
      "MR-APSS: beta =  0.0109 , beta.se =  0.0111 , p-value =  3.2963e-01 . \n",
      "Total NO. of IVs=  135 , NO. of valid IVs with foreground signals:  96.05155 . \n",
      "***********************************************************\n",
      "Pair:  RA ~ CAD \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  RA  on  CAD : \n",
      "MR-APSS: beta =  0.0196 , beta.se =  0.0173 , p-value =  2.5770e-01 . \n",
      "Total NO. of IVs=  135 , NO. of valid IVs with foreground signals:  95.81842 . \n",
      "***********************************************************\n",
      "Pair:  RA ~ HBP \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  RA  on  HBP : \n",
      "MR-APSS: beta =  0.0063 , beta.se =  0.0153 , p-value =  6.8167e-01 . \n",
      "Total NO. of IVs=  135 , NO. of valid IVs with foreground signals:  94.15339 . \n",
      "***********************************************************\n",
      "Pair:  RA ~ Income \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  RA  on  Income : \n",
      "MR-APSS: beta =  -0.0116 , beta.se =  0.0137 , p-value =  3.9953e-01 . \n",
      "Total NO. of IVs=  135 , NO. of valid IVs with foreground signals:  95.70902 . \n",
      "***********************************************************\n",
      "Pair:  RA ~ NEB \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  RA  on  NEB : \n",
      "MR-APSS: beta =  -0.0048 , beta.se =  0.0105 , p-value =  6.4839e-01 . \n",
      "Total NO. of IVs=  130 , NO. of valid IVs with foreground signals:  95.57121 . \n",
      "***********************************************************\n",
      "Pair:  RA ~ Smoking \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  RA  on  Smoking : \n",
      "MR-APSS: beta =  -0.0116 , beta.se =  0.0125 , p-value =  3.5005e-01 . \n",
      "Total NO. of IVs=  134 , NO. of valid IVs with foreground signals:  95.65518 . \n",
      "***********************************************************\n",
      "Pair:  RA ~ Urate \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  RA  on  Urate : \n",
      "MR-APSS: beta =  -0.0047 , beta.se =  0.0198 , p-value =  8.1218e-01 . \n",
      "Total NO. of IVs=  132 , NO. of valid IVs with foreground signals:  94.80694 . \n",
      "***********************************************************\n",
      "Pair:  RA ~ Anorexia \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  RA  on  Anorexia : \n",
      "MR-APSS: beta =  -0.0073 , beta.se =  0.0237 , p-value =  7.5713e-01 . \n",
      "Total NO. of IVs=  129 , NO. of valid IVs with foreground signals:  90.96957 . \n",
      "***********************************************************\n",
      "Pair:  RA ~ CD \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  RA  on  CD : \n",
      "MR-APSS: beta =  -0.0786 , beta.se =  0.0663 , p-value =  2.3604e-01 . \n",
      "Total NO. of IVs=  134 , NO. of valid IVs with foreground signals:  94.29452 . \n",
      "***********************************************************\n",
      "Pair:  RA ~ Height_GIANT \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  RA  on  Height_GIANT : \n",
      "MR-APSS: beta =  0.0136 , beta.se =  0.0195 , p-value =  4.8442e-01 . \n",
      "Total NO. of IVs=  129 , NO. of valid IVs with foreground signals:  94.01523 . \n",
      "***********************************************************\n",
      "Pair:  RA ~ Insomnia \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  RA  on  Insomnia : \n",
      "MR-APSS: beta =  -0.0036 , beta.se =  0.0112 , p-value =  7.4885e-01 . \n",
      "Total NO. of IVs=  134 , NO. of valid IVs with foreground signals:  94.00744 . \n",
      "***********************************************************\n",
      "Pair:  RA ~ Neuroticism \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  RA  on  Neuroticism : \n",
      "MR-APSS: beta =  -0.0079 , beta.se =  0.0129 , p-value =  5.4305e-01 . \n",
      "Total NO. of IVs=  135 , NO. of valid IVs with foreground signals:  93.93225 . \n",
      "***********************************************************\n",
      "Pair:  RA ~ SWB \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  RA  on  SWB : \n",
      "MR-APSS: beta =  -0.0116 , beta.se =  0.0101 , p-value =  2.4911e-01 . \n",
      "Total NO. of IVs=  131 , NO. of valid IVs with foreground signals:  97.25328 . \n",
      "***********************************************************\n",
      "Pair:  T2D ~ AD \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  T2D  on  AD : \n",
      "MR-APSS: beta =  0.0452 , beta.se =  0.0293 , p-value =  1.2304e-01 . \n",
      "Total NO. of IVs=  660 , NO. of valid IVs with foreground signals:  203.9207 . \n",
      "***********************************************************\n",
      "Pair:  T2D ~ ASD \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  T2D  on  ASD : \n",
      "MR-APSS: beta =  0.068 , beta.se =  0.0421 , p-value =  1.0593e-01 . \n",
      "Total NO. of IVs=  659 , NO. of valid IVs with foreground signals:  208.8791 . \n",
      "***********************************************************\n",
      "Pair:  T2D ~ Daytime_Sleepiness \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  T2D  on  Daytime_Sleepiness : \n",
      "MR-APSS: beta =  0.0368 , beta.se =  0.0114 , p-value =  1.3174e-03 . \n",
      "Total NO. of IVs=  659 , NO. of valid IVs with foreground signals:  206.0911 . \n",
      "***********************************************************\n",
      "Pair:  T2D ~ Height_UKB \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  T2D  on  Height_UKB : \n",
      "MR-APSS: beta =  -0.0435 , beta.se =  0.0383 , p-value =  2.5523e-01 . \n",
      "Total NO. of IVs=  652 , NO. of valid IVs with foreground signals:  210.5316 . \n",
      "***********************************************************\n",
      "Pair:  T2D ~ Intelligence \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  T2D  on  Intelligence : \n",
      "MR-APSS: beta =  -0.0381 , beta.se =  0.0239 , p-value =  1.1116e-01 . \n",
      "Total NO. of IVs=  652 , NO. of valid IVs with foreground signals:  212.7662 . \n",
      "***********************************************************\n",
      "Pair:  T2D ~ RA \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  T2D  on  RA : \n",
      "MR-APSS: beta =  -0.04 , beta.se =  0.0261 , p-value =  1.2558e-01 . \n",
      "Total NO. of IVs=  650 , NO. of valid IVs with foreground signals:  194.8502 . \n",
      "***********************************************************\n",
      "Pair:  T2D ~ Alcohol \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  T2D  on  Alcohol : \n",
      "MR-APSS: beta =  -0.0398 , beta.se =  0.0145 , p-value =  5.9645e-03 . \n",
      "Total NO. of IVs=  660 , NO. of valid IVs with foreground signals:  218.0933 . \n",
      "***********************************************************\n",
      "Pair:  T2D ~ BMI \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  T2D  on  BMI : \n",
      "MR-APSS: beta =  0.0567 , beta.se =  0.0339 , p-value =  9.4303e-02 . \n",
      "Total NO. of IVs=  653 , NO. of valid IVs with foreground signals:  240.6408 . \n",
      "***********************************************************\n",
      "Pair:  T2D ~ Depression \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  T2D  on  Depression : \n",
      "MR-APSS: beta =  0.0202 , beta.se =  0.0107 , p-value =  5.9530e-02 . \n",
      "Total NO. of IVs=  652 , NO. of valid IVs with foreground signals:  202.2462 . \n",
      "***********************************************************\n",
      "Pair:  T2D ~ IBD \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  T2D  on  IBD : \n",
      "MR-APSS: beta =  0.0416 , beta.se =  0.0366 , p-value =  2.5544e-01 . \n",
      "Total NO. of IVs=  648 , NO. of valid IVs with foreground signals:  192.8679 . \n",
      "***********************************************************\n",
      "Pair:  T2D ~ MDD \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  T2D  on  MDD : \n",
      "MR-APSS: beta =  -0.011 , beta.se =  0.0113 , p-value =  3.3395e-01 . \n",
      "Total NO. of IVs=  652 , NO. of valid IVs with foreground signals:  199.8462 . \n",
      "***********************************************************\n",
      "Pair:  T2D ~ SCZ \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  T2D  on  SCZ : \n",
      "MR-APSS: beta =  -0.0024 , beta.se =  0.0259 , p-value =  9.2539e-01 . \n",
      "Total NO. of IVs=  651 , NO. of valid IVs with foreground signals:  211.0013 . \n",
      "***********************************************************\n",
      "Pair:  T2D ~ Angina \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  T2D  on  Angina : \n",
      "MR-APSS: beta =  0.057 , beta.se =  0.0139 , p-value =  3.9475e-05 . \n",
      "Total NO. of IVs=  652 , NO. of valid IVs with foreground signals:  198.7099 . \n",
      "***********************************************************\n",
      "Pair:  T2D ~ CAD \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  T2D  on  CAD : \n",
      "MR-APSS: beta =  0.1267 , beta.se =  0.0198 , p-value =  1.4299e-10 . \n",
      "Total NO. of IVs=  660 , NO. of valid IVs with foreground signals:  206.0135 . \n",
      "***********************************************************\n",
      "Pair:  T2D ~ HBP \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  T2D  on  HBP : \n",
      "MR-APSS: beta =  0.1032 , beta.se =  0.021 , p-value =  8.6946e-07 . \n",
      "Total NO. of IVs=  652 , NO. of valid IVs with foreground signals:  202.3063 . \n",
      "***********************************************************\n",
      "Pair:  T2D ~ Income \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  T2D  on  Income : \n",
      "MR-APSS: beta =  -0.0182 , beta.se =  0.0147 , p-value =  2.1562e-01 . \n",
      "Total NO. of IVs=  661 , NO. of valid IVs with foreground signals:  216.5422 . \n",
      "***********************************************************\n",
      "Pair:  T2D ~ NEB \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  T2D  on  NEB : \n",
      "MR-APSS: beta =  0.0201 , beta.se =  0.0099 , p-value =  4.3655e-02 . \n",
      "Total NO. of IVs=  640 , NO. of valid IVs with foreground signals:  203.093 . \n",
      "***********************************************************\n",
      "Pair:  T2D ~ Smoking \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  T2D  on  Smoking : \n",
      "MR-APSS: beta =  0.0025 , beta.se =  0.0139 , p-value =  8.5789e-01 . \n",
      "Total NO. of IVs=  653 , NO. of valid IVs with foreground signals:  209.1439 . \n",
      "***********************************************************\n",
      "Pair:  T2D ~ Urate \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  T2D  on  Urate : \n",
      "MR-APSS: beta =  0.0656 , beta.se =  0.0263 , p-value =  1.2463e-02 . \n",
      "Total NO. of IVs=  641 , NO. of valid IVs with foreground signals:  197.384 . \n",
      "***********************************************************\n",
      "Pair:  T2D ~ Anorexia \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  T2D  on  Anorexia : \n",
      "MR-APSS: beta =  -0.0218 , beta.se =  0.0237 , p-value =  3.5744e-01 . \n",
      "Total NO. of IVs=  608 , NO. of valid IVs with foreground signals:  185.7357 . \n",
      "***********************************************************\n",
      "Pair:  T2D ~ CD \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  T2D  on  CD : \n",
      "MR-APSS: beta =  0.0039 , beta.se =  0.0421 , p-value =  9.2640e-01 . \n",
      "Total NO. of IVs=  648 , NO. of valid IVs with foreground signals:  193.4491 . \n",
      "***********************************************************\n",
      "Pair:  T2D ~ Height_GIANT \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  T2D  on  Height_GIANT : \n",
      "MR-APSS: beta =  -0.0135 , beta.se =  0.0319 , p-value =  6.7107e-01 . \n",
      "Total NO. of IVs=  636 , NO. of valid IVs with foreground signals:  207.2123 . \n",
      "***********************************************************\n",
      "Pair:  T2D ~ Insomnia \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  T2D  on  Insomnia : \n",
      "MR-APSS: beta =  0.0144 , beta.se =  0.012 , p-value =  2.2872e-01 . \n",
      "Total NO. of IVs=  659 , NO. of valid IVs with foreground signals:  211.5066 . \n",
      "***********************************************************\n",
      "Pair:  T2D ~ Neuroticism \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  T2D  on  Neuroticism : \n",
      "MR-APSS: beta =  0.0038 , beta.se =  0.0148 , p-value =  7.9950e-01 . \n",
      "Total NO. of IVs=  652 , NO. of valid IVs with foreground signals:  210.3881 . \n",
      "***********************************************************\n",
      "Pair:  T2D ~ SWB \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  T2D  on  SWB : \n",
      "MR-APSS: beta =  2e-04 , beta.se =  0.008 , p-value =  9.7987e-01 . \n",
      "Total NO. of IVs=  643 , NO. of valid IVs with foreground signals:  205.0521 . \n",
      "***********************************************************\n",
      "Pair:  Alcohol ~ AD \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  Alcohol  on  AD : \n",
      "MR-APSS: beta =  0.0584 , beta.se =  0.0898 , p-value =  5.1535e-01 . \n",
      "Total NO. of IVs=  348 , NO. of valid IVs with foreground signals:  85.1587 . \n",
      "***********************************************************\n",
      "Pair:  Alcohol ~ ASD \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  Alcohol  on  ASD : \n",
      "MR-APSS: beta =  -0.1752 , beta.se =  0.1408 , p-value =  2.1358e-01 . \n",
      "Total NO. of IVs=  344 , NO. of valid IVs with foreground signals:  86.47692 . \n",
      "***********************************************************\n",
      "Pair:  Alcohol ~ Daytime_Sleepiness \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  Alcohol  on  Daytime_Sleepiness : \n",
      "MR-APSS: beta =  -0.1053 , beta.se =  0.0468 , p-value =  2.4346e-02 . \n",
      "Total NO. of IVs=  345 , NO. of valid IVs with foreground signals:  83.57268 . \n",
      "***********************************************************\n",
      "Pair:  Alcohol ~ Height_UKB \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  Alcohol  on  Height_UKB : \n",
      "MR-APSS: beta =  0.176 , beta.se =  0.1016 , p-value =  8.3238e-02 . \n",
      "Total NO. of IVs=  343 , NO. of valid IVs with foreground signals:  81.71853 . \n",
      "***********************************************************\n",
      "Pair:  Alcohol ~ Intelligence \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  Alcohol  on  Intelligence : \n",
      "MR-APSS: beta =  0.0133 , beta.se =  0.096 , p-value =  8.8969e-01 . \n",
      "Total NO. of IVs=  343 , NO. of valid IVs with foreground signals:  82.48352 . \n",
      "***********************************************************\n",
      "Pair:  Alcohol ~ RA \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  Alcohol  on  RA : \n",
      "MR-APSS: beta =  -0.1147 , beta.se =  0.0853 , p-value =  1.7863e-01 . \n",
      "Total NO. of IVs=  343 , NO. of valid IVs with foreground signals:  84.04077 . \n",
      "***********************************************************\n",
      "Pair:  Alcohol ~ T2D \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  Alcohol  on  T2D : \n",
      "MR-APSS: beta =  -0.0938 , beta.se =  0.0889 , p-value =  2.9147e-01 . \n",
      "Total NO. of IVs=  344 , NO. of valid IVs with foreground signals:  76.25706 . \n",
      "***********************************************************\n",
      "Pair:  Alcohol ~ BMI \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  Alcohol  on  BMI : \n",
      "MR-APSS: beta =  -0.1318 , beta.se =  0.0997 , p-value =  1.8599e-01 . \n",
      "Total NO. of IVs=  342 , NO. of valid IVs with foreground signals:  93.81591 . \n",
      "***********************************************************\n",
      "Pair:  Alcohol ~ Depression \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  Alcohol  on  Depression : \n",
      "MR-APSS: beta =  -0.032 , beta.se =  0.0442 , p-value =  4.6877e-01 . \n",
      "Total NO. of IVs=  343 , NO. of valid IVs with foreground signals:  86.8697 . \n",
      "***********************************************************\n",
      "Pair:  Alcohol ~ IBD \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  Alcohol  on  IBD : \n",
      "MR-APSS: beta =  0.0385 , beta.se =  0.1327 , p-value =  7.7203e-01 . \n",
      "Total NO. of IVs=  340 , NO. of valid IVs with foreground signals:  75.21009 . \n",
      "***********************************************************\n",
      "Pair:  Alcohol ~ MDD \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  Alcohol  on  MDD : \n",
      "MR-APSS: beta =  0.0414 , beta.se =  0.0386 , p-value =  2.8386e-01 . \n",
      "Total NO. of IVs=  343 , NO. of valid IVs with foreground signals:  83.56676 . \n",
      "***********************************************************\n",
      "Pair:  Alcohol ~ SCZ \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  Alcohol  on  SCZ : \n",
      "MR-APSS: beta =  0.1807 , beta.se =  0.1318 , p-value =  1.7018e-01 . \n",
      "Total NO. of IVs=  344 , NO. of valid IVs with foreground signals:  90.83674 . \n",
      "***********************************************************\n",
      "Pair:  Alcohol ~ Angina \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  Alcohol  on  Angina : \n",
      "MR-APSS: beta =  0.0474 , beta.se =  0.0454 , p-value =  2.9707e-01 . \n",
      "Total NO. of IVs=  343 , NO. of valid IVs with foreground signals:  76.9163 . \n",
      "***********************************************************\n",
      "Pair:  Alcohol ~ CAD \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  Alcohol  on  CAD : \n",
      "MR-APSS: beta =  0.0113 , beta.se =  0.0578 , p-value =  8.4532e-01 . \n",
      "Total NO. of IVs=  349 , NO. of valid IVs with foreground signals:  91.15161 . \n",
      "***********************************************************\n",
      "Pair:  Alcohol ~ HBP \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  Alcohol  on  HBP : \n",
      "MR-APSS: beta =  -0.0567 , beta.se =  0.0672 , p-value =  3.9938e-01 . \n",
      "Total NO. of IVs=  343 , NO. of valid IVs with foreground signals:  84.66915 . \n",
      "***********************************************************\n",
      "Pair:  Alcohol ~ Income \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  Alcohol  on  Income : \n",
      "MR-APSS: beta =  0.1326 , beta.se =  0.0582 , p-value =  2.2632e-02 . \n",
      "Total NO. of IVs=  349 , NO. of valid IVs with foreground signals:  83.91444 . \n",
      "***********************************************************\n",
      "Pair:  Alcohol ~ NEB \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  Alcohol  on  NEB : \n",
      "MR-APSS: beta =  0.0512 , beta.se =  0.0379 , p-value =  1.7682e-01 . \n",
      "Total NO. of IVs=  339 , NO. of valid IVs with foreground signals:  80.22431 . \n",
      "***********************************************************\n",
      "Pair:  Alcohol ~ Smoking \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  Alcohol  on  Smoking : \n",
      "MR-APSS: beta =  0.2106 , beta.se =  0.0577 , p-value =  2.6028e-04 . \n",
      "Total NO. of IVs=  346 , NO. of valid IVs with foreground signals:  83.36728 . \n",
      "***********************************************************\n",
      "Pair:  Alcohol ~ Urate \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  Alcohol  on  Urate : \n",
      "MR-APSS: beta =  -0.0268 , beta.se =  0.0816 , p-value =  7.4230e-01 . \n",
      "Total NO. of IVs=  341 , NO. of valid IVs with foreground signals:  77.00342 . \n",
      "***********************************************************\n",
      "Pair:  Alcohol ~ Anorexia \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  Alcohol  on  Anorexia : \n",
      "MR-APSS: beta =  -0.2217 , beta.se =  0.0972 , p-value =  2.2610e-02 . \n",
      "Total NO. of IVs=  319 , NO. of valid IVs with foreground signals:  79.08893 . \n",
      "***********************************************************\n",
      "Pair:  Alcohol ~ CD \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  Alcohol  on  CD : \n",
      "MR-APSS: beta =  0.1051 , beta.se =  0.1719 , p-value =  5.4113e-01 . \n",
      "Total NO. of IVs=  340 , NO. of valid IVs with foreground signals:  75.03048 . \n",
      "***********************************************************\n",
      "Pair:  Alcohol ~ Height_GIANT \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  Alcohol  on  Height_GIANT : \n",
      "MR-APSS: beta =  0.1016 , beta.se =  0.0823 , p-value =  2.1709e-01 . \n",
      "Total NO. of IVs=  337 , NO. of valid IVs with foreground signals:  77.86671 . \n",
      "***********************************************************\n",
      "Pair:  Alcohol ~ Insomnia \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  Alcohol  on  Insomnia : \n",
      "MR-APSS: beta =  0.007 , beta.se =  0.0446 , p-value =  8.7445e-01 . \n",
      "Total NO. of IVs=  345 , NO. of valid IVs with foreground signals:  83.75714 . \n",
      "***********************************************************\n",
      "Pair:  Alcohol ~ Neuroticism \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  Alcohol  on  Neuroticism : \n",
      "MR-APSS: beta =  -0.0235 , beta.se =  0.0636 , p-value =  7.1171e-01 . \n",
      "Total NO. of IVs=  343 , NO. of valid IVs with foreground signals:  83.08926 . \n",
      "***********************************************************\n",
      "Pair:  Alcohol ~ SWB \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  Alcohol  on  SWB : \n",
      "MR-APSS: beta =  -0.048 , beta.se =  0.0419 , p-value =  2.5194e-01 . \n",
      "Total NO. of IVs=  340 , NO. of valid IVs with foreground signals:  82.69526 . \n",
      "***********************************************************\n",
      "Pair:  BMI ~ AD \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  BMI  on  AD : \n",
      "MR-APSS: beta =  0.0097 , beta.se =  0.036 , p-value =  7.8668e-01 . \n",
      "Total NO. of IVs=  1295 , NO. of valid IVs with foreground signals:  202.5995 . \n",
      "***********************************************************\n",
      "Pair:  BMI ~ ASD \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  BMI  on  ASD : \n",
      "MR-APSS: beta =  0.0116 , beta.se =  0.0647 , p-value =  8.5772e-01 . \n",
      "Total NO. of IVs=  1292 , NO. of valid IVs with foreground signals:  202.4777 . \n",
      "***********************************************************\n",
      "Pair:  BMI ~ Daytime_Sleepiness \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  BMI  on  Daytime_Sleepiness : \n",
      "MR-APSS: beta =  0.0422 , beta.se =  0.0211 , p-value =  4.5234e-02 . \n",
      "Total NO. of IVs=  1298 , NO. of valid IVs with foreground signals:  209.6101 . \n",
      "***********************************************************\n",
      "Pair:  BMI ~ Height_UKB \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  BMI  on  Height_UKB : \n",
      "MR-APSS: beta =  -0.033 , beta.se =  0.0602 , p-value =  5.8334e-01 . \n",
      "Total NO. of IVs=  1300 , NO. of valid IVs with foreground signals:  217.653 . \n",
      "***********************************************************\n",
      "Pair:  BMI ~ Intelligence \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  BMI  on  Intelligence : \n",
      "MR-APSS: beta =  -0.1283 , beta.se =  0.0428 , p-value =  2.7278e-03 . \n",
      "Total NO. of IVs=  1301 , NO. of valid IVs with foreground signals:  201.8953 . \n",
      "***********************************************************\n",
      "Pair:  BMI ~ RA \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  BMI  on  RA : \n",
      "MR-APSS: beta =  0.0654 , beta.se =  0.0392 , p-value =  9.5029e-02 . \n",
      "Total NO. of IVs=  1298 , NO. of valid IVs with foreground signals:  208.5339 . \n",
      "***********************************************************\n",
      "Pair:  BMI ~ T2D \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  BMI  on  T2D : \n",
      "MR-APSS: beta =  0.3264 , beta.se =  0.0563 , p-value =  6.7718e-09 . \n",
      "Total NO. of IVs=  1296 , NO. of valid IVs with foreground signals:  190.2128 . \n",
      "***********************************************************\n",
      "Pair:  BMI ~ Alcohol \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  BMI  on  Alcohol : \n",
      "MR-APSS: beta =  -0.0432 , beta.se =  0.0238 , p-value =  6.9568e-02 . \n",
      "Total NO. of IVs=  1298 , NO. of valid IVs with foreground signals:  216.0136 . \n",
      "***********************************************************\n",
      "Pair:  BMI ~ Depression \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  BMI  on  Depression : \n",
      "MR-APSS: beta =  0.0727 , beta.se =  0.0171 , p-value =  2.0917e-05 . \n",
      "Total NO. of IVs=  1297 , NO. of valid IVs with foreground signals:  212.3112 . \n",
      "***********************************************************\n",
      "Pair:  BMI ~ IBD \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  BMI  on  IBD : \n",
      "MR-APSS: beta =  -0.0256 , beta.se =  0.0526 , p-value =  6.2633e-01 . \n",
      "Total NO. of IVs=  1293 , NO. of valid IVs with foreground signals:  193.5016 . \n",
      "***********************************************************\n",
      "Pair:  BMI ~ MDD \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  BMI  on  MDD : \n",
      "MR-APSS: beta =  0.0386 , beta.se =  0.0168 , p-value =  2.1309e-02 . \n",
      "Total NO. of IVs=  1301 , NO. of valid IVs with foreground signals:  202.8313 . \n",
      "***********************************************************\n",
      "Pair:  BMI ~ SCZ \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  BMI  on  SCZ : \n",
      "MR-APSS: beta =  -0.0561 , beta.se =  0.0516 , p-value =  2.7643e-01 . \n",
      "Total NO. of IVs=  1275 , NO. of valid IVs with foreground signals:  216.1973 . \n",
      "***********************************************************\n",
      "Pair:  BMI ~ Angina \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  BMI  on  Angina : \n",
      "MR-APSS: beta =  0.0898 , beta.se =  0.0175 , p-value =  3.0347e-07 . \n",
      "Total NO. of IVs=  1301 , NO. of valid IVs with foreground signals:  204.704 . \n",
      "***********************************************************\n",
      "Pair:  BMI ~ CAD \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  BMI  on  CAD : \n",
      "MR-APSS: beta =  0.1535 , beta.se =  0.0282 , p-value =  5.5496e-08 . \n",
      "Total NO. of IVs=  1300 , NO. of valid IVs with foreground signals:  204.9022 . \n",
      "***********************************************************\n",
      "Pair:  BMI ~ HBP \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  BMI  on  HBP : \n",
      "MR-APSS: beta =  0.1824 , beta.se =  0.0355 , p-value =  2.7644e-07 . \n",
      "Total NO. of IVs=  1301 , NO. of valid IVs with foreground signals:  206.198 . \n",
      "***********************************************************\n",
      "Pair:  BMI ~ Income \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  BMI  on  Income : \n",
      "MR-APSS: beta =  -0.1708 , beta.se =  0.0254 , p-value =  1.8333e-11 . \n",
      "Total NO. of IVs=  1300 , NO. of valid IVs with foreground signals:  222.3487 . \n",
      "***********************************************************\n",
      "Pair:  BMI ~ NEB \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  BMI  on  NEB : \n",
      "MR-APSS: beta =  0.0374 , beta.se =  0.016 , p-value =  1.9749e-02 . \n",
      "Total NO. of IVs=  1270 , NO. of valid IVs with foreground signals:  198.1004 . \n",
      "***********************************************************\n",
      "Pair:  BMI ~ Smoking \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  BMI  on  Smoking : \n",
      "MR-APSS: beta =  0.1062 , beta.se =  0.022 , p-value =  1.3576e-06 . \n",
      "Total NO. of IVs=  1284 , NO. of valid IVs with foreground signals:  214.7367 . \n",
      "***********************************************************\n",
      "Pair:  BMI ~ Urate \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  BMI  on  Urate : \n",
      "MR-APSS: beta =  0.2069 , beta.se =  0.0381 , p-value =  5.6925e-08 . \n",
      "Total NO. of IVs=  1278 , NO. of valid IVs with foreground signals:  200.4529 . \n",
      "***********************************************************\n",
      "Pair:  BMI ~ Anorexia \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  BMI  on  Anorexia : \n",
      "MR-APSS: beta =  -0.1259 , beta.se =  0.0441 , p-value =  4.3089e-03 . \n",
      "Total NO. of IVs=  1230 , NO. of valid IVs with foreground signals:  184.1971 . \n",
      "***********************************************************\n",
      "Pair:  BMI ~ CD \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  BMI  on  CD : \n",
      "MR-APSS: beta =  -0.077 , beta.se =  0.0632 , p-value =  2.2320e-01 . \n",
      "Total NO. of IVs=  1293 , NO. of valid IVs with foreground signals:  195.8299 . \n",
      "***********************************************************\n",
      "Pair:  BMI ~ Height_GIANT \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  BMI  on  Height_GIANT : \n",
      "MR-APSS: beta =  -0.0084 , beta.se =  0.0503 , p-value =  8.6800e-01 . \n",
      "Total NO. of IVs=  1266 , NO. of valid IVs with foreground signals:  184.7077 . \n",
      "***********************************************************\n",
      "Pair:  BMI ~ Insomnia \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  BMI  on  Insomnia : \n",
      "MR-APSS: beta =  0.0337 , beta.se =  0.0221 , p-value =  1.2812e-01 . \n",
      "Total NO. of IVs=  1298 , NO. of valid IVs with foreground signals:  219.356 . \n",
      "***********************************************************\n",
      "Pair:  BMI ~ Neuroticism \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  BMI  on  Neuroticism : \n",
      "MR-APSS: beta =  -0.0077 , beta.se =  0.0244 , p-value =  7.5072e-01 . \n",
      "Total NO. of IVs=  1301 , NO. of valid IVs with foreground signals:  225.6292 . \n",
      "***********************************************************\n",
      "Pair:  BMI ~ SWB \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  BMI  on  SWB : \n",
      "MR-APSS: beta =  -0.0316 , beta.se =  0.0169 , p-value =  6.1201e-02 . \n",
      "Total NO. of IVs=  1275 , NO. of valid IVs with foreground signals:  195.6895 . \n",
      "***********************************************************\n",
      "Pair:  Depression ~ AD \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  Depression  on  AD : \n",
      "MR-APSS: beta =  -0.1189 , beta.se =  0.252 , p-value =  6.3713e-01 . \n",
      "Total NO. of IVs=  196 , NO. of valid IVs with foreground signals:  60.20369 . \n",
      "***********************************************************\n",
      "Pair:  Depression ~ ASD \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  Depression  on  ASD : \n",
      "MR-APSS: beta =  0.0739 , beta.se =  0.512 , p-value =  8.8527e-01 . \n",
      "Total NO. of IVs=  196 , NO. of valid IVs with foreground signals:  46.30164 . \n",
      "***********************************************************\n",
      "Pair:  Depression ~ Daytime_Sleepiness \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  Depression  on  Daytime_Sleepiness : \n",
      "MR-APSS: beta =  0.3425 , beta.se =  0.178 , p-value =  5.4413e-02 . \n",
      "Total NO. of IVs=  197 , NO. of valid IVs with foreground signals:  32.49785 . \n",
      "***********************************************************\n",
      "Pair:  Depression ~ Height_UKB \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  Depression  on  Height_UKB : \n",
      "MR-APSS: beta =  -0.1532 , beta.se =  0.3088 , p-value =  6.1974e-01 . \n",
      "Total NO. of IVs=  197 , NO. of valid IVs with foreground signals:  30.24852 . \n",
      "***********************************************************\n",
      "Pair:  Depression ~ Intelligence \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  Depression  on  Intelligence : \n",
      "MR-APSS: beta =  -0.3853 , beta.se =  0.2619 , p-value =  1.4115e-01 . \n",
      "Total NO. of IVs=  197 , NO. of valid IVs with foreground signals:  61.77225 . \n",
      "***********************************************************\n",
      "Pair:  Depression ~ RA \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  Depression  on  RA : \n",
      "MR-APSS: beta =  0.3306 , beta.se =  0.5 , p-value =  5.0852e-01 . \n",
      "Total NO. of IVs=  197 , NO. of valid IVs with foreground signals:  19.49944 . \n",
      "***********************************************************\n",
      "Pair:  Depression ~ T2D \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  Depression  on  T2D : \n",
      "MR-APSS: beta =  0.4445 , beta.se =  0.2148 , p-value =  3.8450e-02 . \n",
      "Total NO. of IVs=  196 , NO. of valid IVs with foreground signals:  43.96433 . \n",
      "***********************************************************\n",
      "Pair:  Depression ~ Alcohol \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  Depression  on  Alcohol : \n",
      "MR-APSS: beta =  -0.0813 , beta.se =  0.1861 , p-value =  6.6234e-01 . \n",
      "Total NO. of IVs=  197 , NO. of valid IVs with foreground signals:  35.13604 . \n",
      "***********************************************************\n",
      "Pair:  Depression ~ BMI \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  Depression  on  BMI : \n",
      "MR-APSS: beta =  0.3305 , beta.se =  0.2096 , p-value =  1.1484e-01 . \n",
      "Total NO. of IVs=  197 , NO. of valid IVs with foreground signals:  61.02776 . \n",
      "***********************************************************\n",
      "Pair:  Depression ~ IBD \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  Depression  on  IBD : \n",
      "MR-APSS: beta =  0.0287 , beta.se =  0.4861 , p-value =  9.5287e-01 . \n",
      "Total NO. of IVs=  194 , NO. of valid IVs with foreground signals:  14.64635 . \n",
      "***********************************************************\n",
      "Pair:  Depression ~ MDD \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  Depression  on  MDD : \n",
      "MR-APSS: beta =  0.3473 , beta.se =  0.1403 , p-value =  1.3334e-02 . \n",
      "Total NO. of IVs=  197 , NO. of valid IVs with foreground signals:  36.91293 . \n",
      "***********************************************************\n",
      "Pair:  Depression ~ SCZ \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  Depression  on  SCZ : \n",
      "MR-APSS: beta =  0.798 , beta.se =  0.2976 , p-value =  7.3267e-03 . \n",
      "Total NO. of IVs=  192 , NO. of valid IVs with foreground signals:  59.88135 . \n",
      "***********************************************************\n",
      "Pair:  Depression ~ Angina \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  Depression  on  Angina : \n",
      "MR-APSS: beta =  0.3303 , beta.se =  0.1003 , p-value =  9.9480e-04 . \n",
      "Total NO. of IVs=  197 , NO. of valid IVs with foreground signals:  73.209 . \n",
      "***********************************************************\n",
      "Pair:  Depression ~ CAD \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  Depression  on  CAD : \n",
      "MR-APSS: beta =  0.3403 , beta.se =  0.1478 , p-value =  2.1329e-02 . \n",
      "Total NO. of IVs=  197 , NO. of valid IVs with foreground signals:  56.59815 . \n",
      "***********************************************************\n",
      "Pair:  Depression ~ HBP \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  Depression  on  HBP : \n",
      "MR-APSS: beta =  0.1415 , beta.se =  0.2289 , p-value =  5.3631e-01 . \n",
      "Total NO. of IVs=  197 , NO. of valid IVs with foreground signals:  29.30594 . \n",
      "***********************************************************\n",
      "Pair:  Depression ~ Income \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  Depression  on  Income : \n",
      "MR-APSS: beta =  -0.5525 , beta.se =  0.1706 , p-value =  1.2011e-03 . \n",
      "Total NO. of IVs=  197 , NO. of valid IVs with foreground signals:  66.64456 . \n",
      "***********************************************************\n",
      "Pair:  Depression ~ NEB \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  Depression  on  NEB : \n",
      "MR-APSS: beta =  -0.0346 , beta.se =  0.1098 , p-value =  7.5246e-01 . \n",
      "Total NO. of IVs=  188 , NO. of valid IVs with foreground signals:  76.56617 . \n",
      "***********************************************************\n",
      "Pair:  Depression ~ Smoking \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  Depression  on  Smoking : \n",
      "MR-APSS: beta =  0.8972 , beta.se =  0.2334 , p-value =  1.2140e-04 . \n",
      "Total NO. of IVs=  195 , NO. of valid IVs with foreground signals:  16.88879 . \n",
      "***********************************************************\n",
      "Pair:  Depression ~ Urate \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  Depression  on  Urate : \n",
      "MR-APSS: beta =  -0.0085 , beta.se =  0.1298 , p-value =  9.4789e-01 . \n",
      "Total NO. of IVs=  190 , NO. of valid IVs with foreground signals:  59.32797 . \n",
      "***********************************************************\n",
      "Pair:  Depression ~ Anorexia \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  Depression  on  Anorexia : \n",
      "MR-APSS: beta =  0.4393 , beta.se =  0.2611 , p-value =  9.2508e-02 . \n",
      "Total NO. of IVs=  177 , NO. of valid IVs with foreground signals:  72.45718 . \n",
      "***********************************************************\n",
      "Pair:  Depression ~ CD \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  Depression  on  CD : \n",
      "MR-APSS: beta =  -0.222 , beta.se =  0.3683 , p-value =  5.4660e-01 . \n",
      "Total NO. of IVs=  194 , NO. of valid IVs with foreground signals:  47.95992 . \n",
      "***********************************************************\n",
      "Pair:  Depression ~ Height_GIANT \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  Depression  on  Height_GIANT : \n",
      "MR-APSS: beta =  -0.2185 , beta.se =  0.2139 , p-value =  3.0717e-01 . \n",
      "Total NO. of IVs=  185 , NO. of valid IVs with foreground signals:  61.30396 . \n",
      "***********************************************************\n",
      "Pair:  Depression ~ Insomnia \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  Depression  on  Insomnia : \n",
      "MR-APSS: beta =  0.5693 , beta.se =  0.1393 , p-value =  4.3776e-05 . \n",
      "Total NO. of IVs=  197 , NO. of valid IVs with foreground signals:  70.33905 . \n",
      "***********************************************************\n",
      "Pair:  Depression ~ Neuroticism \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  Depression  on  Neuroticism : \n",
      "MR-APSS: beta =  1.329 , beta.se =  0.2514 , p-value =  1.2444e-07 . \n",
      "Total NO. of IVs=  197 , NO. of valid IVs with foreground signals:  47.10728 . \n",
      "***********************************************************\n",
      "Pair:  Depression ~ SWB \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  Depression  on  SWB : \n",
      "MR-APSS: beta =  -0.4431 , beta.se =  0.1509 , p-value =  3.3293e-03 . \n",
      "Total NO. of IVs=  191 , NO. of valid IVs with foreground signals:  54.14814 . \n",
      "***********************************************************\n",
      "Pair:  IBD ~ AD \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  IBD  on  AD : \n",
      "MR-APSS: beta =  0.0127 , beta.se =  0.02 , p-value =  5.2408e-01 . \n",
      "Total NO. of IVs=  358 , NO. of valid IVs with foreground signals:  134.6524 . \n",
      "***********************************************************\n",
      "Pair:  IBD ~ ASD \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  IBD  on  ASD : \n",
      "MR-APSS: beta =  -0.011 , beta.se =  0.0305 , p-value =  7.1953e-01 . \n",
      "Total NO. of IVs=  360 , NO. of valid IVs with foreground signals:  132.1705 . \n",
      "***********************************************************\n",
      "Pair:  IBD ~ Daytime_Sleepiness \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  IBD  on  Daytime_Sleepiness : \n",
      "MR-APSS: beta =  -0.0067 , beta.se =  0.0074 , p-value =  3.7089e-01 . \n",
      "Total NO. of IVs=  361 , NO. of valid IVs with foreground signals:  133.4978 . \n",
      "***********************************************************\n",
      "Pair:  IBD ~ Height_UKB \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  IBD  on  Height_UKB : \n",
      "MR-APSS: beta =  0.0307 , beta.se =  0.0226 , p-value =  1.7510e-01 . \n",
      "Total NO. of IVs=  360 , NO. of valid IVs with foreground signals:  142.1956 . \n",
      "***********************************************************\n",
      "Pair:  IBD ~ Intelligence \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  IBD  on  Intelligence : \n",
      "MR-APSS: beta =  0.0115 , beta.se =  0.0157 , p-value =  4.6448e-01 . \n",
      "Total NO. of IVs=  361 , NO. of valid IVs with foreground signals:  133.0909 . \n",
      "***********************************************************\n",
      "Pair:  IBD ~ RA \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  IBD  on  RA : \n",
      "MR-APSS: beta =  -0.0382 , beta.se =  0.0378 , p-value =  3.1195e-01 . \n",
      "Total NO. of IVs=  359 , NO. of valid IVs with foreground signals:  133.6994 . \n",
      "***********************************************************\n",
      "Pair:  IBD ~ T2D \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  IBD  on  T2D : \n",
      "MR-APSS: beta =  -0.0024 , beta.se =  0.0166 , p-value =  8.8596e-01 . \n",
      "Total NO. of IVs=  359 , NO. of valid IVs with foreground signals:  135.6536 . \n",
      "***********************************************************\n",
      "Pair:  IBD ~ Alcohol \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  IBD  on  Alcohol : \n",
      "MR-APSS: beta =  0.0156 , beta.se =  0.0099 , p-value =  1.1340e-01 . \n",
      "Total NO. of IVs=  361 , NO. of valid IVs with foreground signals:  135.2851 . \n",
      "***********************************************************\n",
      "Pair:  IBD ~ BMI \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  IBD  on  BMI : \n",
      "MR-APSS: beta =  5e-04 , beta.se =  0.013 , p-value =  9.6900e-01 . \n",
      "Total NO. of IVs=  361 , NO. of valid IVs with foreground signals:  137.388 . \n",
      "***********************************************************\n",
      "Pair:  IBD ~ Depression \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  IBD  on  Depression : \n",
      "MR-APSS: beta =  -0.0092 , beta.se =  0.0075 , p-value =  2.2415e-01 . \n",
      "Total NO. of IVs=  361 , NO. of valid IVs with foreground signals:  132.0905 . \n",
      "***********************************************************\n",
      "Pair:  IBD ~ MDD \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  IBD  on  MDD : \n",
      "MR-APSS: beta =  -0.0061 , beta.se =  0.0078 , p-value =  4.3527e-01 . \n",
      "Total NO. of IVs=  361 , NO. of valid IVs with foreground signals:  132.4022 . \n",
      "***********************************************************\n",
      "Pair:  IBD ~ SCZ \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  IBD  on  SCZ : \n",
      "MR-APSS: beta =  -0.0179 , beta.se =  0.0192 , p-value =  3.5218e-01 . \n",
      "Total NO. of IVs=  350 , NO. of valid IVs with foreground signals:  129.5812 . \n",
      "***********************************************************\n",
      "Pair:  IBD ~ Angina \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  IBD  on  Angina : \n",
      "MR-APSS: beta =  0.0099 , beta.se =  0.0083 , p-value =  2.3026e-01 . \n",
      "Total NO. of IVs=  361 , NO. of valid IVs with foreground signals:  131.9853 . \n",
      "***********************************************************\n",
      "Pair:  IBD ~ CAD \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  IBD  on  CAD : \n",
      "MR-APSS: beta =  0.0248 , beta.se =  0.0123 , p-value =  4.2702e-02 . \n",
      "Total NO. of IVs=  361 , NO. of valid IVs with foreground signals:  134.5674 . \n",
      "***********************************************************\n",
      "Pair:  IBD ~ HBP \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  IBD  on  HBP : \n",
      "MR-APSS: beta =  -0.0243 , beta.se =  0.0144 , p-value =  9.1451e-02 . \n",
      "Total NO. of IVs=  361 , NO. of valid IVs with foreground signals:  146.2437 . \n",
      "***********************************************************\n",
      "Pair:  IBD ~ Income \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  IBD  on  Income : \n",
      "MR-APSS: beta =  0.021 , beta.se =  0.0098 , p-value =  3.1733e-02 . \n",
      "Total NO. of IVs=  361 , NO. of valid IVs with foreground signals:  131.6227 . \n",
      "***********************************************************\n",
      "Pair:  IBD ~ NEB \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  IBD  on  NEB : \n",
      "MR-APSS: beta =  0.0056 , beta.se =  0.0068 , p-value =  4.0938e-01 . \n",
      "Total NO. of IVs=  349 , NO. of valid IVs with foreground signals:  131.7263 . \n",
      "***********************************************************\n",
      "Pair:  IBD ~ Smoking \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  IBD  on  Smoking : \n",
      "MR-APSS: beta =  -6e-04 , beta.se =  0.0085 , p-value =  9.4563e-01 . \n",
      "Total NO. of IVs=  361 , NO. of valid IVs with foreground signals:  131.679 . \n",
      "***********************************************************\n",
      "Pair:  IBD ~ Urate \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  IBD  on  Urate : \n",
      "MR-APSS: beta =  -0.0204 , beta.se =  0.0169 , p-value =  2.2649e-01 . \n",
      "Total NO. of IVs=  350 , NO. of valid IVs with foreground signals:  132.6169 . \n",
      "***********************************************************\n",
      "Pair:  IBD ~ Anorexia \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  IBD  on  Anorexia : \n",
      "MR-APSS: beta =  0.0052 , beta.se =  0.017 , p-value =  7.6059e-01 . \n",
      "Total NO. of IVs=  327 , NO. of valid IVs with foreground signals:  127.9286 . \n",
      "***********************************************************\n",
      "Pair:  IBD ~ CD \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  IBD  on  CD : \n",
      "MR-APSS: beta =  0.9869 , beta.se =  0.0671 , p-value =  5.1928e-49 . \n",
      "Total NO. of IVs=  362 , NO. of valid IVs with foreground signals:  138.7509 . \n",
      "***********************************************************\n",
      "Pair:  IBD ~ Height_GIANT \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  IBD  on  Height_GIANT : \n",
      "MR-APSS: beta =  0.0295 , beta.se =  0.0195 , p-value =  1.3028e-01 . \n",
      "Total NO. of IVs=  348 , NO. of valid IVs with foreground signals:  137.021 . \n",
      "***********************************************************\n",
      "Pair:  IBD ~ Insomnia \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  IBD  on  Insomnia : \n",
      "MR-APSS: beta =  -0.0031 , beta.se =  0.0078 , p-value =  6.8976e-01 . \n",
      "Total NO. of IVs=  361 , NO. of valid IVs with foreground signals:  132.6674 . \n",
      "***********************************************************\n",
      "Pair:  IBD ~ Neuroticism \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  IBD  on  Neuroticism : \n",
      "MR-APSS: beta =  -0.0173 , beta.se =  0.0098 , p-value =  7.7723e-02 . \n",
      "Total NO. of IVs=  361 , NO. of valid IVs with foreground signals:  133.301 . \n",
      "***********************************************************\n",
      "Pair:  IBD ~ SWB \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  IBD  on  SWB : \n",
      "MR-APSS: beta =  0.0046 , beta.se =  0.0073 , p-value =  5.2390e-01 . \n",
      "Total NO. of IVs=  348 , NO. of valid IVs with foreground signals:  132.6118 . \n",
      "***********************************************************\n",
      "Pair:  MDD ~ AD \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  MDD  on  AD : \n",
      "MR-APSS: beta =  -0.153 , beta.se =  0.3605 , p-value =  6.7128e-01 . \n",
      "Total NO. of IVs=  22 , NO. of valid IVs with foreground signals:  21.99681 . \n",
      "***********************************************************\n",
      "Pair:  MDD ~ ASD \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  MDD  on  ASD : \n",
      "MR-APSS: beta =  0.3692 , beta.se =  0.6589 , p-value =  5.7525e-01 . \n",
      "Total NO. of IVs=  22 , NO. of valid IVs with foreground signals:  21.99679 . \n",
      "***********************************************************\n",
      "Pair:  MDD ~ Daytime_Sleepiness \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  MDD  on  Daytime_Sleepiness : \n",
      "MR-APSS: beta =  0.0329 , beta.se =  0.2399 , p-value =  8.9085e-01 . \n",
      "Total NO. of IVs=  22 , NO. of valid IVs with foreground signals:  20.10173 . \n",
      "***********************************************************\n",
      "Pair:  MDD ~ Height_UKB \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  MDD  on  Height_UKB : \n",
      "MR-APSS: beta =  -0.0365 , beta.se =  0.2874 , p-value =  8.9888e-01 . \n",
      "Total NO. of IVs=  22 , NO. of valid IVs with foreground signals:  21.99698 . \n",
      "***********************************************************\n",
      "Pair:  MDD ~ Intelligence \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  MDD  on  Intelligence : \n",
      "MR-APSS: beta =  -0.0053 , beta.se =  0.3869 , p-value =  9.8903e-01 . \n",
      "Total NO. of IVs=  22 , NO. of valid IVs with foreground signals:  21.99279 . \n",
      "***********************************************************\n",
      "Pair:  MDD ~ RA \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  MDD  on  RA : \n",
      "MR-APSS: beta =  -0.386 , beta.se =  0.3862 , p-value =  3.1754e-01 . \n",
      "Total NO. of IVs=  22 , NO. of valid IVs with foreground signals:  21.9973 . \n",
      "***********************************************************\n",
      "Pair:  MDD ~ T2D \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  MDD  on  T2D : \n",
      "MR-APSS: beta =  0.0901 , beta.se =  0.2453 , p-value =  7.1339e-01 . \n",
      "Total NO. of IVs=  22 , NO. of valid IVs with foreground signals:  21.99698 . \n",
      "***********************************************************\n",
      "Pair:  MDD ~ Alcohol \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  MDD  on  Alcohol : \n",
      "MR-APSS: beta =  -0.0284 , beta.se =  0.1576 , p-value =  8.5694e-01 . \n",
      "Total NO. of IVs=  22 , NO. of valid IVs with foreground signals:  21.99709 . \n",
      "***********************************************************\n",
      "Pair:  MDD ~ BMI \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  MDD  on  BMI : \n",
      "MR-APSS: beta =  0.2075 , beta.se =  0.2595 , p-value =  4.2382e-01 . \n",
      "Total NO. of IVs=  22 , NO. of valid IVs with foreground signals:  21.99727 . \n",
      "***********************************************************\n",
      "Pair:  MDD ~ Depression \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  MDD  on  Depression : \n",
      "MR-APSS: beta =  0.1917 , beta.se =  0.2545 , p-value =  4.5135e-01 . \n",
      "Total NO. of IVs=  22 , NO. of valid IVs with foreground signals:  21.99359 . \n",
      "***********************************************************\n",
      "Pair:  MDD ~ IBD \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  MDD  on  IBD : \n",
      "MR-APSS: beta =  -0.1142 , beta.se =  0.3698 , p-value =  7.5740e-01 . \n",
      "Total NO. of IVs=  22 , NO. of valid IVs with foreground signals:  21.99701 . \n",
      "***********************************************************\n",
      "Pair:  MDD ~ SCZ \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  MDD  on  SCZ : \n",
      "MR-APSS: beta =  -0.2263 , beta.se =  0.3063 , p-value =  4.5995e-01 . \n",
      "Total NO. of IVs=  21 , NO. of valid IVs with foreground signals:  20.99703 . \n",
      "***********************************************************\n",
      "Pair:  MDD ~ Angina \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  MDD  on  Angina : \n",
      "MR-APSS: beta =  0.0919 , beta.se =  0.1548 , p-value =  5.5268e-01 . \n",
      "Total NO. of IVs=  22 , NO. of valid IVs with foreground signals:  21.99711 . \n",
      "***********************************************************\n",
      "Pair:  MDD ~ CAD \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  MDD  on  CAD : \n",
      "MR-APSS: beta =  -0.0095 , beta.se =  0.1944 , p-value =  9.6110e-01 . \n",
      "Total NO. of IVs=  22 , NO. of valid IVs with foreground signals:  21.99702 . \n",
      "***********************************************************\n",
      "Pair:  MDD ~ HBP \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  MDD  on  HBP : \n",
      "MR-APSS: beta =  -0.1288 , beta.se =  0.1814 , p-value =  4.7771e-01 . \n",
      "Total NO. of IVs=  22 , NO. of valid IVs with foreground signals:  21.99593 . \n",
      "***********************************************************\n",
      "Pair:  MDD ~ Income \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  MDD  on  Income : \n",
      "MR-APSS: beta =  -0.0801 , beta.se =  0.2023 , p-value =  6.9216e-01 . \n",
      "Total NO. of IVs=  22 , NO. of valid IVs with foreground signals:  21.99678 . \n",
      "***********************************************************\n",
      "Pair:  MDD ~ NEB \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  MDD  on  NEB : \n",
      "MR-APSS: beta =  0.0477 , beta.se =  0.146 , p-value =  7.4372e-01 . \n",
      "Total NO. of IVs=  21 , NO. of valid IVs with foreground signals:  20.9972 . \n",
      "***********************************************************\n",
      "Pair:  MDD ~ Smoking \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  MDD  on  Smoking : \n",
      "MR-APSS: beta =  -0.0174 , beta.se =  0.2314 , p-value =  9.4008e-01 . \n",
      "Total NO. of IVs=  21 , NO. of valid IVs with foreground signals:  20.99699 . \n",
      "***********************************************************\n",
      "Pair:  MDD ~ Urate \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  MDD  on  Urate : \n",
      "MR-APSS: beta =  0.1994 , beta.se =  0.2261 , p-value =  3.7780e-01 . \n",
      "Total NO. of IVs=  21 , NO. of valid IVs with foreground signals:  20.99717 . \n",
      "***********************************************************\n",
      "Pair:  MDD ~ Anorexia \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  MDD  on  Anorexia : \n",
      "MR-APSS: beta =  0.1222 , beta.se =  0.3843 , p-value =  7.5042e-01 . \n",
      "Total NO. of IVs=  18 , NO. of valid IVs with foreground signals:  17.99777 . \n",
      "***********************************************************\n",
      "Pair:  MDD ~ CD \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  MDD  on  CD : \n",
      "MR-APSS: beta =  -0.5478 , beta.se =  0.4358 , p-value =  2.0872e-01 . \n",
      "Total NO. of IVs=  22 , NO. of valid IVs with foreground signals:  21.9966 . \n",
      "***********************************************************\n",
      "Pair:  MDD ~ Height_GIANT \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  MDD  on  Height_GIANT : \n",
      "MR-APSS: beta =  0.0703 , beta.se =  0.2645 , p-value =  7.9031e-01 . \n",
      "Total NO. of IVs=  20 , NO. of valid IVs with foreground signals:  19.99729 . \n",
      "***********************************************************\n",
      "Pair:  MDD ~ Insomnia \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  MDD  on  Insomnia : \n",
      "MR-APSS: beta =  -0.1584 , beta.se =  0.1722 , p-value =  3.5783e-01 . \n",
      "Total NO. of IVs=  22 , NO. of valid IVs with foreground signals:  21.99721 . \n",
      "***********************************************************\n",
      "Pair:  MDD ~ Neuroticism \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  MDD  on  Neuroticism : \n",
      "MR-APSS: beta =  0.1383 , beta.se =  0.2901 , p-value =  6.3365e-01 . \n",
      "Total NO. of IVs=  22 , NO. of valid IVs with foreground signals:  17.74855 . \n",
      "***********************************************************\n",
      "Pair:  MDD ~ SWB \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  MDD  on  SWB : \n",
      "MR-APSS: beta =  0.1217 , beta.se =  0.1397 , p-value =  3.8333e-01 . \n",
      "Total NO. of IVs=  21 , NO. of valid IVs with foreground signals:  20.99695 . \n",
      "***********************************************************\n",
      "Pair:  SCZ ~ AD \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  SCZ  on  AD : \n",
      "MR-APSS: beta =  0.0045 , beta.se =  0.0355 , p-value =  8.9948e-01 . \n",
      "Total NO. of IVs=  664 , NO. of valid IVs with foreground signals:  165.6573 . \n",
      "***********************************************************\n",
      "Pair:  SCZ ~ ASD \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  SCZ  on  ASD : \n",
      "MR-APSS: beta =  0.1956 , beta.se =  0.071 , p-value =  5.8574e-03 . \n",
      "Total NO. of IVs=  671 , NO. of valid IVs with foreground signals:  163.2267 . \n",
      "***********************************************************\n",
      "Pair:  SCZ ~ Daytime_Sleepiness \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  SCZ  on  Daytime_Sleepiness : \n",
      "MR-APSS: beta =  0.0348 , beta.se =  0.0194 , p-value =  7.2528e-02 . \n",
      "Total NO. of IVs=  671 , NO. of valid IVs with foreground signals:  164.6116 . \n",
      "***********************************************************\n",
      "Pair:  SCZ ~ Height_UKB \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  SCZ  on  Height_UKB : \n",
      "MR-APSS: beta =  -0.0114 , beta.se =  0.0479 , p-value =  8.1254e-01 . \n",
      "Total NO. of IVs=  665 , NO. of valid IVs with foreground signals:  115.7086 . \n",
      "***********************************************************\n",
      "Pair:  SCZ ~ Intelligence \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  SCZ  on  Intelligence : \n",
      "MR-APSS: beta =  -0.1474 , beta.se =  0.0426 , p-value =  5.3676e-04 . \n",
      "Total NO. of IVs=  665 , NO. of valid IVs with foreground signals:  173.8398 . \n",
      "***********************************************************\n",
      "Pair:  SCZ ~ RA \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  SCZ  on  RA : \n",
      "MR-APSS: beta =  0.0131 , beta.se =  0.0323 , p-value =  6.8539e-01 . \n",
      "Total NO. of IVs=  664 , NO. of valid IVs with foreground signals:  156.0231 . \n",
      "***********************************************************\n",
      "Pair:  SCZ ~ T2D \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  SCZ  on  T2D : \n",
      "MR-APSS: beta =  -0.0065 , beta.se =  0.0335 , p-value =  8.4668e-01 . \n",
      "Total NO. of IVs=  671 , NO. of valid IVs with foreground signals:  161.8801 . \n",
      "***********************************************************\n",
      "Pair:  SCZ ~ Alcohol \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  SCZ  on  Alcohol : \n",
      "MR-APSS: beta =  0.0271 , beta.se =  0.0242 , p-value =  2.6341e-01 . \n",
      "Total NO. of IVs=  671 , NO. of valid IVs with foreground signals:  151.9113 . \n",
      "***********************************************************\n",
      "Pair:  SCZ ~ BMI \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  SCZ  on  BMI : \n",
      "MR-APSS: beta =  -0.0116 , beta.se =  0.034 , p-value =  7.3194e-01 . \n",
      "Total NO. of IVs=  665 , NO. of valid IVs with foreground signals:  162.407 . \n",
      "***********************************************************\n",
      "Pair:  SCZ ~ Depression \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  SCZ  on  Depression : \n",
      "MR-APSS: beta =  0.0752 , beta.se =  0.0183 , p-value =  4.0955e-05 . \n",
      "Total NO. of IVs=  664 , NO. of valid IVs with foreground signals:  162.6901 . \n",
      "***********************************************************\n",
      "Pair:  SCZ ~ IBD \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  SCZ  on  IBD : \n",
      "MR-APSS: beta =  -0.1055 , beta.se =  0.0516 , p-value =  4.0754e-02 . \n",
      "Total NO. of IVs=  663 , NO. of valid IVs with foreground signals:  146.9078 . \n",
      "***********************************************************\n",
      "Pair:  SCZ ~ MDD \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  SCZ  on  MDD : \n",
      "MR-APSS: beta =  0.0334 , beta.se =  0.0175 , p-value =  5.6725e-02 . \n",
      "Total NO. of IVs=  665 , NO. of valid IVs with foreground signals:  154.3494 . \n",
      "***********************************************************\n",
      "Pair:  SCZ ~ Angina \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  SCZ  on  Angina : \n",
      "MR-APSS: beta =  -0.0077 , beta.se =  0.0162 , p-value =  6.3370e-01 . \n",
      "Total NO. of IVs=  665 , NO. of valid IVs with foreground signals:  147.2156 . \n",
      "***********************************************************\n",
      "Pair:  SCZ ~ CAD \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  SCZ  on  CAD : \n",
      "MR-APSS: beta =  -0.009 , beta.se =  0.0215 , p-value =  6.7424e-01 . \n",
      "Total NO. of IVs=  670 , NO. of valid IVs with foreground signals:  161.522 . \n",
      "***********************************************************\n",
      "Pair:  SCZ ~ HBP \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  SCZ  on  HBP : \n",
      "MR-APSS: beta =  -0.0129 , beta.se =  0.0292 , p-value =  6.5967e-01 . \n",
      "Total NO. of IVs=  665 , NO. of valid IVs with foreground signals:  129.8444 . \n",
      "***********************************************************\n",
      "Pair:  SCZ ~ Income \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  SCZ  on  Income : \n",
      "MR-APSS: beta =  -0.0465 , beta.se =  0.0247 , p-value =  5.9844e-02 . \n",
      "Total NO. of IVs=  671 , NO. of valid IVs with foreground signals:  160.3086 . \n",
      "***********************************************************\n",
      "Pair:  SCZ ~ NEB \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  SCZ  on  NEB : \n",
      "MR-APSS: beta =  0.0075 , beta.se =  0.0156 , p-value =  6.2820e-01 . \n",
      "Total NO. of IVs=  657 , NO. of valid IVs with foreground signals:  154.1332 . \n",
      "***********************************************************\n",
      "Pair:  SCZ ~ Smoking \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  SCZ  on  Smoking : \n",
      "MR-APSS: beta =  0.0649 , beta.se =  0.0238 , p-value =  6.3886e-03 . \n",
      "Total NO. of IVs=  660 , NO. of valid IVs with foreground signals:  170.5521 . \n",
      "***********************************************************\n",
      "Pair:  SCZ ~ Urate \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  SCZ  on  Urate : \n",
      "MR-APSS: beta =  -0.0092 , beta.se =  0.0254 , p-value =  7.1662e-01 . \n",
      "Total NO. of IVs=  658 , NO. of valid IVs with foreground signals:  160.0826 . \n",
      "***********************************************************\n",
      "Pair:  SCZ ~ Anorexia \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  SCZ  on  Anorexia : \n",
      "MR-APSS: beta =  0.1255 , beta.se =  0.0433 , p-value =  3.7351e-03 . \n",
      "Total NO. of IVs=  639 , NO. of valid IVs with foreground signals:  127.5915 . \n",
      "***********************************************************\n",
      "Pair:  SCZ ~ CD \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  SCZ  on  CD : \n",
      "MR-APSS: beta =  -0.1081 , beta.se =  0.0637 , p-value =  8.9573e-02 . \n",
      "Total NO. of IVs=  663 , NO. of valid IVs with foreground signals:  148.4694 . \n",
      "***********************************************************\n",
      "Pair:  SCZ ~ Height_GIANT \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  SCZ  on  Height_GIANT : \n",
      "MR-APSS: beta =  -3e-04 , beta.se =  0.0164 , p-value =  9.8420e-01 . \n",
      "Total NO. of IVs=  654 , NO. of valid IVs with foreground signals:  124.9249 . \n",
      "***********************************************************\n",
      "Pair:  SCZ ~ Insomnia \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  SCZ  on  Insomnia : \n",
      "MR-APSS: beta =  0.0023 , beta.se =  0.0175 , p-value =  8.9721e-01 . \n",
      "Total NO. of IVs=  671 , NO. of valid IVs with foreground signals:  161.8717 . \n",
      "***********************************************************\n",
      "Pair:  SCZ ~ Neuroticism \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  SCZ  on  Neuroticism : \n",
      "MR-APSS: beta =  0.0874 , beta.se =  0.0271 , p-value =  1.2559e-03 . \n",
      "Total NO. of IVs=  665 , NO. of valid IVs with foreground signals:  166.558 . \n",
      "***********************************************************\n",
      "Pair:  SCZ ~ SWB \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  SCZ  on  SWB : \n",
      "MR-APSS: beta =  -0.0443 , beta.se =  0.0151 , p-value =  3.4465e-03 . \n",
      "Total NO. of IVs=  658 , NO. of valid IVs with foreground signals:  157.0409 . \n",
      "***********************************************************\n",
      "Pair:  Angina ~ AD \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  Angina  on  AD : \n",
      "MR-APSS: beta =  0.0093 , beta.se =  0.1213 , p-value =  9.3878e-01 . \n",
      "Total NO. of IVs=  80 , NO. of valid IVs with foreground signals:  23.36946 . \n",
      "***********************************************************\n",
      "Pair:  Angina ~ ASD \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  Angina  on  ASD : \n",
      "MR-APSS: beta =  0.0474 , beta.se =  0.177 , p-value =  7.8902e-01 . \n",
      "Total NO. of IVs=  79 , NO. of valid IVs with foreground signals:  21.82276 . \n",
      "***********************************************************\n",
      "Pair:  Angina ~ Daytime_Sleepiness \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  Angina  on  Daytime_Sleepiness : \n",
      "MR-APSS: beta =  0.0417 , beta.se =  0.0383 , p-value =  2.7560e-01 . \n",
      "Total NO. of IVs=  80 , NO. of valid IVs with foreground signals:  21.97423 . \n",
      "***********************************************************\n",
      "Pair:  Angina ~ Height_UKB \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  Angina  on  Height_UKB : \n",
      "MR-APSS: beta =  -0.3043 , beta.se =  0.1414 , p-value =  3.1339e-02 . \n",
      "Total NO. of IVs=  80 , NO. of valid IVs with foreground signals:  22.91621 . \n",
      "***********************************************************\n",
      "Pair:  Angina ~ Intelligence \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  Angina  on  Intelligence : \n",
      "MR-APSS: beta =  0.0478 , beta.se =  0.0764 , p-value =  5.3129e-01 . \n",
      "Total NO. of IVs=  80 , NO. of valid IVs with foreground signals:  23.15205 . \n",
      "***********************************************************\n",
      "Pair:  Angina ~ RA \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  Angina  on  RA : \n",
      "MR-APSS: beta =  -0.1701 , beta.se =  0.0986 , p-value =  8.4557e-02 . \n",
      "Total NO. of IVs=  80 , NO. of valid IVs with foreground signals:  21.98279 . \n",
      "***********************************************************\n",
      "Pair:  Angina ~ T2D \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  Angina  on  T2D : \n",
      "MR-APSS: beta =  0.107 , beta.se =  0.1333 , p-value =  4.2222e-01 . \n",
      "Total NO. of IVs=  79 , NO. of valid IVs with foreground signals:  23.26242 . \n",
      "***********************************************************\n",
      "Pair:  Angina ~ Alcohol \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  Angina  on  Alcohol : \n",
      "MR-APSS: beta =  0.1264 , beta.se =  0.0593 , p-value =  3.2898e-02 . \n",
      "Total NO. of IVs=  79 , NO. of valid IVs with foreground signals:  22.09289 . \n",
      "***********************************************************\n",
      "Pair:  Angina ~ BMI \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  Angina  on  BMI : \n",
      "MR-APSS: beta =  -0.2006 , beta.se =  0.0749 , p-value =  7.3652e-03 . \n",
      "Total NO. of IVs=  80 , NO. of valid IVs with foreground signals:  21.56406 . \n",
      "***********************************************************\n",
      "Pair:  Angina ~ Depression \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  Angina  on  Depression : \n",
      "MR-APSS: beta =  0.0263 , beta.se =  0.0413 , p-value =  5.2302e-01 . \n",
      "Total NO. of IVs=  80 , NO. of valid IVs with foreground signals:  21.50565 . \n",
      "***********************************************************\n",
      "Pair:  Angina ~ IBD \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  Angina  on  IBD : \n",
      "MR-APSS: beta =  -0.2461 , beta.se =  0.1366 , p-value =  7.1477e-02 . \n",
      "Total NO. of IVs=  80 , NO. of valid IVs with foreground signals:  22.22595 . \n",
      "***********************************************************\n",
      "Pair:  Angina ~ MDD \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  Angina  on  MDD : \n",
      "MR-APSS: beta =  -0.0377 , beta.se =  0.0456 , p-value =  4.0886e-01 . \n",
      "Total NO. of IVs=  80 , NO. of valid IVs with foreground signals:  21.53351 . \n",
      "***********************************************************\n",
      "Pair:  Angina ~ SCZ \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  Angina  on  SCZ : \n",
      "MR-APSS: beta =  -0.2107 , beta.se =  0.0935 , p-value =  2.4160e-02 . \n",
      "Total NO. of IVs=  78 , NO. of valid IVs with foreground signals:  19.04893 . \n",
      "***********************************************************\n",
      "Pair:  Angina ~ CAD \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  Angina  on  CAD : \n",
      "MR-APSS: beta =  1.3121 , beta.se =  0.1479 , p-value =  7.1554e-19 . \n",
      "Total NO. of IVs=  79 , NO. of valid IVs with foreground signals:  31.80109 . \n",
      "***********************************************************\n",
      "Pair:  Angina ~ HBP \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  Angina  on  HBP : \n",
      "MR-APSS: beta =  0.4578 , beta.se =  0.1467 , p-value =  1.8044e-03 . \n",
      "Total NO. of IVs=  80 , NO. of valid IVs with foreground signals:  20.53202 . \n",
      "***********************************************************\n",
      "Pair:  Angina ~ Income \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  Angina  on  Income : \n",
      "MR-APSS: beta =  -0.0495 , beta.se =  0.0512 , p-value =  3.3344e-01 . \n",
      "Total NO. of IVs=  80 , NO. of valid IVs with foreground signals:  22.51969 . \n",
      "***********************************************************\n",
      "Pair:  Angina ~ NEB \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  Angina  on  NEB : \n",
      "MR-APSS: beta =  0.0622 , beta.se =  0.0405 , p-value =  1.2425e-01 . \n",
      "Total NO. of IVs=  78 , NO. of valid IVs with foreground signals:  20.73498 . \n",
      "***********************************************************\n",
      "Pair:  Angina ~ Smoking \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  Angina  on  Smoking : \n",
      "MR-APSS: beta =  -3e-04 , beta.se =  0.0339 , p-value =  9.9252e-01 . \n",
      "Total NO. of IVs=  78 , NO. of valid IVs with foreground signals:  20.64621 . \n",
      "***********************************************************\n",
      "Pair:  Angina ~ Urate \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  Angina  on  Urate : \n",
      "MR-APSS: beta =  0.14 , beta.se =  0.1073 , p-value =  1.9171e-01 . \n",
      "Total NO. of IVs=  78 , NO. of valid IVs with foreground signals:  26.59247 . \n",
      "***********************************************************\n",
      "Pair:  Angina ~ Anorexia \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  Angina  on  Anorexia : \n",
      "MR-APSS: beta =  -0.0233 , beta.se =  0.1275 , p-value =  8.5520e-01 . \n",
      "Total NO. of IVs=  70 , NO. of valid IVs with foreground signals:  19.43268 . \n",
      "***********************************************************\n",
      "Pair:  Angina ~ CD \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  Angina  on  CD : \n",
      "MR-APSS: beta =  -0.2182 , beta.se =  0.1687 , p-value =  1.9590e-01 . \n",
      "Total NO. of IVs=  80 , NO. of valid IVs with foreground signals:  22.28409 . \n",
      "***********************************************************\n",
      "Pair:  Angina ~ Height_GIANT \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  Angina  on  Height_GIANT : \n",
      "MR-APSS: beta =  -0.2638 , beta.se =  0.1318 , p-value =  4.5238e-02 . \n",
      "Total NO. of IVs=  78 , NO. of valid IVs with foreground signals:  21.79262 . \n",
      "***********************************************************\n",
      "Pair:  Angina ~ Insomnia \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  Angina  on  Insomnia : \n",
      "MR-APSS: beta =  -0.0727 , beta.se =  0.0391 , p-value =  6.3227e-02 . \n",
      "Total NO. of IVs=  80 , NO. of valid IVs with foreground signals:  22.03915 . \n",
      "***********************************************************\n",
      "Pair:  Angina ~ Neuroticism \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  Angina  on  Neuroticism : \n",
      "MR-APSS: beta =  -0.0675 , beta.se =  0.0562 , p-value =  2.2966e-01 . \n",
      "Total NO. of IVs=  80 , NO. of valid IVs with foreground signals:  21.55281 . \n",
      "***********************************************************\n",
      "Pair:  Angina ~ SWB \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  Angina  on  SWB : \n",
      "MR-APSS: beta =  0.0293 , beta.se =  0.0553 , p-value =  5.9579e-01 . \n",
      "Total NO. of IVs=  78 , NO. of valid IVs with foreground signals:  20.36286 . \n",
      "***********************************************************\n",
      "Pair:  CAD ~ AD \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  CAD  on  AD : \n",
      "MR-APSS: beta =  -0.0525 , beta.se =  0.0386 , p-value =  1.7432e-01 . \n",
      "Total NO. of IVs=  158 , NO. of valid IVs with foreground signals:  151.5693 . \n",
      "***********************************************************\n",
      "Pair:  CAD ~ ASD \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  CAD  on  ASD : \n",
      "MR-APSS: beta =  -0.1077 , beta.se =  0.0679 , p-value =  1.1301e-01 . \n",
      "Total NO. of IVs=  156 , NO. of valid IVs with foreground signals:  142.4778 . \n",
      "***********************************************************\n",
      "Pair:  CAD ~ Daytime_Sleepiness \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  CAD  on  Daytime_Sleepiness : \n",
      "MR-APSS: beta =  0.0142 , beta.se =  0.015 , p-value =  3.4282e-01 . \n",
      "Total NO. of IVs=  157 , NO. of valid IVs with foreground signals:  151.2613 . \n",
      "***********************************************************\n",
      "Pair:  CAD ~ Height_UKB \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  CAD  on  Height_UKB : \n",
      "MR-APSS: beta =  -0.1011 , beta.se =  0.0538 , p-value =  6.0373e-02 . \n",
      "Total NO. of IVs=  153 , NO. of valid IVs with foreground signals:  126.071 . \n",
      "***********************************************************\n",
      "Pair:  CAD ~ Intelligence \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  CAD  on  Intelligence : \n",
      "MR-APSS: beta =  -0.071 , beta.se =  0.0326 , p-value =  2.9511e-02 . \n",
      "Total NO. of IVs=  153 , NO. of valid IVs with foreground signals:  144.0606 . \n",
      "***********************************************************\n",
      "Pair:  CAD ~ RA \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  CAD  on  RA : \n",
      "MR-APSS: beta =  -0.1043 , beta.se =  0.0415 , p-value =  1.2041e-02 . \n",
      "Total NO. of IVs=  153 , NO. of valid IVs with foreground signals:  147.2819 . \n",
      "***********************************************************\n",
      "Pair:  CAD ~ T2D \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  CAD  on  T2D : \n",
      "MR-APSS: beta =  0.1164 , beta.se =  0.0488 , p-value =  1.7058e-02 . \n",
      "Total NO. of IVs=  156 , NO. of valid IVs with foreground signals:  119.8261 . \n",
      "***********************************************************\n",
      "Pair:  CAD ~ Alcohol \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  CAD  on  Alcohol : \n",
      "MR-APSS: beta =  0.0017 , beta.se =  0.0195 , p-value =  9.2887e-01 . \n",
      "Total NO. of IVs=  157 , NO. of valid IVs with foreground signals:  137.819 . \n",
      "***********************************************************\n",
      "Pair:  CAD ~ BMI \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  CAD  on  BMI : \n",
      "MR-APSS: beta =  -0.0647 , beta.se =  0.0395 , p-value =  1.0132e-01 . \n",
      "Total NO. of IVs=  153 , NO. of valid IVs with foreground signals:  119.7572 . \n",
      "***********************************************************\n",
      "Pair:  CAD ~ Depression \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  CAD  on  Depression : \n",
      "MR-APSS: beta =  0.0147 , beta.se =  0.0157 , p-value =  3.5017e-01 . \n",
      "Total NO. of IVs=  153 , NO. of valid IVs with foreground signals:  144.961 . \n",
      "***********************************************************\n",
      "Pair:  CAD ~ IBD \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  CAD  on  IBD : \n",
      "MR-APSS: beta =  -0.0208 , beta.se =  0.0559 , p-value =  7.0967e-01 . \n",
      "Total NO. of IVs=  153 , NO. of valid IVs with foreground signals:  143.6474 . \n",
      "***********************************************************\n",
      "Pair:  CAD ~ MDD \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  CAD  on  MDD : \n",
      "MR-APSS: beta =  -0.0028 , beta.se =  0.0166 , p-value =  8.6483e-01 . \n",
      "Total NO. of IVs=  153 , NO. of valid IVs with foreground signals:  147.5578 . \n",
      "***********************************************************\n",
      "Pair:  CAD ~ SCZ \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  CAD  on  SCZ : \n",
      "MR-APSS: beta =  -0.017 , beta.se =  0.0398 , p-value =  6.6981e-01 . \n",
      "Total NO. of IVs=  154 , NO. of valid IVs with foreground signals:  134.7927 . \n",
      "***********************************************************\n",
      "Pair:  CAD ~ Angina \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  CAD  on  Angina : \n",
      "MR-APSS: beta =  0.4426 , beta.se =  0.0375 , p-value =  3.6174e-32 . \n",
      "Total NO. of IVs=  153 , NO. of valid IVs with foreground signals:  111.2672 . \n",
      "***********************************************************\n",
      "Pair:  CAD ~ HBP \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  CAD  on  HBP : \n",
      "MR-APSS: beta =  0.2384 , beta.se =  0.0626 , p-value =  1.3895e-04 . \n",
      "Total NO. of IVs=  153 , NO. of valid IVs with foreground signals:  96.77358 . \n",
      "***********************************************************\n",
      "Pair:  CAD ~ Income \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  CAD  on  Income : \n",
      "MR-APSS: beta =  -0.0604 , beta.se =  0.0207 , p-value =  3.5059e-03 . \n",
      "Total NO. of IVs=  158 , NO. of valid IVs with foreground signals:  142.8893 . \n",
      "***********************************************************\n",
      "Pair:  CAD ~ NEB \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  CAD  on  NEB : \n",
      "MR-APSS: beta =  0.0099 , beta.se =  0.015 , p-value =  5.0909e-01 . \n",
      "Total NO. of IVs=  153 , NO. of valid IVs with foreground signals:  138.6803 . \n",
      "***********************************************************\n",
      "Pair:  CAD ~ Smoking \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  CAD  on  Smoking : \n",
      "MR-APSS: beta =  -0.002 , beta.se =  0.019 , p-value =  9.1413e-01 . \n",
      "Total NO. of IVs=  155 , NO. of valid IVs with foreground signals:  141.5985 . \n",
      "***********************************************************\n",
      "Pair:  CAD ~ Urate \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  CAD  on  Urate : \n",
      "MR-APSS: beta =  0.08 , beta.se =  0.0361 , p-value =  2.6433e-02 . \n",
      "Total NO. of IVs=  155 , NO. of valid IVs with foreground signals:  136.4285 . \n",
      "***********************************************************\n",
      "Pair:  CAD ~ Anorexia \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  CAD  on  Anorexia : \n",
      "MR-APSS: beta =  -0.0195 , beta.se =  0.0364 , p-value =  5.9211e-01 . \n",
      "Total NO. of IVs=  144 , NO. of valid IVs with foreground signals:  127.4986 . \n",
      "***********************************************************\n",
      "Pair:  CAD ~ CD \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  CAD  on  CD : \n",
      "MR-APSS: beta =  0.0065 , beta.se =  0.0672 , p-value =  9.2345e-01 . \n",
      "Total NO. of IVs=  153 , NO. of valid IVs with foreground signals:  139.6353 . \n",
      "***********************************************************\n",
      "Pair:  CAD ~ Height_GIANT \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  CAD  on  Height_GIANT : \n",
      "MR-APSS: beta =  -0.0342 , beta.se =  0.044 , p-value =  4.3713e-01 . \n",
      "Total NO. of IVs=  153 , NO. of valid IVs with foreground signals:  125.2129 . \n",
      "***********************************************************\n",
      "Pair:  CAD ~ Insomnia \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  CAD  on  Insomnia : \n",
      "MR-APSS: beta =  0.0127 , beta.se =  0.0189 , p-value =  5.0405e-01 . \n",
      "Total NO. of IVs=  157 , NO. of valid IVs with foreground signals:  145.6332 . \n",
      "***********************************************************\n",
      "Pair:  CAD ~ Neuroticism \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  CAD  on  Neuroticism : \n",
      "MR-APSS: beta =  0.0017 , beta.se =  0.0213 , p-value =  9.3478e-01 . \n",
      "Total NO. of IVs=  153 , NO. of valid IVs with foreground signals:  142.8735 . \n",
      "***********************************************************\n",
      "Pair:  CAD ~ SWB \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  CAD  on  SWB : \n",
      "MR-APSS: beta =  0.0143 , beta.se =  0.0161 , p-value =  3.7204e-01 . \n",
      "Total NO. of IVs=  156 , NO. of valid IVs with foreground signals:  144.2693 . \n",
      "***********************************************************\n",
      "Pair:  HBP ~ AD \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  HBP  on  AD : \n",
      "MR-APSS: beta =  -0.0261 , beta.se =  0.0357 , p-value =  4.6519e-01 . \n",
      "Total NO. of IVs=  679 , NO. of valid IVs with foreground signals:  184.8174 . \n",
      "***********************************************************\n",
      "Pair:  HBP ~ ASD \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  HBP  on  ASD : \n",
      "MR-APSS: beta =  0.1088 , beta.se =  0.0585 , p-value =  6.2734e-02 . \n",
      "Total NO. of IVs=  678 , NO. of valid IVs with foreground signals:  189.0529 . \n",
      "***********************************************************\n",
      "Pair:  HBP ~ Daytime_Sleepiness \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  HBP  on  Daytime_Sleepiness : \n",
      "MR-APSS: beta =  0.0363 , beta.se =  0.014 , p-value =  9.7247e-03 . \n",
      "Total NO. of IVs=  683 , NO. of valid IVs with foreground signals:  188.5741 . \n",
      "***********************************************************\n",
      "Pair:  HBP ~ Height_UKB \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  HBP  on  Height_UKB : \n",
      "MR-APSS: beta =  -0.1001 , beta.se =  0.0492 , p-value =  4.1770e-02 . \n",
      "Total NO. of IVs=  682 , NO. of valid IVs with foreground signals:  203.7176 . \n",
      "***********************************************************\n",
      "Pair:  HBP ~ Intelligence \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  HBP  on  Intelligence : \n",
      "MR-APSS: beta =  -0.0312 , beta.se =  0.0337 , p-value =  3.5451e-01 . \n",
      "Total NO. of IVs=  684 , NO. of valid IVs with foreground signals:  191.786 . \n",
      "***********************************************************\n",
      "Pair:  HBP ~ RA \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  HBP  on  RA : \n",
      "MR-APSS: beta =  -0.0638 , beta.se =  0.0368 , p-value =  8.3460e-02 . \n",
      "Total NO. of IVs=  679 , NO. of valid IVs with foreground signals:  188.7585 . \n",
      "***********************************************************\n",
      "Pair:  HBP ~ T2D \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  HBP  on  T2D : \n",
      "MR-APSS: beta =  0.1369 , beta.se =  0.041 , p-value =  8.4964e-04 . \n",
      "Total NO. of IVs=  677 , NO. of valid IVs with foreground signals:  208.2825 . \n",
      "***********************************************************\n",
      "Pair:  HBP ~ Alcohol \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  HBP  on  Alcohol : \n",
      "MR-APSS: beta =  -0.0265 , beta.se =  0.0187 , p-value =  1.5699e-01 . \n",
      "Total NO. of IVs=  683 , NO. of valid IVs with foreground signals:  191.0307 . \n",
      "***********************************************************\n",
      "Pair:  HBP ~ BMI \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  HBP  on  BMI : \n",
      "MR-APSS: beta =  0.0292 , beta.se =  0.0344 , p-value =  3.9676e-01 . \n",
      "Total NO. of IVs=  683 , NO. of valid IVs with foreground signals:  225.0749 . \n",
      "***********************************************************\n",
      "Pair:  HBP ~ Depression \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  HBP  on  Depression : \n",
      "MR-APSS: beta =  0.0246 , beta.se =  0.0154 , p-value =  1.0920e-01 . \n",
      "Total NO. of IVs=  683 , NO. of valid IVs with foreground signals:  186.1573 . \n",
      "***********************************************************\n",
      "Pair:  HBP ~ IBD \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  HBP  on  IBD : \n",
      "MR-APSS: beta =  -0.0746 , beta.se =  0.0521 , p-value =  1.5245e-01 . \n",
      "Total NO. of IVs=  678 , NO. of valid IVs with foreground signals:  194.6687 . \n",
      "***********************************************************\n",
      "Pair:  HBP ~ MDD \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  HBP  on  MDD : \n",
      "MR-APSS: beta =  -0.0081 , beta.se =  0.0162 , p-value =  6.1617e-01 . \n",
      "Total NO. of IVs=  684 , NO. of valid IVs with foreground signals:  189.2159 . \n",
      "***********************************************************\n",
      "Pair:  HBP ~ SCZ \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  HBP  on  SCZ : \n",
      "MR-APSS: beta =  0.0014 , beta.se =  0.0357 , p-value =  9.6889e-01 . \n",
      "Total NO. of IVs=  669 , NO. of valid IVs with foreground signals:  184.3279 . \n",
      "***********************************************************\n",
      "Pair:  HBP ~ Angina \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  HBP  on  Angina : \n",
      "MR-APSS: beta =  0.1474 , beta.se =  0.0201 , p-value =  2.1884e-13 . \n",
      "Total NO. of IVs=  684 , NO. of valid IVs with foreground signals:  189.1495 . \n",
      "***********************************************************\n",
      "Pair:  HBP ~ CAD \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  HBP  on  CAD : \n",
      "MR-APSS: beta =  0.3203 , beta.se =  0.0332 , p-value =  4.9179e-22 . \n",
      "Total NO. of IVs=  683 , NO. of valid IVs with foreground signals:  191.7779 . \n",
      "***********************************************************\n",
      "Pair:  HBP ~ Income \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  HBP  on  Income : \n",
      "MR-APSS: beta =  -0.0477 , beta.se =  0.0179 , p-value =  7.8418e-03 . \n",
      "Total NO. of IVs=  684 , NO. of valid IVs with foreground signals:  192.8575 . \n",
      "***********************************************************\n",
      "Pair:  HBP ~ NEB \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  HBP  on  NEB : \n",
      "MR-APSS: beta =  0.0034 , beta.se =  0.0132 , p-value =  7.9550e-01 . \n",
      "Total NO. of IVs=  673 , NO. of valid IVs with foreground signals:  184.6927 . \n",
      "***********************************************************\n",
      "Pair:  HBP ~ Smoking \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  HBP  on  Smoking : \n",
      "MR-APSS: beta =  0.0169 , beta.se =  0.0176 , p-value =  3.3599e-01 . \n",
      "Total NO. of IVs=  673 , NO. of valid IVs with foreground signals:  194.2075 . \n",
      "***********************************************************\n",
      "Pair:  HBP ~ Urate \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  HBP  on  Urate : \n",
      "MR-APSS: beta =  0.0691 , beta.se =  0.0386 , p-value =  7.3125e-02 . \n",
      "Total NO. of IVs=  677 , NO. of valid IVs with foreground signals:  184.513 . \n",
      "***********************************************************\n",
      "Pair:  HBP ~ Anorexia \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  HBP  on  Anorexia : \n",
      "MR-APSS: beta =  -0.0309 , beta.se =  0.0325 , p-value =  3.4235e-01 . \n",
      "Total NO. of IVs=  644 , NO. of valid IVs with foreground signals:  178.119 . \n",
      "***********************************************************\n",
      "Pair:  HBP ~ CD \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  HBP  on  CD : \n",
      "MR-APSS: beta =  -0.0236 , beta.se =  0.0649 , p-value =  7.1676e-01 . \n",
      "Total NO. of IVs=  679 , NO. of valid IVs with foreground signals:  190.1773 . \n",
      "***********************************************************\n",
      "Pair:  HBP ~ Height_GIANT \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  HBP  on  Height_GIANT : \n",
      "MR-APSS: beta =  -0.0804 , beta.se =  0.0493 , p-value =  1.0260e-01 . \n",
      "Total NO. of IVs=  667 , NO. of valid IVs with foreground signals:  188.4798 . \n",
      "***********************************************************\n",
      "Pair:  HBP ~ Insomnia \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  HBP  on  Insomnia : \n",
      "MR-APSS: beta =  0.0299 , beta.se =  0.0177 , p-value =  9.0776e-02 . \n",
      "Total NO. of IVs=  682 , NO. of valid IVs with foreground signals:  190.506 . \n",
      "***********************************************************\n",
      "Pair:  HBP ~ Neuroticism \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  HBP  on  Neuroticism : \n",
      "MR-APSS: beta =  0.057 , beta.se =  0.0195 , p-value =  3.5182e-03 . \n",
      "Total NO. of IVs=  684 , NO. of valid IVs with foreground signals:  190.4888 . \n",
      "***********************************************************\n",
      "Pair:  HBP ~ SWB \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  HBP  on  SWB : \n",
      "MR-APSS: beta =  -0.0117 , beta.se =  0.0158 , p-value =  4.6014e-01 . \n",
      "Total NO. of IVs=  675 , NO. of valid IVs with foreground signals:  185.8298 . \n",
      "***********************************************************\n",
      "Pair:  Income ~ AD \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  Income  on  AD : \n",
      "MR-APSS: beta =  -0.264 , beta.se =  0.0918 , p-value =  4.0091e-03 . \n",
      "Total NO. of IVs=  275 , NO. of valid IVs with foreground signals:  81.15383 . \n",
      "***********************************************************\n",
      "Pair:  Income ~ ASD \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  Income  on  ASD : \n",
      "MR-APSS: beta =  0.5461 , beta.se =  0.2112 , p-value =  9.7308e-03 . \n",
      "Total NO. of IVs=  265 , NO. of valid IVs with foreground signals:  73.35138 . \n",
      "***********************************************************\n",
      "Pair:  Income ~ Daytime_Sleepiness \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  Income  on  Daytime_Sleepiness : \n",
      "MR-APSS: beta =  -0.1872 , beta.se =  0.0656 , p-value =  4.3121e-03 . \n",
      "Total NO. of IVs=  268 , NO. of valid IVs with foreground signals:  62.90805 . \n",
      "***********************************************************\n",
      "Pair:  Income ~ Height_UKB \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  Income  on  Height_UKB : \n",
      "MR-APSS: beta =  0.5326 , beta.se =  0.1482 , p-value =  3.2640e-04 . \n",
      "Total NO. of IVs=  259 , NO. of valid IVs with foreground signals:  57.54688 . \n",
      "***********************************************************\n",
      "Pair:  Income ~ Intelligence \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  Income  on  Intelligence : \n",
      "MR-APSS: beta =  1.0718 , beta.se =  0.1441 , p-value =  1.0090e-13 . \n",
      "Total NO. of IVs=  260 , NO. of valid IVs with foreground signals:  69.7348 . \n",
      "***********************************************************\n",
      "Pair:  Income ~ RA \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  Income  on  RA : \n",
      "MR-APSS: beta =  -0.2787 , beta.se =  0.1269 , p-value =  2.8108e-02 . \n",
      "Total NO. of IVs=  260 , NO. of valid IVs with foreground signals:  52.33636 . \n",
      "***********************************************************\n",
      "Pair:  Income ~ T2D \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  Income  on  T2D : \n",
      "MR-APSS: beta =  -0.269 , beta.se =  0.1171 , p-value =  2.1583e-02 . \n",
      "Total NO. of IVs=  265 , NO. of valid IVs with foreground signals:  69.73868 . \n",
      "***********************************************************\n",
      "Pair:  Income ~ Alcohol \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  Income  on  Alcohol : \n",
      "MR-APSS: beta =  0.2129 , beta.se =  0.0742 , p-value =  4.0934e-03 . \n",
      "Total NO. of IVs=  269 , NO. of valid IVs with foreground signals:  80.78432 . \n",
      "***********************************************************\n",
      "Pair:  Income ~ BMI \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  Income  on  BMI : \n",
      "MR-APSS: beta =  -0.4711 , beta.se =  0.1188 , p-value =  7.2936e-05 . \n",
      "Total NO. of IVs=  260 , NO. of valid IVs with foreground signals:  66.14209 . \n",
      "***********************************************************\n",
      "Pair:  Income ~ Depression \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  Income  on  Depression : \n",
      "MR-APSS: beta =  -0.3482 , beta.se =  0.0592 , p-value =  4.0671e-09 . \n",
      "Total NO. of IVs=  259 , NO. of valid IVs with foreground signals:  73.22184 . \n",
      "***********************************************************\n",
      "Pair:  Income ~ IBD \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  Income  on  IBD : \n",
      "MR-APSS: beta =  0.1061 , beta.se =  0.1584 , p-value =  5.0293e-01 . \n",
      "Total NO. of IVs=  257 , NO. of valid IVs with foreground signals:  58.90956 . \n",
      "***********************************************************\n",
      "Pair:  Income ~ MDD \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  Income  on  MDD : \n",
      "MR-APSS: beta =  -0.0397 , beta.se =  0.0505 , p-value =  4.3203e-01 . \n",
      "Total NO. of IVs=  260 , NO. of valid IVs with foreground signals:  63.4305 . \n",
      "***********************************************************\n",
      "Pair:  Income ~ SCZ \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  Income  on  SCZ : \n",
      "MR-APSS: beta =  -0.2749 , beta.se =  0.1664 , p-value =  9.8548e-02 . \n",
      "Total NO. of IVs=  267 , NO. of valid IVs with foreground signals:  87.12905 . \n",
      "***********************************************************\n",
      "Pair:  Income ~ Angina \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  Income  on  Angina : \n",
      "MR-APSS: beta =  -0.1251 , beta.se =  0.0484 , p-value =  9.8058e-03 . \n",
      "Total NO. of IVs=  260 , NO. of valid IVs with foreground signals:  63.26947 . \n",
      "***********************************************************\n",
      "Pair:  Income ~ CAD \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  Income  on  CAD : \n",
      "MR-APSS: beta =  -0.1605 , beta.se =  0.0777 , p-value =  3.8901e-02 . \n",
      "Total NO. of IVs=  268 , NO. of valid IVs with foreground signals:  75.28052 . \n",
      "***********************************************************\n",
      "Pair:  Income ~ HBP \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  Income  on  HBP : \n",
      "MR-APSS: beta =  -0.0702 , beta.se =  0.0793 , p-value =  3.7582e-01 . \n",
      "Total NO. of IVs=  260 , NO. of valid IVs with foreground signals:  59.9559 . \n",
      "***********************************************************\n",
      "Pair:  Income ~ NEB \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  Income  on  NEB : \n",
      "MR-APSS: beta =  -0.1024 , beta.se =  0.049 , p-value =  3.6548e-02 . \n",
      "Total NO. of IVs=  259 , NO. of valid IVs with foreground signals:  84.5996 . \n",
      "***********************************************************\n",
      "Pair:  Income ~ Smoking \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  Income  on  Smoking : \n",
      "MR-APSS: beta =  -0.2257 , beta.se =  0.0725 , p-value =  1.8595e-03 . \n",
      "Total NO. of IVs=  264 , NO. of valid IVs with foreground signals:  76.15041 . \n",
      "***********************************************************\n",
      "Pair:  Income ~ Urate \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  Income  on  Urate : \n",
      "MR-APSS: beta =  -0.1017 , beta.se =  0.0723 , p-value =  1.5951e-01 . \n",
      "Total NO. of IVs=  265 , NO. of valid IVs with foreground signals:  91.12749 . \n",
      "***********************************************************\n",
      "Pair:  Income ~ Anorexia \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  Income  on  Anorexia : \n",
      "MR-APSS: beta =  0.2891 , beta.se =  0.1244 , p-value =  2.0072e-02 . \n",
      "Total NO. of IVs=  253 , NO. of valid IVs with foreground signals:  57.25858 . \n",
      "***********************************************************\n",
      "Pair:  Income ~ CD \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  Income  on  CD : \n",
      "MR-APSS: beta =  0.1346 , beta.se =  0.2013 , p-value =  5.0355e-01 . \n",
      "Total NO. of IVs=  257 , NO. of valid IVs with foreground signals:  53.67469 . \n",
      "***********************************************************\n",
      "Pair:  Income ~ Height_GIANT \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  Income  on  Height_GIANT : \n",
      "MR-APSS: beta =  0.2494 , beta.se =  0.1242 , p-value =  4.4689e-02 . \n",
      "Total NO. of IVs=  258 , NO. of valid IVs with foreground signals:  71.10325 . \n",
      "***********************************************************\n",
      "Pair:  Income ~ Insomnia \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  Income  on  Insomnia : \n",
      "MR-APSS: beta =  -0.1342 , beta.se =  0.0598 , p-value =  2.4802e-02 . \n",
      "Total NO. of IVs=  268 , NO. of valid IVs with foreground signals:  81.06471 . \n",
      "***********************************************************\n",
      "Pair:  Income ~ Neuroticism \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  Income  on  Neuroticism : \n",
      "MR-APSS: beta =  -0.357 , beta.se =  0.0947 , p-value =  1.6429e-04 . \n",
      "Total NO. of IVs=  260 , NO. of valid IVs with foreground signals:  56.86955 . \n",
      "***********************************************************\n",
      "Pair:  Income ~ SWB \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  Income  on  SWB : \n",
      "MR-APSS: beta =  0.0979 , beta.se =  0.0506 , p-value =  5.3227e-02 . \n",
      "Total NO. of IVs=  258 , NO. of valid IVs with foreground signals:  85.16342 . \n",
      "***********************************************************\n",
      "Pair:  NEB ~ AD \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  NEB  on  AD : \n",
      "MR-APSS: beta =  0.4329 , beta.se =  0.3191 , p-value =  1.7492e-01 . \n",
      "Total NO. of IVs=  64 , NO. of valid IVs with foreground signals:  63.9899 . \n",
      "***********************************************************\n",
      "Pair:  NEB ~ ASD \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  NEB  on  ASD : \n",
      "MR-APSS: beta =  -0.3927 , beta.se =  0.6445 , p-value =  5.4234e-01 . \n",
      "Total NO. of IVs=  65 , NO. of valid IVs with foreground signals:  64.99087 . \n",
      "***********************************************************\n",
      "Pair:  NEB ~ Daytime_Sleepiness \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  NEB  on  Daytime_Sleepiness : \n",
      "MR-APSS: beta =  -2.5123 , beta.se =  2.4279 , p-value =  3.0078e-01 . \n",
      "Total NO. of IVs=  66 , NO. of valid IVs with foreground signals:  1.603301 . \n",
      "***********************************************************\n",
      "Pair:  NEB ~ Height_UKB \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  NEB  on  Height_UKB : \n",
      "MR-APSS: beta =  -0.0528 , beta.se =  0.3212 , p-value =  8.6950e-01 . \n",
      "Total NO. of IVs=  62 , NO. of valid IVs with foreground signals:  61.97674 . \n",
      "***********************************************************\n",
      "Pair:  NEB ~ Intelligence \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  NEB  on  Intelligence : \n",
      "MR-APSS: beta =  -1.0183 , beta.se =  0.358 , p-value =  4.4507e-03 . \n",
      "Total NO. of IVs=  62 , NO. of valid IVs with foreground signals:  61.7288 . \n",
      "***********************************************************\n",
      "Pair:  NEB ~ RA \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  NEB  on  RA : \n",
      "MR-APSS: beta =  -0.3206 , beta.se =  0.3566 , p-value =  3.6859e-01 . \n",
      "Total NO. of IVs=  62 , NO. of valid IVs with foreground signals:  61.99052 . \n",
      "***********************************************************\n",
      "Pair:  NEB ~ T2D \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  NEB  on  T2D : \n",
      "MR-APSS: beta =  3.2527 , beta.se =  2.042 , p-value =  1.1118e-01 . \n",
      "Total NO. of IVs=  66 , NO. of valid IVs with foreground signals:  1.039806 . \n",
      "***********************************************************\n",
      "Pair:  NEB ~ Alcohol \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  NEB  on  Alcohol : \n",
      "MR-APSS: beta =  -0.4008 , beta.se =  1.0218 , p-value =  6.9490e-01 . \n",
      "Total NO. of IVs=  66 , NO. of valid IVs with foreground signals:  5.209734 . \n",
      "***********************************************************\n",
      "Pair:  NEB ~ BMI \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  NEB  on  BMI : \n",
      "MR-APSS: beta =  0.0042 , beta.se =  0.2702 , p-value =  9.8752e-01 . \n",
      "Total NO. of IVs=  62 , NO. of valid IVs with foreground signals:  61.97861 . \n",
      "***********************************************************\n",
      "Pair:  NEB ~ Depression \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  NEB  on  Depression : \n",
      "MR-APSS: beta =  0.1547 , beta.se =  0.1854 , p-value =  4.0409e-01 . \n",
      "Total NO. of IVs=  62 , NO. of valid IVs with foreground signals:  61.99088 . \n",
      "***********************************************************\n",
      "Pair:  NEB ~ IBD \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  NEB  on  IBD : \n",
      "MR-APSS: beta =  0.4075 , beta.se =  0.4543 , p-value =  3.6971e-01 . \n",
      "Total NO. of IVs=  61 , NO. of valid IVs with foreground signals:  60.98869 . \n",
      "***********************************************************\n",
      "Pair:  NEB ~ MDD \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  NEB  on  MDD : \n",
      "MR-APSS: beta =  0.2968 , beta.se =  0.1684 , p-value =  7.8010e-02 . \n",
      "Total NO. of IVs=  62 , NO. of valid IVs with foreground signals:  61.98895 . \n",
      "***********************************************************\n",
      "Pair:  NEB ~ SCZ \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  NEB  on  SCZ : \n",
      "MR-APSS: beta =  -0.576 , beta.se =  0.416 , p-value =  1.6610e-01 . \n",
      "Total NO. of IVs=  64 , NO. of valid IVs with foreground signals:  63.99 . \n",
      "***********************************************************\n",
      "Pair:  NEB ~ Angina \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  NEB  on  Angina : \n",
      "MR-APSS: beta =  0.0238 , beta.se =  0.1565 , p-value =  8.7914e-01 . \n",
      "Total NO. of IVs=  62 , NO. of valid IVs with foreground signals:  61.98632 . \n",
      "***********************************************************\n",
      "Pair:  NEB ~ CAD \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  NEB  on  CAD : \n",
      "MR-APSS: beta =  0.1037 , beta.se =  0.1872 , p-value =  5.7934e-01 . \n",
      "Total NO. of IVs=  65 , NO. of valid IVs with foreground signals:  64.9878 . \n",
      "***********************************************************\n",
      "Pair:  NEB ~ HBP \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  NEB  on  HBP : \n",
      "MR-APSS: beta =  -0.0283 , beta.se =  0.4896 , p-value =  9.5389e-01 . \n",
      "Total NO. of IVs=  62 , NO. of valid IVs with foreground signals:  18.76471 . \n",
      "***********************************************************\n",
      "Pair:  NEB ~ Income \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  NEB  on  Income : \n",
      "MR-APSS: beta =  -0.7584 , beta.se =  0.3931 , p-value =  5.3687e-02 . \n",
      "Total NO. of IVs=  66 , NO. of valid IVs with foreground signals:  19.07947 . \n",
      "***********************************************************\n",
      "Pair:  NEB ~ Smoking \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  NEB  on  Smoking : \n",
      "MR-APSS: beta =  0.368 , beta.se =  0.4149 , p-value =  3.7511e-01 . \n",
      "Total NO. of IVs=  66 , NO. of valid IVs with foreground signals:  28.8041 . \n",
      "***********************************************************\n",
      "Pair:  NEB ~ Urate \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  NEB  on  Urate : \n",
      "MR-APSS: beta =  -3.7981 , beta.se =  2.5247 , p-value =  1.3248e-01 . \n",
      "Total NO. of IVs=  66 , NO. of valid IVs with foreground signals:  1.053967 . \n",
      "***********************************************************\n",
      "Pair:  NEB ~ Anorexia \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  NEB  on  Anorexia : \n",
      "MR-APSS: beta =  -0.1232 , beta.se =  0.5 , p-value =  8.0542e-01 . \n",
      "Total NO. of IVs=  60 , NO. of valid IVs with foreground signals:  59.97475 . \n",
      "***********************************************************\n",
      "Pair:  NEB ~ CD \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  NEB  on  CD : \n",
      "MR-APSS: beta =  0.8526 , beta.se =  0.5415 , p-value =  1.1541e-01 . \n",
      "Total NO. of IVs=  61 , NO. of valid IVs with foreground signals:  60.98672 . \n",
      "***********************************************************\n",
      "Pair:  NEB ~ Height_GIANT \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  NEB  on  Height_GIANT : \n",
      "MR-APSS: beta =  -0.4683 , beta.se =  0.2693 , p-value =  8.2005e-02 . \n",
      "Total NO. of IVs=  66 , NO. of valid IVs with foreground signals:  65.99015 . \n",
      "***********************************************************\n",
      "Pair:  NEB ~ Insomnia \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  NEB  on  Insomnia : \n",
      "MR-APSS: beta =  -0.0879 , beta.se =  0.1557 , p-value =  5.7259e-01 . \n",
      "Total NO. of IVs=  66 , NO. of valid IVs with foreground signals:  65.98406 . \n",
      "***********************************************************\n",
      "Pair:  NEB ~ Neuroticism \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  NEB  on  Neuroticism : \n",
      "MR-APSS: beta =  0.8585 , beta.se =  1.0131 , p-value =  3.9676e-01 . \n",
      "Total NO. of IVs=  62 , NO. of valid IVs with foreground signals:  10.62732 . \n",
      "***********************************************************\n",
      "Pair:  NEB ~ SWB \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  NEB  on  SWB : \n",
      "MR-APSS: beta =  -0.1482 , beta.se =  0.1445 , p-value =  3.0526e-01 . \n",
      "Total NO. of IVs=  65 , NO. of valid IVs with foreground signals:  64.9765 . \n",
      "***********************************************************\n",
      "Pair:  Smoking ~ AD \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  Smoking  on  AD : \n",
      "MR-APSS: beta =  -0.2454 , beta.se =  0.1074 , p-value =  2.2298e-02 . \n",
      "Total NO. of IVs=  143 , NO. of valid IVs with foreground signals:  142.9525 . \n",
      "***********************************************************\n",
      "Pair:  Smoking ~ ASD \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  Smoking  on  ASD : \n",
      "MR-APSS: beta =  0.0977 , beta.se =  0.1939 , p-value =  6.1433e-01 . \n",
      "Total NO. of IVs=  146 , NO. of valid IVs with foreground signals:  145.8509 . \n",
      "***********************************************************\n",
      "Pair:  Smoking ~ Daytime_Sleepiness \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  Smoking  on  Daytime_Sleepiness : \n",
      "MR-APSS: beta =  0.0471 , beta.se =  0.0483 , p-value =  3.2973e-01 . \n",
      "Total NO. of IVs=  146 , NO. of valid IVs with foreground signals:  145.7388 . \n",
      "***********************************************************\n",
      "Pair:  Smoking ~ Height_UKB \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  Smoking  on  Height_UKB : \n",
      "MR-APSS: beta =  0.05 , beta.se =  0.1353 , p-value =  7.1156e-01 . \n",
      "Total NO. of IVs=  142 , NO. of valid IVs with foreground signals:  87.33639 . \n",
      "***********************************************************\n",
      "Pair:  Smoking ~ Intelligence \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  Smoking  on  Intelligence : \n",
      "MR-APSS: beta =  -0.3264 , beta.se =  0.1189 , p-value =  6.0608e-03 . \n",
      "Total NO. of IVs=  142 , NO. of valid IVs with foreground signals:  113.1182 . \n",
      "***********************************************************\n",
      "Pair:  Smoking ~ RA \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  Smoking  on  RA : \n",
      "MR-APSS: beta =  0.2313 , beta.se =  0.1103 , p-value =  3.6043e-02 . \n",
      "Total NO. of IVs=  141 , NO. of valid IVs with foreground signals:  140.9439 . \n",
      "***********************************************************\n",
      "Pair:  Smoking ~ T2D \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  Smoking  on  T2D : \n",
      "MR-APSS: beta =  0.3083 , beta.se =  0.1736 , p-value =  7.5686e-02 . \n",
      "Total NO. of IVs=  146 , NO. of valid IVs with foreground signals:  57.95049 . \n",
      "***********************************************************\n",
      "Pair:  Smoking ~ Alcohol \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  Smoking  on  Alcohol : \n",
      "MR-APSS: beta =  0.2376 , beta.se =  0.0976 , p-value =  1.4852e-02 . \n",
      "Total NO. of IVs=  146 , NO. of valid IVs with foreground signals:  78.85798 . \n",
      "***********************************************************\n",
      "Pair:  Smoking ~ BMI \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  Smoking  on  BMI : \n",
      "MR-APSS: beta =  0.3207 , beta.se =  0.1194 , p-value =  7.2277e-03 . \n",
      "Total NO. of IVs=  142 , NO. of valid IVs with foreground signals:  104.3454 . \n",
      "***********************************************************\n",
      "Pair:  Smoking ~ Depression \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  Smoking  on  Depression : \n",
      "MR-APSS: beta =  0.2619 , beta.se =  0.0825 , p-value =  1.5080e-03 . \n",
      "Total NO. of IVs=  143 , NO. of valid IVs with foreground signals:  96.00146 . \n",
      "***********************************************************\n",
      "Pair:  Smoking ~ IBD \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  Smoking  on  IBD : \n",
      "MR-APSS: beta =  -0.2259 , beta.se =  0.2287 , p-value =  3.2336e-01 . \n",
      "Total NO. of IVs=  138 , NO. of valid IVs with foreground signals:  48.4611 . \n",
      "***********************************************************\n",
      "Pair:  Smoking ~ MDD \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  Smoking  on  MDD : \n",
      "MR-APSS: beta =  0.2075 , beta.se =  0.0562 , p-value =  2.2534e-04 . \n",
      "Total NO. of IVs=  142 , NO. of valid IVs with foreground signals:  141.9643 . \n",
      "***********************************************************\n",
      "Pair:  Smoking ~ SCZ \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  Smoking  on  SCZ : \n",
      "MR-APSS: beta =  0.4474 , beta.se =  0.172 , p-value =  9.2981e-03 . \n",
      "Total NO. of IVs=  143 , NO. of valid IVs with foreground signals:  82.51986 . \n",
      "***********************************************************\n",
      "Pair:  Smoking ~ Angina \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  Smoking  on  Angina : \n",
      "MR-APSS: beta =  0.1431 , beta.se =  0.0485 , p-value =  3.1635e-03 . \n",
      "Total NO. of IVs=  142 , NO. of valid IVs with foreground signals:  141.8989 . \n",
      "***********************************************************\n",
      "Pair:  Smoking ~ CAD \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  Smoking  on  CAD : \n",
      "MR-APSS: beta =  0.1967 , beta.se =  0.066 , p-value =  2.8676e-03 . \n",
      "Total NO. of IVs=  146 , NO. of valid IVs with foreground signals:  145.9418 . \n",
      "***********************************************************\n",
      "Pair:  Smoking ~ HBP \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  Smoking  on  HBP : \n",
      "MR-APSS: beta =  0.1593 , beta.se =  0.0576 , p-value =  5.7260e-03 . \n",
      "Total NO. of IVs=  142 , NO. of valid IVs with foreground signals:  141.9658 . \n",
      "***********************************************************\n",
      "Pair:  Smoking ~ Income \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  Smoking  on  Income : \n",
      "MR-APSS: beta =  -0.253 , beta.se =  0.0819 , p-value =  2.0051e-03 . \n",
      "Total NO. of IVs=  146 , NO. of valid IVs with foreground signals:  120.0483 . \n",
      "***********************************************************\n",
      "Pair:  Smoking ~ NEB \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  Smoking  on  NEB : \n",
      "MR-APSS: beta =  0.0809 , beta.se =  0.0553 , p-value =  1.4364e-01 . \n",
      "Total NO. of IVs=  143 , NO. of valid IVs with foreground signals:  142.9572 . \n",
      "***********************************************************\n",
      "Pair:  Smoking ~ Urate \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  Smoking  on  Urate : \n",
      "MR-APSS: beta =  0.0064 , beta.se =  0.0654 , p-value =  9.2147e-01 . \n",
      "Total NO. of IVs=  143 , NO. of valid IVs with foreground signals:  133.2154 . \n",
      "***********************************************************\n",
      "Pair:  Smoking ~ Anorexia \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  Smoking  on  Anorexia : \n",
      "MR-APSS: beta =  0.2219 , beta.se =  0.12 , p-value =  6.4364e-02 . \n",
      "Total NO. of IVs=  130 , NO. of valid IVs with foreground signals:  129.8983 . \n",
      "***********************************************************\n",
      "Pair:  Smoking ~ CD \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  Smoking  on  CD : \n",
      "MR-APSS: beta =  -0.2169 , beta.se =  0.1798 , p-value =  2.2758e-01 . \n",
      "Total NO. of IVs=  138 , NO. of valid IVs with foreground signals:  103.7994 . \n",
      "***********************************************************\n",
      "Pair:  Smoking ~ Height_GIANT \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  Smoking  on  Height_GIANT : \n",
      "MR-APSS: beta =  0.0669 , beta.se =  0.1006 , p-value =  5.0614e-01 . \n",
      "Total NO. of IVs=  143 , NO. of valid IVs with foreground signals:  138.965 . \n",
      "***********************************************************\n",
      "Pair:  Smoking ~ Insomnia \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  Smoking  on  Insomnia : \n",
      "MR-APSS: beta =  0.1318 , beta.se =  0.054 , p-value =  1.4568e-02 . \n",
      "Total NO. of IVs=  146 , NO. of valid IVs with foreground signals:  145.9228 . \n",
      "***********************************************************\n",
      "Pair:  Smoking ~ Neuroticism \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  Smoking  on  Neuroticism : \n",
      "MR-APSS: beta =  0.3072 , beta.se =  0.1004 , p-value =  2.2242e-03 . \n",
      "Total NO. of IVs=  142 , NO. of valid IVs with foreground signals:  97.2088 . \n",
      "***********************************************************\n",
      "Pair:  Smoking ~ SWB \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  Smoking  on  SWB : \n",
      "MR-APSS: beta =  -0.1858 , beta.se =  0.0567 , p-value =  1.0485e-03 . \n",
      "Total NO. of IVs=  142 , NO. of valid IVs with foreground signals:  141.9662 . \n",
      "***********************************************************\n",
      "Pair:  Urate ~ AD \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  Urate  on  AD : \n",
      "MR-APSS: beta =  0.0169 , beta.se =  0.0312 , p-value =  5.8778e-01 . \n",
      "Total NO. of IVs=  99 , NO. of valid IVs with foreground signals:  84.37811 . \n",
      "***********************************************************\n",
      "Pair:  Urate ~ ASD \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  Urate  on  ASD : \n",
      "MR-APSS: beta =  0.0148 , beta.se =  0.0631 , p-value =  8.1515e-01 . \n",
      "Total NO. of IVs=  97 , NO. of valid IVs with foreground signals:  83.86115 . \n",
      "***********************************************************\n",
      "Pair:  Urate ~ Daytime_Sleepiness \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  Urate  on  Daytime_Sleepiness : \n",
      "MR-APSS: beta =  0.0202 , beta.se =  0.016 , p-value =  2.0553e-01 . \n",
      "Total NO. of IVs=  97 , NO. of valid IVs with foreground signals:  83.22538 . \n",
      "***********************************************************\n",
      "Pair:  Urate ~ Height_UKB \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  Urate  on  Height_UKB : \n",
      "MR-APSS: beta =  -0.0548 , beta.se =  0.0437 , p-value =  2.0968e-01 . \n",
      "Total NO. of IVs=  93 , NO. of valid IVs with foreground signals:  72.94307 . \n",
      "***********************************************************\n",
      "Pair:  Urate ~ Intelligence \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  Urate  on  Intelligence : \n",
      "MR-APSS: beta =  -0.0284 , beta.se =  0.0296 , p-value =  3.3799e-01 . \n",
      "Total NO. of IVs=  93 , NO. of valid IVs with foreground signals:  76.85145 . \n",
      "***********************************************************\n",
      "Pair:  Urate ~ RA \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  Urate  on  RA : \n",
      "MR-APSS: beta =  -0.093 , beta.se =  0.0389 , p-value =  1.6722e-02 . \n",
      "Total NO. of IVs=  93 , NO. of valid IVs with foreground signals:  72.3729 . \n",
      "***********************************************************\n",
      "Pair:  Urate ~ T2D \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  Urate  on  T2D : \n",
      "MR-APSS: beta =  0.0161 , beta.se =  0.0407 , p-value =  6.9356e-01 . \n",
      "Total NO. of IVs=  94 , NO. of valid IVs with foreground signals:  74.12865 . \n",
      "***********************************************************\n",
      "Pair:  Urate ~ Alcohol \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  Urate  on  Alcohol : \n",
      "MR-APSS: beta =  -0.0783 , beta.se =  0.0213 , p-value =  2.4069e-04 . \n",
      "Total NO. of IVs=  96 , NO. of valid IVs with foreground signals:  77.73373 . \n",
      "***********************************************************\n",
      "Pair:  Urate ~ BMI \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  Urate  on  BMI : \n",
      "MR-APSS: beta =  0.0472 , beta.se =  0.0441 , p-value =  2.8448e-01 . \n",
      "Total NO. of IVs=  93 , NO. of valid IVs with foreground signals:  62.68287 . \n",
      "***********************************************************\n",
      "Pair:  Urate ~ Depression \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  Urate  on  Depression : \n",
      "MR-APSS: beta =  -0.0069 , beta.se =  0.0152 , p-value =  6.5244e-01 . \n",
      "Total NO. of IVs=  93 , NO. of valid IVs with foreground signals:  78.06215 . \n",
      "***********************************************************\n",
      "Pair:  Urate ~ IBD \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  Urate  on  IBD : \n",
      "MR-APSS: beta =  0.0414 , beta.se =  0.0521 , p-value =  4.2765e-01 . \n",
      "Total NO. of IVs=  93 , NO. of valid IVs with foreground signals:  72.60014 . \n",
      "***********************************************************\n",
      "Pair:  Urate ~ MDD \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  Urate  on  MDD : \n",
      "MR-APSS: beta =  0.015 , beta.se =  0.0151 , p-value =  3.2002e-01 . \n",
      "Total NO. of IVs=  93 , NO. of valid IVs with foreground signals:  76.53882 . \n",
      "***********************************************************\n",
      "Pair:  Urate ~ SCZ \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  Urate  on  SCZ : \n",
      "MR-APSS: beta =  -0.0161 , beta.se =  0.0324 , p-value =  6.1902e-01 . \n",
      "Total NO. of IVs=  95 , NO. of valid IVs with foreground signals:  81.4214 . \n",
      "***********************************************************\n",
      "Pair:  Urate ~ Angina \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  Urate  on  Angina : \n",
      "MR-APSS: beta =  -0.001 , beta.se =  0.0167 , p-value =  9.5031e-01 . \n",
      "Total NO. of IVs=  93 , NO. of valid IVs with foreground signals:  74.90855 . \n",
      "***********************************************************\n",
      "Pair:  Urate ~ CAD \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  Urate  on  CAD : \n",
      "MR-APSS: beta =  0.0617 , beta.se =  0.0264 , p-value =  1.9410e-02 . \n",
      "Total NO. of IVs=  98 , NO. of valid IVs with foreground signals:  82.49335 . \n",
      "***********************************************************\n",
      "Pair:  Urate ~ HBP \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  Urate  on  HBP : \n",
      "MR-APSS: beta =  0.0922 , beta.se =  0.0641 , p-value =  1.5026e-01 . \n",
      "Total NO. of IVs=  93 , NO. of valid IVs with foreground signals:  55.80027 . \n",
      "***********************************************************\n",
      "Pair:  Urate ~ Income \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  Urate  on  Income : \n",
      "MR-APSS: beta =  -0.0035 , beta.se =  0.0157 , p-value =  8.2336e-01 . \n",
      "Total NO. of IVs=  99 , NO. of valid IVs with foreground signals:  84.28998 . \n",
      "***********************************************************\n",
      "Pair:  Urate ~ NEB \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  Urate  on  NEB : \n",
      "MR-APSS: beta =  -0.0164 , beta.se =  0.0132 , p-value =  2.1503e-01 . \n",
      "Total NO. of IVs=  96 , NO. of valid IVs with foreground signals:  80.34126 . \n",
      "***********************************************************\n",
      "Pair:  Urate ~ Smoking \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  Urate  on  Smoking : \n",
      "MR-APSS: beta =  0.032 , beta.se =  0.0173 , p-value =  6.3769e-02 . \n",
      "Total NO. of IVs=  94 , NO. of valid IVs with foreground signals:  85.36643 . \n",
      "***********************************************************\n",
      "Pair:  Urate ~ Anorexia \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  Urate  on  Anorexia : \n",
      "MR-APSS: beta =  0.0033 , beta.se =  0.0316 , p-value =  9.1671e-01 . \n",
      "Total NO. of IVs=  92 , NO. of valid IVs with foreground signals:  67.9877 . \n",
      "***********************************************************\n",
      "Pair:  Urate ~ CD \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  Urate  on  CD : \n",
      "MR-APSS: beta =  -0.0097 , beta.se =  0.0578 , p-value =  8.6673e-01 . \n",
      "Total NO. of IVs=  93 , NO. of valid IVs with foreground signals:  71.00018 . \n",
      "***********************************************************\n",
      "Pair:  Urate ~ Height_GIANT \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  Urate  on  Height_GIANT : \n",
      "MR-APSS: beta =  -0.0604 , beta.se =  0.0351 , p-value =  8.4916e-02 . \n",
      "Total NO. of IVs=  96 , NO. of valid IVs with foreground signals:  79.4299 . \n",
      "***********************************************************\n",
      "Pair:  Urate ~ Insomnia \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  Urate  on  Insomnia : \n",
      "MR-APSS: beta =  0.0285 , beta.se =  0.0141 , p-value =  4.2832e-02 . \n",
      "Total NO. of IVs=  97 , NO. of valid IVs with foreground signals:  82.09584 . \n",
      "***********************************************************\n",
      "Pair:  Urate ~ Neuroticism \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  Urate  on  Neuroticism : \n",
      "MR-APSS: beta =  0.0061 , beta.se =  0.0187 , p-value =  7.4376e-01 . \n",
      "Total NO. of IVs=  93 , NO. of valid IVs with foreground signals:  77.00377 . \n",
      "***********************************************************\n",
      "Pair:  Urate ~ SWB \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  Urate  on  SWB : \n",
      "MR-APSS: beta =  -0.0055 , beta.se =  0.0144 , p-value =  7.0087e-01 . \n",
      "Total NO. of IVs=  95 , NO. of valid IVs with foreground signals:  82.44641 . \n",
      "***********************************************************\n",
      "Pair:  Anorexia ~ AD \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  Anorexia  on  AD : \n",
      "MR-APSS: beta =  -0.0674 , beta.se =  0.0913 , p-value =  4.6047e-01 . \n",
      "Total NO. of IVs=  119 , NO. of valid IVs with foreground signals:  44.075 . \n",
      "***********************************************************\n",
      "Pair:  Anorexia ~ ASD \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  Anorexia  on  ASD : \n",
      "MR-APSS: beta =  0.298 , beta.se =  0.1708 , p-value =  8.0984e-02 . \n",
      "Total NO. of IVs=  116 , NO. of valid IVs with foreground signals:  36.29192 . \n",
      "***********************************************************\n",
      "Pair:  Anorexia ~ Daytime_Sleepiness \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  Anorexia  on  Daytime_Sleepiness : \n",
      "MR-APSS: beta =  -0.0741 , beta.se =  0.0438 , p-value =  9.0432e-02 . \n",
      "Total NO. of IVs=  114 , NO. of valid IVs with foreground signals:  56.44499 . \n",
      "***********************************************************\n",
      "Pair:  Anorexia ~ Height_UKB \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  Anorexia  on  Height_UKB : \n",
      "MR-APSS: beta =  0.0162 , beta.se =  0.0781 , p-value =  8.3610e-01 . \n",
      "Total NO. of IVs=  114 , NO. of valid IVs with foreground signals:  46.18993 . \n",
      "***********************************************************\n",
      "Pair:  Anorexia ~ Intelligence \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  Anorexia  on  Intelligence : \n",
      "MR-APSS: beta =  0.0256 , beta.se =  0.1205 , p-value =  8.3165e-01 . \n",
      "Total NO. of IVs=  114 , NO. of valid IVs with foreground signals:  41.39825 . \n",
      "***********************************************************\n",
      "Pair:  Anorexia ~ RA \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  Anorexia  on  RA : \n",
      "MR-APSS: beta =  0.0527 , beta.se =  0.0956 , p-value =  5.8148e-01 . \n",
      "Total NO. of IVs=  114 , NO. of valid IVs with foreground signals:  48.70655 . \n",
      "***********************************************************\n",
      "Pair:  Anorexia ~ T2D \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  Anorexia  on  T2D : \n",
      "MR-APSS: beta =  -0.1105 , beta.se =  0.0625 , p-value =  7.7189e-02 . \n",
      "Total NO. of IVs=  113 , NO. of valid IVs with foreground signals:  44.03115 . \n",
      "***********************************************************\n",
      "Pair:  Anorexia ~ Alcohol \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  Anorexia  on  Alcohol : \n",
      "MR-APSS: beta =  -0.0683 , beta.se =  0.0563 , p-value =  2.2467e-01 . \n",
      "Total NO. of IVs=  115 , NO. of valid IVs with foreground signals:  59.65826 . \n",
      "***********************************************************\n",
      "Pair:  Anorexia ~ BMI \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  Anorexia  on  BMI : \n",
      "MR-APSS: beta =  -0.2088 , beta.se =  0.0815 , p-value =  1.0376e-02 . \n",
      "Total NO. of IVs=  114 , NO. of valid IVs with foreground signals:  63.5878 . \n",
      "***********************************************************\n",
      "Pair:  Anorexia ~ Depression \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  Anorexia  on  Depression : \n",
      "MR-APSS: beta =  0.0744 , beta.se =  0.0404 , p-value =  6.5090e-02 . \n",
      "Total NO. of IVs=  113 , NO. of valid IVs with foreground signals:  77.82679 . \n",
      "***********************************************************\n",
      "Pair:  Anorexia ~ IBD \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  Anorexia  on  IBD : \n",
      "MR-APSS: beta =  -0.1343 , beta.se =  0.1696 , p-value =  4.2853e-01 . \n",
      "Total NO. of IVs=  113 , NO. of valid IVs with foreground signals:  28.90759 . \n",
      "***********************************************************\n",
      "Pair:  Anorexia ~ MDD \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  Anorexia  on  MDD : \n",
      "MR-APSS: beta =  0.0367 , beta.se =  0.0423 , p-value =  3.8587e-01 . \n",
      "Total NO. of IVs=  114 , NO. of valid IVs with foreground signals:  47.32181 . \n",
      "***********************************************************\n",
      "Pair:  Anorexia ~ SCZ \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  Anorexia  on  SCZ : \n",
      "MR-APSS: beta =  0.3925 , beta.se =  0.1533 , p-value =  1.0445e-02 . \n",
      "Total NO. of IVs=  114 , NO. of valid IVs with foreground signals:  30.50149 . \n",
      "***********************************************************\n",
      "Pair:  Anorexia ~ Angina \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  Anorexia  on  Angina : \n",
      "MR-APSS: beta =  -0.0015 , beta.se =  0.0266 , p-value =  9.5431e-01 . \n",
      "Total NO. of IVs=  114 , NO. of valid IVs with foreground signals:  46.99075 . \n",
      "***********************************************************\n",
      "Pair:  Anorexia ~ CAD \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  Anorexia  on  CAD : \n",
      "MR-APSS: beta =  -0.0429 , beta.se =  0.0526 , p-value =  4.1415e-01 . \n",
      "Total NO. of IVs=  118 , NO. of valid IVs with foreground signals:  44.93964 . \n",
      "***********************************************************\n",
      "Pair:  Anorexia ~ HBP \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  Anorexia  on  HBP : \n",
      "MR-APSS: beta =  -0.0182 , beta.se =  0.0616 , p-value =  7.6765e-01 . \n",
      "Total NO. of IVs=  114 , NO. of valid IVs with foreground signals:  40.14779 . \n",
      "***********************************************************\n",
      "Pair:  Anorexia ~ Income \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  Anorexia  on  Income : \n",
      "MR-APSS: beta =  0.0672 , beta.se =  0.0798 , p-value =  3.9934e-01 . \n",
      "Total NO. of IVs=  119 , NO. of valid IVs with foreground signals:  31.46174 . \n",
      "***********************************************************\n",
      "Pair:  Anorexia ~ NEB \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  Anorexia  on  NEB : \n",
      "MR-APSS: beta =  -0.09 , beta.se =  0.0374 , p-value =  1.6120e-02 . \n",
      "Total NO. of IVs=  110 , NO. of valid IVs with foreground signals:  41.01732 . \n",
      "***********************************************************\n",
      "Pair:  Anorexia ~ Smoking \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  Anorexia  on  Smoking : \n",
      "MR-APSS: beta =  0.0578 , beta.se =  0.0553 , p-value =  2.9604e-01 . \n",
      "Total NO. of IVs=  112 , NO. of valid IVs with foreground signals:  59.54607 . \n",
      "***********************************************************\n",
      "Pair:  Anorexia ~ Urate \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  Anorexia  on  Urate : \n",
      "MR-APSS: beta =  0.0229 , beta.se =  0.0658 , p-value =  7.2745e-01 . \n",
      "Total NO. of IVs=  114 , NO. of valid IVs with foreground signals:  46.29139 . \n",
      "***********************************************************\n",
      "Pair:  Anorexia ~ CD \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  Anorexia  on  CD : \n",
      "MR-APSS: beta =  -0.1244 , beta.se =  0.2 , p-value =  5.3400e-01 . \n",
      "Total NO. of IVs=  113 , NO. of valid IVs with foreground signals:  27.51312 . \n",
      "***********************************************************\n",
      "Pair:  Anorexia ~ Height_GIANT \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  Anorexia  on  Height_GIANT : \n",
      "MR-APSS: beta =  -0.0026 , beta.se =  0.0615 , p-value =  9.6639e-01 . \n",
      "Total NO. of IVs=  108 , NO. of valid IVs with foreground signals:  48.25095 . \n",
      "***********************************************************\n",
      "Pair:  Anorexia ~ Insomnia \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  Anorexia  on  Insomnia : \n",
      "MR-APSS: beta =  0.0622 , beta.se =  0.0544 , p-value =  2.5350e-01 . \n",
      "Total NO. of IVs=  114 , NO. of valid IVs with foreground signals:  64.47378 . \n",
      "***********************************************************\n",
      "Pair:  Anorexia ~ Neuroticism \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  Anorexia  on  Neuroticism : \n",
      "MR-APSS: beta =  0.107 , beta.se =  0.0594 , p-value =  7.1749e-02 . \n",
      "Total NO. of IVs=  114 , NO. of valid IVs with foreground signals:  103.141 . \n",
      "***********************************************************\n",
      "Pair:  Anorexia ~ SWB \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  Anorexia  on  SWB : \n",
      "MR-APSS: beta =  -0.0292 , beta.se =  0.0439 , p-value =  5.0555e-01 . \n",
      "Total NO. of IVs=  109 , NO. of valid IVs with foreground signals:  48.26264 . \n",
      "***********************************************************\n",
      "Pair:  CD ~ AD \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  CD  on  AD : \n",
      "MR-APSS: beta =  0.0119 , beta.se =  0.0174 , p-value =  4.9361e-01 . \n",
      "Total NO. of IVs=  293 , NO. of valid IVs with foreground signals:  118.7368 . \n",
      "***********************************************************\n",
      "Pair:  CD ~ ASD \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  CD  on  ASD : \n",
      "MR-APSS: beta =  -0.0401 , beta.se =  0.0266 , p-value =  1.3176e-01 . \n",
      "Total NO. of IVs=  292 , NO. of valid IVs with foreground signals:  116.8919 . \n",
      "***********************************************************\n",
      "Pair:  CD ~ Daytime_Sleepiness \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  CD  on  Daytime_Sleepiness : \n",
      "MR-APSS: beta =  -0.0072 , beta.se =  0.0071 , p-value =  3.1513e-01 . \n",
      "Total NO. of IVs=  295 , NO. of valid IVs with foreground signals:  118.0935 . \n",
      "***********************************************************\n",
      "Pair:  CD ~ Height_UKB \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  CD  on  Height_UKB : \n",
      "MR-APSS: beta =  0.0171 , beta.se =  0.0225 , p-value =  4.4883e-01 . \n",
      "Total NO. of IVs=  295 , NO. of valid IVs with foreground signals:  124.5087 . \n",
      "***********************************************************\n",
      "Pair:  CD ~ Intelligence \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  CD  on  Intelligence : \n",
      "MR-APSS: beta =  0.0165 , beta.se =  0.0147 , p-value =  2.6152e-01 . \n",
      "Total NO. of IVs=  295 , NO. of valid IVs with foreground signals:  116.3157 . \n",
      "***********************************************************\n",
      "Pair:  CD ~ RA \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  CD  on  RA : \n",
      "MR-APSS: beta =  -0.0523 , beta.se =  0.0308 , p-value =  9.0259e-02 . \n",
      "Total NO. of IVs=  293 , NO. of valid IVs with foreground signals:  125.0997 . \n",
      "***********************************************************\n",
      "Pair:  CD ~ T2D \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  CD  on  T2D : \n",
      "MR-APSS: beta =  0.0128 , beta.se =  0.0173 , p-value =  4.5938e-01 . \n",
      "Total NO. of IVs=  292 , NO. of valid IVs with foreground signals:  122.2922 . \n",
      "***********************************************************\n",
      "Pair:  CD ~ Alcohol \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  CD  on  Alcohol : \n",
      "MR-APSS: beta =  0.0082 , beta.se =  0.0104 , p-value =  4.3010e-01 . \n",
      "Total NO. of IVs=  295 , NO. of valid IVs with foreground signals:  111.4255 . \n",
      "***********************************************************\n",
      "Pair:  CD ~ BMI \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  CD  on  BMI : \n",
      "MR-APSS: beta =  0.011 , beta.se =  0.0145 , p-value =  4.4903e-01 . \n",
      "Total NO. of IVs=  295 , NO. of valid IVs with foreground signals:  119.1969 . \n",
      "***********************************************************\n",
      "Pair:  CD ~ Depression \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  CD  on  Depression : \n",
      "MR-APSS: beta =  -2e-04 , beta.se =  0.0057 , p-value =  9.7165e-01 . \n",
      "Total NO. of IVs=  295 , NO. of valid IVs with foreground signals:  118.0085 . \n",
      "***********************************************************\n",
      "Pair:  CD ~ IBD \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  CD  on  IBD : \n",
      "MR-APSS: beta =  0.774 , beta.se =  0.0466 , p-value =  5.5261e-62 . \n",
      "Total NO. of IVs=  295 , NO. of valid IVs with foreground signals:  134.7316 . \n",
      "***********************************************************\n",
      "Pair:  CD ~ MDD \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  CD  on  MDD : \n",
      "MR-APSS: beta =  -0.006 , beta.se =  0.0069 , p-value =  3.8440e-01 . \n",
      "Total NO. of IVs=  295 , NO. of valid IVs with foreground signals:  118.0722 . \n",
      "***********************************************************\n",
      "Pair:  CD ~ SCZ \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  CD  on  SCZ : \n",
      "MR-APSS: beta =  -0.006 , beta.se =  0.0181 , p-value =  7.4087e-01 . \n",
      "Total NO. of IVs=  288 , NO. of valid IVs with foreground signals:  112.642 . \n",
      "***********************************************************\n",
      "Pair:  CD ~ Angina \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  CD  on  Angina : \n",
      "MR-APSS: beta =  0.0032 , beta.se =  0.0076 , p-value =  6.7261e-01 . \n",
      "Total NO. of IVs=  295 , NO. of valid IVs with foreground signals:  119.9517 . \n",
      "***********************************************************\n",
      "Pair:  CD ~ CAD \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  CD  on  CAD : \n",
      "MR-APSS: beta =  0.0182 , beta.se =  0.0106 , p-value =  8.5846e-02 . \n",
      "Total NO. of IVs=  294 , NO. of valid IVs with foreground signals:  119.5918 . \n",
      "***********************************************************\n",
      "Pair:  CD ~ HBP \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  CD  on  HBP : \n",
      "MR-APSS: beta =  -0.0119 , beta.se =  0.0107 , p-value =  2.6926e-01 . \n",
      "Total NO. of IVs=  295 , NO. of valid IVs with foreground signals:  118.6396 . \n",
      "***********************************************************\n",
      "Pair:  CD ~ Income \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  CD  on  Income : \n",
      "MR-APSS: beta =  0.0173 , beta.se =  0.0095 , p-value =  6.8117e-02 . \n",
      "Total NO. of IVs=  295 , NO. of valid IVs with foreground signals:  116.9883 . \n",
      "***********************************************************\n",
      "Pair:  CD ~ NEB \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  CD  on  NEB : \n",
      "MR-APSS: beta =  0.0045 , beta.se =  0.0066 , p-value =  4.9674e-01 . \n",
      "Total NO. of IVs=  283 , NO. of valid IVs with foreground signals:  116.7893 . \n",
      "***********************************************************\n",
      "Pair:  CD ~ Smoking \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  CD  on  Smoking : \n",
      "MR-APSS: beta =  0.0086 , beta.se =  0.0076 , p-value =  2.6058e-01 . \n",
      "Total NO. of IVs=  290 , NO. of valid IVs with foreground signals:  117.3077 . \n",
      "***********************************************************\n",
      "Pair:  CD ~ Urate \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  CD  on  Urate : \n",
      "MR-APSS: beta =  -0.0163 , beta.se =  0.015 , p-value =  2.7739e-01 . \n",
      "Total NO. of IVs=  285 , NO. of valid IVs with foreground signals:  121.8245 . \n",
      "***********************************************************\n",
      "Pair:  CD ~ Anorexia \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  CD  on  Anorexia : \n",
      "MR-APSS: beta =  0.004 , beta.se =  0.0146 , p-value =  7.8677e-01 . \n",
      "Total NO. of IVs=  266 , NO. of valid IVs with foreground signals:  111.8034 . \n",
      "***********************************************************\n",
      "Pair:  CD ~ Height_GIANT \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  CD  on  Height_GIANT : \n",
      "MR-APSS: beta =  0.0067 , beta.se =  0.02 , p-value =  7.3593e-01 . \n",
      "Total NO. of IVs=  281 , NO. of valid IVs with foreground signals:  120.7479 . \n",
      "***********************************************************\n",
      "Pair:  CD ~ Insomnia \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  CD  on  Insomnia : \n",
      "MR-APSS: beta =  -2e-04 , beta.se =  0.0059 , p-value =  9.7495e-01 . \n",
      "Total NO. of IVs=  295 , NO. of valid IVs with foreground signals:  117.3642 . \n",
      "***********************************************************\n",
      "Pair:  CD ~ Neuroticism \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  CD  on  Neuroticism : \n",
      "MR-APSS: beta =  -0.0109 , beta.se =  0.008 , p-value =  1.7289e-01 . \n",
      "Total NO. of IVs=  295 , NO. of valid IVs with foreground signals:  118.0706 . \n",
      "***********************************************************\n",
      "Pair:  CD ~ SWB \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  CD  on  SWB : \n",
      "MR-APSS: beta =  0.0062 , beta.se =  0.0066 , p-value =  3.4603e-01 . \n",
      "Total NO. of IVs=  283 , NO. of valid IVs with foreground signals:  116.6359 . \n",
      "***********************************************************\n",
      "Pair:  Height_GIANT ~ AD \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  Height_GIANT  on  AD : \n",
      "MR-APSS: beta =  -0.034 , beta.se =  0.0175 , p-value =  5.2908e-02 . \n",
      "Total NO. of IVs=  1193 , NO. of valid IVs with foreground signals:  320.9587 . \n",
      "***********************************************************\n",
      "Pair:  Height_GIANT ~ ASD \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  Height_GIANT  on  ASD : \n",
      "MR-APSS: beta =  0.0459 , beta.se =  0.0295 , p-value =  1.1950e-01 . \n",
      "Total NO. of IVs=  1197 , NO. of valid IVs with foreground signals:  316.7568 . \n",
      "***********************************************************\n",
      "Pair:  Height_GIANT ~ Daytime_Sleepiness \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  Height_GIANT  on  Daytime_Sleepiness : \n",
      "MR-APSS: beta =  0.0111 , beta.se =  0.0069 , p-value =  1.0857e-01 . \n",
      "Total NO. of IVs=  1197 , NO. of valid IVs with foreground signals:  311.8228 . \n",
      "***********************************************************\n",
      "Pair:  Height_GIANT ~ Height_UKB \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  Height_GIANT  on  Height_UKB : \n",
      "MR-APSS: beta =  1.1594 , beta.se =  0.0337 , p-value =  1.2446e-259 . \n",
      "Total NO. of IVs=  1190 , NO. of valid IVs with foreground signals:  389.8323 . \n",
      "***********************************************************\n",
      "Pair:  Height_GIANT ~ Intelligence \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  Height_GIANT  on  Intelligence : \n",
      "MR-APSS: beta =  0.0618 , beta.se =  0.0168 , p-value =  2.3554e-04 . \n",
      "Total NO. of IVs=  1189 , NO. of valid IVs with foreground signals:  316.9081 . \n",
      "***********************************************************\n",
      "Pair:  Height_GIANT ~ RA \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  Height_GIANT  on  RA : \n",
      "MR-APSS: beta =  0.054 , beta.se =  0.0185 , p-value =  3.4928e-03 . \n",
      "Total NO. of IVs=  1187 , NO. of valid IVs with foreground signals:  318.2067 . \n",
      "***********************************************************\n",
      "Pair:  Height_GIANT ~ T2D \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  Height_GIANT  on  T2D : \n",
      "MR-APSS: beta =  -0.0083 , beta.se =  0.0178 , p-value =  6.4095e-01 . \n",
      "Total NO. of IVs=  1196 , NO. of valid IVs with foreground signals:  325.7013 . \n",
      "***********************************************************\n",
      "Pair:  Height_GIANT ~ Alcohol \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  Height_GIANT  on  Alcohol : \n",
      "MR-APSS: beta =  0.0131 , beta.se =  0.0096 , p-value =  1.7171e-01 . \n",
      "Total NO. of IVs=  1200 , NO. of valid IVs with foreground signals:  317.0023 . \n",
      "***********************************************************\n",
      "Pair:  Height_GIANT ~ BMI \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  Height_GIANT  on  BMI : \n",
      "MR-APSS: beta =  -0.0815 , beta.se =  0.0167 , p-value =  1.0837e-06 . \n",
      "Total NO. of IVs=  1188 , NO. of valid IVs with foreground signals:  319.9915 . \n",
      "***********************************************************\n",
      "Pair:  Height_GIANT ~ Depression \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  Height_GIANT  on  Depression : \n",
      "MR-APSS: beta =  -0.0041 , beta.se =  0.0069 , p-value =  5.4851e-01 . \n",
      "Total NO. of IVs=  1186 , NO. of valid IVs with foreground signals:  313.4398 . \n",
      "***********************************************************\n",
      "Pair:  Height_GIANT ~ IBD \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  Height_GIANT  on  IBD : \n",
      "MR-APSS: beta =  -4e-04 , beta.se =  0.0153 , p-value =  9.7949e-01 . \n",
      "Total NO. of IVs=  1174 , NO. of valid IVs with foreground signals:  315.6913 . \n",
      "***********************************************************\n",
      "Pair:  Height_GIANT ~ MDD \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  Height_GIANT  on  MDD : \n",
      "MR-APSS: beta =  0.0078 , beta.se =  0.0076 , p-value =  3.0507e-01 . \n",
      "Total NO. of IVs=  1189 , NO. of valid IVs with foreground signals:  314.39 . \n",
      "***********************************************************\n",
      "Pair:  Height_GIANT ~ SCZ \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  Height_GIANT  on  SCZ : \n",
      "MR-APSS: beta =  -0.0266 , beta.se =  0.0183 , p-value =  1.4628e-01 . \n",
      "Total NO. of IVs=  1176 , NO. of valid IVs with foreground signals:  316.0336 . \n",
      "***********************************************************\n",
      "Pair:  Height_GIANT ~ Angina \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  Height_GIANT  on  Angina : \n",
      "MR-APSS: beta =  -0.0254 , beta.se =  0.0087 , p-value =  3.4391e-03 . \n",
      "Total NO. of IVs=  1189 , NO. of valid IVs with foreground signals:  315.1331 . \n",
      "***********************************************************\n",
      "Pair:  Height_GIANT ~ CAD \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  Height_GIANT  on  CAD : \n",
      "MR-APSS: beta =  -0.0543 , beta.se =  0.0129 , p-value =  2.5077e-05 . \n",
      "Total NO. of IVs=  1200 , NO. of valid IVs with foreground signals:  318.615 . \n",
      "***********************************************************\n",
      "Pair:  Height_GIANT ~ HBP \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  Height_GIANT  on  HBP : \n",
      "MR-APSS: beta =  -0.0374 , beta.se =  0.0142 , p-value =  8.3281e-03 . \n",
      "Total NO. of IVs=  1189 , NO. of valid IVs with foreground signals:  329.7469 . \n",
      "***********************************************************\n",
      "Pair:  Height_GIANT ~ Income \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  Height_GIANT  on  Income : \n",
      "MR-APSS: beta =  0.0479 , beta.se =  0.0093 , p-value =  2.3542e-07 . \n",
      "Total NO. of IVs=  1201 , NO. of valid IVs with foreground signals:  320.4827 . \n",
      "***********************************************************\n",
      "Pair:  Height_GIANT ~ NEB \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  Height_GIANT  on  NEB : \n",
      "MR-APSS: beta =  -0.0058 , beta.se =  0.0066 , p-value =  3.7881e-01 . \n",
      "Total NO. of IVs=  1201 , NO. of valid IVs with foreground signals:  318.7372 . \n",
      "***********************************************************\n",
      "Pair:  Height_GIANT ~ Smoking \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  Height_GIANT  on  Smoking : \n",
      "MR-APSS: beta =  -0.0089 , beta.se =  0.0087 , p-value =  3.0530e-01 . \n",
      "Total NO. of IVs=  1192 , NO. of valid IVs with foreground signals:  312.1234 . \n",
      "***********************************************************\n",
      "Pair:  Height_GIANT ~ Urate \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  Height_GIANT  on  Urate : \n",
      "MR-APSS: beta =  0.0163 , beta.se =  0.0161 , p-value =  3.1271e-01 . \n",
      "Total NO. of IVs=  1200 , NO. of valid IVs with foreground signals:  320.0592 . \n",
      "***********************************************************\n",
      "Pair:  Height_GIANT ~ Anorexia \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  Height_GIANT  on  Anorexia : \n",
      "MR-APSS: beta =  0.0262 , beta.se =  0.0158 , p-value =  9.7011e-02 . \n",
      "Total NO. of IVs=  1146 , NO. of valid IVs with foreground signals:  282.225 . \n",
      "***********************************************************\n",
      "Pair:  Height_GIANT ~ CD \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  Height_GIANT  on  CD : \n",
      "MR-APSS: beta =  -0.0135 , beta.se =  0.0304 , p-value =  6.5595e-01 . \n",
      "Total NO. of IVs=  1175 , NO. of valid IVs with foreground signals:  309.3107 . \n",
      "***********************************************************\n",
      "Pair:  Height_GIANT ~ Insomnia \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  Height_GIANT  on  Insomnia : \n",
      "MR-APSS: beta =  -0.0148 , beta.se =  0.0084 , p-value =  7.8797e-02 . \n",
      "Total NO. of IVs=  1197 , NO. of valid IVs with foreground signals:  309.308 . \n",
      "***********************************************************\n",
      "Pair:  Height_GIANT ~ Neuroticism \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  Height_GIANT  on  Neuroticism : \n",
      "MR-APSS: beta =  -0.0014 , beta.se =  0.0086 , p-value =  8.6643e-01 . \n",
      "Total NO. of IVs=  1189 , NO. of valid IVs with foreground signals:  314.6524 . \n",
      "***********************************************************\n",
      "Pair:  Height_GIANT ~ SWB \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  Height_GIANT  on  SWB : \n",
      "MR-APSS: beta =  -0.0027 , beta.se =  0.0071 , p-value =  7.0844e-01 . \n",
      "Total NO. of IVs=  1199 , NO. of valid IVs with foreground signals:  313.4255 . \n",
      "***********************************************************\n",
      "Pair:  Insomnia ~ AD \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  Insomnia  on  AD : \n",
      "MR-APSS: beta =  0.0765 , beta.se =  0.1057 , p-value =  4.6922e-01 . \n",
      "Total NO. of IVs=  354 , NO. of valid IVs with foreground signals:  76.54497 . \n",
      "***********************************************************\n",
      "Pair:  Insomnia ~ ASD \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  Insomnia  on  ASD : \n",
      "MR-APSS: beta =  0.009 , beta.se =  0.2078 , p-value =  9.6526e-01 . \n",
      "Total NO. of IVs=  355 , NO. of valid IVs with foreground signals:  79.14058 . \n",
      "***********************************************************\n",
      "Pair:  Insomnia ~ Daytime_Sleepiness \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  Insomnia  on  Daytime_Sleepiness : \n",
      "MR-APSS: beta =  0.1961 , beta.se =  0.0666 , p-value =  3.2488e-03 . \n",
      "Total NO. of IVs=  356 , NO. of valid IVs with foreground signals:  74.12854 . \n",
      "***********************************************************\n",
      "Pair:  Insomnia ~ Height_UKB \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  Insomnia  on  Height_UKB : \n",
      "MR-APSS: beta =  -0.4643 , beta.se =  0.2032 , p-value =  2.2299e-02 . \n",
      "Total NO. of IVs=  348 , NO. of valid IVs with foreground signals:  54.78387 . \n",
      "***********************************************************\n",
      "Pair:  Insomnia ~ Intelligence \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  Insomnia  on  Intelligence : \n",
      "MR-APSS: beta =  0.0572 , beta.se =  0.1278 , p-value =  6.5459e-01 . \n",
      "Total NO. of IVs=  348 , NO. of valid IVs with foreground signals:  91.54433 . \n",
      "***********************************************************\n",
      "Pair:  Insomnia ~ RA \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  Insomnia  on  RA : \n",
      "MR-APSS: beta =  0.1287 , beta.se =  0.1358 , p-value =  3.4342e-01 . \n",
      "Total NO. of IVs=  346 , NO. of valid IVs with foreground signals:  72.08523 . \n",
      "***********************************************************\n",
      "Pair:  Insomnia ~ T2D \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  Insomnia  on  T2D : \n",
      "MR-APSS: beta =  0.3124 , beta.se =  0.1349 , p-value =  2.0525e-02 . \n",
      "Total NO. of IVs=  353 , NO. of valid IVs with foreground signals:  77.96849 . \n",
      "***********************************************************\n",
      "Pair:  Insomnia ~ Alcohol \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  Insomnia  on  Alcohol : \n",
      "MR-APSS: beta =  -0.0037 , beta.se =  0.0608 , p-value =  9.5189e-01 . \n",
      "Total NO. of IVs=  355 , NO. of valid IVs with foreground signals:  92.47784 . \n",
      "***********************************************************\n",
      "Pair:  Insomnia ~ BMI \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  Insomnia  on  BMI : \n",
      "MR-APSS: beta =  0.2735 , beta.se =  0.1238 , p-value =  2.7141e-02 . \n",
      "Total NO. of IVs=  348 , NO. of valid IVs with foreground signals:  87.04938 . \n",
      "***********************************************************\n",
      "Pair:  Insomnia ~ Depression \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  Insomnia  on  Depression : \n",
      "MR-APSS: beta =  0.2549 , beta.se =  0.0641 , p-value =  6.9016e-05 . \n",
      "Total NO. of IVs=  348 , NO. of valid IVs with foreground signals:  80.42134 . \n",
      "***********************************************************\n",
      "Pair:  Insomnia ~ IBD \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  Insomnia  on  IBD : \n",
      "MR-APSS: beta =  -0.0239 , beta.se =  0.1899 , p-value =  8.9991e-01 . \n",
      "Total NO. of IVs=  340 , NO. of valid IVs with foreground signals:  58.60755 . \n",
      "***********************************************************\n",
      "Pair:  Insomnia ~ MDD \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  Insomnia  on  MDD : \n",
      "MR-APSS: beta =  0.1255 , beta.se =  0.0513 , p-value =  1.4318e-02 . \n",
      "Total NO. of IVs=  348 , NO. of valid IVs with foreground signals:  71.88032 . \n",
      "***********************************************************\n",
      "Pair:  Insomnia ~ SCZ \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  Insomnia  on  SCZ : \n",
      "MR-APSS: beta =  0.0404 , beta.se =  0.1477 , p-value =  7.8450e-01 . \n",
      "Total NO. of IVs=  350 , NO. of valid IVs with foreground signals:  79.17986 . \n",
      "***********************************************************\n",
      "Pair:  Insomnia ~ Angina \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  Insomnia  on  Angina : \n",
      "MR-APSS: beta =  0.1122 , beta.se =  0.0492 , p-value =  2.2542e-02 . \n",
      "Total NO. of IVs=  348 , NO. of valid IVs with foreground signals:  72.46094 . \n",
      "***********************************************************\n",
      "Pair:  Insomnia ~ CAD \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  Insomnia  on  CAD : \n",
      "MR-APSS: beta =  0.2461 , beta.se =  0.0995 , p-value =  1.3324e-02 . \n",
      "Total NO. of IVs=  354 , NO. of valid IVs with foreground signals:  84.10328 . \n",
      "***********************************************************\n",
      "Pair:  Insomnia ~ HBP \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  Insomnia  on  HBP : \n",
      "MR-APSS: beta =  0.2341 , beta.se =  0.0882 , p-value =  7.9307e-03 . \n",
      "Total NO. of IVs=  348 , NO. of valid IVs with foreground signals:  67.74107 . \n",
      "***********************************************************\n",
      "Pair:  Insomnia ~ Income \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  Insomnia  on  Income : \n",
      "MR-APSS: beta =  -0.0448 , beta.se =  0.0754 , p-value =  5.5295e-01 . \n",
      "Total NO. of IVs=  356 , NO. of valid IVs with foreground signals:  69.47699 . \n",
      "***********************************************************\n",
      "Pair:  Insomnia ~ NEB \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  Insomnia  on  NEB : \n",
      "MR-APSS: beta =  0.0325 , beta.se =  0.0491 , p-value =  5.0777e-01 . \n",
      "Total NO. of IVs=  347 , NO. of valid IVs with foreground signals:  69.1539 . \n",
      "***********************************************************\n",
      "Pair:  Insomnia ~ Smoking \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  Insomnia  on  Smoking : \n",
      "MR-APSS: beta =  0.2449 , beta.se =  0.0806 , p-value =  2.3838e-03 . \n",
      "Total NO. of IVs=  351 , NO. of valid IVs with foreground signals:  83.18932 . \n",
      "***********************************************************\n",
      "Pair:  Insomnia ~ Urate \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  Insomnia  on  Urate : \n",
      "MR-APSS: beta =  0.0285 , beta.se =  0.0777 , p-value =  7.1401e-01 . \n",
      "Total NO. of IVs=  347 , NO. of valid IVs with foreground signals:  70.38443 . \n",
      "***********************************************************\n",
      "Pair:  Insomnia ~ Anorexia \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  Insomnia  on  Anorexia : \n",
      "MR-APSS: beta =  0.2916 , beta.se =  0.144 , p-value =  4.2919e-02 . \n",
      "Total NO. of IVs=  317 , NO. of valid IVs with foreground signals:  92.78592 . \n",
      "***********************************************************\n",
      "Pair:  Insomnia ~ CD \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  Insomnia  on  CD : \n",
      "MR-APSS: beta =  0.0591 , beta.se =  0.2022 , p-value =  7.6993e-01 . \n",
      "Total NO. of IVs=  340 , NO. of valid IVs with foreground signals:  68.48038 . \n",
      "***********************************************************\n",
      "Pair:  Insomnia ~ Height_GIANT \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  Insomnia  on  Height_GIANT : \n",
      "MR-APSS: beta =  -0.4657 , beta.se =  0.1915 , p-value =  1.5021e-02 . \n",
      "Total NO. of IVs=  345 , NO. of valid IVs with foreground signals:  51.32272 . \n",
      "***********************************************************\n",
      "Pair:  Insomnia ~ Neuroticism \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  Insomnia  on  Neuroticism : \n",
      "MR-APSS: beta =  0.4663 , beta.se =  0.0864 , p-value =  6.7490e-08 . \n",
      "Total NO. of IVs=  348 , NO. of valid IVs with foreground signals:  87.72839 . \n",
      "***********************************************************\n",
      "Pair:  Insomnia ~ SWB \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  Insomnia  on  SWB : \n",
      "MR-APSS: beta =  -0.1895 , beta.se =  0.0496 , p-value =  1.3238e-04 . \n",
      "Total NO. of IVs=  345 , NO. of valid IVs with foreground signals:  71.87257 . \n",
      "***********************************************************\n",
      "Pair:  Neuroticism ~ AD \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  Neuroticism  on  AD : \n",
      "MR-APSS: beta =  0.0181 , beta.se =  0.0837 , p-value =  8.2869e-01 . \n",
      "Total NO. of IVs=  459 , NO. of valid IVs with foreground signals:  138.2892 . \n",
      "***********************************************************\n",
      "Pair:  Neuroticism ~ ASD \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  Neuroticism  on  ASD : \n",
      "MR-APSS: beta =  0.0969 , beta.se =  0.1315 , p-value =  4.6122e-01 . \n",
      "Total NO. of IVs=  458 , NO. of valid IVs with foreground signals:  140.3971 . \n",
      "***********************************************************\n",
      "Pair:  Neuroticism ~ Daytime_Sleepiness \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  Neuroticism  on  Daytime_Sleepiness : \n",
      "MR-APSS: beta =  0.1276 , beta.se =  0.0392 , p-value =  1.1241e-03 . \n",
      "Total NO. of IVs=  463 , NO. of valid IVs with foreground signals:  142.9873 . \n",
      "***********************************************************\n",
      "Pair:  Neuroticism ~ Height_UKB \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  Neuroticism  on  Height_UKB : \n",
      "MR-APSS: beta =  -0.1071 , beta.se =  0.1052 , p-value =  3.0897e-01 . \n",
      "Total NO. of IVs=  463 , NO. of valid IVs with foreground signals:  100.2384 . \n",
      "***********************************************************\n",
      "Pair:  Neuroticism ~ Intelligence \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  Neuroticism  on  Intelligence : \n",
      "MR-APSS: beta =  -0.2179 , beta.se =  0.0744 , p-value =  3.3998e-03 . \n",
      "Total NO. of IVs=  463 , NO. of valid IVs with foreground signals:  144.3509 . \n",
      "***********************************************************\n",
      "Pair:  Neuroticism ~ RA \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  Neuroticism  on  RA : \n",
      "MR-APSS: beta =  0.0285 , beta.se =  0.07 , p-value =  6.8447e-01 . \n",
      "Total NO. of IVs=  462 , NO. of valid IVs with foreground signals:  143.1945 . \n",
      "***********************************************************\n",
      "Pair:  Neuroticism ~ T2D \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  Neuroticism  on  T2D : \n",
      "MR-APSS: beta =  -0.0419 , beta.se =  0.0699 , p-value =  5.4932e-01 . \n",
      "Total NO. of IVs=  461 , NO. of valid IVs with foreground signals:  139.7499 . \n",
      "***********************************************************\n",
      "Pair:  Neuroticism ~ Alcohol \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  Neuroticism  on  Alcohol : \n",
      "MR-APSS: beta =  -0.0549 , beta.se =  0.0455 , p-value =  2.2809e-01 . \n",
      "Total NO. of IVs=  463 , NO. of valid IVs with foreground signals:  140.3346 . \n",
      "***********************************************************\n",
      "Pair:  Neuroticism ~ BMI \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  Neuroticism  on  BMI : \n",
      "MR-APSS: beta =  -0.0956 , beta.se =  0.0715 , p-value =  1.8093e-01 . \n",
      "Total NO. of IVs=  463 , NO. of valid IVs with foreground signals:  153.1441 . \n",
      "***********************************************************\n",
      "Pair:  Neuroticism ~ Depression \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  Neuroticism  on  Depression : \n",
      "MR-APSS: beta =  0.5086 , beta.se =  0.0485 , p-value =  9.1856e-26 . \n",
      "Total NO. of IVs=  462 , NO. of valid IVs with foreground signals:  137.3705 . \n",
      "***********************************************************\n",
      "Pair:  Neuroticism ~ IBD \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  Neuroticism  on  IBD : \n",
      "MR-APSS: beta =  -0.1275 , beta.se =  0.1096 , p-value =  2.4481e-01 . \n",
      "Total NO. of IVs=  461 , NO. of valid IVs with foreground signals:  113.3155 . \n",
      "***********************************************************\n",
      "Pair:  Neuroticism ~ MDD \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  Neuroticism  on  MDD : \n",
      "MR-APSS: beta =  0.1757 , beta.se =  0.0413 , p-value =  2.0569e-05 . \n",
      "Total NO. of IVs=  463 , NO. of valid IVs with foreground signals:  150.6083 . \n",
      "***********************************************************\n",
      "Pair:  Neuroticism ~ SCZ \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  Neuroticism  on  SCZ : \n",
      "MR-APSS: beta =  0.5708 , beta.se =  0.1151 , p-value =  7.0239e-07 . \n",
      "Total NO. of IVs=  457 , NO. of valid IVs with foreground signals:  122.8707 . \n",
      "***********************************************************\n",
      "Pair:  Neuroticism ~ Angina \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  Neuroticism  on  Angina : \n",
      "MR-APSS: beta =  0.0958 , beta.se =  0.0332 , p-value =  3.9070e-03 . \n",
      "Total NO. of IVs=  463 , NO. of valid IVs with foreground signals:  146.9606 . \n",
      "***********************************************************\n",
      "Pair:  Neuroticism ~ CAD \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  Neuroticism  on  CAD : \n",
      "MR-APSS: beta =  0.0318 , beta.se =  0.0524 , p-value =  5.4391e-01 . \n",
      "Total NO. of IVs=  463 , NO. of valid IVs with foreground signals:  133.5902 . \n",
      "***********************************************************\n",
      "Pair:  Neuroticism ~ HBP \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  Neuroticism  on  HBP : \n",
      "MR-APSS: beta =  -0.0315 , beta.se =  0.0627 , p-value =  6.1470e-01 . \n",
      "Total NO. of IVs=  463 , NO. of valid IVs with foreground signals:  120.0115 . \n",
      "***********************************************************\n",
      "Pair:  Neuroticism ~ Income \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  Neuroticism  on  Income : \n",
      "MR-APSS: beta =  -0.2217 , beta.se =  0.0571 , p-value =  1.0445e-04 . \n",
      "Total NO. of IVs=  463 , NO. of valid IVs with foreground signals:  133.7061 . \n",
      "***********************************************************\n",
      "Pair:  Neuroticism ~ NEB \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  Neuroticism  on  NEB : \n",
      "MR-APSS: beta =  0.0051 , beta.se =  0.0342 , p-value =  8.8211e-01 . \n",
      "Total NO. of IVs=  447 , NO. of valid IVs with foreground signals:  143.8767 . \n",
      "***********************************************************\n",
      "Pair:  Neuroticism ~ Smoking \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  Neuroticism  on  Smoking : \n",
      "MR-APSS: beta =  0.1134 , beta.se =  0.0516 , p-value =  2.7872e-02 . \n",
      "Total NO. of IVs=  454 , NO. of valid IVs with foreground signals:  150.127 . \n",
      "***********************************************************\n",
      "Pair:  Neuroticism ~ Urate \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  Neuroticism  on  Urate : \n",
      "MR-APSS: beta =  -0.0299 , beta.se =  0.0557 , p-value =  5.9101e-01 . \n",
      "Total NO. of IVs=  450 , NO. of valid IVs with foreground signals:  146.6474 . \n",
      "***********************************************************\n",
      "Pair:  Neuroticism ~ Anorexia \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  Neuroticism  on  Anorexia : \n",
      "MR-APSS: beta =  0.4004 , beta.se =  0.0807 , p-value =  6.9010e-07 . \n",
      "Total NO. of IVs=  430 , NO. of valid IVs with foreground signals:  155.2941 . \n",
      "***********************************************************\n",
      "Pair:  Neuroticism ~ CD \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  Neuroticism  on  CD : \n",
      "MR-APSS: beta =  -0.2209 , beta.se =  0.1294 , p-value =  8.7719e-02 . \n",
      "Total NO. of IVs=  461 , NO. of valid IVs with foreground signals:  123.2826 . \n",
      "***********************************************************\n",
      "Pair:  Neuroticism ~ Height_GIANT \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  Neuroticism  on  Height_GIANT : \n",
      "MR-APSS: beta =  -0.1337 , beta.se =  0.0754 , p-value =  7.6346e-02 . \n",
      "Total NO. of IVs=  443 , NO. of valid IVs with foreground signals:  114.3406 . \n",
      "***********************************************************\n",
      "Pair:  Neuroticism ~ Insomnia \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  Neuroticism  on  Insomnia : \n",
      "MR-APSS: beta =  0.2948 , beta.se =  0.0467 , p-value =  2.7001e-10 . \n",
      "Total NO. of IVs=  463 , NO. of valid IVs with foreground signals:  141.0674 . \n",
      "***********************************************************\n",
      "Pair:  Neuroticism ~ SWB \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  Neuroticism  on  SWB : \n",
      "MR-APSS: beta =  -0.23 , beta.se =  0.0393 , p-value =  5.0462e-09 . \n",
      "Total NO. of IVs=  450 , NO. of valid IVs with foreground signals:  140.6947 . \n",
      "***********************************************************\n",
      "Pair:  SWB ~ AD \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  SWB  on  AD : \n",
      "MR-APSS: beta =  -0.1675 , beta.se =  0.7043 , p-value =  8.1200e-01 . \n",
      "Total NO. of IVs=  66 , NO. of valid IVs with foreground signals:  11.9378 . \n",
      "***********************************************************\n",
      "Pair:  SWB ~ ASD \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  SWB  on  ASD : \n",
      "MR-APSS: beta =  -0.9431 , beta.se =  0.9783 , p-value =  3.3508e-01 . \n",
      "Total NO. of IVs=  65 , NO. of valid IVs with foreground signals:  5.636613 . \n",
      "***********************************************************\n",
      "Pair:  SWB ~ Daytime_Sleepiness \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  SWB  on  Daytime_Sleepiness : \n",
      "MR-APSS: beta =  -0.1103 , beta.se =  0.3353 , p-value =  7.4232e-01 . \n",
      "Total NO. of IVs=  65 , NO. of valid IVs with foreground signals:  6.765954 . \n",
      "***********************************************************\n",
      "Pair:  SWB ~ Height_UKB \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  SWB  on  Height_UKB : \n",
      "MR-APSS: beta =  -2.7013 , beta.se =  1.8558 , p-value =  1.4552e-01 . \n",
      "Total NO. of IVs=  65 , NO. of valid IVs with foreground signals:  1.212259 . \n",
      "***********************************************************\n",
      "Pair:  SWB ~ Intelligence \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  SWB  on  Intelligence : \n",
      "MR-APSS: beta =  -0.076 , beta.se =  0.5171 , p-value =  8.8313e-01 . \n",
      "Total NO. of IVs=  65 , NO. of valid IVs with foreground signals:  7.115277 . \n",
      "***********************************************************\n",
      "Pair:  SWB ~ RA \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  SWB  on  RA : \n",
      "MR-APSS: beta =  -0.3805 , beta.se =  0.6887 , p-value =  5.8055e-01 . \n",
      "Total NO. of IVs=  64 , NO. of valid IVs with foreground signals:  10.44736 . \n",
      "***********************************************************\n",
      "Pair:  SWB ~ T2D \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  SWB  on  T2D : \n",
      "MR-APSS: beta =  -2.2999 , beta.se =  1.4661 , p-value =  1.1671e-01 . \n",
      "Total NO. of IVs=  66 , NO. of valid IVs with foreground signals:  1.154669 . \n",
      "***********************************************************\n",
      "Pair:  SWB ~ Alcohol \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  SWB  on  Alcohol : \n",
      "MR-APSS: beta =  -8.7657 , beta.se =  12.3115 , p-value =  4.7647e-01 . \n",
      "Total NO. of IVs=  66 , NO. of valid IVs with foreground signals:  5.939245 . \n",
      "***********************************************************\n",
      "Pair:  SWB ~ BMI \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  SWB  on  BMI : \n",
      "MR-APSS: beta =  1.6433 , beta.se =  1.1174 , p-value =  1.4138e-01 . \n",
      "Total NO. of IVs=  65 , NO. of valid IVs with foreground signals:  11.81909 . \n",
      "***********************************************************\n",
      "Pair:  SWB ~ Depression \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  SWB  on  Depression : \n",
      "MR-APSS: beta =  -1.4178 , beta.se =  0.8901 , p-value =  1.1119e-01 . \n",
      "Total NO. of IVs=  64 , NO. of valid IVs with foreground signals:  3.040341 . \n",
      "***********************************************************\n",
      "Pair:  SWB ~ IBD \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  SWB  on  IBD : \n",
      "MR-APSS: beta =  0.0474 , beta.se =  0.6296 , p-value =  9.4002e-01 . \n",
      "Total NO. of IVs=  65 , NO. of valid IVs with foreground signals:  7.533886 . \n",
      "***********************************************************\n",
      "Pair:  SWB ~ MDD \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  SWB  on  MDD : \n",
      "MR-APSS: beta =  -0.3235 , beta.se =  0.4205 , p-value =  4.4162e-01 . \n",
      "Total NO. of IVs=  65 , NO. of valid IVs with foreground signals:  9.266651 . \n",
      "***********************************************************\n",
      "Pair:  SWB ~ SCZ \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  SWB  on  SCZ : \n",
      "MR-APSS: beta =  -0.3742 , beta.se =  0.5703 , p-value =  5.1171e-01 . \n",
      "Total NO. of IVs=  65 , NO. of valid IVs with foreground signals:  7.798626 . \n",
      "***********************************************************\n",
      "Pair:  SWB ~ Angina \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  SWB  on  Angina : \n",
      "MR-APSS: beta =  -0.0227 , beta.se =  0.2817 , p-value =  9.3588e-01 . \n",
      "Total NO. of IVs=  65 , NO. of valid IVs with foreground signals:  8.447758 . \n",
      "***********************************************************\n",
      "Pair:  SWB ~ CAD \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  SWB  on  CAD : \n",
      "MR-APSS: beta =  0.1165 , beta.se =  0.2854 , p-value =  6.8319e-01 . \n",
      "Total NO. of IVs=  66 , NO. of valid IVs with foreground signals:  8.59457 . \n",
      "***********************************************************\n",
      "Pair:  SWB ~ HBP \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  SWB  on  HBP : \n",
      "MR-APSS: beta =  0.5916 , beta.se =  0.4732 , p-value =  2.1123e-01 . \n",
      "Total NO. of IVs=  65 , NO. of valid IVs with foreground signals:  5.362534 . \n",
      "***********************************************************\n",
      "Pair:  SWB ~ Income \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  SWB  on  Income : \n",
      "MR-APSS: beta =  5.2565 , beta.se =  4.7429 , p-value =  2.6774e-01 . \n",
      "Total NO. of IVs=  66 , NO. of valid IVs with foreground signals:  65.98627 . \n",
      "***********************************************************\n",
      "Pair:  SWB ~ NEB \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  SWB  on  NEB : \n",
      "MR-APSS: beta =  -0.0013 , beta.se =  0.1363 , p-value =  9.9225e-01 . \n",
      "Total NO. of IVs=  65 , NO. of valid IVs with foreground signals:  7.289643 . \n",
      "***********************************************************\n",
      "Pair:  SWB ~ Smoking \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  SWB  on  Smoking : \n",
      "MR-APSS: beta =  0.4109 , beta.se =  0.5814 , p-value =  4.7978e-01 . \n",
      "Total NO. of IVs=  66 , NO. of valid IVs with foreground signals:  14.57048 . \n",
      "***********************************************************\n",
      "Pair:  SWB ~ Urate \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  SWB  on  Urate : \n",
      "MR-APSS: beta =  0.2611 , beta.se =  0.3765 , p-value =  4.8798e-01 . \n",
      "Total NO. of IVs=  66 , NO. of valid IVs with foreground signals:  8.380742 . \n",
      "***********************************************************\n",
      "Pair:  SWB ~ Anorexia \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  SWB  on  Anorexia : \n",
      "MR-APSS: beta =  -0.9625 , beta.se =  0.4346 , p-value =  2.6773e-02 . \n",
      "Total NO. of IVs=  57 , NO. of valid IVs with foreground signals:  10.06635 . \n",
      "***********************************************************\n",
      "Pair:  SWB ~ CD \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  SWB  on  CD : \n",
      "MR-APSS: beta =  -0.0858 , beta.se =  0.8007 , p-value =  9.1466e-01 . \n",
      "Total NO. of IVs=  65 , NO. of valid IVs with foreground signals:  7.058192 . \n",
      "***********************************************************\n",
      "Pair:  SWB ~ Height_GIANT \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  SWB  on  Height_GIANT : \n",
      "MR-APSS: beta =  1.6141 , beta.se =  1.7595 , p-value =  3.5896e-01 . \n",
      "Total NO. of IVs=  65 , NO. of valid IVs with foreground signals:  3.281521 . \n",
      "***********************************************************\n",
      "Pair:  SWB ~ Insomnia \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  SWB  on  Insomnia : \n",
      "MR-APSS: beta =  -0.4026 , beta.se =  0.2239 , p-value =  7.2138e-02 . \n",
      "Total NO. of IVs=  65 , NO. of valid IVs with foreground signals:  10.16022 . \n",
      "***********************************************************\n",
      "Pair:  SWB ~ Neuroticism \n",
      "Run MR-APSS ... \n",
      "IV selection threshold: 5e-05 \n",
      "***********************************************************\n",
      "MR test results of  SWB  on  Neuroticism : \n",
      "MR-APSS: beta =  -1.6633 , beta.se =  1.0139 , p-value =  1.0089e-01 . \n",
      "Total NO. of IVs=  65 , NO. of valid IVs with foreground signals:  3.740949 . \n",
      "***********************************************************\n",
      "     user    system   elapsed \n",
      "25142.961  6163.566 17961.738 \n"
     ]
    }
   ],
   "source": [
    "# All the results will be saved to the file \"Traits_MRAPSS.MRres\"\n",
    "start = proc.time()\n",
    "\n",
    "ts1 = c(\"AD\", \"ASD\", \"Daytime_Sleepiness\", \"Height_UKB\",  \"Intelligence\", \"RA\",      \n",
    "        \"T2D\", \"Alcohol\", \"BMI\", \"Depression\", \"IBD\", \"MDD\", \"SCZ\", \"Angina\", \n",
    "        \"CAD\", \"HBP\", \"Income\", \"NEB\", \"Smoking\", \"Urate\", \"Anorexia\", \n",
    "        \"CD\", \"Height_GIANT\", \"Insomnia\", \"Neuroticism\", \"SWB\")\n",
    "\n",
    "ts2 = ts1\n",
    "\n",
    "IV.Threshold = 5e-05\n",
    "\n",
    "for( exposure in ts1){\n",
    "  \n",
    "  for( outcome in ts2){\n",
    "    \n",
    "    if(exposure==outcome) next\n",
    "      \n",
    "    cat(\"Pair: \", exposure,\"~\", outcome,\"\\n\")\n",
    "      \n",
    "    # read in GWAS summary data for IVs\n",
    "    clumped = try(read.table(paste0(\"./MRdat/\", exposure,\"~\",outcome), header = T))\n",
    "    \n",
    "    # read in background parameters Omega and C\n",
    "    C = try(as.matrix(read.table(paste0(\"./pairs_bg_paras/\",exposure, \"~\", outcome,\"_C\"),\n",
    "                                 header = F)))\n",
    "    \n",
    "    C = matrix(C[nrow(C), ], 2,2)\n",
    "    \n",
    "    Omega = try(as.matrix(read.table(paste0(\"./pairs_bg_paras/\", exposure, \"~\", outcome,\"_Omega\"),\n",
    "                                     header = F)))\n",
    "      \n",
    "    Omega = matrix(Omega[nrow(Omega), ], 2, 2)\n",
    "    \n",
    "    if(inherits(clumped , 'try-error')) clumped = NULL\n",
    "    if(inherits(C, 'try-error')) next\n",
    "    if(inherits(Omega, 'try-error')) next\n",
    "    if(nrow(clumped) < 4 ) next\n",
    "    \n",
    "    # The p-value threshold for selection bias correction\n",
    "    Threshold =  ifelse(IV.Threshold==5e-05, unique(clumped$Threshold), IV.Threshold)\n",
    "    \n",
    "    # MR-APSS\n",
    "    cat(\"Run MR-APSS ... \\n\")\n",
    "    res = run_APSS_func(clumped = clumped,\n",
    "                        exposure = exposure,\n",
    "                        outcome = outcome,\n",
    "                        C = C,\n",
    "                        Omega=Omega,\n",
    "                        IV.Threshold = IV.Threshold,\n",
    "                        Threshold = Threshold,\n",
    "                        Cor.SelectionBias = T)\n",
    "    \n",
    "     \n",
    "     # saving resuts\n",
    "     write.table(res, \"Traits_MRAPSS.MRres\", quote=F, col.names = F, append = T,row.names = F)\n",
    "     \n",
    "     \n",
    "}\n",
    "  \n",
    "}\n",
    "\n",
    "print(proc.time()-start)"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 4,
   "metadata": {},
   "outputs": [],
   "source": [
    "apss_res = read.table(\"Traits_MRAPSS.MRres\", header = F)\n",
    "colnames(apss_res) = c(\"exposure\",\"outcome\", \"nsnp\",\"pi\",\"nvalid\",\"sigma.sq\",\"tau.sq\",\"b\",\"se\",\"pval\",\n",
    "                        \"Method\", \"cor.Threshold\", \"IVstrength\", \"Threshold\")\n",
    "write.table(apss_res, \"Traits_MRAPSS.MRres\", quote=F, col.names = T, append = F,row.names = F)"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": null,
   "metadata": {},
   "outputs": [],
   "source": []
  }
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