Format_GWASdata.html

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  content: "\e252";
}
.glyphicon-triangle-top:before {
  content: "\e253";
}
.glyphicon-console:before {
  content: "\e254";
}
.glyphicon-superscript:before {
  content: "\e255";
}
.glyphicon-subscript:before {
  content: "\e256";
}
.glyphicon-menu-left:before {
  content: "\e257";
}
.glyphicon-menu-right:before {
  content: "\e258";
}
.glyphicon-menu-down:before {
  content: "\e259";
}
.glyphicon-menu-up:before {
  content: "\e260";
}
* {
  -webkit-box-sizing: border-box;
  -moz-box-sizing: border-box;
  box-sizing: border-box;
}
*:before,
*:after {
  -webkit-box-sizing: border-box;
  -moz-box-sizing: border-box;
  box-sizing: border-box;
}
html {
  font-size: 10px;
  -webkit-tap-highlight-color: rgba(0, 0, 0, 0);
}
body {
  font-family: "Helvetica Neue", Helvetica, Arial, sans-serif;
  font-size: 13px;
  line-height: 1.42857143;
  color: #000;
  background-color: #fff;
}
input,
button,
select,
textarea {
  font-family: inherit;
  font-size: inherit;
  line-height: inherit;
}
a {
  color: #337ab7;
  text-decoration: none;
}
a:hover,
a:focus {
  color: #23527c;
  text-decoration: underline;
}
a:focus {
  outline: 5px auto -webkit-focus-ring-color;
  outline-offset: -2px;
}
figure {
  margin: 0;
}
img {
  vertical-align: middle;
}
.img-responsive,
.thumbnail > img,
.thumbnail a > img,
.carousel-inner > .item > img,
.carousel-inner > .item > a > img {
  display: block;
  max-width: 100%;
  height: auto;
}
.img-rounded {
  border-radius: 3px;
}
.img-thumbnail {
  padding: 4px;
  line-height: 1.42857143;
  background-color: #fff;
  border: 1px solid #ddd;
  border-radius: 2px;
  -webkit-transition: all 0.2s ease-in-out;
  -o-transition: all 0.2s ease-in-out;
  transition: all 0.2s ease-in-out;
  display: inline-block;
  max-width: 100%;
  height: auto;
}
.img-circle {
  border-radius: 50%;
}
hr {
  margin-top: 18px;
  margin-bottom: 18px;
  border: 0;
  border-top: 1px solid #eeeeee;
}
.sr-only {
  position: absolute;
  width: 1px;
  height: 1px;
  margin: -1px;
  padding: 0;
  overflow: hidden;
  clip: rect(0, 0, 0, 0);
  border: 0;
}
.sr-only-focusable:active,
.sr-only-focusable:focus {
  position: static;
  width: auto;
  height: auto;
  margin: 0;
  overflow: visible;
  clip: auto;
}
[role="button"] {
  cursor: pointer;
}
h1,
h2,
h3,
h4,
h5,
h6,
.h1,
.h2,
.h3,
.h4,
.h5,
.h6 {
  font-family: inherit;
  font-weight: 500;
  line-height: 1.1;
  color: inherit;
}
h1 small,
h2 small,
h3 small,
h4 small,
h5 small,
h6 small,
.h1 small,
.h2 small,
.h3 small,
.h4 small,
.h5 small,
.h6 small,
h1 .small,
h2 .small,
h3 .small,
h4 .small,
h5 .small,
h6 .small,
.h1 .small,
.h2 .small,
.h3 .small,
.h4 .small,
.h5 .small,
.h6 .small {
  font-weight: normal;
  line-height: 1;
  color: #777777;
}
h1,
.h1,
h2,
.h2,
h3,
.h3 {
  margin-top: 18px;
  margin-bottom: 9px;
}
h1 small,
.h1 small,
h2 small,
.h2 small,
h3 small,
.h3 small,
h1 .small,
.h1 .small,
h2 .small,
.h2 .small,
h3 .small,
.h3 .small {
  font-size: 65%;
}
h4,
.h4,
h5,
.h5,
h6,
.h6 {
  margin-top: 9px;
  margin-bottom: 9px;
}
h4 small,
.h4 small,
h5 small,
.h5 small,
h6 small,
.h6 small,
h4 .small,
.h4 .small,
h5 .small,
.h5 .small,
h6 .small,
.h6 .small {
  font-size: 75%;
}
h1,
.h1 {
  font-size: 33px;
}
h2,
.h2 {
  font-size: 27px;
}
h3,
.h3 {
  font-size: 23px;
}
h4,
.h4 {
  font-size: 17px;
}
h5,
.h5 {
  font-size: 13px;
}
h6,
.h6 {
  font-size: 12px;
}
p {
  margin: 0 0 9px;
}
.lead {
  margin-bottom: 18px;
  font-size: 14px;
  font-weight: 300;
  line-height: 1.4;
}
@media (min-width: 768px) {
  .lead {
    font-size: 19.5px;
  }
}
small,
.small {
  font-size: 92%;
}
mark,
.mark {
  background-color: #fcf8e3;
  padding: .2em;
}
.text-left {
  text-align: left;
}
.text-right {
  text-align: right;
}
.text-center {
  text-align: center;
}
.text-justify {
  text-align: justify;
}
.text-nowrap {
  white-space: nowrap;
}
.text-lowercase {
  text-transform: lowercase;
}
.text-uppercase {
  text-transform: uppercase;
}
.text-capitalize {
  text-transform: capitalize;
}
.text-muted {
  color: #777777;
}
.text-primary {
  color: #337ab7;
}
a.text-primary:hover,
a.text-primary:focus {
  color: #286090;
}
.text-success {
  color: #3c763d;
}
a.text-success:hover,
a.text-success:focus {
  color: #2b542c;
}
.text-info {
  color: #31708f;
}
a.text-info:hover,
a.text-info:focus {
  color: #245269;
}
.text-warning {
  color: #8a6d3b;
}
a.text-warning:hover,
a.text-warning:focus {
  color: #66512c;
}
.text-danger {
  color: #a94442;
}
a.text-danger:hover,
a.text-danger:focus {
  color: #843534;
}
.bg-primary {
  color: #fff;
  background-color: #337ab7;
}
a.bg-primary:hover,
a.bg-primary:focus {
  background-color: #286090;
}
.bg-success {
  background-color: #dff0d8;
}
a.bg-success:hover,
a.bg-success:focus {
  background-color: #c1e2b3;
}
.bg-info {
  background-color: #d9edf7;
}
a.bg-info:hover,
a.bg-info:focus {
  background-color: #afd9ee;
}
.bg-warning {
  background-color: #fcf8e3;
}
a.bg-warning:hover,
a.bg-warning:focus {
  background-color: #f7ecb5;
}
.bg-danger {
  background-color: #f2dede;
}
a.bg-danger:hover,
a.bg-danger:focus {
  background-color: #e4b9b9;
}
.page-header {
  padding-bottom: 8px;
  margin: 36px 0 18px;
  border-bottom: 1px solid #eeeeee;
}
ul,
ol {
  margin-top: 0;
  margin-bottom: 9px;
}
ul ul,
ol ul,
ul ol,
ol ol {
  margin-bottom: 0;
}
.list-unstyled {
  padding-left: 0;
  list-style: none;
}
.list-inline {
  padding-left: 0;
  list-style: none;
  margin-left: -5px;
}
.list-inline > li {
  display: inline-block;
  padding-left: 5px;
  padding-right: 5px;
}
dl {
  margin-top: 0;
  margin-bottom: 18px;
}
dt,
dd {
  line-height: 1.42857143;
}
dt {
  font-weight: bold;
}
dd {
  margin-left: 0;
}
@media (min-width: 541px) {
  .dl-horizontal dt {
    float: left;
    width: 160px;
    clear: left;
    text-align: right;
    overflow: hidden;
    text-overflow: ellipsis;
    white-space: nowrap;
  }
  .dl-horizontal dd {
    margin-left: 180px;
  }
}
abbr[title],
abbr[data-original-title] {
  cursor: help;
  border-bottom: 1px dotted #777777;
}
.initialism {
  font-size: 90%;
  text-transform: uppercase;
}
blockquote {
  padding: 9px 18px;
  margin: 0 0 18px;
  font-size: inherit;
  border-left: 5px solid #eeeeee;
}
blockquote p:last-child,
blockquote ul:last-child,
blockquote ol:last-child {
  margin-bottom: 0;
}
blockquote footer,
blockquote small,
blockquote .small {
  display: block;
  font-size: 80%;
  line-height: 1.42857143;
  color: #777777;
}
blockquote footer:before,
blockquote small:before,
blockquote .small:before {
  content: '\2014 \00A0';
}
.blockquote-reverse,
blockquote.pull-right {
  padding-right: 15px;
  padding-left: 0;
  border-right: 5px solid #eeeeee;
  border-left: 0;
  text-align: right;
}
.blockquote-reverse footer:before,
blockquote.pull-right footer:before,
.blockquote-reverse small:before,
blockquote.pull-right small:before,
.blockquote-reverse .small:before,
blockquote.pull-right .small:before {
  content: '';
}
.blockquote-reverse footer:after,
blockquote.pull-right footer:after,
.blockquote-reverse small:after,
blockquote.pull-right small:after,
.blockquote-reverse .small:after,
blockquote.pull-right .small:after {
  content: '\00A0 \2014';
}
address {
  margin-bottom: 18px;
  font-style: normal;
  line-height: 1.42857143;
}
code,
kbd,
pre,
samp {
  font-family: monospace;
}
code {
  padding: 2px 4px;
  font-size: 90%;
  color: #c7254e;
  background-color: #f9f2f4;
  border-radius: 2px;
}
kbd {
  padding: 2px 4px;
  font-size: 90%;
  color: #888;
  background-color: transparent;
  border-radius: 1px;
  box-shadow: inset 0 -1px 0 rgba(0, 0, 0, 0.25);
}
kbd kbd {
  padding: 0;
  font-size: 100%;
  font-weight: bold;
  box-shadow: none;
}
pre {
  display: block;
  padding: 8.5px;
  margin: 0 0 9px;
  font-size: 12px;
  line-height: 1.42857143;
  word-break: break-all;
  word-wrap: break-word;
  color: #333333;
  background-color: #f5f5f5;
  border: 1px solid #ccc;
  border-radius: 2px;
}
pre code {
  padding: 0;
  font-size: inherit;
  color: inherit;
  white-space: pre-wrap;
  background-color: transparent;
  border-radius: 0;
}
.pre-scrollable {
  max-height: 340px;
  overflow-y: scroll;
}
.container {
  margin-right: auto;
  margin-left: auto;
  padding-left: 0px;
  padding-right: 0px;
}
@media (min-width: 768px) {
  .container {
    width: 768px;
  }
}
@media (min-width: 992px) {
  .container {
    width: 940px;
  }
}
@media (min-width: 1200px) {
  .container {
    width: 1140px;
  }
}
.container-fluid {
  margin-right: auto;
  margin-left: auto;
  padding-left: 0px;
  padding-right: 0px;
}
.row {
  margin-left: 0px;
  margin-right: 0px;
}
.col-xs-1, .col-sm-1, .col-md-1, .col-lg-1, .col-xs-2, .col-sm-2, .col-md-2, .col-lg-2, .col-xs-3, .col-sm-3, .col-md-3, .col-lg-3, .col-xs-4, .col-sm-4, .col-md-4, .col-lg-4, .col-xs-5, .col-sm-5, .col-md-5, .col-lg-5, .col-xs-6, .col-sm-6, .col-md-6, .col-lg-6, .col-xs-7, .col-sm-7, .col-md-7, .col-lg-7, .col-xs-8, .col-sm-8, .col-md-8, .col-lg-8, .col-xs-9, .col-sm-9, .col-md-9, .col-lg-9, .col-xs-10, .col-sm-10, .col-md-10, .col-lg-10, .col-xs-11, .col-sm-11, .col-md-11, .col-lg-11, .col-xs-12, .col-sm-12, .col-md-12, .col-lg-12 {
  position: relative;
  min-height: 1px;
  padding-left: 0px;
  padding-right: 0px;
}
.col-xs-1, .col-xs-2, .col-xs-3, .col-xs-4, .col-xs-5, .col-xs-6, .col-xs-7, .col-xs-8, .col-xs-9, .col-xs-10, .col-xs-11, .col-xs-12 {
  float: left;
}
.col-xs-12 {
  width: 100%;
}
.col-xs-11 {
  width: 91.66666667%;
}
.col-xs-10 {
  width: 83.33333333%;
}
.col-xs-9 {
  width: 75%;
}
.col-xs-8 {
  width: 66.66666667%;
}
.col-xs-7 {
  width: 58.33333333%;
}
.col-xs-6 {
  width: 50%;
}
.col-xs-5 {
  width: 41.66666667%;
}
.col-xs-4 {
  width: 33.33333333%;
}
.col-xs-3 {
  width: 25%;
}
.col-xs-2 {
  width: 16.66666667%;
}
.col-xs-1 {
  width: 8.33333333%;
}
.col-xs-pull-12 {
  right: 100%;
}
.col-xs-pull-11 {
  right: 91.66666667%;
}
.col-xs-pull-10 {
  right: 83.33333333%;
}
.col-xs-pull-9 {
  right: 75%;
}
.col-xs-pull-8 {
  right: 66.66666667%;
}
.col-xs-pull-7 {
  right: 58.33333333%;
}
.col-xs-pull-6 {
  right: 50%;
}
.col-xs-pull-5 {
  right: 41.66666667%;
}
.col-xs-pull-4 {
  right: 33.33333333%;
}
.col-xs-pull-3 {
  right: 25%;
}
.col-xs-pull-2 {
  right: 16.66666667%;
}
.col-xs-pull-1 {
  right: 8.33333333%;
}
.col-xs-pull-0 {
  right: auto;
}
.col-xs-push-12 {
  left: 100%;
}
.col-xs-push-11 {
  left: 91.66666667%;
}
.col-xs-push-10 {
  left: 83.33333333%;
}
.col-xs-push-9 {
  left: 75%;
}
.col-xs-push-8 {
  left: 66.66666667%;
}
.col-xs-push-7 {
  left: 58.33333333%;
}
.col-xs-push-6 {
  left: 50%;
}
.col-xs-push-5 {
  left: 41.66666667%;
}
.col-xs-push-4 {
  left: 33.33333333%;
}
.col-xs-push-3 {
  left: 25%;
}
.col-xs-push-2 {
  left: 16.66666667%;
}
.col-xs-push-1 {
  left: 8.33333333%;
}
.col-xs-push-0 {
  left: auto;
}
.col-xs-offset-12 {
  margin-left: 100%;
}
.col-xs-offset-11 {
  margin-left: 91.66666667%;
}
.col-xs-offset-10 {
  margin-left: 83.33333333%;
}
.col-xs-offset-9 {
  margin-left: 75%;
}
.col-xs-offset-8 {
  margin-left: 66.66666667%;
}
.col-xs-offset-7 {
  margin-left: 58.33333333%;
}
.col-xs-offset-6 {
  margin-left: 50%;
}
.col-xs-offset-5 {
  margin-left: 41.66666667%;
}
.col-xs-offset-4 {
  margin-left: 33.33333333%;
}
.col-xs-offset-3 {
  margin-left: 25%;
}
.col-xs-offset-2 {
  margin-left: 16.66666667%;
}
.col-xs-offset-1 {
  margin-left: 8.33333333%;
}
.col-xs-offset-0 {
  margin-left: 0%;
}
@media (min-width: 768px) {
  .col-sm-1, .col-sm-2, .col-sm-3, .col-sm-4, .col-sm-5, .col-sm-6, .col-sm-7, .col-sm-8, .col-sm-9, .col-sm-10, .col-sm-11, .col-sm-12 {
    float: left;
  }
  .col-sm-12 {
    width: 100%;
  }
  .col-sm-11 {
    width: 91.66666667%;
  }
  .col-sm-10 {
    width: 83.33333333%;
  }
  .col-sm-9 {
    width: 75%;
  }
  .col-sm-8 {
    width: 66.66666667%;
  }
  .col-sm-7 {
    width: 58.33333333%;
  }
  .col-sm-6 {
    width: 50%;
  }
  .col-sm-5 {
    width: 41.66666667%;
  }
  .col-sm-4 {
    width: 33.33333333%;
  }
  .col-sm-3 {
    width: 25%;
  }
  .col-sm-2 {
    width: 16.66666667%;
  }
  .col-sm-1 {
    width: 8.33333333%;
  }
  .col-sm-pull-12 {
    right: 100%;
  }
  .col-sm-pull-11 {
    right: 91.66666667%;
  }
  .col-sm-pull-10 {
    right: 83.33333333%;
  }
  .col-sm-pull-9 {
    right: 75%;
  }
  .col-sm-pull-8 {
    right: 66.66666667%;
  }
  .col-sm-pull-7 {
    right: 58.33333333%;
  }
  .col-sm-pull-6 {
    right: 50%;
  }
  .col-sm-pull-5 {
    right: 41.66666667%;
  }
  .col-sm-pull-4 {
    right: 33.33333333%;
  }
  .col-sm-pull-3 {
    right: 25%;
  }
  .col-sm-pull-2 {
    right: 16.66666667%;
  }
  .col-sm-pull-1 {
    right: 8.33333333%;
  }
  .col-sm-pull-0 {
    right: auto;
  }
  .col-sm-push-12 {
    left: 100%;
  }
  .col-sm-push-11 {
    left: 91.66666667%;
  }
  .col-sm-push-10 {
    left: 83.33333333%;
  }
  .col-sm-push-9 {
    left: 75%;
  }
  .col-sm-push-8 {
    left: 66.66666667%;
  }
  .col-sm-push-7 {
    left: 58.33333333%;
  }
  .col-sm-push-6 {
    left: 50%;
  }
  .col-sm-push-5 {
    left: 41.66666667%;
  }
  .col-sm-push-4 {
    left: 33.33333333%;
  }
  .col-sm-push-3 {
    left: 25%;
  }
  .col-sm-push-2 {
    left: 16.66666667%;
  }
  .col-sm-push-1 {
    left: 8.33333333%;
  }
  .col-sm-push-0 {
    left: auto;
  }
  .col-sm-offset-12 {
    margin-left: 100%;
  }
  .col-sm-offset-11 {
    margin-left: 91.66666667%;
  }
  .col-sm-offset-10 {
    margin-left: 83.33333333%;
  }
  .col-sm-offset-9 {
    margin-left: 75%;
  }
  .col-sm-offset-8 {
    margin-left: 66.66666667%;
  }
  .col-sm-offset-7 {
    margin-left: 58.33333333%;
  }
  .col-sm-offset-6 {
    margin-left: 50%;
  }
  .col-sm-offset-5 {
    margin-left: 41.66666667%;
  }
  .col-sm-offset-4 {
    margin-left: 33.33333333%;
  }
  .col-sm-offset-3 {
    margin-left: 25%;
  }
  .col-sm-offset-2 {
    margin-left: 16.66666667%;
  }
  .col-sm-offset-1 {
    margin-left: 8.33333333%;
  }
  .col-sm-offset-0 {
    margin-left: 0%;
  }
}
@media (min-width: 992px) {
  .col-md-1, .col-md-2, .col-md-3, .col-md-4, .col-md-5, .col-md-6, .col-md-7, .col-md-8, .col-md-9, .col-md-10, .col-md-11, .col-md-12 {
    float: left;
  }
  .col-md-12 {
    width: 100%;
  }
  .col-md-11 {
    width: 91.66666667%;
  }
  .col-md-10 {
    width: 83.33333333%;
  }
  .col-md-9 {
    width: 75%;
  }
  .col-md-8 {
    width: 66.66666667%;
  }
  .col-md-7 {
    width: 58.33333333%;
  }
  .col-md-6 {
    width: 50%;
  }
  .col-md-5 {
    width: 41.66666667%;
  }
  .col-md-4 {
    width: 33.33333333%;
  }
  .col-md-3 {
    width: 25%;
  }
  .col-md-2 {
    width: 16.66666667%;
  }
  .col-md-1 {
    width: 8.33333333%;
  }
  .col-md-pull-12 {
    right: 100%;
  }
  .col-md-pull-11 {
    right: 91.66666667%;
  }
  .col-md-pull-10 {
    right: 83.33333333%;
  }
  .col-md-pull-9 {
    right: 75%;
  }
  .col-md-pull-8 {
    right: 66.66666667%;
  }
  .col-md-pull-7 {
    right: 58.33333333%;
  }
  .col-md-pull-6 {
    right: 50%;
  }
  .col-md-pull-5 {
    right: 41.66666667%;
  }
  .col-md-pull-4 {
    right: 33.33333333%;
  }
  .col-md-pull-3 {
    right: 25%;
  }
  .col-md-pull-2 {
    right: 16.66666667%;
  }
  .col-md-pull-1 {
    right: 8.33333333%;
  }
  .col-md-pull-0 {
    right: auto;
  }
  .col-md-push-12 {
    left: 100%;
  }
  .col-md-push-11 {
    left: 91.66666667%;
  }
  .col-md-push-10 {
    left: 83.33333333%;
  }
  .col-md-push-9 {
    left: 75%;
  }
  .col-md-push-8 {
    left: 66.66666667%;
  }
  .col-md-push-7 {
    left: 58.33333333%;
  }
  .col-md-push-6 {
    left: 50%;
  }
  .col-md-push-5 {
    left: 41.66666667%;
  }
  .col-md-push-4 {
    left: 33.33333333%;
  }
  .col-md-push-3 {
    left: 25%;
  }
  .col-md-push-2 {
    left: 16.66666667%;
  }
  .col-md-push-1 {
    left: 8.33333333%;
  }
  .col-md-push-0 {
    left: auto;
  }
  .col-md-offset-12 {
    margin-left: 100%;
  }
  .col-md-offset-11 {
    margin-left: 91.66666667%;
  }
  .col-md-offset-10 {
    margin-left: 83.33333333%;
  }
  .col-md-offset-9 {
    margin-left: 75%;
  }
  .col-md-offset-8 {
    margin-left: 66.66666667%;
  }
  .col-md-offset-7 {
    margin-left: 58.33333333%;
  }
  .col-md-offset-6 {
    margin-left: 50%;
  }
  .col-md-offset-5 {
    margin-left: 41.66666667%;
  }
  .col-md-offset-4 {
    margin-left: 33.33333333%;
  }
  .col-md-offset-3 {
    margin-left: 25%;
  }
  .col-md-offset-2 {
    margin-left: 16.66666667%;
  }
  .col-md-offset-1 {
    margin-left: 8.33333333%;
  }
  .col-md-offset-0 {
    margin-left: 0%;
  }
}
@media (min-width: 1200px) {
  .col-lg-1, .col-lg-2, .col-lg-3, .col-lg-4, .col-lg-5, .col-lg-6, .col-lg-7, .col-lg-8, .col-lg-9, .col-lg-10, .col-lg-11, .col-lg-12 {
    float: left;
  }
  .col-lg-12 {
    width: 100%;
  }
  .col-lg-11 {
    width: 91.66666667%;
  }
  .col-lg-10 {
    width: 83.33333333%;
  }
  .col-lg-9 {
    width: 75%;
  }
  .col-lg-8 {
    width: 66.66666667%;
  }
  .col-lg-7 {
    width: 58.33333333%;
  }
  .col-lg-6 {
    width: 50%;
  }
  .col-lg-5 {
    width: 41.66666667%;
  }
  .col-lg-4 {
    width: 33.33333333%;
  }
  .col-lg-3 {
    width: 25%;
  }
  .col-lg-2 {
    width: 16.66666667%;
  }
  .col-lg-1 {
    width: 8.33333333%;
  }
  .col-lg-pull-12 {
    right: 100%;
  }
  .col-lg-pull-11 {
    right: 91.66666667%;
  }
  .col-lg-pull-10 {
    right: 83.33333333%;
  }
  .col-lg-pull-9 {
    right: 75%;
  }
  .col-lg-pull-8 {
    right: 66.66666667%;
  }
  .col-lg-pull-7 {
    right: 58.33333333%;
  }
  .col-lg-pull-6 {
    right: 50%;
  }
  .col-lg-pull-5 {
    right: 41.66666667%;
  }
  .col-lg-pull-4 {
    right: 33.33333333%;
  }
  .col-lg-pull-3 {
    right: 25%;
  }
  .col-lg-pull-2 {
    right: 16.66666667%;
  }
  .col-lg-pull-1 {
    right: 8.33333333%;
  }
  .col-lg-pull-0 {
    right: auto;
  }
  .col-lg-push-12 {
    left: 100%;
  }
  .col-lg-push-11 {
    left: 91.66666667%;
  }
  .col-lg-push-10 {
    left: 83.33333333%;
  }
  .col-lg-push-9 {
    left: 75%;
  }
  .col-lg-push-8 {
    left: 66.66666667%;
  }
  .col-lg-push-7 {
    left: 58.33333333%;
  }
  .col-lg-push-6 {
    left: 50%;
  }
  .col-lg-push-5 {
    left: 41.66666667%;
  }
  .col-lg-push-4 {
    left: 33.33333333%;
  }
  .col-lg-push-3 {
    left: 25%;
  }
  .col-lg-push-2 {
    left: 16.66666667%;
  }
  .col-lg-push-1 {
    left: 8.33333333%;
  }
  .col-lg-push-0 {
    left: auto;
  }
  .col-lg-offset-12 {
    margin-left: 100%;
  }
  .col-lg-offset-11 {
    margin-left: 91.66666667%;
  }
  .col-lg-offset-10 {
    margin-left: 83.33333333%;
  }
  .col-lg-offset-9 {
    margin-left: 75%;
  }
  .col-lg-offset-8 {
    margin-left: 66.66666667%;
  }
  .col-lg-offset-7 {
    margin-left: 58.33333333%;
  }
  .col-lg-offset-6 {
    margin-left: 50%;
  }
  .col-lg-offset-5 {
    margin-left: 41.66666667%;
  }
  .col-lg-offset-4 {
    margin-left: 33.33333333%;
  }
  .col-lg-offset-3 {
    margin-left: 25%;
  }
  .col-lg-offset-2 {
    margin-left: 16.66666667%;
  }
  .col-lg-offset-1 {
    margin-left: 8.33333333%;
  }
  .col-lg-offset-0 {
    margin-left: 0%;
  }
}
table {
  background-color: transparent;
}
caption {
  padding-top: 8px;
  padding-bottom: 8px;
  color: #777777;
  text-align: left;
}
th {
  text-align: left;
}
.table {
  width: 100%;
  max-width: 100%;
  margin-bottom: 18px;
}
.table > thead > tr > th,
.table > tbody > tr > th,
.table > tfoot > tr > th,
.table > thead > tr > td,
.table > tbody > tr > td,
.table > tfoot > tr > td {
  padding: 8px;
  line-height: 1.42857143;
  vertical-align: top;
  border-top: 1px solid #ddd;
}
.table > thead > tr > th {
  vertical-align: bottom;
  border-bottom: 2px solid #ddd;
}
.table > caption + thead > tr:first-child > th,
.table > colgroup + thead > tr:first-child > th,
.table > thead:first-child > tr:first-child > th,
.table > caption + thead > tr:first-child > td,
.table > colgroup + thead > tr:first-child > td,
.table > thead:first-child > tr:first-child > td {
  border-top: 0;
}
.table > tbody + tbody {
  border-top: 2px solid #ddd;
}
.table .table {
  background-color: #fff;
}
.table-condensed > thead > tr > th,
.table-condensed > tbody > tr > th,
.table-condensed > tfoot > tr > th,
.table-condensed > thead > tr > td,
.table-condensed > tbody > tr > td,
.table-condensed > tfoot > tr > td {
  padding: 5px;
}
.table-bordered {
  border: 1px solid #ddd;
}
.table-bordered > thead > tr > th,
.table-bordered > tbody > tr > th,
.table-bordered > tfoot > tr > th,
.table-bordered > thead > tr > td,
.table-bordered > tbody > tr > td,
.table-bordered > tfoot > tr > td {
  border: 1px solid #ddd;
}
.table-bordered > thead > tr > th,
.table-bordered > thead > tr > td {
  border-bottom-width: 2px;
}
.table-striped > tbody > tr:nth-of-type(odd) {
  background-color: #f9f9f9;
}
.table-hover > tbody > tr:hover {
  background-color: #f5f5f5;
}
table col[class*="col-"] {
  position: static;
  float: none;
  display: table-column;
}
table td[class*="col-"],
table th[class*="col-"] {
  position: static;
  float: none;
  display: table-cell;
}
.table > thead > tr > td.active,
.table > tbody > tr > td.active,
.table > tfoot > tr > td.active,
.table > thead > tr > th.active,
.table > tbody > tr > th.active,
.table > tfoot > tr > th.active,
.table > thead > tr.active > td,
.table > tbody > tr.active > td,
.table > tfoot > tr.active > td,
.table > thead > tr.active > th,
.table > tbody > tr.active > th,
.table > tfoot > tr.active > th {
  background-color: #f5f5f5;
}
.table-hover > tbody > tr > td.active:hover,
.table-hover > tbody > tr > th.active:hover,
.table-hover > tbody > tr.active:hover > td,
.table-hover > tbody > tr:hover > .active,
.table-hover > tbody > tr.active:hover > th {
  background-color: #e8e8e8;
}
.table > thead > tr > td.success,
.table > tbody > tr > td.success,
.table > tfoot > tr > td.success,
.table > thead > tr > th.success,
.table > tbody > tr > th.success,
.table > tfoot > tr > th.success,
.table > thead > tr.success > td,
.table > tbody > tr.success > td,
.table > tfoot > tr.success > td,
.table > thead > tr.success > th,
.table > tbody > tr.success > th,
.table > tfoot > tr.success > th {
  background-color: #dff0d8;
}
.table-hover > tbody > tr > td.success:hover,
.table-hover > tbody > tr > th.success:hover,
.table-hover > tbody > tr.success:hover > td,
.table-hover > tbody > tr:hover > .success,
.table-hover > tbody > tr.success:hover > th {
  background-color: #d0e9c6;
}
.table > thead > tr > td.info,
.table > tbody > tr > td.info,
.table > tfoot > tr > td.info,
.table > thead > tr > th.info,
.table > tbody > tr > th.info,
.table > tfoot > tr > th.info,
.table > thead > tr.info > td,
.table > tbody > tr.info > td,
.table > tfoot > tr.info > td,
.table > thead > tr.info > th,
.table > tbody > tr.info > th,
.table > tfoot > tr.info > th {
  background-color: #d9edf7;
}
.table-hover > tbody > tr > td.info:hover,
.table-hover > tbody > tr > th.info:hover,
.table-hover > tbody > tr.info:hover > td,
.table-hover > tbody > tr:hover > .info,
.table-hover > tbody > tr.info:hover > th {
  background-color: #c4e3f3;
}
.table > thead > tr > td.warning,
.table > tbody > tr > td.warning,
.table > tfoot > tr > td.warning,
.table > thead > tr > th.warning,
.table > tbody > tr > th.warning,
.table > tfoot > tr > th.warning,
.table > thead > tr.warning > td,
.table > tbody > tr.warning > td,
.table > tfoot > tr.warning > td,
.table > thead > tr.warning > th,
.table > tbody > tr.warning > th,
.table > tfoot > tr.warning > th {
  background-color: #fcf8e3;
}
.table-hover > tbody > tr > td.warning:hover,
.table-hover > tbody > tr > th.warning:hover,
.table-hover > tbody > tr.warning:hover > td,
.table-hover > tbody > tr:hover > .warning,
.table-hover > tbody > tr.warning:hover > th {
  background-color: #faf2cc;
}
.table > thead > tr > td.danger,
.table > tbody > tr > td.danger,
.table > tfoot > tr > td.danger,
.table > thead > tr > th.danger,
.table > tbody > tr > th.danger,
.table > tfoot > tr > th.danger,
.table > thead > tr.danger > td,
.table > tbody > tr.danger > td,
.table > tfoot > tr.danger > td,
.table > thead > tr.danger > th,
.table > tbody > tr.danger > th,
.table > tfoot > tr.danger > th {
  background-color: #f2dede;
}
.table-hover > tbody > tr > td.danger:hover,
.table-hover > tbody > tr > th.danger:hover,
.table-hover > tbody > tr.danger:hover > td,
.table-hover > tbody > tr:hover > .danger,
.table-hover > tbody > tr.danger:hover > th {
  background-color: #ebcccc;
}
.table-responsive {
  overflow-x: auto;
  min-height: 0.01%;
}
@media screen and (max-width: 767px) {
  .table-responsive {
    width: 100%;
    margin-bottom: 13.5px;
    overflow-y: hidden;
    -ms-overflow-style: -ms-autohiding-scrollbar;
    border: 1px solid #ddd;
  }
  .table-responsive > .table {
    margin-bottom: 0;
  }
  .table-responsive > .table > thead > tr > th,
  .table-responsive > .table > tbody > tr > th,
  .table-responsive > .table > tfoot > tr > th,
  .table-responsive > .table > thead > tr > td,
  .table-responsive > .table > tbody > tr > td,
  .table-responsive > .table > tfoot > tr > td {
    white-space: nowrap;
  }
  .table-responsive > .table-bordered {
    border: 0;
  }
  .table-responsive > .table-bordered > thead > tr > th:first-child,
  .table-responsive > .table-bordered > tbody > tr > th:first-child,
  .table-responsive > .table-bordered > tfoot > tr > th:first-child,
  .table-responsive > .table-bordered > thead > tr > td:first-child,
  .table-responsive > .table-bordered > tbody > tr > td:first-child,
  .table-responsive > .table-bordered > tfoot > tr > td:first-child {
    border-left: 0;
  }
  .table-responsive > .table-bordered > thead > tr > th:last-child,
  .table-responsive > .table-bordered > tbody > tr > th:last-child,
  .table-responsive > .table-bordered > tfoot > tr > th:last-child,
  .table-responsive > .table-bordered > thead > tr > td:last-child,
  .table-responsive > .table-bordered > tbody > tr > td:last-child,
  .table-responsive > .table-bordered > tfoot > tr > td:last-child {
    border-right: 0;
  }
  .table-responsive > .table-bordered > tbody > tr:last-child > th,
  .table-responsive > .table-bordered > tfoot > tr:last-child > th,
  .table-responsive > .table-bordered > tbody > tr:last-child > td,
  .table-responsive > .table-bordered > tfoot > tr:last-child > td {
    border-bottom: 0;
  }
}
fieldset {
  padding: 0;
  margin: 0;
  border: 0;
  min-width: 0;
}
legend {
  display: block;
  width: 100%;
  padding: 0;
  margin-bottom: 18px;
  font-size: 19.5px;
  line-height: inherit;
  color: #333333;
  border: 0;
  border-bottom: 1px solid #e5e5e5;
}
label {
  display: inline-block;
  max-width: 100%;
  margin-bottom: 5px;
  font-weight: bold;
}
input[type="search"] {
  -webkit-box-sizing: border-box;
  -moz-box-sizing: border-box;
  box-sizing: border-box;
}
input[type="radio"],
input[type="checkbox"] {
  margin: 4px 0 0;
  margin-top: 1px \9;
  line-height: normal;
}
input[type="file"] {
  display: block;
}
input[type="range"] {
  display: block;
  width: 100%;
}
select[multiple],
select[size] {
  height: auto;
}
input[type="file"]:focus,
input[type="radio"]:focus,
input[type="checkbox"]:focus {
  outline: 5px auto -webkit-focus-ring-color;
  outline-offset: -2px;
}
output {
  display: block;
  padding-top: 7px;
  font-size: 13px;
  line-height: 1.42857143;
  color: #555555;
}
.form-control {
  display: block;
  width: 100%;
  height: 32px;
  padding: 6px 12px;
  font-size: 13px;
  line-height: 1.42857143;
  color: #555555;
  background-color: #fff;
  background-image: none;
  border: 1px solid #ccc;
  border-radius: 2px;
  -webkit-box-shadow: inset 0 1px 1px rgba(0, 0, 0, 0.075);
  box-shadow: inset 0 1px 1px rgba(0, 0, 0, 0.075);
  -webkit-transition: border-color ease-in-out .15s, box-shadow ease-in-out .15s;
  -o-transition: border-color ease-in-out .15s, box-shadow ease-in-out .15s;
  transition: border-color ease-in-out .15s, box-shadow ease-in-out .15s;
}
.form-control:focus {
  border-color: #66afe9;
  outline: 0;
  -webkit-box-shadow: inset 0 1px 1px rgba(0,0,0,.075), 0 0 8px rgba(102, 175, 233, 0.6);
  box-shadow: inset 0 1px 1px rgba(0,0,0,.075), 0 0 8px rgba(102, 175, 233, 0.6);
}
.form-control::-moz-placeholder {
  color: #999;
  opacity: 1;
}
.form-control:-ms-input-placeholder {
  color: #999;
}
.form-control::-webkit-input-placeholder {
  color: #999;
}
.form-control::-ms-expand {
  border: 0;
  background-color: transparent;
}
.form-control[disabled],
.form-control[readonly],
fieldset[disabled] .form-control {
  background-color: #eeeeee;
  opacity: 1;
}
.form-control[disabled],
fieldset[disabled] .form-control {
  cursor: not-allowed;
}
textarea.form-control {
  height: auto;
}
input[type="search"] {
  -webkit-appearance: none;
}
@media screen and (-webkit-min-device-pixel-ratio: 0) {
  input[type="date"].form-control,
  input[type="time"].form-control,
  input[type="datetime-local"].form-control,
  input[type="month"].form-control {
    line-height: 32px;
  }
  input[type="date"].input-sm,
  input[type="time"].input-sm,
  input[type="datetime-local"].input-sm,
  input[type="month"].input-sm,
  .input-group-sm input[type="date"],
  .input-group-sm input[type="time"],
  .input-group-sm input[type="datetime-local"],
  .input-group-sm input[type="month"] {
    line-height: 30px;
  }
  input[type="date"].input-lg,
  input[type="time"].input-lg,
  input[type="datetime-local"].input-lg,
  input[type="month"].input-lg,
  .input-group-lg input[type="date"],
  .input-group-lg input[type="time"],
  .input-group-lg input[type="datetime-local"],
  .input-group-lg input[type="month"] {
    line-height: 45px;
  }
}
.form-group {
  margin-bottom: 15px;
}
.radio,
.checkbox {
  position: relative;
  display: block;
  margin-top: 10px;
  margin-bottom: 10px;
}
.radio label,
.checkbox label {
  min-height: 18px;
  padding-left: 20px;
  margin-bottom: 0;
  font-weight: normal;
  cursor: pointer;
}
.radio input[type="radio"],
.radio-inline input[type="radio"],
.checkbox input[type="checkbox"],
.checkbox-inline input[type="checkbox"] {
  position: absolute;
  margin-left: -20px;
  margin-top: 4px \9;
}
.radio + .radio,
.checkbox + .checkbox {
  margin-top: -5px;
}
.radio-inline,
.checkbox-inline {
  position: relative;
  display: inline-block;
  padding-left: 20px;
  margin-bottom: 0;
  vertical-align: middle;
  font-weight: normal;
  cursor: pointer;
}
.radio-inline + .radio-inline,
.checkbox-inline + .checkbox-inline {
  margin-top: 0;
  margin-left: 10px;
}
input[type="radio"][disabled],
input[type="checkbox"][disabled],
input[type="radio"].disabled,
input[type="checkbox"].disabled,
fieldset[disabled] input[type="radio"],
fieldset[disabled] input[type="checkbox"] {
  cursor: not-allowed;
}
.radio-inline.disabled,
.checkbox-inline.disabled,
fieldset[disabled] .radio-inline,
fieldset[disabled] .checkbox-inline {
  cursor: not-allowed;
}
.radio.disabled label,
.checkbox.disabled label,
fieldset[disabled] .radio label,
fieldset[disabled] .checkbox label {
  cursor: not-allowed;
}
.form-control-static {
  padding-top: 7px;
  padding-bottom: 7px;
  margin-bottom: 0;
  min-height: 31px;
}
.form-control-static.input-lg,
.form-control-static.input-sm {
  padding-left: 0;
  padding-right: 0;
}
.input-sm {
  height: 30px;
  padding: 5px 10px;
  font-size: 12px;
  line-height: 1.5;
  border-radius: 1px;
}
select.input-sm {
  height: 30px;
  line-height: 30px;
}
textarea.input-sm,
select[multiple].input-sm {
  height: auto;
}
.form-group-sm .form-control {
  height: 30px;
  padding: 5px 10px;
  font-size: 12px;
  line-height: 1.5;
  border-radius: 1px;
}
.form-group-sm select.form-control {
  height: 30px;
  line-height: 30px;
}
.form-group-sm textarea.form-control,
.form-group-sm select[multiple].form-control {
  height: auto;
}
.form-group-sm .form-control-static {
  height: 30px;
  min-height: 30px;
  padding: 6px 10px;
  font-size: 12px;
  line-height: 1.5;
}
.input-lg {
  height: 45px;
  padding: 10px 16px;
  font-size: 17px;
  line-height: 1.3333333;
  border-radius: 3px;
}
select.input-lg {
  height: 45px;
  line-height: 45px;
}
textarea.input-lg,
select[multiple].input-lg {
  height: auto;
}
.form-group-lg .form-control {
  height: 45px;
  padding: 10px 16px;
  font-size: 17px;
  line-height: 1.3333333;
  border-radius: 3px;
}
.form-group-lg select.form-control {
  height: 45px;
  line-height: 45px;
}
.form-group-lg textarea.form-control,
.form-group-lg select[multiple].form-control {
  height: auto;
}
.form-group-lg .form-control-static {
  height: 45px;
  min-height: 35px;
  padding: 11px 16px;
  font-size: 17px;
  line-height: 1.3333333;
}
.has-feedback {
  position: relative;
}
.has-feedback .form-control {
  padding-right: 40px;
}
.form-control-feedback {
  position: absolute;
  top: 0;
  right: 0;
  z-index: 2;
  display: block;
  width: 32px;
  height: 32px;
  line-height: 32px;
  text-align: center;
  pointer-events: none;
}
.input-lg + .form-control-feedback,
.input-group-lg + .form-control-feedback,
.form-group-lg .form-control + .form-control-feedback {
  width: 45px;
  height: 45px;
  line-height: 45px;
}
.input-sm + .form-control-feedback,
.input-group-sm + .form-control-feedback,
.form-group-sm .form-control + .form-control-feedback {
  width: 30px;
  height: 30px;
  line-height: 30px;
}
.has-success .help-block,
.has-success .control-label,
.has-success .radio,
.has-success .checkbox,
.has-success .radio-inline,
.has-success .checkbox-inline,
.has-success.radio label,
.has-success.checkbox label,
.has-success.radio-inline label,
.has-success.checkbox-inline label {
  color: #3c763d;
}
.has-success .form-control {
  border-color: #3c763d;
  -webkit-box-shadow: inset 0 1px 1px rgba(0, 0, 0, 0.075);
  box-shadow: inset 0 1px 1px rgba(0, 0, 0, 0.075);
}
.has-success .form-control:focus {
  border-color: #2b542c;
  -webkit-box-shadow: inset 0 1px 1px rgba(0, 0, 0, 0.075), 0 0 6px #67b168;
  box-shadow: inset 0 1px 1px rgba(0, 0, 0, 0.075), 0 0 6px #67b168;
}
.has-success .input-group-addon {
  color: #3c763d;
  border-color: #3c763d;
  background-color: #dff0d8;
}
.has-success .form-control-feedback {
  color: #3c763d;
}
.has-warning .help-block,
.has-warning .control-label,
.has-warning .radio,
.has-warning .checkbox,
.has-warning .radio-inline,
.has-warning .checkbox-inline,
.has-warning.radio label,
.has-warning.checkbox label,
.has-warning.radio-inline label,
.has-warning.checkbox-inline label {
  color: #8a6d3b;
}
.has-warning .form-control {
  border-color: #8a6d3b;
  -webkit-box-shadow: inset 0 1px 1px rgba(0, 0, 0, 0.075);
  box-shadow: inset 0 1px 1px rgba(0, 0, 0, 0.075);
}
.has-warning .form-control:focus {
  border-color: #66512c;
  -webkit-box-shadow: inset 0 1px 1px rgba(0, 0, 0, 0.075), 0 0 6px #c0a16b;
  box-shadow: inset 0 1px 1px rgba(0, 0, 0, 0.075), 0 0 6px #c0a16b;
}
.has-warning .input-group-addon {
  color: #8a6d3b;
  border-color: #8a6d3b;
  background-color: #fcf8e3;
}
.has-warning .form-control-feedback {
  color: #8a6d3b;
}
.has-error .help-block,
.has-error .control-label,
.has-error .radio,
.has-error .checkbox,
.has-error .radio-inline,
.has-error .checkbox-inline,
.has-error.radio label,
.has-error.checkbox label,
.has-error.radio-inline label,
.has-error.checkbox-inline label {
  color: #a94442;
}
.has-error .form-control {
  border-color: #a94442;
  -webkit-box-shadow: inset 0 1px 1px rgba(0, 0, 0, 0.075);
  box-shadow: inset 0 1px 1px rgba(0, 0, 0, 0.075);
}
.has-error .form-control:focus {
  border-color: #843534;
  -webkit-box-shadow: inset 0 1px 1px rgba(0, 0, 0, 0.075), 0 0 6px #ce8483;
  box-shadow: inset 0 1px 1px rgba(0, 0, 0, 0.075), 0 0 6px #ce8483;
}
.has-error .input-group-addon {
  color: #a94442;
  border-color: #a94442;
  background-color: #f2dede;
}
.has-error .form-control-feedback {
  color: #a94442;
}
.has-feedback label ~ .form-control-feedback {
  top: 23px;
}
.has-feedback label.sr-only ~ .form-control-feedback {
  top: 0;
}
.help-block {
  display: block;
  margin-top: 5px;
  margin-bottom: 10px;
  color: #404040;
}
@media (min-width: 768px) {
  .form-inline .form-group {
    display: inline-block;
    margin-bottom: 0;
    vertical-align: middle;
  }
  .form-inline .form-control {
    display: inline-block;
    width: auto;
    vertical-align: middle;
  }
  .form-inline .form-control-static {
    display: inline-block;
  }
  .form-inline .input-group {
    display: inline-table;
    vertical-align: middle;
  }
  .form-inline .input-group .input-group-addon,
  .form-inline .input-group .input-group-btn,
  .form-inline .input-group .form-control {
    width: auto;
  }
  .form-inline .input-group > .form-control {
    width: 100%;
  }
  .form-inline .control-label {
    margin-bottom: 0;
    vertical-align: middle;
  }
  .form-inline .radio,
  .form-inline .checkbox {
    display: inline-block;
    margin-top: 0;
    margin-bottom: 0;
    vertical-align: middle;
  }
  .form-inline .radio label,
  .form-inline .checkbox label {
    padding-left: 0;
  }
  .form-inline .radio input[type="radio"],
  .form-inline .checkbox input[type="checkbox"] {
    position: relative;
    margin-left: 0;
  }
  .form-inline .has-feedback .form-control-feedback {
    top: 0;
  }
}
.form-horizontal .radio,
.form-horizontal .checkbox,
.form-horizontal .radio-inline,
.form-horizontal .checkbox-inline {
  margin-top: 0;
  margin-bottom: 0;
  padding-top: 7px;
}
.form-horizontal .radio,
.form-horizontal .checkbox {
  min-height: 25px;
}
.form-horizontal .form-group {
  margin-left: 0px;
  margin-right: 0px;
}
@media (min-width: 768px) {
  .form-horizontal .control-label {
    text-align: right;
    margin-bottom: 0;
    padding-top: 7px;
  }
}
.form-horizontal .has-feedback .form-control-feedback {
  right: 0px;
}
@media (min-width: 768px) {
  .form-horizontal .form-group-lg .control-label {
    padding-top: 11px;
    font-size: 17px;
  }
}
@media (min-width: 768px) {
  .form-horizontal .form-group-sm .control-label {
    padding-top: 6px;
    font-size: 12px;
  }
}
.btn {
  display: inline-block;
  margin-bottom: 0;
  font-weight: normal;
  text-align: center;
  vertical-align: middle;
  touch-action: manipulation;
  cursor: pointer;
  background-image: none;
  border: 1px solid transparent;
  white-space: nowrap;
  padding: 6px 12px;
  font-size: 13px;
  line-height: 1.42857143;
  border-radius: 2px;
  -webkit-user-select: none;
  -moz-user-select: none;
  -ms-user-select: none;
  user-select: none;
}
.btn:focus,
.btn:active:focus,
.btn.active:focus,
.btn.focus,
.btn:active.focus,
.btn.active.focus {
  outline: 5px auto -webkit-focus-ring-color;
  outline-offset: -2px;
}
.btn:hover,
.btn:focus,
.btn.focus {
  color: #333;
  text-decoration: none;
}
.btn:active,
.btn.active {
  outline: 0;
  background-image: none;
  -webkit-box-shadow: inset 0 3px 5px rgba(0, 0, 0, 0.125);
  box-shadow: inset 0 3px 5px rgba(0, 0, 0, 0.125);
}
.btn.disabled,
.btn[disabled],
fieldset[disabled] .btn {
  cursor: not-allowed;
  opacity: 0.65;
  filter: alpha(opacity=65);
  -webkit-box-shadow: none;
  box-shadow: none;
}
a.btn.disabled,
fieldset[disabled] a.btn {
  pointer-events: none;
}
.btn-default {
  color: #333;
  background-color: #fff;
  border-color: #ccc;
}
.btn-default:focus,
.btn-default.focus {
  color: #333;
  background-color: #e6e6e6;
  border-color: #8c8c8c;
}
.btn-default:hover {
  color: #333;
  background-color: #e6e6e6;
  border-color: #adadad;
}
.btn-default:active,
.btn-default.active,
.open > .dropdown-toggle.btn-default {
  color: #333;
  background-color: #e6e6e6;
  border-color: #adadad;
}
.btn-default:active:hover,
.btn-default.active:hover,
.open > .dropdown-toggle.btn-default:hover,
.btn-default:active:focus,
.btn-default.active:focus,
.open > .dropdown-toggle.btn-default:focus,
.btn-default:active.focus,
.btn-default.active.focus,
.open > .dropdown-toggle.btn-default.focus {
  color: #333;
  background-color: #d4d4d4;
  border-color: #8c8c8c;
}
.btn-default:active,
.btn-default.active,
.open > .dropdown-toggle.btn-default {
  background-image: none;
}
.btn-default.disabled:hover,
.btn-default[disabled]:hover,
fieldset[disabled] .btn-default:hover,
.btn-default.disabled:focus,
.btn-default[disabled]:focus,
fieldset[disabled] .btn-default:focus,
.btn-default.disabled.focus,
.btn-default[disabled].focus,
fieldset[disabled] .btn-default.focus {
  background-color: #fff;
  border-color: #ccc;
}
.btn-default .badge {
  color: #fff;
  background-color: #333;
}
.btn-primary {
  color: #fff;
  background-color: #337ab7;
  border-color: #2e6da4;
}
.btn-primary:focus,
.btn-primary.focus {
  color: #fff;
  background-color: #286090;
  border-color: #122b40;
}
.btn-primary:hover {
  color: #fff;
  background-color: #286090;
  border-color: #204d74;
}
.btn-primary:active,
.btn-primary.active,
.open > .dropdown-toggle.btn-primary {
  color: #fff;
  background-color: #286090;
  border-color: #204d74;
}
.btn-primary:active:hover,
.btn-primary.active:hover,
.open > .dropdown-toggle.btn-primary:hover,
.btn-primary:active:focus,
.btn-primary.active:focus,
.open > .dropdown-toggle.btn-primary:focus,
.btn-primary:active.focus,
.btn-primary.active.focus,
.open > .dropdown-toggle.btn-primary.focus {
  color: #fff;
  background-color: #204d74;
  border-color: #122b40;
}
.btn-primary:active,
.btn-primary.active,
.open > .dropdown-toggle.btn-primary {
  background-image: none;
}
.btn-primary.disabled:hover,
.btn-primary[disabled]:hover,
fieldset[disabled] .btn-primary:hover,
.btn-primary.disabled:focus,
.btn-primary[disabled]:focus,
fieldset[disabled] .btn-primary:focus,
.btn-primary.disabled.focus,
.btn-primary[disabled].focus,
fieldset[disabled] .btn-primary.focus {
  background-color: #337ab7;
  border-color: #2e6da4;
}
.btn-primary .badge {
  color: #337ab7;
  background-color: #fff;
}
.btn-success {
  color: #fff;
  background-color: #5cb85c;
  border-color: #4cae4c;
}
.btn-success:focus,
.btn-success.focus {
  color: #fff;
  background-color: #449d44;
  border-color: #255625;
}
.btn-success:hover {
  color: #fff;
  background-color: #449d44;
  border-color: #398439;
}
.btn-success:active,
.btn-success.active,
.open > .dropdown-toggle.btn-success {
  color: #fff;
  background-color: #449d44;
  border-color: #398439;
}
.btn-success:active:hover,
.btn-success.active:hover,
.open > .dropdown-toggle.btn-success:hover,
.btn-success:active:focus,
.btn-success.active:focus,
.open > .dropdown-toggle.btn-success:focus,
.btn-success:active.focus,
.btn-success.active.focus,
.open > .dropdown-toggle.btn-success.focus {
  color: #fff;
  background-color: #398439;
  border-color: #255625;
}
.btn-success:active,
.btn-success.active,
.open > .dropdown-toggle.btn-success {
  background-image: none;
}
.btn-success.disabled:hover,
.btn-success[disabled]:hover,
fieldset[disabled] .btn-success:hover,
.btn-success.disabled:focus,
.btn-success[disabled]:focus,
fieldset[disabled] .btn-success:focus,
.btn-success.disabled.focus,
.btn-success[disabled].focus,
fieldset[disabled] .btn-success.focus {
  background-color: #5cb85c;
  border-color: #4cae4c;
}
.btn-success .badge {
  color: #5cb85c;
  background-color: #fff;
}
.btn-info {
  color: #fff;
  background-color: #5bc0de;
  border-color: #46b8da;
}
.btn-info:focus,
.btn-info.focus {
  color: #fff;
  background-color: #31b0d5;
  border-color: #1b6d85;
}
.btn-info:hover {
  color: #fff;
  background-color: #31b0d5;
  border-color: #269abc;
}
.btn-info:active,
.btn-info.active,
.open > .dropdown-toggle.btn-info {
  color: #fff;
  background-color: #31b0d5;
  border-color: #269abc;
}
.btn-info:active:hover,
.btn-info.active:hover,
.open > .dropdown-toggle.btn-info:hover,
.btn-info:active:focus,
.btn-info.active:focus,
.open > .dropdown-toggle.btn-info:focus,
.btn-info:active.focus,
.btn-info.active.focus,
.open > .dropdown-toggle.btn-info.focus {
  color: #fff;
  background-color: #269abc;
  border-color: #1b6d85;
}
.btn-info:active,
.btn-info.active,
.open > .dropdown-toggle.btn-info {
  background-image: none;
}
.btn-info.disabled:hover,
.btn-info[disabled]:hover,
fieldset[disabled] .btn-info:hover,
.btn-info.disabled:focus,
.btn-info[disabled]:focus,
fieldset[disabled] .btn-info:focus,
.btn-info.disabled.focus,
.btn-info[disabled].focus,
fieldset[disabled] .btn-info.focus {
  background-color: #5bc0de;
  border-color: #46b8da;
}
.btn-info .badge {
  color: #5bc0de;
  background-color: #fff;
}
.btn-warning {
  color: #fff;
  background-color: #f0ad4e;
  border-color: #eea236;
}
.btn-warning:focus,
.btn-warning.focus {
  color: #fff;
  background-color: #ec971f;
  border-color: #985f0d;
}
.btn-warning:hover {
  color: #fff;
  background-color: #ec971f;
  border-color: #d58512;
}
.btn-warning:active,
.btn-warning.active,
.open > .dropdown-toggle.btn-warning {
  color: #fff;
  background-color: #ec971f;
  border-color: #d58512;
}
.btn-warning:active:hover,
.btn-warning.active:hover,
.open > .dropdown-toggle.btn-warning:hover,
.btn-warning:active:focus,
.btn-warning.active:focus,
.open > .dropdown-toggle.btn-warning:focus,
.btn-warning:active.focus,
.btn-warning.active.focus,
.open > .dropdown-toggle.btn-warning.focus {
  color: #fff;
  background-color: #d58512;
  border-color: #985f0d;
}
.btn-warning:active,
.btn-warning.active,
.open > .dropdown-toggle.btn-warning {
  background-image: none;
}
.btn-warning.disabled:hover,
.btn-warning[disabled]:hover,
fieldset[disabled] .btn-warning:hover,
.btn-warning.disabled:focus,
.btn-warning[disabled]:focus,
fieldset[disabled] .btn-warning:focus,
.btn-warning.disabled.focus,
.btn-warning[disabled].focus,
fieldset[disabled] .btn-warning.focus {
  background-color: #f0ad4e;
  border-color: #eea236;
}
.btn-warning .badge {
  color: #f0ad4e;
  background-color: #fff;
}
.btn-danger {
  color: #fff;
  background-color: #d9534f;
  border-color: #d43f3a;
}
.btn-danger:focus,
.btn-danger.focus {
  color: #fff;
  background-color: #c9302c;
  border-color: #761c19;
}
.btn-danger:hover {
  color: #fff;
  background-color: #c9302c;
  border-color: #ac2925;
}
.btn-danger:active,
.btn-danger.active,
.open > .dropdown-toggle.btn-danger {
  color: #fff;
  background-color: #c9302c;
  border-color: #ac2925;
}
.btn-danger:active:hover,
.btn-danger.active:hover,
.open > .dropdown-toggle.btn-danger:hover,
.btn-danger:active:focus,
.btn-danger.active:focus,
.open > .dropdown-toggle.btn-danger:focus,
.btn-danger:active.focus,
.btn-danger.active.focus,
.open > .dropdown-toggle.btn-danger.focus {
  color: #fff;
  background-color: #ac2925;
  border-color: #761c19;
}
.btn-danger:active,
.btn-danger.active,
.open > .dropdown-toggle.btn-danger {
  background-image: none;
}
.btn-danger.disabled:hover,
.btn-danger[disabled]:hover,
fieldset[disabled] .btn-danger:hover,
.btn-danger.disabled:focus,
.btn-danger[disabled]:focus,
fieldset[disabled] .btn-danger:focus,
.btn-danger.disabled.focus,
.btn-danger[disabled].focus,
fieldset[disabled] .btn-danger.focus {
  background-color: #d9534f;
  border-color: #d43f3a;
}
.btn-danger .badge {
  color: #d9534f;
  background-color: #fff;
}
.btn-link {
  color: #337ab7;
  font-weight: normal;
  border-radius: 0;
}
.btn-link,
.btn-link:active,
.btn-link.active,
.btn-link[disabled],
fieldset[disabled] .btn-link {
  background-color: transparent;
  -webkit-box-shadow: none;
  box-shadow: none;
}
.btn-link,
.btn-link:hover,
.btn-link:focus,
.btn-link:active {
  border-color: transparent;
}
.btn-link:hover,
.btn-link:focus {
  color: #23527c;
  text-decoration: underline;
  background-color: transparent;
}
.btn-link[disabled]:hover,
fieldset[disabled] .btn-link:hover,
.btn-link[disabled]:focus,
fieldset[disabled] .btn-link:focus {
  color: #777777;
  text-decoration: none;
}
.btn-lg,
.btn-group-lg > .btn {
  padding: 10px 16px;
  font-size: 17px;
  line-height: 1.3333333;
  border-radius: 3px;
}
.btn-sm,
.btn-group-sm > .btn {
  padding: 5px 10px;
  font-size: 12px;
  line-height: 1.5;
  border-radius: 1px;
}
.btn-xs,
.btn-group-xs > .btn {
  padding: 1px 5px;
  font-size: 12px;
  line-height: 1.5;
  border-radius: 1px;
}
.btn-block {
  display: block;
  width: 100%;
}
.btn-block + .btn-block {
  margin-top: 5px;
}
input[type="submit"].btn-block,
input[type="reset"].btn-block,
input[type="button"].btn-block {
  width: 100%;
}
.fade {
  opacity: 0;
  -webkit-transition: opacity 0.15s linear;
  -o-transition: opacity 0.15s linear;
  transition: opacity 0.15s linear;
}
.fade.in {
  opacity: 1;
}
.collapse {
  display: none;
}
.collapse.in {
  display: block;
}
tr.collapse.in {
  display: table-row;
}
tbody.collapse.in {
  display: table-row-group;
}
.collapsing {
  position: relative;
  height: 0;
  overflow: hidden;
  -webkit-transition-property: height, visibility;
  transition-property: height, visibility;
  -webkit-transition-duration: 0.35s;
  transition-duration: 0.35s;
  -webkit-transition-timing-function: ease;
  transition-timing-function: ease;
}
.caret {
  display: inline-block;
  width: 0;
  height: 0;
  margin-left: 2px;
  vertical-align: middle;
  border-top: 4px dashed;
  border-top: 4px solid \9;
  border-right: 4px solid transparent;
  border-left: 4px solid transparent;
}
.dropup,
.dropdown {
  position: relative;
}
.dropdown-toggle:focus {
  outline: 0;
}
.dropdown-menu {
  position: absolute;
  top: 100%;
  left: 0;
  z-index: 1000;
  display: none;
  float: left;
  min-width: 160px;
  padding: 5px 0;
  margin: 2px 0 0;
  list-style: none;
  font-size: 13px;
  text-align: left;
  background-color: #fff;
  border: 1px solid #ccc;
  border: 1px solid rgba(0, 0, 0, 0.15);
  border-radius: 2px;
  -webkit-box-shadow: 0 6px 12px rgba(0, 0, 0, 0.175);
  box-shadow: 0 6px 12px rgba(0, 0, 0, 0.175);
  background-clip: padding-box;
}
.dropdown-menu.pull-right {
  right: 0;
  left: auto;
}
.dropdown-menu .divider {
  height: 1px;
  margin: 8px 0;
  overflow: hidden;
  background-color: #e5e5e5;
}
.dropdown-menu > li > a {
  display: block;
  padding: 3px 20px;
  clear: both;
  font-weight: normal;
  line-height: 1.42857143;
  color: #333333;
  white-space: nowrap;
}
.dropdown-menu > li > a:hover,
.dropdown-menu > li > a:focus {
  text-decoration: none;
  color: #262626;
  background-color: #f5f5f5;
}
.dropdown-menu > .active > a,
.dropdown-menu > .active > a:hover,
.dropdown-menu > .active > a:focus {
  color: #fff;
  text-decoration: none;
  outline: 0;
  background-color: #337ab7;
}
.dropdown-menu > .disabled > a,
.dropdown-menu > .disabled > a:hover,
.dropdown-menu > .disabled > a:focus {
  color: #777777;
}
.dropdown-menu > .disabled > a:hover,
.dropdown-menu > .disabled > a:focus {
  text-decoration: none;
  background-color: transparent;
  background-image: none;
  filter: progid:DXImageTransform.Microsoft.gradient(enabled = false);
  cursor: not-allowed;
}
.open > .dropdown-menu {
  display: block;
}
.open > a {
  outline: 0;
}
.dropdown-menu-right {
  left: auto;
  right: 0;
}
.dropdown-menu-left {
  left: 0;
  right: auto;
}
.dropdown-header {
  display: block;
  padding: 3px 20px;
  font-size: 12px;
  line-height: 1.42857143;
  color: #777777;
  white-space: nowrap;
}
.dropdown-backdrop {
  position: fixed;
  left: 0;
  right: 0;
  bottom: 0;
  top: 0;
  z-index: 990;
}
.pull-right > .dropdown-menu {
  right: 0;
  left: auto;
}
.dropup .caret,
.navbar-fixed-bottom .dropdown .caret {
  border-top: 0;
  border-bottom: 4px dashed;
  border-bottom: 4px solid \9;
  content: "";
}
.dropup .dropdown-menu,
.navbar-fixed-bottom .dropdown .dropdown-menu {
  top: auto;
  bottom: 100%;
  margin-bottom: 2px;
}
@media (min-width: 541px) {
  .navbar-right .dropdown-menu {
    left: auto;
    right: 0;
  }
  .navbar-right .dropdown-menu-left {
    left: 0;
    right: auto;
  }
}
.btn-group,
.btn-group-vertical {
  position: relative;
  display: inline-block;
  vertical-align: middle;
}
.btn-group > .btn,
.btn-group-vertical > .btn {
  position: relative;
  float: left;
}
.btn-group > .btn:hover,
.btn-group-vertical > .btn:hover,
.btn-group > .btn:focus,
.btn-group-vertical > .btn:focus,
.btn-group > .btn:active,
.btn-group-vertical > .btn:active,
.btn-group > .btn.active,
.btn-group-vertical > .btn.active {
  z-index: 2;
}
.btn-group .btn + .btn,
.btn-group .btn + .btn-group,
.btn-group .btn-group + .btn,
.btn-group .btn-group + .btn-group {
  margin-left: -1px;
}
.btn-toolbar {
  margin-left: -5px;
}
.btn-toolbar .btn,
.btn-toolbar .btn-group,
.btn-toolbar .input-group {
  float: left;
}
.btn-toolbar > .btn,
.btn-toolbar > .btn-group,
.btn-toolbar > .input-group {
  margin-left: 5px;
}
.btn-group > .btn:not(:first-child):not(:last-child):not(.dropdown-toggle) {
  border-radius: 0;
}
.btn-group > .btn:first-child {
  margin-left: 0;
}
.btn-group > .btn:first-child:not(:last-child):not(.dropdown-toggle) {
  border-bottom-right-radius: 0;
  border-top-right-radius: 0;
}
.btn-group > .btn:last-child:not(:first-child),
.btn-group > .dropdown-toggle:not(:first-child) {
  border-bottom-left-radius: 0;
  border-top-left-radius: 0;
}
.btn-group > .btn-group {
  float: left;
}
.btn-group > .btn-group:not(:first-child):not(:last-child) > .btn {
  border-radius: 0;
}
.btn-group > .btn-group:first-child:not(:last-child) > .btn:last-child,
.btn-group > .btn-group:first-child:not(:last-child) > .dropdown-toggle {
  border-bottom-right-radius: 0;
  border-top-right-radius: 0;
}
.btn-group > .btn-group:last-child:not(:first-child) > .btn:first-child {
  border-bottom-left-radius: 0;
  border-top-left-radius: 0;
}
.btn-group .dropdown-toggle:active,
.btn-group.open .dropdown-toggle {
  outline: 0;
}
.btn-group > .btn + .dropdown-toggle {
  padding-left: 8px;
  padding-right: 8px;
}
.btn-group > .btn-lg + .dropdown-toggle {
  padding-left: 12px;
  padding-right: 12px;
}
.btn-group.open .dropdown-toggle {
  -webkit-box-shadow: inset 0 3px 5px rgba(0, 0, 0, 0.125);
  box-shadow: inset 0 3px 5px rgba(0, 0, 0, 0.125);
}
.btn-group.open .dropdown-toggle.btn-link {
  -webkit-box-shadow: none;
  box-shadow: none;
}
.btn .caret {
  margin-left: 0;
}
.btn-lg .caret {
  border-width: 5px 5px 0;
  border-bottom-width: 0;
}
.dropup .btn-lg .caret {
  border-width: 0 5px 5px;
}
.btn-group-vertical > .btn,
.btn-group-vertical > .btn-group,
.btn-group-vertical > .btn-group > .btn {
  display: block;
  float: none;
  width: 100%;
  max-width: 100%;
}
.btn-group-vertical > .btn-group > .btn {
  float: none;
}
.btn-group-vertical > .btn + .btn,
.btn-group-vertical > .btn + .btn-group,
.btn-group-vertical > .btn-group + .btn,
.btn-group-vertical > .btn-group + .btn-group {
  margin-top: -1px;
  margin-left: 0;
}
.btn-group-vertical > .btn:not(:first-child):not(:last-child) {
  border-radius: 0;
}
.btn-group-vertical > .btn:first-child:not(:last-child) {
  border-top-right-radius: 2px;
  border-top-left-radius: 2px;
  border-bottom-right-radius: 0;
  border-bottom-left-radius: 0;
}
.btn-group-vertical > .btn:last-child:not(:first-child) {
  border-top-right-radius: 0;
  border-top-left-radius: 0;
  border-bottom-right-radius: 2px;
  border-bottom-left-radius: 2px;
}
.btn-group-vertical > .btn-group:not(:first-child):not(:last-child) > .btn {
  border-radius: 0;
}
.btn-group-vertical > .btn-group:first-child:not(:last-child) > .btn:last-child,
.btn-group-vertical > .btn-group:first-child:not(:last-child) > .dropdown-toggle {
  border-bottom-right-radius: 0;
  border-bottom-left-radius: 0;
}
.btn-group-vertical > .btn-group:last-child:not(:first-child) > .btn:first-child {
  border-top-right-radius: 0;
  border-top-left-radius: 0;
}
.btn-group-justified {
  display: table;
  width: 100%;
  table-layout: fixed;
  border-collapse: separate;
}
.btn-group-justified > .btn,
.btn-group-justified > .btn-group {
  float: none;
  display: table-cell;
  width: 1%;
}
.btn-group-justified > .btn-group .btn {
  width: 100%;
}
.btn-group-justified > .btn-group .dropdown-menu {
  left: auto;
}
[data-toggle="buttons"] > .btn input[type="radio"],
[data-toggle="buttons"] > .btn-group > .btn input[type="radio"],
[data-toggle="buttons"] > .btn input[type="checkbox"],
[data-toggle="buttons"] > .btn-group > .btn input[type="checkbox"] {
  position: absolute;
  clip: rect(0, 0, 0, 0);
  pointer-events: none;
}
.input-group {
  position: relative;
  display: table;
  border-collapse: separate;
}
.input-group[class*="col-"] {
  float: none;
  padding-left: 0;
  padding-right: 0;
}
.input-group .form-control {
  position: relative;
  z-index: 2;
  float: left;
  width: 100%;
  margin-bottom: 0;
}
.input-group .form-control:focus {
  z-index: 3;
}
.input-group-lg > .form-control,
.input-group-lg > .input-group-addon,
.input-group-lg > .input-group-btn > .btn {
  height: 45px;
  padding: 10px 16px;
  font-size: 17px;
  line-height: 1.3333333;
  border-radius: 3px;
}
select.input-group-lg > .form-control,
select.input-group-lg > .input-group-addon,
select.input-group-lg > .input-group-btn > .btn {
  height: 45px;
  line-height: 45px;
}
textarea.input-group-lg > .form-control,
textarea.input-group-lg > .input-group-addon,
textarea.input-group-lg > .input-group-btn > .btn,
select[multiple].input-group-lg > .form-control,
select[multiple].input-group-lg > .input-group-addon,
select[multiple].input-group-lg > .input-group-btn > .btn {
  height: auto;
}
.input-group-sm > .form-control,
.input-group-sm > .input-group-addon,
.input-group-sm > .input-group-btn > .btn {
  height: 30px;
  padding: 5px 10px;
  font-size: 12px;
  line-height: 1.5;
  border-radius: 1px;
}
select.input-group-sm > .form-control,
select.input-group-sm > .input-group-addon,
select.input-group-sm > .input-group-btn > .btn {
  height: 30px;
  line-height: 30px;
}
textarea.input-group-sm > .form-control,
textarea.input-group-sm > .input-group-addon,
textarea.input-group-sm > .input-group-btn > .btn,
select[multiple].input-group-sm > .form-control,
select[multiple].input-group-sm > .input-group-addon,
select[multiple].input-group-sm > .input-group-btn > .btn {
  height: auto;
}
.input-group-addon,
.input-group-btn,
.input-group .form-control {
  display: table-cell;
}
.input-group-addon:not(:first-child):not(:last-child),
.input-group-btn:not(:first-child):not(:last-child),
.input-group .form-control:not(:first-child):not(:last-child) {
  border-radius: 0;
}
.input-group-addon,
.input-group-btn {
  width: 1%;
  white-space: nowrap;
  vertical-align: middle;
}
.input-group-addon {
  padding: 6px 12px;
  font-size: 13px;
  font-weight: normal;
  line-height: 1;
  color: #555555;
  text-align: center;
  background-color: #eeeeee;
  border: 1px solid #ccc;
  border-radius: 2px;
}
.input-group-addon.input-sm {
  padding: 5px 10px;
  font-size: 12px;
  border-radius: 1px;
}
.input-group-addon.input-lg {
  padding: 10px 16px;
  font-size: 17px;
  border-radius: 3px;
}
.input-group-addon input[type="radio"],
.input-group-addon input[type="checkbox"] {
  margin-top: 0;
}
.input-group .form-control:first-child,
.input-group-addon:first-child,
.input-group-btn:first-child > .btn,
.input-group-btn:first-child > .btn-group > .btn,
.input-group-btn:first-child > .dropdown-toggle,
.input-group-btn:last-child > .btn:not(:last-child):not(.dropdown-toggle),
.input-group-btn:last-child > .btn-group:not(:last-child) > .btn {
  border-bottom-right-radius: 0;
  border-top-right-radius: 0;
}
.input-group-addon:first-child {
  border-right: 0;
}
.input-group .form-control:last-child,
.input-group-addon:last-child,
.input-group-btn:last-child > .btn,
.input-group-btn:last-child > .btn-group > .btn,
.input-group-btn:last-child > .dropdown-toggle,
.input-group-btn:first-child > .btn:not(:first-child),
.input-group-btn:first-child > .btn-group:not(:first-child) > .btn {
  border-bottom-left-radius: 0;
  border-top-left-radius: 0;
}
.input-group-addon:last-child {
  border-left: 0;
}
.input-group-btn {
  position: relative;
  font-size: 0;
  white-space: nowrap;
}
.input-group-btn > .btn {
  position: relative;
}
.input-group-btn > .btn + .btn {
  margin-left: -1px;
}
.input-group-btn > .btn:hover,
.input-group-btn > .btn:focus,
.input-group-btn > .btn:active {
  z-index: 2;
}
.input-group-btn:first-child > .btn,
.input-group-btn:first-child > .btn-group {
  margin-right: -1px;
}
.input-group-btn:last-child > .btn,
.input-group-btn:last-child > .btn-group {
  z-index: 2;
  margin-left: -1px;
}
.nav {
  margin-bottom: 0;
  padding-left: 0;
  list-style: none;
}
.nav > li {
  position: relative;
  display: block;
}
.nav > li > a {
  position: relative;
  display: block;
  padding: 10px 15px;
}
.nav > li > a:hover,
.nav > li > a:focus {
  text-decoration: none;
  background-color: #eeeeee;
}
.nav > li.disabled > a {
  color: #777777;
}
.nav > li.disabled > a:hover,
.nav > li.disabled > a:focus {
  color: #777777;
  text-decoration: none;
  background-color: transparent;
  cursor: not-allowed;
}
.nav .open > a,
.nav .open > a:hover,
.nav .open > a:focus {
  background-color: #eeeeee;
  border-color: #337ab7;
}
.nav .nav-divider {
  height: 1px;
  margin: 8px 0;
  overflow: hidden;
  background-color: #e5e5e5;
}
.nav > li > a > img {
  max-width: none;
}
.nav-tabs {
  border-bottom: 1px solid #ddd;
}
.nav-tabs > li {
  float: left;
  margin-bottom: -1px;
}
.nav-tabs > li > a {
  margin-right: 2px;
  line-height: 1.42857143;
  border: 1px solid transparent;
  border-radius: 2px 2px 0 0;
}
.nav-tabs > li > a:hover {
  border-color: #eeeeee #eeeeee #ddd;
}
.nav-tabs > li.active > a,
.nav-tabs > li.active > a:hover,
.nav-tabs > li.active > a:focus {
  color: #555555;
  background-color: #fff;
  border: 1px solid #ddd;
  border-bottom-color: transparent;
  cursor: default;
}
.nav-tabs.nav-justified {
  width: 100%;
  border-bottom: 0;
}
.nav-tabs.nav-justified > li {
  float: none;
}
.nav-tabs.nav-justified > li > a {
  text-align: center;
  margin-bottom: 5px;
}
.nav-tabs.nav-justified > .dropdown .dropdown-menu {
  top: auto;
  left: auto;
}
@media (min-width: 768px) {
  .nav-tabs.nav-justified > li {
    display: table-cell;
    width: 1%;
  }
  .nav-tabs.nav-justified > li > a {
    margin-bottom: 0;
  }
}
.nav-tabs.nav-justified > li > a {
  margin-right: 0;
  border-radius: 2px;
}
.nav-tabs.nav-justified > .active > a,
.nav-tabs.nav-justified > .active > a:hover,
.nav-tabs.nav-justified > .active > a:focus {
  border: 1px solid #ddd;
}
@media (min-width: 768px) {
  .nav-tabs.nav-justified > li > a {
    border-bottom: 1px solid #ddd;
    border-radius: 2px 2px 0 0;
  }
  .nav-tabs.nav-justified > .active > a,
  .nav-tabs.nav-justified > .active > a:hover,
  .nav-tabs.nav-justified > .active > a:focus {
    border-bottom-color: #fff;
  }
}
.nav-pills > li {
  float: left;
}
.nav-pills > li > a {
  border-radius: 2px;
}
.nav-pills > li + li {
  margin-left: 2px;
}
.nav-pills > li.active > a,
.nav-pills > li.active > a:hover,
.nav-pills > li.active > a:focus {
  color: #fff;
  background-color: #337ab7;
}
.nav-stacked > li {
  float: none;
}
.nav-stacked > li + li {
  margin-top: 2px;
  margin-left: 0;
}
.nav-justified {
  width: 100%;
}
.nav-justified > li {
  float: none;
}
.nav-justified > li > a {
  text-align: center;
  margin-bottom: 5px;
}
.nav-justified > .dropdown .dropdown-menu {
  top: auto;
  left: auto;
}
@media (min-width: 768px) {
  .nav-justified > li {
    display: table-cell;
    width: 1%;
  }
  .nav-justified > li > a {
    margin-bottom: 0;
  }
}
.nav-tabs-justified {
  border-bottom: 0;
}
.nav-tabs-justified > li > a {
  margin-right: 0;
  border-radius: 2px;
}
.nav-tabs-justified > .active > a,
.nav-tabs-justified > .active > a:hover,
.nav-tabs-justified > .active > a:focus {
  border: 1px solid #ddd;
}
@media (min-width: 768px) {
  .nav-tabs-justified > li > a {
    border-bottom: 1px solid #ddd;
    border-radius: 2px 2px 0 0;
  }
  .nav-tabs-justified > .active > a,
  .nav-tabs-justified > .active > a:hover,
  .nav-tabs-justified > .active > a:focus {
    border-bottom-color: #fff;
  }
}
.tab-content > .tab-pane {
  display: none;
}
.tab-content > .active {
  display: block;
}
.nav-tabs .dropdown-menu {
  margin-top: -1px;
  border-top-right-radius: 0;
  border-top-left-radius: 0;
}
.navbar {
  position: relative;
  min-height: 30px;
  margin-bottom: 18px;
  border: 1px solid transparent;
}
@media (min-width: 541px) {
  .navbar {
    border-radius: 2px;
  }
}
@media (min-width: 541px) {
  .navbar-header {
    float: left;
  }
}
.navbar-collapse {
  overflow-x: visible;
  padding-right: 0px;
  padding-left: 0px;
  border-top: 1px solid transparent;
  box-shadow: inset 0 1px 0 rgba(255, 255, 255, 0.1);
  -webkit-overflow-scrolling: touch;
}
.navbar-collapse.in {
  overflow-y: auto;
}
@media (min-width: 541px) {
  .navbar-collapse {
    width: auto;
    border-top: 0;
    box-shadow: none;
  }
  .navbar-collapse.collapse {
    display: block !important;
    height: auto !important;
    padding-bottom: 0;
    overflow: visible !important;
  }
  .navbar-collapse.in {
    overflow-y: visible;
  }
  .navbar-fixed-top .navbar-collapse,
  .navbar-static-top .navbar-collapse,
  .navbar-fixed-bottom .navbar-collapse {
    padding-left: 0;
    padding-right: 0;
  }
}
.navbar-fixed-top .navbar-collapse,
.navbar-fixed-bottom .navbar-collapse {
  max-height: 340px;
}
@media (max-device-width: 540px) and (orientation: landscape) {
  .navbar-fixed-top .navbar-collapse,
  .navbar-fixed-bottom .navbar-collapse {
    max-height: 200px;
  }
}
.container > .navbar-header,
.container-fluid > .navbar-header,
.container > .navbar-collapse,
.container-fluid > .navbar-collapse {
  margin-right: 0px;
  margin-left: 0px;
}
@media (min-width: 541px) {
  .container > .navbar-header,
  .container-fluid > .navbar-header,
  .container > .navbar-collapse,
  .container-fluid > .navbar-collapse {
    margin-right: 0;
    margin-left: 0;
  }
}
.navbar-static-top {
  z-index: 1000;
  border-width: 0 0 1px;
}
@media (min-width: 541px) {
  .navbar-static-top {
    border-radius: 0;
  }
}
.navbar-fixed-top,
.navbar-fixed-bottom {
  position: fixed;
  right: 0;
  left: 0;
  z-index: 1030;
}
@media (min-width: 541px) {
  .navbar-fixed-top,
  .navbar-fixed-bottom {
    border-radius: 0;
  }
}
.navbar-fixed-top {
  top: 0;
  border-width: 0 0 1px;
}
.navbar-fixed-bottom {
  bottom: 0;
  margin-bottom: 0;
  border-width: 1px 0 0;
}
.navbar-brand {
  float: left;
  padding: 6px 0px;
  font-size: 17px;
  line-height: 18px;
  height: 30px;
}
.navbar-brand:hover,
.navbar-brand:focus {
  text-decoration: none;
}
.navbar-brand > img {
  display: block;
}
@media (min-width: 541px) {
  .navbar > .container .navbar-brand,
  .navbar > .container-fluid .navbar-brand {
    margin-left: 0px;
  }
}
.navbar-toggle {
  position: relative;
  float: right;
  margin-right: 0px;
  padding: 9px 10px;
  margin-top: -2px;
  margin-bottom: -2px;
  background-color: transparent;
  background-image: none;
  border: 1px solid transparent;
  border-radius: 2px;
}
.navbar-toggle:focus {
  outline: 0;
}
.navbar-toggle .icon-bar {
  display: block;
  width: 22px;
  height: 2px;
  border-radius: 1px;
}
.navbar-toggle .icon-bar + .icon-bar {
  margin-top: 4px;
}
@media (min-width: 541px) {
  .navbar-toggle {
    display: none;
  }
}
.navbar-nav {
  margin: 3px 0px;
}
.navbar-nav > li > a {
  padding-top: 10px;
  padding-bottom: 10px;
  line-height: 18px;
}
@media (max-width: 540px) {
  .navbar-nav .open .dropdown-menu {
    position: static;
    float: none;
    width: auto;
    margin-top: 0;
    background-color: transparent;
    border: 0;
    box-shadow: none;
  }
  .navbar-nav .open .dropdown-menu > li > a,
  .navbar-nav .open .dropdown-menu .dropdown-header {
    padding: 5px 15px 5px 25px;
  }
  .navbar-nav .open .dropdown-menu > li > a {
    line-height: 18px;
  }
  .navbar-nav .open .dropdown-menu > li > a:hover,
  .navbar-nav .open .dropdown-menu > li > a:focus {
    background-image: none;
  }
}
@media (min-width: 541px) {
  .navbar-nav {
    float: left;
    margin: 0;
  }
  .navbar-nav > li {
    float: left;
  }
  .navbar-nav > li > a {
    padding-top: 6px;
    padding-bottom: 6px;
  }
}
.navbar-form {
  margin-left: 0px;
  margin-right: 0px;
  padding: 10px 0px;
  border-top: 1px solid transparent;
  border-bottom: 1px solid transparent;
  -webkit-box-shadow: inset 0 1px 0 rgba(255, 255, 255, 0.1), 0 1px 0 rgba(255, 255, 255, 0.1);
  box-shadow: inset 0 1px 0 rgba(255, 255, 255, 0.1), 0 1px 0 rgba(255, 255, 255, 0.1);
  margin-top: -1px;
  margin-bottom: -1px;
}
@media (min-width: 768px) {
  .navbar-form .form-group {
    display: inline-block;
    margin-bottom: 0;
    vertical-align: middle;
  }
  .navbar-form .form-control {
    display: inline-block;
    width: auto;
    vertical-align: middle;
  }
  .navbar-form .form-control-static {
    display: inline-block;
  }
  .navbar-form .input-group {
    display: inline-table;
    vertical-align: middle;
  }
  .navbar-form .input-group .input-group-addon,
  .navbar-form .input-group .input-group-btn,
  .navbar-form .input-group .form-control {
    width: auto;
  }
  .navbar-form .input-group > .form-control {
    width: 100%;
  }
  .navbar-form .control-label {
    margin-bottom: 0;
    vertical-align: middle;
  }
  .navbar-form .radio,
  .navbar-form .checkbox {
    display: inline-block;
    margin-top: 0;
    margin-bottom: 0;
    vertical-align: middle;
  }
  .navbar-form .radio label,
  .navbar-form .checkbox label {
    padding-left: 0;
  }
  .navbar-form .radio input[type="radio"],
  .navbar-form .checkbox input[type="checkbox"] {
    position: relative;
    margin-left: 0;
  }
  .navbar-form .has-feedback .form-control-feedback {
    top: 0;
  }
}
@media (max-width: 540px) {
  .navbar-form .form-group {
    margin-bottom: 5px;
  }
  .navbar-form .form-group:last-child {
    margin-bottom: 0;
  }
}
@media (min-width: 541px) {
  .navbar-form {
    width: auto;
    border: 0;
    margin-left: 0;
    margin-right: 0;
    padding-top: 0;
    padding-bottom: 0;
    -webkit-box-shadow: none;
    box-shadow: none;
  }
}
.navbar-nav > li > .dropdown-menu {
  margin-top: 0;
  border-top-right-radius: 0;
  border-top-left-radius: 0;
}
.navbar-fixed-bottom .navbar-nav > li > .dropdown-menu {
  margin-bottom: 0;
  border-top-right-radius: 2px;
  border-top-left-radius: 2px;
  border-bottom-right-radius: 0;
  border-bottom-left-radius: 0;
}
.navbar-btn {
  margin-top: -1px;
  margin-bottom: -1px;
}
.navbar-btn.btn-sm {
  margin-top: 0px;
  margin-bottom: 0px;
}
.navbar-btn.btn-xs {
  margin-top: 4px;
  margin-bottom: 4px;
}
.navbar-text {
  margin-top: 6px;
  margin-bottom: 6px;
}
@media (min-width: 541px) {
  .navbar-text {
    float: left;
    margin-left: 0px;
    margin-right: 0px;
  }
}
@media (min-width: 541px) {
  .navbar-left {
    float: left !important;
    float: left;
  }
  .navbar-right {
    float: right !important;
    float: right;
    margin-right: 0px;
  }
  .navbar-right ~ .navbar-right {
    margin-right: 0;
  }
}
.navbar-default {
  background-color: #f8f8f8;
  border-color: #e7e7e7;
}
.navbar-default .navbar-brand {
  color: #777;
}
.navbar-default .navbar-brand:hover,
.navbar-default .navbar-brand:focus {
  color: #5e5e5e;
  background-color: transparent;
}
.navbar-default .navbar-text {
  color: #777;
}
.navbar-default .navbar-nav > li > a {
  color: #777;
}
.navbar-default .navbar-nav > li > a:hover,
.navbar-default .navbar-nav > li > a:focus {
  color: #333;
  background-color: transparent;
}
.navbar-default .navbar-nav > .active > a,
.navbar-default .navbar-nav > .active > a:hover,
.navbar-default .navbar-nav > .active > a:focus {
  color: #555;
  background-color: #e7e7e7;
}
.navbar-default .navbar-nav > .disabled > a,
.navbar-default .navbar-nav > .disabled > a:hover,
.navbar-default .navbar-nav > .disabled > a:focus {
  color: #ccc;
  background-color: transparent;
}
.navbar-default .navbar-toggle {
  border-color: #ddd;
}
.navbar-default .navbar-toggle:hover,
.navbar-default .navbar-toggle:focus {
  background-color: #ddd;
}
.navbar-default .navbar-toggle .icon-bar {
  background-color: #888;
}
.navbar-default .navbar-collapse,
.navbar-default .navbar-form {
  border-color: #e7e7e7;
}
.navbar-default .navbar-nav > .open > a,
.navbar-default .navbar-nav > .open > a:hover,
.navbar-default .navbar-nav > .open > a:focus {
  background-color: #e7e7e7;
  color: #555;
}
@media (max-width: 540px) {
  .navbar-default .navbar-nav .open .dropdown-menu > li > a {
    color: #777;
  }
  .navbar-default .navbar-nav .open .dropdown-menu > li > a:hover,
  .navbar-default .navbar-nav .open .dropdown-menu > li > a:focus {
    color: #333;
    background-color: transparent;
  }
  .navbar-default .navbar-nav .open .dropdown-menu > .active > a,
  .navbar-default .navbar-nav .open .dropdown-menu > .active > a:hover,
  .navbar-default .navbar-nav .open .dropdown-menu > .active > a:focus {
    color: #555;
    background-color: #e7e7e7;
  }
  .navbar-default .navbar-nav .open .dropdown-menu > .disabled > a,
  .navbar-default .navbar-nav .open .dropdown-menu > .disabled > a:hover,
  .navbar-default .navbar-nav .open .dropdown-menu > .disabled > a:focus {
    color: #ccc;
    background-color: transparent;
  }
}
.navbar-default .navbar-link {
  color: #777;
}
.navbar-default .navbar-link:hover {
  color: #333;
}
.navbar-default .btn-link {
  color: #777;
}
.navbar-default .btn-link:hover,
.navbar-default .btn-link:focus {
  color: #333;
}
.navbar-default .btn-link[disabled]:hover,
fieldset[disabled] .navbar-default .btn-link:hover,
.navbar-default .btn-link[disabled]:focus,
fieldset[disabled] .navbar-default .btn-link:focus {
  color: #ccc;
}
.navbar-inverse {
  background-color: #222;
  border-color: #080808;
}
.navbar-inverse .navbar-brand {
  color: #9d9d9d;
}
.navbar-inverse .navbar-brand:hover,
.navbar-inverse .navbar-brand:focus {
  color: #fff;
  background-color: transparent;
}
.navbar-inverse .navbar-text {
  color: #9d9d9d;
}
.navbar-inverse .navbar-nav > li > a {
  color: #9d9d9d;
}
.navbar-inverse .navbar-nav > li > a:hover,
.navbar-inverse .navbar-nav > li > a:focus {
  color: #fff;
  background-color: transparent;
}
.navbar-inverse .navbar-nav > .active > a,
.navbar-inverse .navbar-nav > .active > a:hover,
.navbar-inverse .navbar-nav > .active > a:focus {
  color: #fff;
  background-color: #080808;
}
.navbar-inverse .navbar-nav > .disabled > a,
.navbar-inverse .navbar-nav > .disabled > a:hover,
.navbar-inverse .navbar-nav > .disabled > a:focus {
  color: #444;
  background-color: transparent;
}
.navbar-inverse .navbar-toggle {
  border-color: #333;
}
.navbar-inverse .navbar-toggle:hover,
.navbar-inverse .navbar-toggle:focus {
  background-color: #333;
}
.navbar-inverse .navbar-toggle .icon-bar {
  background-color: #fff;
}
.navbar-inverse .navbar-collapse,
.navbar-inverse .navbar-form {
  border-color: #101010;
}
.navbar-inverse .navbar-nav > .open > a,
.navbar-inverse .navbar-nav > .open > a:hover,
.navbar-inverse .navbar-nav > .open > a:focus {
  background-color: #080808;
  color: #fff;
}
@media (max-width: 540px) {
  .navbar-inverse .navbar-nav .open .dropdown-menu > .dropdown-header {
    border-color: #080808;
  }
  .navbar-inverse .navbar-nav .open .dropdown-menu .divider {
    background-color: #080808;
  }
  .navbar-inverse .navbar-nav .open .dropdown-menu > li > a {
    color: #9d9d9d;
  }
  .navbar-inverse .navbar-nav .open .dropdown-menu > li > a:hover,
  .navbar-inverse .navbar-nav .open .dropdown-menu > li > a:focus {
    color: #fff;
    background-color: transparent;
  }
  .navbar-inverse .navbar-nav .open .dropdown-menu > .active > a,
  .navbar-inverse .navbar-nav .open .dropdown-menu > .active > a:hover,
  .navbar-inverse .navbar-nav .open .dropdown-menu > .active > a:focus {
    color: #fff;
    background-color: #080808;
  }
  .navbar-inverse .navbar-nav .open .dropdown-menu > .disabled > a,
  .navbar-inverse .navbar-nav .open .dropdown-menu > .disabled > a:hover,
  .navbar-inverse .navbar-nav .open .dropdown-menu > .disabled > a:focus {
    color: #444;
    background-color: transparent;
  }
}
.navbar-inverse .navbar-link {
  color: #9d9d9d;
}
.navbar-inverse .navbar-link:hover {
  color: #fff;
}
.navbar-inverse .btn-link {
  color: #9d9d9d;
}
.navbar-inverse .btn-link:hover,
.navbar-inverse .btn-link:focus {
  color: #fff;
}
.navbar-inverse .btn-link[disabled]:hover,
fieldset[disabled] .navbar-inverse .btn-link:hover,
.navbar-inverse .btn-link[disabled]:focus,
fieldset[disabled] .navbar-inverse .btn-link:focus {
  color: #444;
}
.breadcrumb {
  padding: 8px 15px;
  margin-bottom: 18px;
  list-style: none;
  background-color: #f5f5f5;
  border-radius: 2px;
}
.breadcrumb > li {
  display: inline-block;
}
.breadcrumb > li + li:before {
  content: "/\00a0";
  padding: 0 5px;
  color: #5e5e5e;
}
.breadcrumb > .active {
  color: #777777;
}
.pagination {
  display: inline-block;
  padding-left: 0;
  margin: 18px 0;
  border-radius: 2px;
}
.pagination > li {
  display: inline;
}
.pagination > li > a,
.pagination > li > span {
  position: relative;
  float: left;
  padding: 6px 12px;
  line-height: 1.42857143;
  text-decoration: none;
  color: #337ab7;
  background-color: #fff;
  border: 1px solid #ddd;
  margin-left: -1px;
}
.pagination > li:first-child > a,
.pagination > li:first-child > span {
  margin-left: 0;
  border-bottom-left-radius: 2px;
  border-top-left-radius: 2px;
}
.pagination > li:last-child > a,
.pagination > li:last-child > span {
  border-bottom-right-radius: 2px;
  border-top-right-radius: 2px;
}
.pagination > li > a:hover,
.pagination > li > span:hover,
.pagination > li > a:focus,
.pagination > li > span:focus {
  z-index: 2;
  color: #23527c;
  background-color: #eeeeee;
  border-color: #ddd;
}
.pagination > .active > a,
.pagination > .active > span,
.pagination > .active > a:hover,
.pagination > .active > span:hover,
.pagination > .active > a:focus,
.pagination > .active > span:focus {
  z-index: 3;
  color: #fff;
  background-color: #337ab7;
  border-color: #337ab7;
  cursor: default;
}
.pagination > .disabled > span,
.pagination > .disabled > span:hover,
.pagination > .disabled > span:focus,
.pagination > .disabled > a,
.pagination > .disabled > a:hover,
.pagination > .disabled > a:focus {
  color: #777777;
  background-color: #fff;
  border-color: #ddd;
  cursor: not-allowed;
}
.pagination-lg > li > a,
.pagination-lg > li > span {
  padding: 10px 16px;
  font-size: 17px;
  line-height: 1.3333333;
}
.pagination-lg > li:first-child > a,
.pagination-lg > li:first-child > span {
  border-bottom-left-radius: 3px;
  border-top-left-radius: 3px;
}
.pagination-lg > li:last-child > a,
.pagination-lg > li:last-child > span {
  border-bottom-right-radius: 3px;
  border-top-right-radius: 3px;
}
.pagination-sm > li > a,
.pagination-sm > li > span {
  padding: 5px 10px;
  font-size: 12px;
  line-height: 1.5;
}
.pagination-sm > li:first-child > a,
.pagination-sm > li:first-child > span {
  border-bottom-left-radius: 1px;
  border-top-left-radius: 1px;
}
.pagination-sm > li:last-child > a,
.pagination-sm > li:last-child > span {
  border-bottom-right-radius: 1px;
  border-top-right-radius: 1px;
}
.pager {
  padding-left: 0;
  margin: 18px 0;
  list-style: none;
  text-align: center;
}
.pager li {
  display: inline;
}
.pager li > a,
.pager li > span {
  display: inline-block;
  padding: 5px 14px;
  background-color: #fff;
  border: 1px solid #ddd;
  border-radius: 15px;
}
.pager li > a:hover,
.pager li > a:focus {
  text-decoration: none;
  background-color: #eeeeee;
}
.pager .next > a,
.pager .next > span {
  float: right;
}
.pager .previous > a,
.pager .previous > span {
  float: left;
}
.pager .disabled > a,
.pager .disabled > a:hover,
.pager .disabled > a:focus,
.pager .disabled > span {
  color: #777777;
  background-color: #fff;
  cursor: not-allowed;
}
.label {
  display: inline;
  padding: .2em .6em .3em;
  font-size: 75%;
  font-weight: bold;
  line-height: 1;
  color: #fff;
  text-align: center;
  white-space: nowrap;
  vertical-align: baseline;
  border-radius: .25em;
}
a.label:hover,
a.label:focus {
  color: #fff;
  text-decoration: none;
  cursor: pointer;
}
.label:empty {
  display: none;
}
.btn .label {
  position: relative;
  top: -1px;
}
.label-default {
  background-color: #777777;
}
.label-default[href]:hover,
.label-default[href]:focus {
  background-color: #5e5e5e;
}
.label-primary {
  background-color: #337ab7;
}
.label-primary[href]:hover,
.label-primary[href]:focus {
  background-color: #286090;
}
.label-success {
  background-color: #5cb85c;
}
.label-success[href]:hover,
.label-success[href]:focus {
  background-color: #449d44;
}
.label-info {
  background-color: #5bc0de;
}
.label-info[href]:hover,
.label-info[href]:focus {
  background-color: #31b0d5;
}
.label-warning {
  background-color: #f0ad4e;
}
.label-warning[href]:hover,
.label-warning[href]:focus {
  background-color: #ec971f;
}
.label-danger {
  background-color: #d9534f;
}
.label-danger[href]:hover,
.label-danger[href]:focus {
  background-color: #c9302c;
}
.badge {
  display: inline-block;
  min-width: 10px;
  padding: 3px 7px;
  font-size: 12px;
  font-weight: bold;
  color: #fff;
  line-height: 1;
  vertical-align: middle;
  white-space: nowrap;
  text-align: center;
  background-color: #777777;
  border-radius: 10px;
}
.badge:empty {
  display: none;
}
.btn .badge {
  position: relative;
  top: -1px;
}
.btn-xs .badge,
.btn-group-xs > .btn .badge {
  top: 0;
  padding: 1px 5px;
}
a.badge:hover,
a.badge:focus {
  color: #fff;
  text-decoration: none;
  cursor: pointer;
}
.list-group-item.active > .badge,
.nav-pills > .active > a > .badge {
  color: #337ab7;
  background-color: #fff;
}
.list-group-item > .badge {
  float: right;
}
.list-group-item > .badge + .badge {
  margin-right: 5px;
}
.nav-pills > li > a > .badge {
  margin-left: 3px;
}
.jumbotron {
  padding-top: 30px;
  padding-bottom: 30px;
  margin-bottom: 30px;
  color: inherit;
  background-color: #eeeeee;
}
.jumbotron h1,
.jumbotron .h1 {
  color: inherit;
}
.jumbotron p {
  margin-bottom: 15px;
  font-size: 20px;
  font-weight: 200;
}
.jumbotron > hr {
  border-top-color: #d5d5d5;
}
.container .jumbotron,
.container-fluid .jumbotron {
  border-radius: 3px;
  padding-left: 0px;
  padding-right: 0px;
}
.jumbotron .container {
  max-width: 100%;
}
@media screen and (min-width: 768px) {
  .jumbotron {
    padding-top: 48px;
    padding-bottom: 48px;
  }
  .container .jumbotron,
  .container-fluid .jumbotron {
    padding-left: 60px;
    padding-right: 60px;
  }
  .jumbotron h1,
  .jumbotron .h1 {
    font-size: 59px;
  }
}
.thumbnail {
  display: block;
  padding: 4px;
  margin-bottom: 18px;
  line-height: 1.42857143;
  background-color: #fff;
  border: 1px solid #ddd;
  border-radius: 2px;
  -webkit-transition: border 0.2s ease-in-out;
  -o-transition: border 0.2s ease-in-out;
  transition: border 0.2s ease-in-out;
}
.thumbnail > img,
.thumbnail a > img {
  margin-left: auto;
  margin-right: auto;
}
a.thumbnail:hover,
a.thumbnail:focus,
a.thumbnail.active {
  border-color: #337ab7;
}
.thumbnail .caption {
  padding: 9px;
  color: #000;
}
.alert {
  padding: 15px;
  margin-bottom: 18px;
  border: 1px solid transparent;
  border-radius: 2px;
}
.alert h4 {
  margin-top: 0;
  color: inherit;
}
.alert .alert-link {
  font-weight: bold;
}
.alert > p,
.alert > ul {
  margin-bottom: 0;
}
.alert > p + p {
  margin-top: 5px;
}
.alert-dismissable,
.alert-dismissible {
  padding-right: 35px;
}
.alert-dismissable .close,
.alert-dismissible .close {
  position: relative;
  top: -2px;
  right: -21px;
  color: inherit;
}
.alert-success {
  background-color: #dff0d8;
  border-color: #d6e9c6;
  color: #3c763d;
}
.alert-success hr {
  border-top-color: #c9e2b3;
}
.alert-success .alert-link {
  color: #2b542c;
}
.alert-info {
  background-color: #d9edf7;
  border-color: #bce8f1;
  color: #31708f;
}
.alert-info hr {
  border-top-color: #a6e1ec;
}
.alert-info .alert-link {
  color: #245269;
}
.alert-warning {
  background-color: #fcf8e3;
  border-color: #faebcc;
  color: #8a6d3b;
}
.alert-warning hr {
  border-top-color: #f7e1b5;
}
.alert-warning .alert-link {
  color: #66512c;
}
.alert-danger {
  background-color: #f2dede;
  border-color: #ebccd1;
  color: #a94442;
}
.alert-danger hr {
  border-top-color: #e4b9c0;
}
.alert-danger .alert-link {
  color: #843534;
}
@-webkit-keyframes progress-bar-stripes {
  from {
    background-position: 40px 0;
  }
  to {
    background-position: 0 0;
  }
}
@keyframes progress-bar-stripes {
  from {
    background-position: 40px 0;
  }
  to {
    background-position: 0 0;
  }
}
.progress {
  overflow: hidden;
  height: 18px;
  margin-bottom: 18px;
  background-color: #f5f5f5;
  border-radius: 2px;
  -webkit-box-shadow: inset 0 1px 2px rgba(0, 0, 0, 0.1);
  box-shadow: inset 0 1px 2px rgba(0, 0, 0, 0.1);
}
.progress-bar {
  float: left;
  width: 0%;
  height: 100%;
  font-size: 12px;
  line-height: 18px;
  color: #fff;
  text-align: center;
  background-color: #337ab7;
  -webkit-box-shadow: inset 0 -1px 0 rgba(0, 0, 0, 0.15);
  box-shadow: inset 0 -1px 0 rgba(0, 0, 0, 0.15);
  -webkit-transition: width 0.6s ease;
  -o-transition: width 0.6s ease;
  transition: width 0.6s ease;
}
.progress-striped .progress-bar,
.progress-bar-striped {
  background-image: -webkit-linear-gradient(45deg, rgba(255, 255, 255, 0.15) 25%, transparent 25%, transparent 50%, rgba(255, 255, 255, 0.15) 50%, rgba(255, 255, 255, 0.15) 75%, transparent 75%, transparent);
  background-image: -o-linear-gradient(45deg, rgba(255, 255, 255, 0.15) 25%, transparent 25%, transparent 50%, rgba(255, 255, 255, 0.15) 50%, rgba(255, 255, 255, 0.15) 75%, transparent 75%, transparent);
  background-image: linear-gradient(45deg, rgba(255, 255, 255, 0.15) 25%, transparent 25%, transparent 50%, rgba(255, 255, 255, 0.15) 50%, rgba(255, 255, 255, 0.15) 75%, transparent 75%, transparent);
  background-size: 40px 40px;
}
.progress.active .progress-bar,
.progress-bar.active {
  -webkit-animation: progress-bar-stripes 2s linear infinite;
  -o-animation: progress-bar-stripes 2s linear infinite;
  animation: progress-bar-stripes 2s linear infinite;
}
.progress-bar-success {
  background-color: #5cb85c;
}
.progress-striped .progress-bar-success {
  background-image: -webkit-linear-gradient(45deg, rgba(255, 255, 255, 0.15) 25%, transparent 25%, transparent 50%, rgba(255, 255, 255, 0.15) 50%, rgba(255, 255, 255, 0.15) 75%, transparent 75%, transparent);
  background-image: -o-linear-gradient(45deg, rgba(255, 255, 255, 0.15) 25%, transparent 25%, transparent 50%, rgba(255, 255, 255, 0.15) 50%, rgba(255, 255, 255, 0.15) 75%, transparent 75%, transparent);
  background-image: linear-gradient(45deg, rgba(255, 255, 255, 0.15) 25%, transparent 25%, transparent 50%, rgba(255, 255, 255, 0.15) 50%, rgba(255, 255, 255, 0.15) 75%, transparent 75%, transparent);
}
.progress-bar-info {
  background-color: #5bc0de;
}
.progress-striped .progress-bar-info {
  background-image: -webkit-linear-gradient(45deg, rgba(255, 255, 255, 0.15) 25%, transparent 25%, transparent 50%, rgba(255, 255, 255, 0.15) 50%, rgba(255, 255, 255, 0.15) 75%, transparent 75%, transparent);
  background-image: -o-linear-gradient(45deg, rgba(255, 255, 255, 0.15) 25%, transparent 25%, transparent 50%, rgba(255, 255, 255, 0.15) 50%, rgba(255, 255, 255, 0.15) 75%, transparent 75%, transparent);
  background-image: linear-gradient(45deg, rgba(255, 255, 255, 0.15) 25%, transparent 25%, transparent 50%, rgba(255, 255, 255, 0.15) 50%, rgba(255, 255, 255, 0.15) 75%, transparent 75%, transparent);
}
.progress-bar-warning {
  background-color: #f0ad4e;
}
.progress-striped .progress-bar-warning {
  background-image: -webkit-linear-gradient(45deg, rgba(255, 255, 255, 0.15) 25%, transparent 25%, transparent 50%, rgba(255, 255, 255, 0.15) 50%, rgba(255, 255, 255, 0.15) 75%, transparent 75%, transparent);
  background-image: -o-linear-gradient(45deg, rgba(255, 255, 255, 0.15) 25%, transparent 25%, transparent 50%, rgba(255, 255, 255, 0.15) 50%, rgba(255, 255, 255, 0.15) 75%, transparent 75%, transparent);
  background-image: linear-gradient(45deg, rgba(255, 255, 255, 0.15) 25%, transparent 25%, transparent 50%, rgba(255, 255, 255, 0.15) 50%, rgba(255, 255, 255, 0.15) 75%, transparent 75%, transparent);
}
.progress-bar-danger {
  background-color: #d9534f;
}
.progress-striped .progress-bar-danger {
  background-image: -webkit-linear-gradient(45deg, rgba(255, 255, 255, 0.15) 25%, transparent 25%, transparent 50%, rgba(255, 255, 255, 0.15) 50%, rgba(255, 255, 255, 0.15) 75%, transparent 75%, transparent);
  background-image: -o-linear-gradient(45deg, rgba(255, 255, 255, 0.15) 25%, transparent 25%, transparent 50%, rgba(255, 255, 255, 0.15) 50%, rgba(255, 255, 255, 0.15) 75%, transparent 75%, transparent);
  background-image: linear-gradient(45deg, rgba(255, 255, 255, 0.15) 25%, transparent 25%, transparent 50%, rgba(255, 255, 255, 0.15) 50%, rgba(255, 255, 255, 0.15) 75%, transparent 75%, transparent);
}
.media {
  margin-top: 15px;
}
.media:first-child {
  margin-top: 0;
}
.media,
.media-body {
  zoom: 1;
  overflow: hidden;
}
.media-body {
  width: 10000px;
}
.media-object {
  display: block;
}
.media-object.img-thumbnail {
  max-width: none;
}
.media-right,
.media > .pull-right {
  padding-left: 10px;
}
.media-left,
.media > .pull-left {
  padding-right: 10px;
}
.media-left,
.media-right,
.media-body {
  display: table-cell;
  vertical-align: top;
}
.media-middle {
  vertical-align: middle;
}
.media-bottom {
  vertical-align: bottom;
}
.media-heading {
  margin-top: 0;
  margin-bottom: 5px;
}
.media-list {
  padding-left: 0;
  list-style: none;
}
.list-group {
  margin-bottom: 20px;
  padding-left: 0;
}
.list-group-item {
  position: relative;
  display: block;
  padding: 10px 15px;
  margin-bottom: -1px;
  background-color: #fff;
  border: 1px solid #ddd;
}
.list-group-item:first-child {
  border-top-right-radius: 2px;
  border-top-left-radius: 2px;
}
.list-group-item:last-child {
  margin-bottom: 0;
  border-bottom-right-radius: 2px;
  border-bottom-left-radius: 2px;
}
a.list-group-item,
button.list-group-item {
  color: #555;
}
a.list-group-item .list-group-item-heading,
button.list-group-item .list-group-item-heading {
  color: #333;
}
a.list-group-item:hover,
button.list-group-item:hover,
a.list-group-item:focus,
button.list-group-item:focus {
  text-decoration: none;
  color: #555;
  background-color: #f5f5f5;
}
button.list-group-item {
  width: 100%;
  text-align: left;
}
.list-group-item.disabled,
.list-group-item.disabled:hover,
.list-group-item.disabled:focus {
  background-color: #eeeeee;
  color: #777777;
  cursor: not-allowed;
}
.list-group-item.disabled .list-group-item-heading,
.list-group-item.disabled:hover .list-group-item-heading,
.list-group-item.disabled:focus .list-group-item-heading {
  color: inherit;
}
.list-group-item.disabled .list-group-item-text,
.list-group-item.disabled:hover .list-group-item-text,
.list-group-item.disabled:focus .list-group-item-text {
  color: #777777;
}
.list-group-item.active,
.list-group-item.active:hover,
.list-group-item.active:focus {
  z-index: 2;
  color: #fff;
  background-color: #337ab7;
  border-color: #337ab7;
}
.list-group-item.active .list-group-item-heading,
.list-group-item.active:hover .list-group-item-heading,
.list-group-item.active:focus .list-group-item-heading,
.list-group-item.active .list-group-item-heading > small,
.list-group-item.active:hover .list-group-item-heading > small,
.list-group-item.active:focus .list-group-item-heading > small,
.list-group-item.active .list-group-item-heading > .small,
.list-group-item.active:hover .list-group-item-heading > .small,
.list-group-item.active:focus .list-group-item-heading > .small {
  color: inherit;
}
.list-group-item.active .list-group-item-text,
.list-group-item.active:hover .list-group-item-text,
.list-group-item.active:focus .list-group-item-text {
  color: #c7ddef;
}
.list-group-item-success {
  color: #3c763d;
  background-color: #dff0d8;
}
a.list-group-item-success,
button.list-group-item-success {
  color: #3c763d;
}
a.list-group-item-success .list-group-item-heading,
button.list-group-item-success .list-group-item-heading {
  color: inherit;
}
a.list-group-item-success:hover,
button.list-group-item-success:hover,
a.list-group-item-success:focus,
button.list-group-item-success:focus {
  color: #3c763d;
  background-color: #d0e9c6;
}
a.list-group-item-success.active,
button.list-group-item-success.active,
a.list-group-item-success.active:hover,
button.list-group-item-success.active:hover,
a.list-group-item-success.active:focus,
button.list-group-item-success.active:focus {
  color: #fff;
  background-color: #3c763d;
  border-color: #3c763d;
}
.list-group-item-info {
  color: #31708f;
  background-color: #d9edf7;
}
a.list-group-item-info,
button.list-group-item-info {
  color: #31708f;
}
a.list-group-item-info .list-group-item-heading,
button.list-group-item-info .list-group-item-heading {
  color: inherit;
}
a.list-group-item-info:hover,
button.list-group-item-info:hover,
a.list-group-item-info:focus,
button.list-group-item-info:focus {
  color: #31708f;
  background-color: #c4e3f3;
}
a.list-group-item-info.active,
button.list-group-item-info.active,
a.list-group-item-info.active:hover,
button.list-group-item-info.active:hover,
a.list-group-item-info.active:focus,
button.list-group-item-info.active:focus {
  color: #fff;
  background-color: #31708f;
  border-color: #31708f;
}
.list-group-item-warning {
  color: #8a6d3b;
  background-color: #fcf8e3;
}
a.list-group-item-warning,
button.list-group-item-warning {
  color: #8a6d3b;
}
a.list-group-item-warning .list-group-item-heading,
button.list-group-item-warning .list-group-item-heading {
  color: inherit;
}
a.list-group-item-warning:hover,
button.list-group-item-warning:hover,
a.list-group-item-warning:focus,
button.list-group-item-warning:focus {
  color: #8a6d3b;
  background-color: #faf2cc;
}
a.list-group-item-warning.active,
button.list-group-item-warning.active,
a.list-group-item-warning.active:hover,
button.list-group-item-warning.active:hover,
a.list-group-item-warning.active:focus,
button.list-group-item-warning.active:focus {
  color: #fff;
  background-color: #8a6d3b;
  border-color: #8a6d3b;
}
.list-group-item-danger {
  color: #a94442;
  background-color: #f2dede;
}
a.list-group-item-danger,
button.list-group-item-danger {
  color: #a94442;
}
a.list-group-item-danger .list-group-item-heading,
button.list-group-item-danger .list-group-item-heading {
  color: inherit;
}
a.list-group-item-danger:hover,
button.list-group-item-danger:hover,
a.list-group-item-danger:focus,
button.list-group-item-danger:focus {
  color: #a94442;
  background-color: #ebcccc;
}
a.list-group-item-danger.active,
button.list-group-item-danger.active,
a.list-group-item-danger.active:hover,
button.list-group-item-danger.active:hover,
a.list-group-item-danger.active:focus,
button.list-group-item-danger.active:focus {
  color: #fff;
  background-color: #a94442;
  border-color: #a94442;
}
.list-group-item-heading {
  margin-top: 0;
  margin-bottom: 5px;
}
.list-group-item-text {
  margin-bottom: 0;
  line-height: 1.3;
}
.panel {
  margin-bottom: 18px;
  background-color: #fff;
  border: 1px solid transparent;
  border-radius: 2px;
  -webkit-box-shadow: 0 1px 1px rgba(0, 0, 0, 0.05);
  box-shadow: 0 1px 1px rgba(0, 0, 0, 0.05);
}
.panel-body {
  padding: 15px;
}
.panel-heading {
  padding: 10px 15px;
  border-bottom: 1px solid transparent;
  border-top-right-radius: 1px;
  border-top-left-radius: 1px;
}
.panel-heading > .dropdown .dropdown-toggle {
  color: inherit;
}
.panel-title {
  margin-top: 0;
  margin-bottom: 0;
  font-size: 15px;
  color: inherit;
}
.panel-title > a,
.panel-title > small,
.panel-title > .small,
.panel-title > small > a,
.panel-title > .small > a {
  color: inherit;
}
.panel-footer {
  padding: 10px 15px;
  background-color: #f5f5f5;
  border-top: 1px solid #ddd;
  border-bottom-right-radius: 1px;
  border-bottom-left-radius: 1px;
}
.panel > .list-group,
.panel > .panel-collapse > .list-group {
  margin-bottom: 0;
}
.panel > .list-group .list-group-item,
.panel > .panel-collapse > .list-group .list-group-item {
  border-width: 1px 0;
  border-radius: 0;
}
.panel > .list-group:first-child .list-group-item:first-child,
.panel > .panel-collapse > .list-group:first-child .list-group-item:first-child {
  border-top: 0;
  border-top-right-radius: 1px;
  border-top-left-radius: 1px;
}
.panel > .list-group:last-child .list-group-item:last-child,
.panel > .panel-collapse > .list-group:last-child .list-group-item:last-child {
  border-bottom: 0;
  border-bottom-right-radius: 1px;
  border-bottom-left-radius: 1px;
}
.panel > .panel-heading + .panel-collapse > .list-group .list-group-item:first-child {
  border-top-right-radius: 0;
  border-top-left-radius: 0;
}
.panel-heading + .list-group .list-group-item:first-child {
  border-top-width: 0;
}
.list-group + .panel-footer {
  border-top-width: 0;
}
.panel > .table,
.panel > .table-responsive > .table,
.panel > .panel-collapse > .table {
  margin-bottom: 0;
}
.panel > .table caption,
.panel > .table-responsive > .table caption,
.panel > .panel-collapse > .table caption {
  padding-left: 15px;
  padding-right: 15px;
}
.panel > .table:first-child,
.panel > .table-responsive:first-child > .table:first-child {
  border-top-right-radius: 1px;
  border-top-left-radius: 1px;
}
.panel > .table:first-child > thead:first-child > tr:first-child,
.panel > .table-responsive:first-child > .table:first-child > thead:first-child > tr:first-child,
.panel > .table:first-child > tbody:first-child > tr:first-child,
.panel > .table-responsive:first-child > .table:first-child > tbody:first-child > tr:first-child {
  border-top-left-radius: 1px;
  border-top-right-radius: 1px;
}
.panel > .table:first-child > thead:first-child > tr:first-child td:first-child,
.panel > .table-responsive:first-child > .table:first-child > thead:first-child > tr:first-child td:first-child,
.panel > .table:first-child > tbody:first-child > tr:first-child td:first-child,
.panel > .table-responsive:first-child > .table:first-child > tbody:first-child > tr:first-child td:first-child,
.panel > .table:first-child > thead:first-child > tr:first-child th:first-child,
.panel > .table-responsive:first-child > .table:first-child > thead:first-child > tr:first-child th:first-child,
.panel > .table:first-child > tbody:first-child > tr:first-child th:first-child,
.panel > .table-responsive:first-child > .table:first-child > tbody:first-child > tr:first-child th:first-child {
  border-top-left-radius: 1px;
}
.panel > .table:first-child > thead:first-child > tr:first-child td:last-child,
.panel > .table-responsive:first-child > .table:first-child > thead:first-child > tr:first-child td:last-child,
.panel > .table:first-child > tbody:first-child > tr:first-child td:last-child,
.panel > .table-responsive:first-child > .table:first-child > tbody:first-child > tr:first-child td:last-child,
.panel > .table:first-child > thead:first-child > tr:first-child th:last-child,
.panel > .table-responsive:first-child > .table:first-child > thead:first-child > tr:first-child th:last-child,
.panel > .table:first-child > tbody:first-child > tr:first-child th:last-child,
.panel > .table-responsive:first-child > .table:first-child > tbody:first-child > tr:first-child th:last-child {
  border-top-right-radius: 1px;
}
.panel > .table:last-child,
.panel > .table-responsive:last-child > .table:last-child {
  border-bottom-right-radius: 1px;
  border-bottom-left-radius: 1px;
}
.panel > .table:last-child > tbody:last-child > tr:last-child,
.panel > .table-responsive:last-child > .table:last-child > tbody:last-child > tr:last-child,
.panel > .table:last-child > tfoot:last-child > tr:last-child,
.panel > .table-responsive:last-child > .table:last-child > tfoot:last-child > tr:last-child {
  border-bottom-left-radius: 1px;
  border-bottom-right-radius: 1px;
}
.panel > .table:last-child > tbody:last-child > tr:last-child td:first-child,
.panel > .table-responsive:last-child > .table:last-child > tbody:last-child > tr:last-child td:first-child,
.panel > .table:last-child > tfoot:last-child > tr:last-child td:first-child,
.panel > .table-responsive:last-child > .table:last-child > tfoot:last-child > tr:last-child td:first-child,
.panel > .table:last-child > tbody:last-child > tr:last-child th:first-child,
.panel > .table-responsive:last-child > .table:last-child > tbody:last-child > tr:last-child th:first-child,
.panel > .table:last-child > tfoot:last-child > tr:last-child th:first-child,
.panel > .table-responsive:last-child > .table:last-child > tfoot:last-child > tr:last-child th:first-child {
  border-bottom-left-radius: 1px;
}
.panel > .table:last-child > tbody:last-child > tr:last-child td:last-child,
.panel > .table-responsive:last-child > .table:last-child > tbody:last-child > tr:last-child td:last-child,
.panel > .table:last-child > tfoot:last-child > tr:last-child td:last-child,
.panel > .table-responsive:last-child > .table:last-child > tfoot:last-child > tr:last-child td:last-child,
.panel > .table:last-child > tbody:last-child > tr:last-child th:last-child,
.panel > .table-responsive:last-child > .table:last-child > tbody:last-child > tr:last-child th:last-child,
.panel > .table:last-child > tfoot:last-child > tr:last-child th:last-child,
.panel > .table-responsive:last-child > .table:last-child > tfoot:last-child > tr:last-child th:last-child {
  border-bottom-right-radius: 1px;
}
.panel > .panel-body + .table,
.panel > .panel-body + .table-responsive,
.panel > .table + .panel-body,
.panel > .table-responsive + .panel-body {
  border-top: 1px solid #ddd;
}
.panel > .table > tbody:first-child > tr:first-child th,
.panel > .table > tbody:first-child > tr:first-child td {
  border-top: 0;
}
.panel > .table-bordered,
.panel > .table-responsive > .table-bordered {
  border: 0;
}
.panel > .table-bordered > thead > tr > th:first-child,
.panel > .table-responsive > .table-bordered > thead > tr > th:first-child,
.panel > .table-bordered > tbody > tr > th:first-child,
.panel > .table-responsive > .table-bordered > tbody > tr > th:first-child,
.panel > .table-bordered > tfoot > tr > th:first-child,
.panel > .table-responsive > .table-bordered > tfoot > tr > th:first-child,
.panel > .table-bordered > thead > tr > td:first-child,
.panel > .table-responsive > .table-bordered > thead > tr > td:first-child,
.panel > .table-bordered > tbody > tr > td:first-child,
.panel > .table-responsive > .table-bordered > tbody > tr > td:first-child,
.panel > .table-bordered > tfoot > tr > td:first-child,
.panel > .table-responsive > .table-bordered > tfoot > tr > td:first-child {
  border-left: 0;
}
.panel > .table-bordered > thead > tr > th:last-child,
.panel > .table-responsive > .table-bordered > thead > tr > th:last-child,
.panel > .table-bordered > tbody > tr > th:last-child,
.panel > .table-responsive > .table-bordered > tbody > tr > th:last-child,
.panel > .table-bordered > tfoot > tr > th:last-child,
.panel > .table-responsive > .table-bordered > tfoot > tr > th:last-child,
.panel > .table-bordered > thead > tr > td:last-child,
.panel > .table-responsive > .table-bordered > thead > tr > td:last-child,
.panel > .table-bordered > tbody > tr > td:last-child,
.panel > .table-responsive > .table-bordered > tbody > tr > td:last-child,
.panel > .table-bordered > tfoot > tr > td:last-child,
.panel > .table-responsive > .table-bordered > tfoot > tr > td:last-child {
  border-right: 0;
}
.panel > .table-bordered > thead > tr:first-child > td,
.panel > .table-responsive > .table-bordered > thead > tr:first-child > td,
.panel > .table-bordered > tbody > tr:first-child > td,
.panel > .table-responsive > .table-bordered > tbody > tr:first-child > td,
.panel > .table-bordered > thead > tr:first-child > th,
.panel > .table-responsive > .table-bordered > thead > tr:first-child > th,
.panel > .table-bordered > tbody > tr:first-child > th,
.panel > .table-responsive > .table-bordered > tbody > tr:first-child > th {
  border-bottom: 0;
}
.panel > .table-bordered > tbody > tr:last-child > td,
.panel > .table-responsive > .table-bordered > tbody > tr:last-child > td,
.panel > .table-bordered > tfoot > tr:last-child > td,
.panel > .table-responsive > .table-bordered > tfoot > tr:last-child > td,
.panel > .table-bordered > tbody > tr:last-child > th,
.panel > .table-responsive > .table-bordered > tbody > tr:last-child > th,
.panel > .table-bordered > tfoot > tr:last-child > th,
.panel > .table-responsive > .table-bordered > tfoot > tr:last-child > th {
  border-bottom: 0;
}
.panel > .table-responsive {
  border: 0;
  margin-bottom: 0;
}
.panel-group {
  margin-bottom: 18px;
}
.panel-group .panel {
  margin-bottom: 0;
  border-radius: 2px;
}
.panel-group .panel + .panel {
  margin-top: 5px;
}
.panel-group .panel-heading {
  border-bottom: 0;
}
.panel-group .panel-heading + .panel-collapse > .panel-body,
.panel-group .panel-heading + .panel-collapse > .list-group {
  border-top: 1px solid #ddd;
}
.panel-group .panel-footer {
  border-top: 0;
}
.panel-group .panel-footer + .panel-collapse .panel-body {
  border-bottom: 1px solid #ddd;
}
.panel-default {
  border-color: #ddd;
}
.panel-default > .panel-heading {
  color: #333333;
  background-color: #f5f5f5;
  border-color: #ddd;
}
.panel-default > .panel-heading + .panel-collapse > .panel-body {
  border-top-color: #ddd;
}
.panel-default > .panel-heading .badge {
  color: #f5f5f5;
  background-color: #333333;
}
.panel-default > .panel-footer + .panel-collapse > .panel-body {
  border-bottom-color: #ddd;
}
.panel-primary {
  border-color: #337ab7;
}
.panel-primary > .panel-heading {
  color: #fff;
  background-color: #337ab7;
  border-color: #337ab7;
}
.panel-primary > .panel-heading + .panel-collapse > .panel-body {
  border-top-color: #337ab7;
}
.panel-primary > .panel-heading .badge {
  color: #337ab7;
  background-color: #fff;
}
.panel-primary > .panel-footer + .panel-collapse > .panel-body {
  border-bottom-color: #337ab7;
}
.panel-success {
  border-color: #d6e9c6;
}
.panel-success > .panel-heading {
  color: #3c763d;
  background-color: #dff0d8;
  border-color: #d6e9c6;
}
.panel-success > .panel-heading + .panel-collapse > .panel-body {
  border-top-color: #d6e9c6;
}
.panel-success > .panel-heading .badge {
  color: #dff0d8;
  background-color: #3c763d;
}
.panel-success > .panel-footer + .panel-collapse > .panel-body {
  border-bottom-color: #d6e9c6;
}
.panel-info {
  border-color: #bce8f1;
}
.panel-info > .panel-heading {
  color: #31708f;
  background-color: #d9edf7;
  border-color: #bce8f1;
}
.panel-info > .panel-heading + .panel-collapse > .panel-body {
  border-top-color: #bce8f1;
}
.panel-info > .panel-heading .badge {
  color: #d9edf7;
  background-color: #31708f;
}
.panel-info > .panel-footer + .panel-collapse > .panel-body {
  border-bottom-color: #bce8f1;
}
.panel-warning {
  border-color: #faebcc;
}
.panel-warning > .panel-heading {
  color: #8a6d3b;
  background-color: #fcf8e3;
  border-color: #faebcc;
}
.panel-warning > .panel-heading + .panel-collapse > .panel-body {
  border-top-color: #faebcc;
}
.panel-warning > .panel-heading .badge {
  color: #fcf8e3;
  background-color: #8a6d3b;
}
.panel-warning > .panel-footer + .panel-collapse > .panel-body {
  border-bottom-color: #faebcc;
}
.panel-danger {
  border-color: #ebccd1;
}
.panel-danger > .panel-heading {
  color: #a94442;
  background-color: #f2dede;
  border-color: #ebccd1;
}
.panel-danger > .panel-heading + .panel-collapse > .panel-body {
  border-top-color: #ebccd1;
}
.panel-danger > .panel-heading .badge {
  color: #f2dede;
  background-color: #a94442;
}
.panel-danger > .panel-footer + .panel-collapse > .panel-body {
  border-bottom-color: #ebccd1;
}
.embed-responsive {
  position: relative;
  display: block;
  height: 0;
  padding: 0;
  overflow: hidden;
}
.embed-responsive .embed-responsive-item,
.embed-responsive iframe,
.embed-responsive embed,
.embed-responsive object,
.embed-responsive video {
  position: absolute;
  top: 0;
  left: 0;
  bottom: 0;
  height: 100%;
  width: 100%;
  border: 0;
}
.embed-responsive-16by9 {
  padding-bottom: 56.25%;
}
.embed-responsive-4by3 {
  padding-bottom: 75%;
}
.well {
  min-height: 20px;
  padding: 19px;
  margin-bottom: 20px;
  background-color: #f5f5f5;
  border: 1px solid #e3e3e3;
  border-radius: 2px;
  -webkit-box-shadow: inset 0 1px 1px rgba(0, 0, 0, 0.05);
  box-shadow: inset 0 1px 1px rgba(0, 0, 0, 0.05);
}
.well blockquote {
  border-color: #ddd;
  border-color: rgba(0, 0, 0, 0.15);
}
.well-lg {
  padding: 24px;
  border-radius: 3px;
}
.well-sm {
  padding: 9px;
  border-radius: 1px;
}
.close {
  float: right;
  font-size: 19.5px;
  font-weight: bold;
  line-height: 1;
  color: #000;
  text-shadow: 0 1px 0 #fff;
  opacity: 0.2;
  filter: alpha(opacity=20);
}
.close:hover,
.close:focus {
  color: #000;
  text-decoration: none;
  cursor: pointer;
  opacity: 0.5;
  filter: alpha(opacity=50);
}
button.close {
  padding: 0;
  cursor: pointer;
  background: transparent;
  border: 0;
  -webkit-appearance: none;
}
.modal-open {
  overflow: hidden;
}
.modal {
  display: none;
  overflow: hidden;
  position: fixed;
  top: 0;
  right: 0;
  bottom: 0;
  left: 0;
  z-index: 1050;
  -webkit-overflow-scrolling: touch;
  outline: 0;
}
.modal.fade .modal-dialog {
  -webkit-transform: translate(0, -25%);
  -ms-transform: translate(0, -25%);
  -o-transform: translate(0, -25%);
  transform: translate(0, -25%);
  -webkit-transition: -webkit-transform 0.3s ease-out;
  -moz-transition: -moz-transform 0.3s ease-out;
  -o-transition: -o-transform 0.3s ease-out;
  transition: transform 0.3s ease-out;
}
.modal.in .modal-dialog {
  -webkit-transform: translate(0, 0);
  -ms-transform: translate(0, 0);
  -o-transform: translate(0, 0);
  transform: translate(0, 0);
}
.modal-open .modal {
  overflow-x: hidden;
  overflow-y: auto;
}
.modal-dialog {
  position: relative;
  width: auto;
  margin: 10px;
}
.modal-content {
  position: relative;
  background-color: #fff;
  border: 1px solid #999;
  border: 1px solid rgba(0, 0, 0, 0.2);
  border-radius: 3px;
  -webkit-box-shadow: 0 3px 9px rgba(0, 0, 0, 0.5);
  box-shadow: 0 3px 9px rgba(0, 0, 0, 0.5);
  background-clip: padding-box;
  outline: 0;
}
.modal-backdrop {
  position: fixed;
  top: 0;
  right: 0;
  bottom: 0;
  left: 0;
  z-index: 1040;
  background-color: #000;
}
.modal-backdrop.fade {
  opacity: 0;
  filter: alpha(opacity=0);
}
.modal-backdrop.in {
  opacity: 0.5;
  filter: alpha(opacity=50);
}
.modal-header {
  padding: 15px;
  border-bottom: 1px solid #e5e5e5;
}
.modal-header .close {
  margin-top: -2px;
}
.modal-title {
  margin: 0;
  line-height: 1.42857143;
}
.modal-body {
  position: relative;
  padding: 15px;
}
.modal-footer {
  padding: 15px;
  text-align: right;
  border-top: 1px solid #e5e5e5;
}
.modal-footer .btn + .btn {
  margin-left: 5px;
  margin-bottom: 0;
}
.modal-footer .btn-group .btn + .btn {
  margin-left: -1px;
}
.modal-footer .btn-block + .btn-block {
  margin-left: 0;
}
.modal-scrollbar-measure {
  position: absolute;
  top: -9999px;
  width: 50px;
  height: 50px;
  overflow: scroll;
}
@media (min-width: 768px) {
  .modal-dialog {
    width: 600px;
    margin: 30px auto;
  }
  .modal-content {
    -webkit-box-shadow: 0 5px 15px rgba(0, 0, 0, 0.5);
    box-shadow: 0 5px 15px rgba(0, 0, 0, 0.5);
  }
  .modal-sm {
    width: 300px;
  }
}
@media (min-width: 992px) {
  .modal-lg {
    width: 900px;
  }
}
.tooltip {
  position: absolute;
  z-index: 1070;
  display: block;
  font-family: "Helvetica Neue", Helvetica, Arial, sans-serif;
  font-style: normal;
  font-weight: normal;
  letter-spacing: normal;
  line-break: auto;
  line-height: 1.42857143;
  text-align: left;
  text-align: start;
  text-decoration: none;
  text-shadow: none;
  text-transform: none;
  white-space: normal;
  word-break: normal;
  word-spacing: normal;
  word-wrap: normal;
  font-size: 12px;
  opacity: 0;
  filter: alpha(opacity=0);
}
.tooltip.in {
  opacity: 0.9;
  filter: alpha(opacity=90);
}
.tooltip.top {
  margin-top: -3px;
  padding: 5px 0;
}
.tooltip.right {
  margin-left: 3px;
  padding: 0 5px;
}
.tooltip.bottom {
  margin-top: 3px;
  padding: 5px 0;
}
.tooltip.left {
  margin-left: -3px;
  padding: 0 5px;
}
.tooltip-inner {
  max-width: 200px;
  padding: 3px 8px;
  color: #fff;
  text-align: center;
  background-color: #000;
  border-radius: 2px;
}
.tooltip-arrow {
  position: absolute;
  width: 0;
  height: 0;
  border-color: transparent;
  border-style: solid;
}
.tooltip.top .tooltip-arrow {
  bottom: 0;
  left: 50%;
  margin-left: -5px;
  border-width: 5px 5px 0;
  border-top-color: #000;
}
.tooltip.top-left .tooltip-arrow {
  bottom: 0;
  right: 5px;
  margin-bottom: -5px;
  border-width: 5px 5px 0;
  border-top-color: #000;
}
.tooltip.top-right .tooltip-arrow {
  bottom: 0;
  left: 5px;
  margin-bottom: -5px;
  border-width: 5px 5px 0;
  border-top-color: #000;
}
.tooltip.right .tooltip-arrow {
  top: 50%;
  left: 0;
  margin-top: -5px;
  border-width: 5px 5px 5px 0;
  border-right-color: #000;
}
.tooltip.left .tooltip-arrow {
  top: 50%;
  right: 0;
  margin-top: -5px;
  border-width: 5px 0 5px 5px;
  border-left-color: #000;
}
.tooltip.bottom .tooltip-arrow {
  top: 0;
  left: 50%;
  margin-left: -5px;
  border-width: 0 5px 5px;
  border-bottom-color: #000;
}
.tooltip.bottom-left .tooltip-arrow {
  top: 0;
  right: 5px;
  margin-top: -5px;
  border-width: 0 5px 5px;
  border-bottom-color: #000;
}
.tooltip.bottom-right .tooltip-arrow {
  top: 0;
  left: 5px;
  margin-top: -5px;
  border-width: 0 5px 5px;
  border-bottom-color: #000;
}
.popover {
  position: absolute;
  top: 0;
  left: 0;
  z-index: 1060;
  display: none;
  max-width: 276px;
  padding: 1px;
  font-family: "Helvetica Neue", Helvetica, Arial, sans-serif;
  font-style: normal;
  font-weight: normal;
  letter-spacing: normal;
  line-break: auto;
  line-height: 1.42857143;
  text-align: left;
  text-align: start;
  text-decoration: none;
  text-shadow: none;
  text-transform: none;
  white-space: normal;
  word-break: normal;
  word-spacing: normal;
  word-wrap: normal;
  font-size: 13px;
  background-color: #fff;
  background-clip: padding-box;
  border: 1px solid #ccc;
  border: 1px solid rgba(0, 0, 0, 0.2);
  border-radius: 3px;
  -webkit-box-shadow: 0 5px 10px rgba(0, 0, 0, 0.2);
  box-shadow: 0 5px 10px rgba(0, 0, 0, 0.2);
}
.popover.top {
  margin-top: -10px;
}
.popover.right {
  margin-left: 10px;
}
.popover.bottom {
  margin-top: 10px;
}
.popover.left {
  margin-left: -10px;
}
.popover-title {
  margin: 0;
  padding: 8px 14px;
  font-size: 13px;
  background-color: #f7f7f7;
  border-bottom: 1px solid #ebebeb;
  border-radius: 2px 2px 0 0;
}
.popover-content {
  padding: 9px 14px;
}
.popover > .arrow,
.popover > .arrow:after {
  position: absolute;
  display: block;
  width: 0;
  height: 0;
  border-color: transparent;
  border-style: solid;
}
.popover > .arrow {
  border-width: 11px;
}
.popover > .arrow:after {
  border-width: 10px;
  content: "";
}
.popover.top > .arrow {
  left: 50%;
  margin-left: -11px;
  border-bottom-width: 0;
  border-top-color: #999999;
  border-top-color: rgba(0, 0, 0, 0.25);
  bottom: -11px;
}
.popover.top > .arrow:after {
  content: " ";
  bottom: 1px;
  margin-left: -10px;
  border-bottom-width: 0;
  border-top-color: #fff;
}
.popover.right > .arrow {
  top: 50%;
  left: -11px;
  margin-top: -11px;
  border-left-width: 0;
  border-right-color: #999999;
  border-right-color: rgba(0, 0, 0, 0.25);
}
.popover.right > .arrow:after {
  content: " ";
  left: 1px;
  bottom: -10px;
  border-left-width: 0;
  border-right-color: #fff;
}
.popover.bottom > .arrow {
  left: 50%;
  margin-left: -11px;
  border-top-width: 0;
  border-bottom-color: #999999;
  border-bottom-color: rgba(0, 0, 0, 0.25);
  top: -11px;
}
.popover.bottom > .arrow:after {
  content: " ";
  top: 1px;
  margin-left: -10px;
  border-top-width: 0;
  border-bottom-color: #fff;
}
.popover.left > .arrow {
  top: 50%;
  right: -11px;
  margin-top: -11px;
  border-right-width: 0;
  border-left-color: #999999;
  border-left-color: rgba(0, 0, 0, 0.25);
}
.popover.left > .arrow:after {
  content: " ";
  right: 1px;
  border-right-width: 0;
  border-left-color: #fff;
  bottom: -10px;
}
.carousel {
  position: relative;
}
.carousel-inner {
  position: relative;
  overflow: hidden;
  width: 100%;
}
.carousel-inner > .item {
  display: none;
  position: relative;
  -webkit-transition: 0.6s ease-in-out left;
  -o-transition: 0.6s ease-in-out left;
  transition: 0.6s ease-in-out left;
}
.carousel-inner > .item > img,
.carousel-inner > .item > a > img {
  line-height: 1;
}
@media all and (transform-3d), (-webkit-transform-3d) {
  .carousel-inner > .item {
    -webkit-transition: -webkit-transform 0.6s ease-in-out;
    -moz-transition: -moz-transform 0.6s ease-in-out;
    -o-transition: -o-transform 0.6s ease-in-out;
    transition: transform 0.6s ease-in-out;
    -webkit-backface-visibility: hidden;
    -moz-backface-visibility: hidden;
    backface-visibility: hidden;
    -webkit-perspective: 1000px;
    -moz-perspective: 1000px;
    perspective: 1000px;
  }
  .carousel-inner > .item.next,
  .carousel-inner > .item.active.right {
    -webkit-transform: translate3d(100%, 0, 0);
    transform: translate3d(100%, 0, 0);
    left: 0;
  }
  .carousel-inner > .item.prev,
  .carousel-inner > .item.active.left {
    -webkit-transform: translate3d(-100%, 0, 0);
    transform: translate3d(-100%, 0, 0);
    left: 0;
  }
  .carousel-inner > .item.next.left,
  .carousel-inner > .item.prev.right,
  .carousel-inner > .item.active {
    -webkit-transform: translate3d(0, 0, 0);
    transform: translate3d(0, 0, 0);
    left: 0;
  }
}
.carousel-inner > .active,
.carousel-inner > .next,
.carousel-inner > .prev {
  display: block;
}
.carousel-inner > .active {
  left: 0;
}
.carousel-inner > .next,
.carousel-inner > .prev {
  position: absolute;
  top: 0;
  width: 100%;
}
.carousel-inner > .next {
  left: 100%;
}
.carousel-inner > .prev {
  left: -100%;
}
.carousel-inner > .next.left,
.carousel-inner > .prev.right {
  left: 0;
}
.carousel-inner > .active.left {
  left: -100%;
}
.carousel-inner > .active.right {
  left: 100%;
}
.carousel-control {
  position: absolute;
  top: 0;
  left: 0;
  bottom: 0;
  width: 15%;
  opacity: 0.5;
  filter: alpha(opacity=50);
  font-size: 20px;
  color: #fff;
  text-align: center;
  text-shadow: 0 1px 2px rgba(0, 0, 0, 0.6);
  background-color: rgba(0, 0, 0, 0);
}
.carousel-control.left {
  background-image: -webkit-linear-gradient(left, rgba(0, 0, 0, 0.5) 0%, rgba(0, 0, 0, 0.0001) 100%);
  background-image: -o-linear-gradient(left, rgba(0, 0, 0, 0.5) 0%, rgba(0, 0, 0, 0.0001) 100%);
  background-image: linear-gradient(to right, rgba(0, 0, 0, 0.5) 0%, rgba(0, 0, 0, 0.0001) 100%);
  background-repeat: repeat-x;
  filter: progid:DXImageTransform.Microsoft.gradient(startColorstr='#80000000', endColorstr='#00000000', GradientType=1);
}
.carousel-control.right {
  left: auto;
  right: 0;
  background-image: -webkit-linear-gradient(left, rgba(0, 0, 0, 0.0001) 0%, rgba(0, 0, 0, 0.5) 100%);
  background-image: -o-linear-gradient(left, rgba(0, 0, 0, 0.0001) 0%, rgba(0, 0, 0, 0.5) 100%);
  background-image: linear-gradient(to right, rgba(0, 0, 0, 0.0001) 0%, rgba(0, 0, 0, 0.5) 100%);
  background-repeat: repeat-x;
  filter: progid:DXImageTransform.Microsoft.gradient(startColorstr='#00000000', endColorstr='#80000000', GradientType=1);
}
.carousel-control:hover,
.carousel-control:focus {
  outline: 0;
  color: #fff;
  text-decoration: none;
  opacity: 0.9;
  filter: alpha(opacity=90);
}
.carousel-control .icon-prev,
.carousel-control .icon-next,
.carousel-control .glyphicon-chevron-left,
.carousel-control .glyphicon-chevron-right {
  position: absolute;
  top: 50%;
  margin-top: -10px;
  z-index: 5;
  display: inline-block;
}
.carousel-control .icon-prev,
.carousel-control .glyphicon-chevron-left {
  left: 50%;
  margin-left: -10px;
}
.carousel-control .icon-next,
.carousel-control .glyphicon-chevron-right {
  right: 50%;
  margin-right: -10px;
}
.carousel-control .icon-prev,
.carousel-control .icon-next {
  width: 20px;
  height: 20px;
  line-height: 1;
  font-family: serif;
}
.carousel-control .icon-prev:before {
  content: '\2039';
}
.carousel-control .icon-next:before {
  content: '\203a';
}
.carousel-indicators {
  position: absolute;
  bottom: 10px;
  left: 50%;
  z-index: 15;
  width: 60%;
  margin-left: -30%;
  padding-left: 0;
  list-style: none;
  text-align: center;
}
.carousel-indicators li {
  display: inline-block;
  width: 10px;
  height: 10px;
  margin: 1px;
  text-indent: -999px;
  border: 1px solid #fff;
  border-radius: 10px;
  cursor: pointer;
  background-color: #000 \9;
  background-color: rgba(0, 0, 0, 0);
}
.carousel-indicators .active {
  margin: 0;
  width: 12px;
  height: 12px;
  background-color: #fff;
}
.carousel-caption {
  position: absolute;
  left: 15%;
  right: 15%;
  bottom: 20px;
  z-index: 10;
  padding-top: 20px;
  padding-bottom: 20px;
  color: #fff;
  text-align: center;
  text-shadow: 0 1px 2px rgba(0, 0, 0, 0.6);
}
.carousel-caption .btn {
  text-shadow: none;
}
@media screen and (min-width: 768px) {
  .carousel-control .glyphicon-chevron-left,
  .carousel-control .glyphicon-chevron-right,
  .carousel-control .icon-prev,
  .carousel-control .icon-next {
    width: 30px;
    height: 30px;
    margin-top: -10px;
    font-size: 30px;
  }
  .carousel-control .glyphicon-chevron-left,
  .carousel-control .icon-prev {
    margin-left: -10px;
  }
  .carousel-control .glyphicon-chevron-right,
  .carousel-control .icon-next {
    margin-right: -10px;
  }
  .carousel-caption {
    left: 20%;
    right: 20%;
    padding-bottom: 30px;
  }
  .carousel-indicators {
    bottom: 20px;
  }
}
.clearfix:before,
.clearfix:after,
.dl-horizontal dd:before,
.dl-horizontal dd:after,
.container:before,
.container:after,
.container-fluid:before,
.container-fluid:after,
.row:before,
.row:after,
.form-horizontal .form-group:before,
.form-horizontal .form-group:after,
.btn-toolbar:before,
.btn-toolbar:after,
.btn-group-vertical > .btn-group:before,
.btn-group-vertical > .btn-group:after,
.nav:before,
.nav:after,
.navbar:before,
.navbar:after,
.navbar-header:before,
.navbar-header:after,
.navbar-collapse:before,
.navbar-collapse:after,
.pager:before,
.pager:after,
.panel-body:before,
.panel-body:after,
.modal-header:before,
.modal-header:after,
.modal-footer:before,
.modal-footer:after,
.item_buttons:before,
.item_buttons:after {
  content: " ";
  display: table;
}
.clearfix:after,
.dl-horizontal dd:after,
.container:after,
.container-fluid:after,
.row:after,
.form-horizontal .form-group:after,
.btn-toolbar:after,
.btn-group-vertical > .btn-group:after,
.nav:after,
.navbar:after,
.navbar-header:after,
.navbar-collapse:after,
.pager:after,
.panel-body:after,
.modal-header:after,
.modal-footer:after,
.item_buttons:after {
  clear: both;
}
.center-block {
  display: block;
  margin-left: auto;
  margin-right: auto;
}
.pull-right {
  float: right !important;
}
.pull-left {
  float: left !important;
}
.hide {
  display: none !important;
}
.show {
  display: block !important;
}
.invisible {
  visibility: hidden;
}
.text-hide {
  font: 0/0 a;
  color: transparent;
  text-shadow: none;
  background-color: transparent;
  border: 0;
}
.hidden {
  display: none !important;
}
.affix {
  position: fixed;
}
@-ms-viewport {
  width: device-width;
}
.visible-xs,
.visible-sm,
.visible-md,
.visible-lg {
  display: none !important;
}
.visible-xs-block,
.visible-xs-inline,
.visible-xs-inline-block,
.visible-sm-block,
.visible-sm-inline,
.visible-sm-inline-block,
.visible-md-block,
.visible-md-inline,
.visible-md-inline-block,
.visible-lg-block,
.visible-lg-inline,
.visible-lg-inline-block {
  display: none !important;
}
@media (max-width: 767px) {
  .visible-xs {
    display: block !important;
  }
  table.visible-xs {
    display: table !important;
  }
  tr.visible-xs {
    display: table-row !important;
  }
  th.visible-xs,
  td.visible-xs {
    display: table-cell !important;
  }
}
@media (max-width: 767px) {
  .visible-xs-block {
    display: block !important;
  }
}
@media (max-width: 767px) {
  .visible-xs-inline {
    display: inline !important;
  }
}
@media (max-width: 767px) {
  .visible-xs-inline-block {
    display: inline-block !important;
  }
}
@media (min-width: 768px) and (max-width: 991px) {
  .visible-sm {
    display: block !important;
  }
  table.visible-sm {
    display: table !important;
  }
  tr.visible-sm {
    display: table-row !important;
  }
  th.visible-sm,
  td.visible-sm {
    display: table-cell !important;
  }
}
@media (min-width: 768px) and (max-width: 991px) {
  .visible-sm-block {
    display: block !important;
  }
}
@media (min-width: 768px) and (max-width: 991px) {
  .visible-sm-inline {
    display: inline !important;
  }
}
@media (min-width: 768px) and (max-width: 991px) {
  .visible-sm-inline-block {
    display: inline-block !important;
  }
}
@media (min-width: 992px) and (max-width: 1199px) {
  .visible-md {
    display: block !important;
  }
  table.visible-md {
    display: table !important;
  }
  tr.visible-md {
    display: table-row !important;
  }
  th.visible-md,
  td.visible-md {
    display: table-cell !important;
  }
}
@media (min-width: 992px) and (max-width: 1199px) {
  .visible-md-block {
    display: block !important;
  }
}
@media (min-width: 992px) and (max-width: 1199px) {
  .visible-md-inline {
    display: inline !important;
  }
}
@media (min-width: 992px) and (max-width: 1199px) {
  .visible-md-inline-block {
    display: inline-block !important;
  }
}
@media (min-width: 1200px) {
  .visible-lg {
    display: block !important;
  }
  table.visible-lg {
    display: table !important;
  }
  tr.visible-lg {
    display: table-row !important;
  }
  th.visible-lg,
  td.visible-lg {
    display: table-cell !important;
  }
}
@media (min-width: 1200px) {
  .visible-lg-block {
    display: block !important;
  }
}
@media (min-width: 1200px) {
  .visible-lg-inline {
    display: inline !important;
  }
}
@media (min-width: 1200px) {
  .visible-lg-inline-block {
    display: inline-block !important;
  }
}
@media (max-width: 767px) {
  .hidden-xs {
    display: none !important;
  }
}
@media (min-width: 768px) and (max-width: 991px) {
  .hidden-sm {
    display: none !important;
  }
}
@media (min-width: 992px) and (max-width: 1199px) {
  .hidden-md {
    display: none !important;
  }
}
@media (min-width: 1200px) {
  .hidden-lg {
    display: none !important;
  }
}
.visible-print {
  display: none !important;
}
@media print {
  .visible-print {
    display: block !important;
  }
  table.visible-print {
    display: table !important;
  }
  tr.visible-print {
    display: table-row !important;
  }
  th.visible-print,
  td.visible-print {
    display: table-cell !important;
  }
}
.visible-print-block {
  display: none !important;
}
@media print {
  .visible-print-block {
    display: block !important;
  }
}
.visible-print-inline {
  display: none !important;
}
@media print {
  .visible-print-inline {
    display: inline !important;
  }
}
.visible-print-inline-block {
  display: none !important;
}
@media print {
  .visible-print-inline-block {
    display: inline-block !important;
  }
}
@media print {
  .hidden-print {
    display: none !important;
  }
}
/*!
*
* Font Awesome
*
*/
/*!
 *  Font Awesome 4.7.0 by @davegandy - http://fontawesome.io - @fontawesome
 *  License - http://fontawesome.io/license (Font: SIL OFL 1.1, CSS: MIT License)
 */
/* FONT PATH
 * -------------------------- */
@font-face {
  font-family: 'FontAwesome';
  src: url('../components/font-awesome/fonts/fontawesome-webfont.eot?v=4.7.0');
  src: url('../components/font-awesome/fonts/fontawesome-webfont.eot?#iefix&v=4.7.0') format('embedded-opentype'), url('../components/font-awesome/fonts/fontawesome-webfont.woff2?v=4.7.0') format('woff2'), url('../components/font-awesome/fonts/fontawesome-webfont.woff?v=4.7.0') format('woff'), url('../components/font-awesome/fonts/fontawesome-webfont.ttf?v=4.7.0') format('truetype'), url('../components/font-awesome/fonts/fontawesome-webfont.svg?v=4.7.0#fontawesomeregular') format('svg');
  font-weight: normal;
  font-style: normal;
}
.fa {
  display: inline-block;
  font: normal normal normal 14px/1 FontAwesome;
  font-size: inherit;
  text-rendering: auto;
  -webkit-font-smoothing: antialiased;
  -moz-osx-font-smoothing: grayscale;
}
/* makes the font 33% larger relative to the icon container */
.fa-lg {
  font-size: 1.33333333em;
  line-height: 0.75em;
  vertical-align: -15%;
}
.fa-2x {
  font-size: 2em;
}
.fa-3x {
  font-size: 3em;
}
.fa-4x {
  font-size: 4em;
}
.fa-5x {
  font-size: 5em;
}
.fa-fw {
  width: 1.28571429em;
  text-align: center;
}
.fa-ul {
  padding-left: 0;
  margin-left: 2.14285714em;
  list-style-type: none;
}
.fa-ul > li {
  position: relative;
}
.fa-li {
  position: absolute;
  left: -2.14285714em;
  width: 2.14285714em;
  top: 0.14285714em;
  text-align: center;
}
.fa-li.fa-lg {
  left: -1.85714286em;
}
.fa-border {
  padding: .2em .25em .15em;
  border: solid 0.08em #eee;
  border-radius: .1em;
}
.fa-pull-left {
  float: left;
}
.fa-pull-right {
  float: right;
}
.fa.fa-pull-left {
  margin-right: .3em;
}
.fa.fa-pull-right {
  margin-left: .3em;
}
/* Deprecated as of 4.4.0 */
.pull-right {
  float: right;
}
.pull-left {
  float: left;
}
.fa.pull-left {
  margin-right: .3em;
}
.fa.pull-right {
  margin-left: .3em;
}
.fa-spin {
  -webkit-animation: fa-spin 2s infinite linear;
  animation: fa-spin 2s infinite linear;
}
.fa-pulse {
  -webkit-animation: fa-spin 1s infinite steps(8);
  animation: fa-spin 1s infinite steps(8);
}
@-webkit-keyframes fa-spin {
  0% {
    -webkit-transform: rotate(0deg);
    transform: rotate(0deg);
  }
  100% {
    -webkit-transform: rotate(359deg);
    transform: rotate(359deg);
  }
}
@keyframes fa-spin {
  0% {
    -webkit-transform: rotate(0deg);
    transform: rotate(0deg);
  }
  100% {
    -webkit-transform: rotate(359deg);
    transform: rotate(359deg);
  }
}
.fa-rotate-90 {
  -ms-filter: "progid:DXImageTransform.Microsoft.BasicImage(rotation=1)";
  -webkit-transform: rotate(90deg);
  -ms-transform: rotate(90deg);
  transform: rotate(90deg);
}
.fa-rotate-180 {
  -ms-filter: "progid:DXImageTransform.Microsoft.BasicImage(rotation=2)";
  -webkit-transform: rotate(180deg);
  -ms-transform: rotate(180deg);
  transform: rotate(180deg);
}
.fa-rotate-270 {
  -ms-filter: "progid:DXImageTransform.Microsoft.BasicImage(rotation=3)";
  -webkit-transform: rotate(270deg);
  -ms-transform: rotate(270deg);
  transform: rotate(270deg);
}
.fa-flip-horizontal {
  -ms-filter: "progid:DXImageTransform.Microsoft.BasicImage(rotation=0, mirror=1)";
  -webkit-transform: scale(-1, 1);
  -ms-transform: scale(-1, 1);
  transform: scale(-1, 1);
}
.fa-flip-vertical {
  -ms-filter: "progid:DXImageTransform.Microsoft.BasicImage(rotation=2, mirror=1)";
  -webkit-transform: scale(1, -1);
  -ms-transform: scale(1, -1);
  transform: scale(1, -1);
}
:root .fa-rotate-90,
:root .fa-rotate-180,
:root .fa-rotate-270,
:root .fa-flip-horizontal,
:root .fa-flip-vertical {
  filter: none;
}
.fa-stack {
  position: relative;
  display: inline-block;
  width: 2em;
  height: 2em;
  line-height: 2em;
  vertical-align: middle;
}
.fa-stack-1x,
.fa-stack-2x {
  position: absolute;
  left: 0;
  width: 100%;
  text-align: center;
}
.fa-stack-1x {
  line-height: inherit;
}
.fa-stack-2x {
  font-size: 2em;
}
.fa-inverse {
  color: #fff;
}
/* Font Awesome uses the Unicode Private Use Area (PUA) to ensure screen
   readers do not read off random characters that represent icons */
.fa-glass:before {
  content: "\f000";
}
.fa-music:before {
  content: "\f001";
}
.fa-search:before {
  content: "\f002";
}
.fa-envelope-o:before {
  content: "\f003";
}
.fa-heart:before {
  content: "\f004";
}
.fa-star:before {
  content: "\f005";
}
.fa-star-o:before {
  content: "\f006";
}
.fa-user:before {
  content: "\f007";
}
.fa-film:before {
  content: "\f008";
}
.fa-th-large:before {
  content: "\f009";
}
.fa-th:before {
  content: "\f00a";
}
.fa-th-list:before {
  content: "\f00b";
}
.fa-check:before {
  content: "\f00c";
}
.fa-remove:before,
.fa-close:before,
.fa-times:before {
  content: "\f00d";
}
.fa-search-plus:before {
  content: "\f00e";
}
.fa-search-minus:before {
  content: "\f010";
}
.fa-power-off:before {
  content: "\f011";
}
.fa-signal:before {
  content: "\f012";
}
.fa-gear:before,
.fa-cog:before {
  content: "\f013";
}
.fa-trash-o:before {
  content: "\f014";
}
.fa-home:before {
  content: "\f015";
}
.fa-file-o:before {
  content: "\f016";
}
.fa-clock-o:before {
  content: "\f017";
}
.fa-road:before {
  content: "\f018";
}
.fa-download:before {
  content: "\f019";
}
.fa-arrow-circle-o-down:before {
  content: "\f01a";
}
.fa-arrow-circle-o-up:before {
  content: "\f01b";
}
.fa-inbox:before {
  content: "\f01c";
}
.fa-play-circle-o:before {
  content: "\f01d";
}
.fa-rotate-right:before,
.fa-repeat:before {
  content: "\f01e";
}
.fa-refresh:before {
  content: "\f021";
}
.fa-list-alt:before {
  content: "\f022";
}
.fa-lock:before {
  content: "\f023";
}
.fa-flag:before {
  content: "\f024";
}
.fa-headphones:before {
  content: "\f025";
}
.fa-volume-off:before {
  content: "\f026";
}
.fa-volume-down:before {
  content: "\f027";
}
.fa-volume-up:before {
  content: "\f028";
}
.fa-qrcode:before {
  content: "\f029";
}
.fa-barcode:before {
  content: "\f02a";
}
.fa-tag:before {
  content: "\f02b";
}
.fa-tags:before {
  content: "\f02c";
}
.fa-book:before {
  content: "\f02d";
}
.fa-bookmark:before {
  content: "\f02e";
}
.fa-print:before {
  content: "\f02f";
}
.fa-camera:before {
  content: "\f030";
}
.fa-font:before {
  content: "\f031";
}
.fa-bold:before {
  content: "\f032";
}
.fa-italic:before {
  content: "\f033";
}
.fa-text-height:before {
  content: "\f034";
}
.fa-text-width:before {
  content: "\f035";
}
.fa-align-left:before {
  content: "\f036";
}
.fa-align-center:before {
  content: "\f037";
}
.fa-align-right:before {
  content: "\f038";
}
.fa-align-justify:before {
  content: "\f039";
}
.fa-list:before {
  content: "\f03a";
}
.fa-dedent:before,
.fa-outdent:before {
  content: "\f03b";
}
.fa-indent:before {
  content: "\f03c";
}
.fa-video-camera:before {
  content: "\f03d";
}
.fa-photo:before,
.fa-image:before,
.fa-picture-o:before {
  content: "\f03e";
}
.fa-pencil:before {
  content: "\f040";
}
.fa-map-marker:before {
  content: "\f041";
}
.fa-adjust:before {
  content: "\f042";
}
.fa-tint:before {
  content: "\f043";
}
.fa-edit:before,
.fa-pencil-square-o:before {
  content: "\f044";
}
.fa-share-square-o:before {
  content: "\f045";
}
.fa-check-square-o:before {
  content: "\f046";
}
.fa-arrows:before {
  content: "\f047";
}
.fa-step-backward:before {
  content: "\f048";
}
.fa-fast-backward:before {
  content: "\f049";
}
.fa-backward:before {
  content: "\f04a";
}
.fa-play:before {
  content: "\f04b";
}
.fa-pause:before {
  content: "\f04c";
}
.fa-stop:before {
  content: "\f04d";
}
.fa-forward:before {
  content: "\f04e";
}
.fa-fast-forward:before {
  content: "\f050";
}
.fa-step-forward:before {
  content: "\f051";
}
.fa-eject:before {
  content: "\f052";
}
.fa-chevron-left:before {
  content: "\f053";
}
.fa-chevron-right:before {
  content: "\f054";
}
.fa-plus-circle:before {
  content: "\f055";
}
.fa-minus-circle:before {
  content: "\f056";
}
.fa-times-circle:before {
  content: "\f057";
}
.fa-check-circle:before {
  content: "\f058";
}
.fa-question-circle:before {
  content: "\f059";
}
.fa-info-circle:before {
  content: "\f05a";
}
.fa-crosshairs:before {
  content: "\f05b";
}
.fa-times-circle-o:before {
  content: "\f05c";
}
.fa-check-circle-o:before {
  content: "\f05d";
}
.fa-ban:before {
  content: "\f05e";
}
.fa-arrow-left:before {
  content: "\f060";
}
.fa-arrow-right:before {
  content: "\f061";
}
.fa-arrow-up:before {
  content: "\f062";
}
.fa-arrow-down:before {
  content: "\f063";
}
.fa-mail-forward:before,
.fa-share:before {
  content: "\f064";
}
.fa-expand:before {
  content: "\f065";
}
.fa-compress:before {
  content: "\f066";
}
.fa-plus:before {
  content: "\f067";
}
.fa-minus:before {
  content: "\f068";
}
.fa-asterisk:before {
  content: "\f069";
}
.fa-exclamation-circle:before {
  content: "\f06a";
}
.fa-gift:before {
  content: "\f06b";
}
.fa-leaf:before {
  content: "\f06c";
}
.fa-fire:before {
  content: "\f06d";
}
.fa-eye:before {
  content: "\f06e";
}
.fa-eye-slash:before {
  content: "\f070";
}
.fa-warning:before,
.fa-exclamation-triangle:before {
  content: "\f071";
}
.fa-plane:before {
  content: "\f072";
}
.fa-calendar:before {
  content: "\f073";
}
.fa-random:before {
  content: "\f074";
}
.fa-comment:before {
  content: "\f075";
}
.fa-magnet:before {
  content: "\f076";
}
.fa-chevron-up:before {
  content: "\f077";
}
.fa-chevron-down:before {
  content: "\f078";
}
.fa-retweet:before {
  content: "\f079";
}
.fa-shopping-cart:before {
  content: "\f07a";
}
.fa-folder:before {
  content: "\f07b";
}
.fa-folder-open:before {
  content: "\f07c";
}
.fa-arrows-v:before {
  content: "\f07d";
}
.fa-arrows-h:before {
  content: "\f07e";
}
.fa-bar-chart-o:before,
.fa-bar-chart:before {
  content: "\f080";
}
.fa-twitter-square:before {
  content: "\f081";
}
.fa-facebook-square:before {
  content: "\f082";
}
.fa-camera-retro:before {
  content: "\f083";
}
.fa-key:before {
  content: "\f084";
}
.fa-gears:before,
.fa-cogs:before {
  content: "\f085";
}
.fa-comments:before {
  content: "\f086";
}
.fa-thumbs-o-up:before {
  content: "\f087";
}
.fa-thumbs-o-down:before {
  content: "\f088";
}
.fa-star-half:before {
  content: "\f089";
}
.fa-heart-o:before {
  content: "\f08a";
}
.fa-sign-out:before {
  content: "\f08b";
}
.fa-linkedin-square:before {
  content: "\f08c";
}
.fa-thumb-tack:before {
  content: "\f08d";
}
.fa-external-link:before {
  content: "\f08e";
}
.fa-sign-in:before {
  content: "\f090";
}
.fa-trophy:before {
  content: "\f091";
}
.fa-github-square:before {
  content: "\f092";
}
.fa-upload:before {
  content: "\f093";
}
.fa-lemon-o:before {
  content: "\f094";
}
.fa-phone:before {
  content: "\f095";
}
.fa-square-o:before {
  content: "\f096";
}
.fa-bookmark-o:before {
  content: "\f097";
}
.fa-phone-square:before {
  content: "\f098";
}
.fa-twitter:before {
  content: "\f099";
}
.fa-facebook-f:before,
.fa-facebook:before {
  content: "\f09a";
}
.fa-github:before {
  content: "\f09b";
}
.fa-unlock:before {
  content: "\f09c";
}
.fa-credit-card:before {
  content: "\f09d";
}
.fa-feed:before,
.fa-rss:before {
  content: "\f09e";
}
.fa-hdd-o:before {
  content: "\f0a0";
}
.fa-bullhorn:before {
  content: "\f0a1";
}
.fa-bell:before {
  content: "\f0f3";
}
.fa-certificate:before {
  content: "\f0a3";
}
.fa-hand-o-right:before {
  content: "\f0a4";
}
.fa-hand-o-left:before {
  content: "\f0a5";
}
.fa-hand-o-up:before {
  content: "\f0a6";
}
.fa-hand-o-down:before {
  content: "\f0a7";
}
.fa-arrow-circle-left:before {
  content: "\f0a8";
}
.fa-arrow-circle-right:before {
  content: "\f0a9";
}
.fa-arrow-circle-up:before {
  content: "\f0aa";
}
.fa-arrow-circle-down:before {
  content: "\f0ab";
}
.fa-globe:before {
  content: "\f0ac";
}
.fa-wrench:before {
  content: "\f0ad";
}
.fa-tasks:before {
  content: "\f0ae";
}
.fa-filter:before {
  content: "\f0b0";
}
.fa-briefcase:before {
  content: "\f0b1";
}
.fa-arrows-alt:before {
  content: "\f0b2";
}
.fa-group:before,
.fa-users:before {
  content: "\f0c0";
}
.fa-chain:before,
.fa-link:before {
  content: "\f0c1";
}
.fa-cloud:before {
  content: "\f0c2";
}
.fa-flask:before {
  content: "\f0c3";
}
.fa-cut:before,
.fa-scissors:before {
  content: "\f0c4";
}
.fa-copy:before,
.fa-files-o:before {
  content: "\f0c5";
}
.fa-paperclip:before {
  content: "\f0c6";
}
.fa-save:before,
.fa-floppy-o:before {
  content: "\f0c7";
}
.fa-square:before {
  content: "\f0c8";
}
.fa-navicon:before,
.fa-reorder:before,
.fa-bars:before {
  content: "\f0c9";
}
.fa-list-ul:before {
  content: "\f0ca";
}
.fa-list-ol:before {
  content: "\f0cb";
}
.fa-strikethrough:before {
  content: "\f0cc";
}
.fa-underline:before {
  content: "\f0cd";
}
.fa-table:before {
  content: "\f0ce";
}
.fa-magic:before {
  content: "\f0d0";
}
.fa-truck:before {
  content: "\f0d1";
}
.fa-pinterest:before {
  content: "\f0d2";
}
.fa-pinterest-square:before {
  content: "\f0d3";
}
.fa-google-plus-square:before {
  content: "\f0d4";
}
.fa-google-plus:before {
  content: "\f0d5";
}
.fa-money:before {
  content: "\f0d6";
}
.fa-caret-down:before {
  content: "\f0d7";
}
.fa-caret-up:before {
  content: "\f0d8";
}
.fa-caret-left:before {
  content: "\f0d9";
}
.fa-caret-right:before {
  content: "\f0da";
}
.fa-columns:before {
  content: "\f0db";
}
.fa-unsorted:before,
.fa-sort:before {
  content: "\f0dc";
}
.fa-sort-down:before,
.fa-sort-desc:before {
  content: "\f0dd";
}
.fa-sort-up:before,
.fa-sort-asc:before {
  content: "\f0de";
}
.fa-envelope:before {
  content: "\f0e0";
}
.fa-linkedin:before {
  content: "\f0e1";
}
.fa-rotate-left:before,
.fa-undo:before {
  content: "\f0e2";
}
.fa-legal:before,
.fa-gavel:before {
  content: "\f0e3";
}
.fa-dashboard:before,
.fa-tachometer:before {
  content: "\f0e4";
}
.fa-comment-o:before {
  content: "\f0e5";
}
.fa-comments-o:before {
  content: "\f0e6";
}
.fa-flash:before,
.fa-bolt:before {
  content: "\f0e7";
}
.fa-sitemap:before {
  content: "\f0e8";
}
.fa-umbrella:before {
  content: "\f0e9";
}
.fa-paste:before,
.fa-clipboard:before {
  content: "\f0ea";
}
.fa-lightbulb-o:before {
  content: "\f0eb";
}
.fa-exchange:before {
  content: "\f0ec";
}
.fa-cloud-download:before {
  content: "\f0ed";
}
.fa-cloud-upload:before {
  content: "\f0ee";
}
.fa-user-md:before {
  content: "\f0f0";
}
.fa-stethoscope:before {
  content: "\f0f1";
}
.fa-suitcase:before {
  content: "\f0f2";
}
.fa-bell-o:before {
  content: "\f0a2";
}
.fa-coffee:before {
  content: "\f0f4";
}
.fa-cutlery:before {
  content: "\f0f5";
}
.fa-file-text-o:before {
  content: "\f0f6";
}
.fa-building-o:before {
  content: "\f0f7";
}
.fa-hospital-o:before {
  content: "\f0f8";
}
.fa-ambulance:before {
  content: "\f0f9";
}
.fa-medkit:before {
  content: "\f0fa";
}
.fa-fighter-jet:before {
  content: "\f0fb";
}
.fa-beer:before {
  content: "\f0fc";
}
.fa-h-square:before {
  content: "\f0fd";
}
.fa-plus-square:before {
  content: "\f0fe";
}
.fa-angle-double-left:before {
  content: "\f100";
}
.fa-angle-double-right:before {
  content: "\f101";
}
.fa-angle-double-up:before {
  content: "\f102";
}
.fa-angle-double-down:before {
  content: "\f103";
}
.fa-angle-left:before {
  content: "\f104";
}
.fa-angle-right:before {
  content: "\f105";
}
.fa-angle-up:before {
  content: "\f106";
}
.fa-angle-down:before {
  content: "\f107";
}
.fa-desktop:before {
  content: "\f108";
}
.fa-laptop:before {
  content: "\f109";
}
.fa-tablet:before {
  content: "\f10a";
}
.fa-mobile-phone:before,
.fa-mobile:before {
  content: "\f10b";
}
.fa-circle-o:before {
  content: "\f10c";
}
.fa-quote-left:before {
  content: "\f10d";
}
.fa-quote-right:before {
  content: "\f10e";
}
.fa-spinner:before {
  content: "\f110";
}
.fa-circle:before {
  content: "\f111";
}
.fa-mail-reply:before,
.fa-reply:before {
  content: "\f112";
}
.fa-github-alt:before {
  content: "\f113";
}
.fa-folder-o:before {
  content: "\f114";
}
.fa-folder-open-o:before {
  content: "\f115";
}
.fa-smile-o:before {
  content: "\f118";
}
.fa-frown-o:before {
  content: "\f119";
}
.fa-meh-o:before {
  content: "\f11a";
}
.fa-gamepad:before {
  content: "\f11b";
}
.fa-keyboard-o:before {
  content: "\f11c";
}
.fa-flag-o:before {
  content: "\f11d";
}
.fa-flag-checkered:before {
  content: "\f11e";
}
.fa-terminal:before {
  content: "\f120";
}
.fa-code:before {
  content: "\f121";
}
.fa-mail-reply-all:before,
.fa-reply-all:before {
  content: "\f122";
}
.fa-star-half-empty:before,
.fa-star-half-full:before,
.fa-star-half-o:before {
  content: "\f123";
}
.fa-location-arrow:before {
  content: "\f124";
}
.fa-crop:before {
  content: "\f125";
}
.fa-code-fork:before {
  content: "\f126";
}
.fa-unlink:before,
.fa-chain-broken:before {
  content: "\f127";
}
.fa-question:before {
  content: "\f128";
}
.fa-info:before {
  content: "\f129";
}
.fa-exclamation:before {
  content: "\f12a";
}
.fa-superscript:before {
  content: "\f12b";
}
.fa-subscript:before {
  content: "\f12c";
}
.fa-eraser:before {
  content: "\f12d";
}
.fa-puzzle-piece:before {
  content: "\f12e";
}
.fa-microphone:before {
  content: "\f130";
}
.fa-microphone-slash:before {
  content: "\f131";
}
.fa-shield:before {
  content: "\f132";
}
.fa-calendar-o:before {
  content: "\f133";
}
.fa-fire-extinguisher:before {
  content: "\f134";
}
.fa-rocket:before {
  content: "\f135";
}
.fa-maxcdn:before {
  content: "\f136";
}
.fa-chevron-circle-left:before {
  content: "\f137";
}
.fa-chevron-circle-right:before {
  content: "\f138";
}
.fa-chevron-circle-up:before {
  content: "\f139";
}
.fa-chevron-circle-down:before {
  content: "\f13a";
}
.fa-html5:before {
  content: "\f13b";
}
.fa-css3:before {
  content: "\f13c";
}
.fa-anchor:before {
  content: "\f13d";
}
.fa-unlock-alt:before {
  content: "\f13e";
}
.fa-bullseye:before {
  content: "\f140";
}
.fa-ellipsis-h:before {
  content: "\f141";
}
.fa-ellipsis-v:before {
  content: "\f142";
}
.fa-rss-square:before {
  content: "\f143";
}
.fa-play-circle:before {
  content: "\f144";
}
.fa-ticket:before {
  content: "\f145";
}
.fa-minus-square:before {
  content: "\f146";
}
.fa-minus-square-o:before {
  content: "\f147";
}
.fa-level-up:before {
  content: "\f148";
}
.fa-level-down:before {
  content: "\f149";
}
.fa-check-square:before {
  content: "\f14a";
}
.fa-pencil-square:before {
  content: "\f14b";
}
.fa-external-link-square:before {
  content: "\f14c";
}
.fa-share-square:before {
  content: "\f14d";
}
.fa-compass:before {
  content: "\f14e";
}
.fa-toggle-down:before,
.fa-caret-square-o-down:before {
  content: "\f150";
}
.fa-toggle-up:before,
.fa-caret-square-o-up:before {
  content: "\f151";
}
.fa-toggle-right:before,
.fa-caret-square-o-right:before {
  content: "\f152";
}
.fa-euro:before,
.fa-eur:before {
  content: "\f153";
}
.fa-gbp:before {
  content: "\f154";
}
.fa-dollar:before,
.fa-usd:before {
  content: "\f155";
}
.fa-rupee:before,
.fa-inr:before {
  content: "\f156";
}
.fa-cny:before,
.fa-rmb:before,
.fa-yen:before,
.fa-jpy:before {
  content: "\f157";
}
.fa-ruble:before,
.fa-rouble:before,
.fa-rub:before {
  content: "\f158";
}
.fa-won:before,
.fa-krw:before {
  content: "\f159";
}
.fa-bitcoin:before,
.fa-btc:before {
  content: "\f15a";
}
.fa-file:before {
  content: "\f15b";
}
.fa-file-text:before {
  content: "\f15c";
}
.fa-sort-alpha-asc:before {
  content: "\f15d";
}
.fa-sort-alpha-desc:before {
  content: "\f15e";
}
.fa-sort-amount-asc:before {
  content: "\f160";
}
.fa-sort-amount-desc:before {
  content: "\f161";
}
.fa-sort-numeric-asc:before {
  content: "\f162";
}
.fa-sort-numeric-desc:before {
  content: "\f163";
}
.fa-thumbs-up:before {
  content: "\f164";
}
.fa-thumbs-down:before {
  content: "\f165";
}
.fa-youtube-square:before {
  content: "\f166";
}
.fa-youtube:before {
  content: "\f167";
}
.fa-xing:before {
  content: "\f168";
}
.fa-xing-square:before {
  content: "\f169";
}
.fa-youtube-play:before {
  content: "\f16a";
}
.fa-dropbox:before {
  content: "\f16b";
}
.fa-stack-overflow:before {
  content: "\f16c";
}
.fa-instagram:before {
  content: "\f16d";
}
.fa-flickr:before {
  content: "\f16e";
}
.fa-adn:before {
  content: "\f170";
}
.fa-bitbucket:before {
  content: "\f171";
}
.fa-bitbucket-square:before {
  content: "\f172";
}
.fa-tumblr:before {
  content: "\f173";
}
.fa-tumblr-square:before {
  content: "\f174";
}
.fa-long-arrow-down:before {
  content: "\f175";
}
.fa-long-arrow-up:before {
  content: "\f176";
}
.fa-long-arrow-left:before {
  content: "\f177";
}
.fa-long-arrow-right:before {
  content: "\f178";
}
.fa-apple:before {
  content: "\f179";
}
.fa-windows:before {
  content: "\f17a";
}
.fa-android:before {
  content: "\f17b";
}
.fa-linux:before {
  content: "\f17c";
}
.fa-dribbble:before {
  content: "\f17d";
}
.fa-skype:before {
  content: "\f17e";
}
.fa-foursquare:before {
  content: "\f180";
}
.fa-trello:before {
  content: "\f181";
}
.fa-female:before {
  content: "\f182";
}
.fa-male:before {
  content: "\f183";
}
.fa-gittip:before,
.fa-gratipay:before {
  content: "\f184";
}
.fa-sun-o:before {
  content: "\f185";
}
.fa-moon-o:before {
  content: "\f186";
}
.fa-archive:before {
  content: "\f187";
}
.fa-bug:before {
  content: "\f188";
}
.fa-vk:before {
  content: "\f189";
}
.fa-weibo:before {
  content: "\f18a";
}
.fa-renren:before {
  content: "\f18b";
}
.fa-pagelines:before {
  content: "\f18c";
}
.fa-stack-exchange:before {
  content: "\f18d";
}
.fa-arrow-circle-o-right:before {
  content: "\f18e";
}
.fa-arrow-circle-o-left:before {
  content: "\f190";
}
.fa-toggle-left:before,
.fa-caret-square-o-left:before {
  content: "\f191";
}
.fa-dot-circle-o:before {
  content: "\f192";
}
.fa-wheelchair:before {
  content: "\f193";
}
.fa-vimeo-square:before {
  content: "\f194";
}
.fa-turkish-lira:before,
.fa-try:before {
  content: "\f195";
}
.fa-plus-square-o:before {
  content: "\f196";
}
.fa-space-shuttle:before {
  content: "\f197";
}
.fa-slack:before {
  content: "\f198";
}
.fa-envelope-square:before {
  content: "\f199";
}
.fa-wordpress:before {
  content: "\f19a";
}
.fa-openid:before {
  content: "\f19b";
}
.fa-institution:before,
.fa-bank:before,
.fa-university:before {
  content: "\f19c";
}
.fa-mortar-board:before,
.fa-graduation-cap:before {
  content: "\f19d";
}
.fa-yahoo:before {
  content: "\f19e";
}
.fa-google:before {
  content: "\f1a0";
}
.fa-reddit:before {
  content: "\f1a1";
}
.fa-reddit-square:before {
  content: "\f1a2";
}
.fa-stumbleupon-circle:before {
  content: "\f1a3";
}
.fa-stumbleupon:before {
  content: "\f1a4";
}
.fa-delicious:before {
  content: "\f1a5";
}
.fa-digg:before {
  content: "\f1a6";
}
.fa-pied-piper-pp:before {
  content: "\f1a7";
}
.fa-pied-piper-alt:before {
  content: "\f1a8";
}
.fa-drupal:before {
  content: "\f1a9";
}
.fa-joomla:before {
  content: "\f1aa";
}
.fa-language:before {
  content: "\f1ab";
}
.fa-fax:before {
  content: "\f1ac";
}
.fa-building:before {
  content: "\f1ad";
}
.fa-child:before {
  content: "\f1ae";
}
.fa-paw:before {
  content: "\f1b0";
}
.fa-spoon:before {
  content: "\f1b1";
}
.fa-cube:before {
  content: "\f1b2";
}
.fa-cubes:before {
  content: "\f1b3";
}
.fa-behance:before {
  content: "\f1b4";
}
.fa-behance-square:before {
  content: "\f1b5";
}
.fa-steam:before {
  content: "\f1b6";
}
.fa-steam-square:before {
  content: "\f1b7";
}
.fa-recycle:before {
  content: "\f1b8";
}
.fa-automobile:before,
.fa-car:before {
  content: "\f1b9";
}
.fa-cab:before,
.fa-taxi:before {
  content: "\f1ba";
}
.fa-tree:before {
  content: "\f1bb";
}
.fa-spotify:before {
  content: "\f1bc";
}
.fa-deviantart:before {
  content: "\f1bd";
}
.fa-soundcloud:before {
  content: "\f1be";
}
.fa-database:before {
  content: "\f1c0";
}
.fa-file-pdf-o:before {
  content: "\f1c1";
}
.fa-file-word-o:before {
  content: "\f1c2";
}
.fa-file-excel-o:before {
  content: "\f1c3";
}
.fa-file-powerpoint-o:before {
  content: "\f1c4";
}
.fa-file-photo-o:before,
.fa-file-picture-o:before,
.fa-file-image-o:before {
  content: "\f1c5";
}
.fa-file-zip-o:before,
.fa-file-archive-o:before {
  content: "\f1c6";
}
.fa-file-sound-o:before,
.fa-file-audio-o:before {
  content: "\f1c7";
}
.fa-file-movie-o:before,
.fa-file-video-o:before {
  content: "\f1c8";
}
.fa-file-code-o:before {
  content: "\f1c9";
}
.fa-vine:before {
  content: "\f1ca";
}
.fa-codepen:before {
  content: "\f1cb";
}
.fa-jsfiddle:before {
  content: "\f1cc";
}
.fa-life-bouy:before,
.fa-life-buoy:before,
.fa-life-saver:before,
.fa-support:before,
.fa-life-ring:before {
  content: "\f1cd";
}
.fa-circle-o-notch:before {
  content: "\f1ce";
}
.fa-ra:before,
.fa-resistance:before,
.fa-rebel:before {
  content: "\f1d0";
}
.fa-ge:before,
.fa-empire:before {
  content: "\f1d1";
}
.fa-git-square:before {
  content: "\f1d2";
}
.fa-git:before {
  content: "\f1d3";
}
.fa-y-combinator-square:before,
.fa-yc-square:before,
.fa-hacker-news:before {
  content: "\f1d4";
}
.fa-tencent-weibo:before {
  content: "\f1d5";
}
.fa-qq:before {
  content: "\f1d6";
}
.fa-wechat:before,
.fa-weixin:before {
  content: "\f1d7";
}
.fa-send:before,
.fa-paper-plane:before {
  content: "\f1d8";
}
.fa-send-o:before,
.fa-paper-plane-o:before {
  content: "\f1d9";
}
.fa-history:before {
  content: "\f1da";
}
.fa-circle-thin:before {
  content: "\f1db";
}
.fa-header:before {
  content: "\f1dc";
}
.fa-paragraph:before {
  content: "\f1dd";
}
.fa-sliders:before {
  content: "\f1de";
}
.fa-share-alt:before {
  content: "\f1e0";
}
.fa-share-alt-square:before {
  content: "\f1e1";
}
.fa-bomb:before {
  content: "\f1e2";
}
.fa-soccer-ball-o:before,
.fa-futbol-o:before {
  content: "\f1e3";
}
.fa-tty:before {
  content: "\f1e4";
}
.fa-binoculars:before {
  content: "\f1e5";
}
.fa-plug:before {
  content: "\f1e6";
}
.fa-slideshare:before {
  content: "\f1e7";
}
.fa-twitch:before {
  content: "\f1e8";
}
.fa-yelp:before {
  content: "\f1e9";
}
.fa-newspaper-o:before {
  content: "\f1ea";
}
.fa-wifi:before {
  content: "\f1eb";
}
.fa-calculator:before {
  content: "\f1ec";
}
.fa-paypal:before {
  content: "\f1ed";
}
.fa-google-wallet:before {
  content: "\f1ee";
}
.fa-cc-visa:before {
  content: "\f1f0";
}
.fa-cc-mastercard:before {
  content: "\f1f1";
}
.fa-cc-discover:before {
  content: "\f1f2";
}
.fa-cc-amex:before {
  content: "\f1f3";
}
.fa-cc-paypal:before {
  content: "\f1f4";
}
.fa-cc-stripe:before {
  content: "\f1f5";
}
.fa-bell-slash:before {
  content: "\f1f6";
}
.fa-bell-slash-o:before {
  content: "\f1f7";
}
.fa-trash:before {
  content: "\f1f8";
}
.fa-copyright:before {
  content: "\f1f9";
}
.fa-at:before {
  content: "\f1fa";
}
.fa-eyedropper:before {
  content: "\f1fb";
}
.fa-paint-brush:before {
  content: "\f1fc";
}
.fa-birthday-cake:before {
  content: "\f1fd";
}
.fa-area-chart:before {
  content: "\f1fe";
}
.fa-pie-chart:before {
  content: "\f200";
}
.fa-line-chart:before {
  content: "\f201";
}
.fa-lastfm:before {
  content: "\f202";
}
.fa-lastfm-square:before {
  content: "\f203";
}
.fa-toggle-off:before {
  content: "\f204";
}
.fa-toggle-on:before {
  content: "\f205";
}
.fa-bicycle:before {
  content: "\f206";
}
.fa-bus:before {
  content: "\f207";
}
.fa-ioxhost:before {
  content: "\f208";
}
.fa-angellist:before {
  content: "\f209";
}
.fa-cc:before {
  content: "\f20a";
}
.fa-shekel:before,
.fa-sheqel:before,
.fa-ils:before {
  content: "\f20b";
}
.fa-meanpath:before {
  content: "\f20c";
}
.fa-buysellads:before {
  content: "\f20d";
}
.fa-connectdevelop:before {
  content: "\f20e";
}
.fa-dashcube:before {
  content: "\f210";
}
.fa-forumbee:before {
  content: "\f211";
}
.fa-leanpub:before {
  content: "\f212";
}
.fa-sellsy:before {
  content: "\f213";
}
.fa-shirtsinbulk:before {
  content: "\f214";
}
.fa-simplybuilt:before {
  content: "\f215";
}
.fa-skyatlas:before {
  content: "\f216";
}
.fa-cart-plus:before {
  content: "\f217";
}
.fa-cart-arrow-down:before {
  content: "\f218";
}
.fa-diamond:before {
  content: "\f219";
}
.fa-ship:before {
  content: "\f21a";
}
.fa-user-secret:before {
  content: "\f21b";
}
.fa-motorcycle:before {
  content: "\f21c";
}
.fa-street-view:before {
  content: "\f21d";
}
.fa-heartbeat:before {
  content: "\f21e";
}
.fa-venus:before {
  content: "\f221";
}
.fa-mars:before {
  content: "\f222";
}
.fa-mercury:before {
  content: "\f223";
}
.fa-intersex:before,
.fa-transgender:before {
  content: "\f224";
}
.fa-transgender-alt:before {
  content: "\f225";
}
.fa-venus-double:before {
  content: "\f226";
}
.fa-mars-double:before {
  content: "\f227";
}
.fa-venus-mars:before {
  content: "\f228";
}
.fa-mars-stroke:before {
  content: "\f229";
}
.fa-mars-stroke-v:before {
  content: "\f22a";
}
.fa-mars-stroke-h:before {
  content: "\f22b";
}
.fa-neuter:before {
  content: "\f22c";
}
.fa-genderless:before {
  content: "\f22d";
}
.fa-facebook-official:before {
  content: "\f230";
}
.fa-pinterest-p:before {
  content: "\f231";
}
.fa-whatsapp:before {
  content: "\f232";
}
.fa-server:before {
  content: "\f233";
}
.fa-user-plus:before {
  content: "\f234";
}
.fa-user-times:before {
  content: "\f235";
}
.fa-hotel:before,
.fa-bed:before {
  content: "\f236";
}
.fa-viacoin:before {
  content: "\f237";
}
.fa-train:before {
  content: "\f238";
}
.fa-subway:before {
  content: "\f239";
}
.fa-medium:before {
  content: "\f23a";
}
.fa-yc:before,
.fa-y-combinator:before {
  content: "\f23b";
}
.fa-optin-monster:before {
  content: "\f23c";
}
.fa-opencart:before {
  content: "\f23d";
}
.fa-expeditedssl:before {
  content: "\f23e";
}
.fa-battery-4:before,
.fa-battery:before,
.fa-battery-full:before {
  content: "\f240";
}
.fa-battery-3:before,
.fa-battery-three-quarters:before {
  content: "\f241";
}
.fa-battery-2:before,
.fa-battery-half:before {
  content: "\f242";
}
.fa-battery-1:before,
.fa-battery-quarter:before {
  content: "\f243";
}
.fa-battery-0:before,
.fa-battery-empty:before {
  content: "\f244";
}
.fa-mouse-pointer:before {
  content: "\f245";
}
.fa-i-cursor:before {
  content: "\f246";
}
.fa-object-group:before {
  content: "\f247";
}
.fa-object-ungroup:before {
  content: "\f248";
}
.fa-sticky-note:before {
  content: "\f249";
}
.fa-sticky-note-o:before {
  content: "\f24a";
}
.fa-cc-jcb:before {
  content: "\f24b";
}
.fa-cc-diners-club:before {
  content: "\f24c";
}
.fa-clone:before {
  content: "\f24d";
}
.fa-balance-scale:before {
  content: "\f24e";
}
.fa-hourglass-o:before {
  content: "\f250";
}
.fa-hourglass-1:before,
.fa-hourglass-start:before {
  content: "\f251";
}
.fa-hourglass-2:before,
.fa-hourglass-half:before {
  content: "\f252";
}
.fa-hourglass-3:before,
.fa-hourglass-end:before {
  content: "\f253";
}
.fa-hourglass:before {
  content: "\f254";
}
.fa-hand-grab-o:before,
.fa-hand-rock-o:before {
  content: "\f255";
}
.fa-hand-stop-o:before,
.fa-hand-paper-o:before {
  content: "\f256";
}
.fa-hand-scissors-o:before {
  content: "\f257";
}
.fa-hand-lizard-o:before {
  content: "\f258";
}
.fa-hand-spock-o:before {
  content: "\f259";
}
.fa-hand-pointer-o:before {
  content: "\f25a";
}
.fa-hand-peace-o:before {
  content: "\f25b";
}
.fa-trademark:before {
  content: "\f25c";
}
.fa-registered:before {
  content: "\f25d";
}
.fa-creative-commons:before {
  content: "\f25e";
}
.fa-gg:before {
  content: "\f260";
}
.fa-gg-circle:before {
  content: "\f261";
}
.fa-tripadvisor:before {
  content: "\f262";
}
.fa-odnoklassniki:before {
  content: "\f263";
}
.fa-odnoklassniki-square:before {
  content: "\f264";
}
.fa-get-pocket:before {
  content: "\f265";
}
.fa-wikipedia-w:before {
  content: "\f266";
}
.fa-safari:before {
  content: "\f267";
}
.fa-chrome:before {
  content: "\f268";
}
.fa-firefox:before {
  content: "\f269";
}
.fa-opera:before {
  content: "\f26a";
}
.fa-internet-explorer:before {
  content: "\f26b";
}
.fa-tv:before,
.fa-television:before {
  content: "\f26c";
}
.fa-contao:before {
  content: "\f26d";
}
.fa-500px:before {
  content: "\f26e";
}
.fa-amazon:before {
  content: "\f270";
}
.fa-calendar-plus-o:before {
  content: "\f271";
}
.fa-calendar-minus-o:before {
  content: "\f272";
}
.fa-calendar-times-o:before {
  content: "\f273";
}
.fa-calendar-check-o:before {
  content: "\f274";
}
.fa-industry:before {
  content: "\f275";
}
.fa-map-pin:before {
  content: "\f276";
}
.fa-map-signs:before {
  content: "\f277";
}
.fa-map-o:before {
  content: "\f278";
}
.fa-map:before {
  content: "\f279";
}
.fa-commenting:before {
  content: "\f27a";
}
.fa-commenting-o:before {
  content: "\f27b";
}
.fa-houzz:before {
  content: "\f27c";
}
.fa-vimeo:before {
  content: "\f27d";
}
.fa-black-tie:before {
  content: "\f27e";
}
.fa-fonticons:before {
  content: "\f280";
}
.fa-reddit-alien:before {
  content: "\f281";
}
.fa-edge:before {
  content: "\f282";
}
.fa-credit-card-alt:before {
  content: "\f283";
}
.fa-codiepie:before {
  content: "\f284";
}
.fa-modx:before {
  content: "\f285";
}
.fa-fort-awesome:before {
  content: "\f286";
}
.fa-usb:before {
  content: "\f287";
}
.fa-product-hunt:before {
  content: "\f288";
}
.fa-mixcloud:before {
  content: "\f289";
}
.fa-scribd:before {
  content: "\f28a";
}
.fa-pause-circle:before {
  content: "\f28b";
}
.fa-pause-circle-o:before {
  content: "\f28c";
}
.fa-stop-circle:before {
  content: "\f28d";
}
.fa-stop-circle-o:before {
  content: "\f28e";
}
.fa-shopping-bag:before {
  content: "\f290";
}
.fa-shopping-basket:before {
  content: "\f291";
}
.fa-hashtag:before {
  content: "\f292";
}
.fa-bluetooth:before {
  content: "\f293";
}
.fa-bluetooth-b:before {
  content: "\f294";
}
.fa-percent:before {
  content: "\f295";
}
.fa-gitlab:before {
  content: "\f296";
}
.fa-wpbeginner:before {
  content: "\f297";
}
.fa-wpforms:before {
  content: "\f298";
}
.fa-envira:before {
  content: "\f299";
}
.fa-universal-access:before {
  content: "\f29a";
}
.fa-wheelchair-alt:before {
  content: "\f29b";
}
.fa-question-circle-o:before {
  content: "\f29c";
}
.fa-blind:before {
  content: "\f29d";
}
.fa-audio-description:before {
  content: "\f29e";
}
.fa-volume-control-phone:before {
  content: "\f2a0";
}
.fa-braille:before {
  content: "\f2a1";
}
.fa-assistive-listening-systems:before {
  content: "\f2a2";
}
.fa-asl-interpreting:before,
.fa-american-sign-language-interpreting:before {
  content: "\f2a3";
}
.fa-deafness:before,
.fa-hard-of-hearing:before,
.fa-deaf:before {
  content: "\f2a4";
}
.fa-glide:before {
  content: "\f2a5";
}
.fa-glide-g:before {
  content: "\f2a6";
}
.fa-signing:before,
.fa-sign-language:before {
  content: "\f2a7";
}
.fa-low-vision:before {
  content: "\f2a8";
}
.fa-viadeo:before {
  content: "\f2a9";
}
.fa-viadeo-square:before {
  content: "\f2aa";
}
.fa-snapchat:before {
  content: "\f2ab";
}
.fa-snapchat-ghost:before {
  content: "\f2ac";
}
.fa-snapchat-square:before {
  content: "\f2ad";
}
.fa-pied-piper:before {
  content: "\f2ae";
}
.fa-first-order:before {
  content: "\f2b0";
}
.fa-yoast:before {
  content: "\f2b1";
}
.fa-themeisle:before {
  content: "\f2b2";
}
.fa-google-plus-circle:before,
.fa-google-plus-official:before {
  content: "\f2b3";
}
.fa-fa:before,
.fa-font-awesome:before {
  content: "\f2b4";
}
.fa-handshake-o:before {
  content: "\f2b5";
}
.fa-envelope-open:before {
  content: "\f2b6";
}
.fa-envelope-open-o:before {
  content: "\f2b7";
}
.fa-linode:before {
  content: "\f2b8";
}
.fa-address-book:before {
  content: "\f2b9";
}
.fa-address-book-o:before {
  content: "\f2ba";
}
.fa-vcard:before,
.fa-address-card:before {
  content: "\f2bb";
}
.fa-vcard-o:before,
.fa-address-card-o:before {
  content: "\f2bc";
}
.fa-user-circle:before {
  content: "\f2bd";
}
.fa-user-circle-o:before {
  content: "\f2be";
}
.fa-user-o:before {
  content: "\f2c0";
}
.fa-id-badge:before {
  content: "\f2c1";
}
.fa-drivers-license:before,
.fa-id-card:before {
  content: "\f2c2";
}
.fa-drivers-license-o:before,
.fa-id-card-o:before {
  content: "\f2c3";
}
.fa-quora:before {
  content: "\f2c4";
}
.fa-free-code-camp:before {
  content: "\f2c5";
}
.fa-telegram:before {
  content: "\f2c6";
}
.fa-thermometer-4:before,
.fa-thermometer:before,
.fa-thermometer-full:before {
  content: "\f2c7";
}
.fa-thermometer-3:before,
.fa-thermometer-three-quarters:before {
  content: "\f2c8";
}
.fa-thermometer-2:before,
.fa-thermometer-half:before {
  content: "\f2c9";
}
.fa-thermometer-1:before,
.fa-thermometer-quarter:before {
  content: "\f2ca";
}
.fa-thermometer-0:before,
.fa-thermometer-empty:before {
  content: "\f2cb";
}
.fa-shower:before {
  content: "\f2cc";
}
.fa-bathtub:before,
.fa-s15:before,
.fa-bath:before {
  content: "\f2cd";
}
.fa-podcast:before {
  content: "\f2ce";
}
.fa-window-maximize:before {
  content: "\f2d0";
}
.fa-window-minimize:before {
  content: "\f2d1";
}
.fa-window-restore:before {
  content: "\f2d2";
}
.fa-times-rectangle:before,
.fa-window-close:before {
  content: "\f2d3";
}
.fa-times-rectangle-o:before,
.fa-window-close-o:before {
  content: "\f2d4";
}
.fa-bandcamp:before {
  content: "\f2d5";
}
.fa-grav:before {
  content: "\f2d6";
}
.fa-etsy:before {
  content: "\f2d7";
}
.fa-imdb:before {
  content: "\f2d8";
}
.fa-ravelry:before {
  content: "\f2d9";
}
.fa-eercast:before {
  content: "\f2da";
}
.fa-microchip:before {
  content: "\f2db";
}
.fa-snowflake-o:before {
  content: "\f2dc";
}
.fa-superpowers:before {
  content: "\f2dd";
}
.fa-wpexplorer:before {
  content: "\f2de";
}
.fa-meetup:before {
  content: "\f2e0";
}
.sr-only {
  position: absolute;
  width: 1px;
  height: 1px;
  padding: 0;
  margin: -1px;
  overflow: hidden;
  clip: rect(0, 0, 0, 0);
  border: 0;
}
.sr-only-focusable:active,
.sr-only-focusable:focus {
  position: static;
  width: auto;
  height: auto;
  margin: 0;
  overflow: visible;
  clip: auto;
}
.sr-only-focusable:active,
.sr-only-focusable:focus {
  position: static;
  width: auto;
  height: auto;
  margin: 0;
  overflow: visible;
  clip: auto;
}
/*!
*
* IPython base
*
*/
.modal.fade .modal-dialog {
  -webkit-transform: translate(0, 0);
  -ms-transform: translate(0, 0);
  -o-transform: translate(0, 0);
  transform: translate(0, 0);
}
code {
  color: #000;
}
pre {
  font-size: inherit;
  line-height: inherit;
}
label {
  font-weight: normal;
}
/* Make the page background atleast 100% the height of the view port */
/* Make the page itself atleast 70% the height of the view port */
.border-box-sizing {
  box-sizing: border-box;
  -moz-box-sizing: border-box;
  -webkit-box-sizing: border-box;
}
.corner-all {
  border-radius: 2px;
}
.no-padding {
  padding: 0px;
}
/* Flexible box model classes */
/* Taken from Alex Russell http://infrequently.org/2009/08/css-3-progress/ */
/* This file is a compatability layer.  It allows the usage of flexible box 
model layouts accross multiple browsers, including older browsers.  The newest,
universal implementation of the flexible box model is used when available (see
`Modern browsers` comments below).  Browsers that are known to implement this 
new spec completely include:

    Firefox 28.0+
    Chrome 29.0+
    Internet Explorer 11+ 
    Opera 17.0+

Browsers not listed, including Safari, are supported via the styling under the
`Old browsers` comments below.
*/
.hbox {
  /* Old browsers */
  display: -webkit-box;
  -webkit-box-orient: horizontal;
  -webkit-box-align: stretch;
  display: -moz-box;
  -moz-box-orient: horizontal;
  -moz-box-align: stretch;
  display: box;
  box-orient: horizontal;
  box-align: stretch;
  /* Modern browsers */
  display: flex;
  flex-direction: row;
  align-items: stretch;
}
.hbox > * {
  /* Old browsers */
  -webkit-box-flex: 0;
  -moz-box-flex: 0;
  box-flex: 0;
  /* Modern browsers */
  flex: none;
}
.vbox {
  /* Old browsers */
  display: -webkit-box;
  -webkit-box-orient: vertical;
  -webkit-box-align: stretch;
  display: -moz-box;
  -moz-box-orient: vertical;
  -moz-box-align: stretch;
  display: box;
  box-orient: vertical;
  box-align: stretch;
  /* Modern browsers */
  display: flex;
  flex-direction: column;
  align-items: stretch;
}
.vbox > * {
  /* Old browsers */
  -webkit-box-flex: 0;
  -moz-box-flex: 0;
  box-flex: 0;
  /* Modern browsers */
  flex: none;
}
.hbox.reverse,
.vbox.reverse,
.reverse {
  /* Old browsers */
  -webkit-box-direction: reverse;
  -moz-box-direction: reverse;
  box-direction: reverse;
  /* Modern browsers */
  flex-direction: row-reverse;
}
.hbox.box-flex0,
.vbox.box-flex0,
.box-flex0 {
  /* Old browsers */
  -webkit-box-flex: 0;
  -moz-box-flex: 0;
  box-flex: 0;
  /* Modern browsers */
  flex: none;
  width: auto;
}
.hbox.box-flex1,
.vbox.box-flex1,
.box-flex1 {
  /* Old browsers */
  -webkit-box-flex: 1;
  -moz-box-flex: 1;
  box-flex: 1;
  /* Modern browsers */
  flex: 1;
}
.hbox.box-flex,
.vbox.box-flex,
.box-flex {
  /* Old browsers */
  /* Old browsers */
  -webkit-box-flex: 1;
  -moz-box-flex: 1;
  box-flex: 1;
  /* Modern browsers */
  flex: 1;
}
.hbox.box-flex2,
.vbox.box-flex2,
.box-flex2 {
  /* Old browsers */
  -webkit-box-flex: 2;
  -moz-box-flex: 2;
  box-flex: 2;
  /* Modern browsers */
  flex: 2;
}
.box-group1 {
  /*  Deprecated */
  -webkit-box-flex-group: 1;
  -moz-box-flex-group: 1;
  box-flex-group: 1;
}
.box-group2 {
  /* Deprecated */
  -webkit-box-flex-group: 2;
  -moz-box-flex-group: 2;
  box-flex-group: 2;
}
.hbox.start,
.vbox.start,
.start {
  /* Old browsers */
  -webkit-box-pack: start;
  -moz-box-pack: start;
  box-pack: start;
  /* Modern browsers */
  justify-content: flex-start;
}
.hbox.end,
.vbox.end,
.end {
  /* Old browsers */
  -webkit-box-pack: end;
  -moz-box-pack: end;
  box-pack: end;
  /* Modern browsers */
  justify-content: flex-end;
}
.hbox.center,
.vbox.center,
.center {
  /* Old browsers */
  -webkit-box-pack: center;
  -moz-box-pack: center;
  box-pack: center;
  /* Modern browsers */
  justify-content: center;
}
.hbox.baseline,
.vbox.baseline,
.baseline {
  /* Old browsers */
  -webkit-box-pack: baseline;
  -moz-box-pack: baseline;
  box-pack: baseline;
  /* Modern browsers */
  justify-content: baseline;
}
.hbox.stretch,
.vbox.stretch,
.stretch {
  /* Old browsers */
  -webkit-box-pack: stretch;
  -moz-box-pack: stretch;
  box-pack: stretch;
  /* Modern browsers */
  justify-content: stretch;
}
.hbox.align-start,
.vbox.align-start,
.align-start {
  /* Old browsers */
  -webkit-box-align: start;
  -moz-box-align: start;
  box-align: start;
  /* Modern browsers */
  align-items: flex-start;
}
.hbox.align-end,
.vbox.align-end,
.align-end {
  /* Old browsers */
  -webkit-box-align: end;
  -moz-box-align: end;
  box-align: end;
  /* Modern browsers */
  align-items: flex-end;
}
.hbox.align-center,
.vbox.align-center,
.align-center {
  /* Old browsers */
  -webkit-box-align: center;
  -moz-box-align: center;
  box-align: center;
  /* Modern browsers */
  align-items: center;
}
.hbox.align-baseline,
.vbox.align-baseline,
.align-baseline {
  /* Old browsers */
  -webkit-box-align: baseline;
  -moz-box-align: baseline;
  box-align: baseline;
  /* Modern browsers */
  align-items: baseline;
}
.hbox.align-stretch,
.vbox.align-stretch,
.align-stretch {
  /* Old browsers */
  -webkit-box-align: stretch;
  -moz-box-align: stretch;
  box-align: stretch;
  /* Modern browsers */
  align-items: stretch;
}
div.error {
  margin: 2em;
  text-align: center;
}
div.error > h1 {
  font-size: 500%;
  line-height: normal;
}
div.error > p {
  font-size: 200%;
  line-height: normal;
}
div.traceback-wrapper {
  text-align: left;
  max-width: 800px;
  margin: auto;
}
div.traceback-wrapper pre.traceback {
  max-height: 600px;
  overflow: auto;
}
/**
 * Primary styles
 *
 * Author: Jupyter Development Team
 */
body {
  background-color: #fff;
  /* This makes sure that the body covers the entire window and needs to
       be in a different element than the display: box in wrapper below */
  position: absolute;
  left: 0px;
  right: 0px;
  top: 0px;
  bottom: 0px;
  overflow: visible;
}
body > #header {
  /* Initially hidden to prevent FLOUC */
  display: none;
  background-color: #fff;
  /* Display over codemirror */
  position: relative;
  z-index: 100;
}
body > #header #header-container {
  display: flex;
  flex-direction: row;
  justify-content: space-between;
  padding: 5px;
  padding-bottom: 5px;
  padding-top: 5px;
  box-sizing: border-box;
  -moz-box-sizing: border-box;
  -webkit-box-sizing: border-box;
}
body > #header .header-bar {
  width: 100%;
  height: 1px;
  background: #e7e7e7;
  margin-bottom: -1px;
}
@media print {
  body > #header {
    display: none !important;
  }
}
#header-spacer {
  width: 100%;
  visibility: hidden;
}
@media print {
  #header-spacer {
    display: none;
  }
}
#ipython_notebook {
  padding-left: 0px;
  padding-top: 1px;
  padding-bottom: 1px;
}
[dir="rtl"] #ipython_notebook {
  margin-right: 10px;
  margin-left: 0;
}
[dir="rtl"] #ipython_notebook.pull-left {
  float: right !important;
  float: right;
}
.flex-spacer {
  flex: 1;
}
#noscript {
  width: auto;
  padding-top: 16px;
  padding-bottom: 16px;
  text-align: center;
  font-size: 22px;
  color: red;
  font-weight: bold;
}
#ipython_notebook img {
  height: 28px;
}
#site {
  width: 100%;
  display: none;
  box-sizing: border-box;
  -moz-box-sizing: border-box;
  -webkit-box-sizing: border-box;
  overflow: auto;
}
@media print {
  #site {
    height: auto !important;
  }
}
/* Smaller buttons */
.ui-button .ui-button-text {
  padding: 0.2em 0.8em;
  font-size: 77%;
}
input.ui-button {
  padding: 0.3em 0.9em;
}
span#kernel_logo_widget {
  margin: 0 10px;
}
span#login_widget {
  float: right;
}
[dir="rtl"] span#login_widget {
  float: left;
}
span#login_widget > .button,
#logout {
  color: #333;
  background-color: #fff;
  border-color: #ccc;
}
span#login_widget > .button:focus,
#logout:focus,
span#login_widget > .button.focus,
#logout.focus {
  color: #333;
  background-color: #e6e6e6;
  border-color: #8c8c8c;
}
span#login_widget > .button:hover,
#logout:hover {
  color: #333;
  background-color: #e6e6e6;
  border-color: #adadad;
}
span#login_widget > .button:active,
#logout:active,
span#login_widget > .button.active,
#logout.active,
.open > .dropdown-togglespan#login_widget > .button,
.open > .dropdown-toggle#logout {
  color: #333;
  background-color: #e6e6e6;
  border-color: #adadad;
}
span#login_widget > .button:active:hover,
#logout:active:hover,
span#login_widget > .button.active:hover,
#logout.active:hover,
.open > .dropdown-togglespan#login_widget > .button:hover,
.open > .dropdown-toggle#logout:hover,
span#login_widget > .button:active:focus,
#logout:active:focus,
span#login_widget > .button.active:focus,
#logout.active:focus,
.open > .dropdown-togglespan#login_widget > .button:focus,
.open > .dropdown-toggle#logout:focus,
span#login_widget > .button:active.focus,
#logout:active.focus,
span#login_widget > .button.active.focus,
#logout.active.focus,
.open > .dropdown-togglespan#login_widget > .button.focus,
.open > .dropdown-toggle#logout.focus {
  color: #333;
  background-color: #d4d4d4;
  border-color: #8c8c8c;
}
span#login_widget > .button:active,
#logout:active,
span#login_widget > .button.active,
#logout.active,
.open > .dropdown-togglespan#login_widget > .button,
.open > .dropdown-toggle#logout {
  background-image: none;
}
span#login_widget > .button.disabled:hover,
#logout.disabled:hover,
span#login_widget > .button[disabled]:hover,
#logout[disabled]:hover,
fieldset[disabled] span#login_widget > .button:hover,
fieldset[disabled] #logout:hover,
span#login_widget > .button.disabled:focus,
#logout.disabled:focus,
span#login_widget > .button[disabled]:focus,
#logout[disabled]:focus,
fieldset[disabled] span#login_widget > .button:focus,
fieldset[disabled] #logout:focus,
span#login_widget > .button.disabled.focus,
#logout.disabled.focus,
span#login_widget > .button[disabled].focus,
#logout[disabled].focus,
fieldset[disabled] span#login_widget > .button.focus,
fieldset[disabled] #logout.focus {
  background-color: #fff;
  border-color: #ccc;
}
span#login_widget > .button .badge,
#logout .badge {
  color: #fff;
  background-color: #333;
}
.nav-header {
  text-transform: none;
}
#header > span {
  margin-top: 10px;
}
.modal_stretch .modal-dialog {
  /* Old browsers */
  display: -webkit-box;
  -webkit-box-orient: vertical;
  -webkit-box-align: stretch;
  display: -moz-box;
  -moz-box-orient: vertical;
  -moz-box-align: stretch;
  display: box;
  box-orient: vertical;
  box-align: stretch;
  /* Modern browsers */
  display: flex;
  flex-direction: column;
  align-items: stretch;
  min-height: 80vh;
}
.modal_stretch .modal-dialog .modal-body {
  max-height: calc(100vh - 200px);
  overflow: auto;
  flex: 1;
}
.modal-header {
  cursor: move;
}
@media (min-width: 768px) {
  .modal .modal-dialog {
    width: 700px;
  }
}
@media (min-width: 768px) {
  select.form-control {
    margin-left: 12px;
    margin-right: 12px;
  }
}
/*!
*
* IPython auth
*
*/
.center-nav {
  display: inline-block;
  margin-bottom: -4px;
}
[dir="rtl"] .center-nav form.pull-left {
  float: right !important;
  float: right;
}
[dir="rtl"] .center-nav .navbar-text {
  float: right;
}
[dir="rtl"] .navbar-inner {
  text-align: right;
}
[dir="rtl"] div.text-left {
  text-align: right;
}
/*!
*
* IPython tree view
*
*/
/* We need an invisible input field on top of the sentense*/
/* "Drag file onto the list ..." */
.alternate_upload {
  background-color: none;
  display: inline;
}
.alternate_upload.form {
  padding: 0;
  margin: 0;
}
.alternate_upload input.fileinput {
  position: absolute;
  display: block;
  width: 100%;
  height: 100%;
  overflow: hidden;
  cursor: pointer;
  opacity: 0;
  z-index: 2;
}
.alternate_upload .btn-xs > input.fileinput {
  margin: -1px -5px;
}
.alternate_upload .btn-upload {
  position: relative;
  height: 22px;
}
::-webkit-file-upload-button {
  cursor: pointer;
}
/**
 * Primary styles
 *
 * Author: Jupyter Development Team
 */
ul#tabs {
  margin-bottom: 4px;
}
ul#tabs a {
  padding-top: 6px;
  padding-bottom: 4px;
}
[dir="rtl"] ul#tabs.nav-tabs > li {
  float: right;
}
[dir="rtl"] ul#tabs.nav.nav-tabs {
  padding-right: 0;
}
ul.breadcrumb a:focus,
ul.breadcrumb a:hover {
  text-decoration: none;
}
ul.breadcrumb i.icon-home {
  font-size: 16px;
  margin-right: 4px;
}
ul.breadcrumb span {
  color: #5e5e5e;
}
.list_toolbar {
  padding: 4px 0 4px 0;
  vertical-align: middle;
}
.list_toolbar .tree-buttons {
  padding-top: 1px;
}
[dir="rtl"] .list_toolbar .tree-buttons .pull-right {
  float: left !important;
  float: left;
}
[dir="rtl"] .list_toolbar .col-sm-4,
[dir="rtl"] .list_toolbar .col-sm-8 {
  float: right;
}
.dynamic-buttons {
  padding-top: 3px;
  display: inline-block;
}
.list_toolbar [class*="span"] {
  min-height: 24px;
}
.list_header {
  font-weight: bold;
  background-color: #EEE;
}
.list_placeholder {
  font-weight: bold;
  padding-top: 4px;
  padding-bottom: 4px;
  padding-left: 7px;
  padding-right: 7px;
}
.list_container {
  margin-top: 4px;
  margin-bottom: 20px;
  border: 1px solid #ddd;
  border-radius: 2px;
}
.list_container > div {
  border-bottom: 1px solid #ddd;
}
.list_container > div:hover .list-item {
  background-color: red;
}
.list_container > div:last-child {
  border: none;
}
.list_item:hover .list_item {
  background-color: #ddd;
}
.list_item a {
  text-decoration: none;
}
.list_item:hover {
  background-color: #fafafa;
}
.list_header > div,
.list_item > div {
  padding-top: 4px;
  padding-bottom: 4px;
  padding-left: 7px;
  padding-right: 7px;
  line-height: 22px;
}
.list_header > div input,
.list_item > div input {
  margin-right: 7px;
  margin-left: 14px;
  vertical-align: text-bottom;
  line-height: 22px;
  position: relative;
  top: -1px;
}
.list_header > div .item_link,
.list_item > div .item_link {
  margin-left: -1px;
  vertical-align: baseline;
  line-height: 22px;
}
[dir="rtl"] .list_item > div input {
  margin-right: 0;
}
.new-file input[type=checkbox] {
  visibility: hidden;
}
.item_name {
  line-height: 22px;
  height: 24px;
}
.item_icon {
  font-size: 14px;
  color: #5e5e5e;
  margin-right: 7px;
  margin-left: 7px;
  line-height: 22px;
  vertical-align: baseline;
}
.item_modified {
  margin-right: 7px;
  margin-left: 7px;
}
[dir="rtl"] .item_modified.pull-right {
  float: left !important;
  float: left;
}
.item_buttons {
  line-height: 1em;
  margin-left: -5px;
}
.item_buttons .btn,
.item_buttons .btn-group,
.item_buttons .input-group {
  float: left;
}
.item_buttons > .btn,
.item_buttons > .btn-group,
.item_buttons > .input-group {
  margin-left: 5px;
}
.item_buttons .btn {
  min-width: 13ex;
}
.item_buttons .running-indicator {
  padding-top: 4px;
  color: #5cb85c;
}
.item_buttons .kernel-name {
  padding-top: 4px;
  color: #5bc0de;
  margin-right: 7px;
  float: left;
}
[dir="rtl"] .item_buttons.pull-right {
  float: left !important;
  float: left;
}
[dir="rtl"] .item_buttons .kernel-name {
  margin-left: 7px;
  float: right;
}
.toolbar_info {
  height: 24px;
  line-height: 24px;
}
.list_item input:not([type=checkbox]) {
  padding-top: 3px;
  padding-bottom: 3px;
  height: 22px;
  line-height: 14px;
  margin: 0px;
}
.highlight_text {
  color: blue;
}
#project_name {
  display: inline-block;
  padding-left: 7px;
  margin-left: -2px;
}
#project_name > .breadcrumb {
  padding: 0px;
  margin-bottom: 0px;
  background-color: transparent;
  font-weight: bold;
}
.sort_button {
  display: inline-block;
  padding-left: 7px;
}
[dir="rtl"] .sort_button.pull-right {
  float: left !important;
  float: left;
}
#tree-selector {
  padding-right: 0px;
}
#button-select-all {
  min-width: 50px;
}
[dir="rtl"] #button-select-all.btn {
  float: right ;
}
#select-all {
  margin-left: 7px;
  margin-right: 2px;
  margin-top: 2px;
  height: 16px;
}
[dir="rtl"] #select-all.pull-left {
  float: right !important;
  float: right;
}
.menu_icon {
  margin-right: 2px;
}
.tab-content .row {
  margin-left: 0px;
  margin-right: 0px;
}
.folder_icon:before {
  display: inline-block;
  font: normal normal normal 14px/1 FontAwesome;
  font-size: inherit;
  text-rendering: auto;
  -webkit-font-smoothing: antialiased;
  -moz-osx-font-smoothing: grayscale;
  content: "\f114";
}
.folder_icon:before.fa-pull-left {
  margin-right: .3em;
}
.folder_icon:before.fa-pull-right {
  margin-left: .3em;
}
.folder_icon:before.pull-left {
  margin-right: .3em;
}
.folder_icon:before.pull-right {
  margin-left: .3em;
}
.notebook_icon:before {
  display: inline-block;
  font: normal normal normal 14px/1 FontAwesome;
  font-size: inherit;
  text-rendering: auto;
  -webkit-font-smoothing: antialiased;
  -moz-osx-font-smoothing: grayscale;
  content: "\f02d";
  position: relative;
  top: -1px;
}
.notebook_icon:before.fa-pull-left {
  margin-right: .3em;
}
.notebook_icon:before.fa-pull-right {
  margin-left: .3em;
}
.notebook_icon:before.pull-left {
  margin-right: .3em;
}
.notebook_icon:before.pull-right {
  margin-left: .3em;
}
.running_notebook_icon:before {
  display: inline-block;
  font: normal normal normal 14px/1 FontAwesome;
  font-size: inherit;
  text-rendering: auto;
  -webkit-font-smoothing: antialiased;
  -moz-osx-font-smoothing: grayscale;
  content: "\f02d";
  position: relative;
  top: -1px;
  color: #5cb85c;
}
.running_notebook_icon:before.fa-pull-left {
  margin-right: .3em;
}
.running_notebook_icon:before.fa-pull-right {
  margin-left: .3em;
}
.running_notebook_icon:before.pull-left {
  margin-right: .3em;
}
.running_notebook_icon:before.pull-right {
  margin-left: .3em;
}
.file_icon:before {
  display: inline-block;
  font: normal normal normal 14px/1 FontAwesome;
  font-size: inherit;
  text-rendering: auto;
  -webkit-font-smoothing: antialiased;
  -moz-osx-font-smoothing: grayscale;
  content: "\f016";
  position: relative;
  top: -2px;
}
.file_icon:before.fa-pull-left {
  margin-right: .3em;
}
.file_icon:before.fa-pull-right {
  margin-left: .3em;
}
.file_icon:before.pull-left {
  margin-right: .3em;
}
.file_icon:before.pull-right {
  margin-left: .3em;
}
#notebook_toolbar .pull-right {
  padding-top: 0px;
  margin-right: -1px;
}
ul#new-menu {
  left: auto;
  right: 0;
}
#new-menu .dropdown-header {
  font-size: 10px;
  border-bottom: 1px solid #e5e5e5;
  padding: 0 0 3px;
  margin: -3px 20px 0;
}
.kernel-menu-icon {
  padding-right: 12px;
  width: 24px;
  content: "\f096";
}
.kernel-menu-icon:before {
  content: "\f096";
}
.kernel-menu-icon-current:before {
  content: "\f00c";
}
#tab_content {
  padding-top: 20px;
}
#running .panel-group .panel {
  margin-top: 3px;
  margin-bottom: 1em;
}
#running .panel-group .panel .panel-heading {
  background-color: #EEE;
  padding-top: 4px;
  padding-bottom: 4px;
  padding-left: 7px;
  padding-right: 7px;
  line-height: 22px;
}
#running .panel-group .panel .panel-heading a:focus,
#running .panel-group .panel .panel-heading a:hover {
  text-decoration: none;
}
#running .panel-group .panel .panel-body {
  padding: 0px;
}
#running .panel-group .panel .panel-body .list_container {
  margin-top: 0px;
  margin-bottom: 0px;
  border: 0px;
  border-radius: 0px;
}
#running .panel-group .panel .panel-body .list_container .list_item {
  border-bottom: 1px solid #ddd;
}
#running .panel-group .panel .panel-body .list_container .list_item:last-child {
  border-bottom: 0px;
}
.delete-button {
  display: none;
}
.duplicate-button {
  display: none;
}
.rename-button {
  display: none;
}
.move-button {
  display: none;
}
.download-button {
  display: none;
}
.shutdown-button {
  display: none;
}
.dynamic-instructions {
  display: inline-block;
  padding-top: 4px;
}
/*!
*
* IPython text editor webapp
*
*/
.selected-keymap i.fa {
  padding: 0px 5px;
}
.selected-keymap i.fa:before {
  content: "\f00c";
}
#mode-menu {
  overflow: auto;
  max-height: 20em;
}
.edit_app #header {
  -webkit-box-shadow: 0px 0px 12px 1px rgba(87, 87, 87, 0.2);
  box-shadow: 0px 0px 12px 1px rgba(87, 87, 87, 0.2);
}
.edit_app #menubar .navbar {
  /* Use a negative 1 bottom margin, so the border overlaps the border of the
    header */
  margin-bottom: -1px;
}
.dirty-indicator {
  display: inline-block;
  font: normal normal normal 14px/1 FontAwesome;
  font-size: inherit;
  text-rendering: auto;
  -webkit-font-smoothing: antialiased;
  -moz-osx-font-smoothing: grayscale;
  width: 20px;
}
.dirty-indicator.fa-pull-left {
  margin-right: .3em;
}
.dirty-indicator.fa-pull-right {
  margin-left: .3em;
}
.dirty-indicator.pull-left {
  margin-right: .3em;
}
.dirty-indicator.pull-right {
  margin-left: .3em;
}
.dirty-indicator-dirty {
  display: inline-block;
  font: normal normal normal 14px/1 FontAwesome;
  font-size: inherit;
  text-rendering: auto;
  -webkit-font-smoothing: antialiased;
  -moz-osx-font-smoothing: grayscale;
  width: 20px;
}
.dirty-indicator-dirty.fa-pull-left {
  margin-right: .3em;
}
.dirty-indicator-dirty.fa-pull-right {
  margin-left: .3em;
}
.dirty-indicator-dirty.pull-left {
  margin-right: .3em;
}
.dirty-indicator-dirty.pull-right {
  margin-left: .3em;
}
.dirty-indicator-clean {
  display: inline-block;
  font: normal normal normal 14px/1 FontAwesome;
  font-size: inherit;
  text-rendering: auto;
  -webkit-font-smoothing: antialiased;
  -moz-osx-font-smoothing: grayscale;
  width: 20px;
}
.dirty-indicator-clean.fa-pull-left {
  margin-right: .3em;
}
.dirty-indicator-clean.fa-pull-right {
  margin-left: .3em;
}
.dirty-indicator-clean.pull-left {
  margin-right: .3em;
}
.dirty-indicator-clean.pull-right {
  margin-left: .3em;
}
.dirty-indicator-clean:before {
  display: inline-block;
  font: normal normal normal 14px/1 FontAwesome;
  font-size: inherit;
  text-rendering: auto;
  -webkit-font-smoothing: antialiased;
  -moz-osx-font-smoothing: grayscale;
  content: "\f00c";
}
.dirty-indicator-clean:before.fa-pull-left {
  margin-right: .3em;
}
.dirty-indicator-clean:before.fa-pull-right {
  margin-left: .3em;
}
.dirty-indicator-clean:before.pull-left {
  margin-right: .3em;
}
.dirty-indicator-clean:before.pull-right {
  margin-left: .3em;
}
#filename {
  font-size: 16pt;
  display: table;
  padding: 0px 5px;
}
#current-mode {
  padding-left: 5px;
  padding-right: 5px;
}
#texteditor-backdrop {
  padding-top: 20px;
  padding-bottom: 20px;
}
@media not print {
  #texteditor-backdrop {
    background-color: #EEE;
  }
}
@media print {
  #texteditor-backdrop #texteditor-container .CodeMirror-gutter,
  #texteditor-backdrop #texteditor-container .CodeMirror-gutters {
    background-color: #fff;
  }
}
@media not print {
  #texteditor-backdrop #texteditor-container .CodeMirror-gutter,
  #texteditor-backdrop #texteditor-container .CodeMirror-gutters {
    background-color: #fff;
  }
}
@media not print {
  #texteditor-backdrop #texteditor-container {
    padding: 0px;
    background-color: #fff;
    -webkit-box-shadow: 0px 0px 12px 1px rgba(87, 87, 87, 0.2);
    box-shadow: 0px 0px 12px 1px rgba(87, 87, 87, 0.2);
  }
}
.CodeMirror-dialog {
  background-color: #fff;
}
/*!
*
* IPython notebook
*
*/
/* CSS font colors for translated ANSI escape sequences */
/* The color values are a mix of
   http://www.xcolors.net/dl/baskerville-ivorylight and
   http://www.xcolors.net/dl/euphrasia */
.ansi-black-fg {
  color: #3E424D;
}
.ansi-black-bg {
  background-color: #3E424D;
}
.ansi-black-intense-fg {
  color: #282C36;
}
.ansi-black-intense-bg {
  background-color: #282C36;
}
.ansi-red-fg {
  color: #E75C58;
}
.ansi-red-bg {
  background-color: #E75C58;
}
.ansi-red-intense-fg {
  color: #B22B31;
}
.ansi-red-intense-bg {
  background-color: #B22B31;
}
.ansi-green-fg {
  color: #00A250;
}
.ansi-green-bg {
  background-color: #00A250;
}
.ansi-green-intense-fg {
  color: #007427;
}
.ansi-green-intense-bg {
  background-color: #007427;
}
.ansi-yellow-fg {
  color: #DDB62B;
}
.ansi-yellow-bg {
  background-color: #DDB62B;
}
.ansi-yellow-intense-fg {
  color: #B27D12;
}
.ansi-yellow-intense-bg {
  background-color: #B27D12;
}
.ansi-blue-fg {
  color: #208FFB;
}
.ansi-blue-bg {
  background-color: #208FFB;
}
.ansi-blue-intense-fg {
  color: #0065CA;
}
.ansi-blue-intense-bg {
  background-color: #0065CA;
}
.ansi-magenta-fg {
  color: #D160C4;
}
.ansi-magenta-bg {
  background-color: #D160C4;
}
.ansi-magenta-intense-fg {
  color: #A03196;
}
.ansi-magenta-intense-bg {
  background-color: #A03196;
}
.ansi-cyan-fg {
  color: #60C6C8;
}
.ansi-cyan-bg {
  background-color: #60C6C8;
}
.ansi-cyan-intense-fg {
  color: #258F8F;
}
.ansi-cyan-intense-bg {
  background-color: #258F8F;
}
.ansi-white-fg {
  color: #C5C1B4;
}
.ansi-white-bg {
  background-color: #C5C1B4;
}
.ansi-white-intense-fg {
  color: #A1A6B2;
}
.ansi-white-intense-bg {
  background-color: #A1A6B2;
}
.ansi-default-inverse-fg {
  color: #FFFFFF;
}
.ansi-default-inverse-bg {
  background-color: #000000;
}
.ansi-bold {
  font-weight: bold;
}
.ansi-underline {
  text-decoration: underline;
}
/* The following styles are deprecated an will be removed in a future version */
.ansibold {
  font-weight: bold;
}
.ansi-inverse {
  outline: 0.5px dotted;
}
/* use dark versions for foreground, to improve visibility */
.ansiblack {
  color: black;
}
.ansired {
  color: darkred;
}
.ansigreen {
  color: darkgreen;
}
.ansiyellow {
  color: #c4a000;
}
.ansiblue {
  color: darkblue;
}
.ansipurple {
  color: darkviolet;
}
.ansicyan {
  color: steelblue;
}
.ansigray {
  color: gray;
}
/* and light for background, for the same reason */
.ansibgblack {
  background-color: black;
}
.ansibgred {
  background-color: red;
}
.ansibggreen {
  background-color: green;
}
.ansibgyellow {
  background-color: yellow;
}
.ansibgblue {
  background-color: blue;
}
.ansibgpurple {
  background-color: magenta;
}
.ansibgcyan {
  background-color: cyan;
}
.ansibggray {
  background-color: gray;
}
div.cell {
  /* Old browsers */
  display: -webkit-box;
  -webkit-box-orient: vertical;
  -webkit-box-align: stretch;
  display: -moz-box;
  -moz-box-orient: vertical;
  -moz-box-align: stretch;
  display: box;
  box-orient: vertical;
  box-align: stretch;
  /* Modern browsers */
  display: flex;
  flex-direction: column;
  align-items: stretch;
  border-radius: 2px;
  box-sizing: border-box;
  -moz-box-sizing: border-box;
  -webkit-box-sizing: border-box;
  border-width: 1px;
  border-style: solid;
  border-color: transparent;
  width: 100%;
  padding: 5px;
  /* This acts as a spacer between cells, that is outside the border */
  margin: 0px;
  outline: none;
  position: relative;
  overflow: visible;
}
div.cell:before {
  position: absolute;
  display: block;
  top: -1px;
  left: -1px;
  width: 5px;
  height: calc(100% +  2px);
  content: '';
  background: transparent;
}
div.cell.jupyter-soft-selected {
  border-left-color: #E3F2FD;
  border-left-width: 1px;
  padding-left: 5px;
  border-right-color: #E3F2FD;
  border-right-width: 1px;
  background: #E3F2FD;
}
@media print {
  div.cell.jupyter-soft-selected {
    border-color: transparent;
  }
}
div.cell.selected,
div.cell.selected.jupyter-soft-selected {
  border-color: #ababab;
}
div.cell.selected:before,
div.cell.selected.jupyter-soft-selected:before {
  position: absolute;
  display: block;
  top: -1px;
  left: -1px;
  width: 5px;
  height: calc(100% +  2px);
  content: '';
  background: #42A5F5;
}
@media print {
  div.cell.selected,
  div.cell.selected.jupyter-soft-selected {
    border-color: transparent;
  }
}
.edit_mode div.cell.selected {
  border-color: #66BB6A;
}
.edit_mode div.cell.selected:before {
  position: absolute;
  display: block;
  top: -1px;
  left: -1px;
  width: 5px;
  height: calc(100% +  2px);
  content: '';
  background: #66BB6A;
}
@media print {
  .edit_mode div.cell.selected {
    border-color: transparent;
  }
}
.prompt {
  /* This needs to be wide enough for 3 digit prompt numbers: In[100]: */
  min-width: 14ex;
  /* This padding is tuned to match the padding on the CodeMirror editor. */
  padding: 0.4em;
  margin: 0px;
  font-family: monospace;
  text-align: right;
  /* This has to match that of the the CodeMirror class line-height below */
  line-height: 1.21429em;
  /* Don't highlight prompt number selection */
  -webkit-touch-callout: none;
  -webkit-user-select: none;
  -khtml-user-select: none;
  -moz-user-select: none;
  -ms-user-select: none;
  user-select: none;
  /* Use default cursor */
  cursor: default;
}
@media (max-width: 540px) {
  .prompt {
    text-align: left;
  }
}
div.inner_cell {
  min-width: 0;
  /* Old browsers */
  display: -webkit-box;
  -webkit-box-orient: vertical;
  -webkit-box-align: stretch;
  display: -moz-box;
  -moz-box-orient: vertical;
  -moz-box-align: stretch;
  display: box;
  box-orient: vertical;
  box-align: stretch;
  /* Modern browsers */
  display: flex;
  flex-direction: column;
  align-items: stretch;
  /* Old browsers */
  -webkit-box-flex: 1;
  -moz-box-flex: 1;
  box-flex: 1;
  /* Modern browsers */
  flex: 1;
}
/* input_area and input_prompt must match in top border and margin for alignment */
div.input_area {
  border: 1px solid #cfcfcf;
  border-radius: 2px;
  background: #f7f7f7;
  line-height: 1.21429em;
}
/* This is needed so that empty prompt areas can collapse to zero height when there
   is no content in the output_subarea and the prompt. The main purpose of this is
   to make sure that empty JavaScript output_subareas have no height. */
div.prompt:empty {
  padding-top: 0;
  padding-bottom: 0;
}
div.unrecognized_cell {
  padding: 5px 5px 5px 0px;
  /* Old browsers */
  display: -webkit-box;
  -webkit-box-orient: horizontal;
  -webkit-box-align: stretch;
  display: -moz-box;
  -moz-box-orient: horizontal;
  -moz-box-align: stretch;
  display: box;
  box-orient: horizontal;
  box-align: stretch;
  /* Modern browsers */
  display: flex;
  flex-direction: row;
  align-items: stretch;
}
div.unrecognized_cell .inner_cell {
  border-radius: 2px;
  padding: 5px;
  font-weight: bold;
  color: red;
  border: 1px solid #cfcfcf;
  background: #eaeaea;
}
div.unrecognized_cell .inner_cell a {
  color: inherit;
  text-decoration: none;
}
div.unrecognized_cell .inner_cell a:hover {
  color: inherit;
  text-decoration: none;
}
@media (max-width: 540px) {
  div.unrecognized_cell > div.prompt {
    display: none;
  }
}
div.code_cell {
  /* avoid page breaking on code cells when printing */
}
@media print {
  div.code_cell {
    page-break-inside: avoid;
  }
}
/* any special styling for code cells that are currently running goes here */
div.input {
  page-break-inside: avoid;
  /* Old browsers */
  display: -webkit-box;
  -webkit-box-orient: horizontal;
  -webkit-box-align: stretch;
  display: -moz-box;
  -moz-box-orient: horizontal;
  -moz-box-align: stretch;
  display: box;
  box-orient: horizontal;
  box-align: stretch;
  /* Modern browsers */
  display: flex;
  flex-direction: row;
  align-items: stretch;
}
@media (max-width: 540px) {
  div.input {
    /* Old browsers */
    display: -webkit-box;
    -webkit-box-orient: vertical;
    -webkit-box-align: stretch;
    display: -moz-box;
    -moz-box-orient: vertical;
    -moz-box-align: stretch;
    display: box;
    box-orient: vertical;
    box-align: stretch;
    /* Modern browsers */
    display: flex;
    flex-direction: column;
    align-items: stretch;
  }
}
/* input_area and input_prompt must match in top border and margin for alignment */
div.input_prompt {
  color: #303F9F;
  border-top: 1px solid transparent;
}
div.input_area > div.highlight {
  margin: 0.4em;
  border: none;
  padding: 0px;
  background-color: transparent;
}
div.input_area > div.highlight > pre {
  margin: 0px;
  border: none;
  padding: 0px;
  background-color: transparent;
}
/* The following gets added to the <head> if it is detected that the user has a
 * monospace font with inconsistent normal/bold/italic height.  See
 * notebookmain.js.  Such fonts will have keywords vertically offset with
 * respect to the rest of the text.  The user should select a better font.
 * See: https://github.com/ipython/ipython/issues/1503
 *
 * .CodeMirror span {
 *      vertical-align: bottom;
 * }
 */
.CodeMirror {
  line-height: 1.21429em;
  /* Changed from 1em to our global default */
  font-size: 14px;
  height: auto;
  /* Changed to auto to autogrow */
  background: none;
  /* Changed from white to allow our bg to show through */
}
.CodeMirror-scroll {
  /*  The CodeMirror docs are a bit fuzzy on if overflow-y should be hidden or visible.*/
  /*  We have found that if it is visible, vertical scrollbars appear with font size changes.*/
  overflow-y: hidden;
  overflow-x: auto;
}
.CodeMirror-lines {
  /* In CM2, this used to be 0.4em, but in CM3 it went to 4px. We need the em value because */
  /* we have set a different line-height and want this to scale with that. */
  /* Note that this should set vertical padding only, since CodeMirror assumes
       that horizontal padding will be set on CodeMirror pre */
  padding: 0.4em 0;
}
.CodeMirror-linenumber {
  padding: 0 8px 0 4px;
}
.CodeMirror-gutters {
  border-bottom-left-radius: 2px;
  border-top-left-radius: 2px;
}
.CodeMirror pre {
  /* In CM3 this went to 4px from 0 in CM2. This sets horizontal padding only,
    use .CodeMirror-lines for vertical */
  padding: 0 0.4em;
  border: 0;
  border-radius: 0;
}
.CodeMirror-cursor {
  border-left: 1.4px solid black;
}
@media screen and (min-width: 2138px) and (max-width: 4319px) {
  .CodeMirror-cursor {
    border-left: 2px solid black;
  }
}
@media screen and (min-width: 4320px) {
  .CodeMirror-cursor {
    border-left: 4px solid black;
  }
}
/*

Original style from softwaremaniacs.org (c) Ivan Sagalaev <Maniac@SoftwareManiacs.Org>
Adapted from GitHub theme

*/
.highlight-base {
  color: #000;
}
.highlight-variable {
  color: #000;
}
.highlight-variable-2 {
  color: #1a1a1a;
}
.highlight-variable-3 {
  color: #333333;
}
.highlight-string {
  color: #BA2121;
}
.highlight-comment {
  color: #408080;
  font-style: italic;
}
.highlight-number {
  color: #080;
}
.highlight-atom {
  color: #88F;
}
.highlight-keyword {
  color: #008000;
  font-weight: bold;
}
.highlight-builtin {
  color: #008000;
}
.highlight-error {
  color: #f00;
}
.highlight-operator {
  color: #AA22FF;
  font-weight: bold;
}
.highlight-meta {
  color: #AA22FF;
}
/* previously not defined, copying from default codemirror */
.highlight-def {
  color: #00f;
}
.highlight-string-2 {
  color: #f50;
}
.highlight-qualifier {
  color: #555;
}
.highlight-bracket {
  color: #997;
}
.highlight-tag {
  color: #170;
}
.highlight-attribute {
  color: #00c;
}
.highlight-header {
  color: blue;
}
.highlight-quote {
  color: #090;
}
.highlight-link {
  color: #00c;
}
/* apply the same style to codemirror */
.cm-s-ipython span.cm-keyword {
  color: #008000;
  font-weight: bold;
}
.cm-s-ipython span.cm-atom {
  color: #88F;
}
.cm-s-ipython span.cm-number {
  color: #080;
}
.cm-s-ipython span.cm-def {
  color: #00f;
}
.cm-s-ipython span.cm-variable {
  color: #000;
}
.cm-s-ipython span.cm-operator {
  color: #AA22FF;
  font-weight: bold;
}
.cm-s-ipython span.cm-variable-2 {
  color: #1a1a1a;
}
.cm-s-ipython span.cm-variable-3 {
  color: #333333;
}
.cm-s-ipython span.cm-comment {
  color: #408080;
  font-style: italic;
}
.cm-s-ipython span.cm-string {
  color: #BA2121;
}
.cm-s-ipython span.cm-string-2 {
  color: #f50;
}
.cm-s-ipython span.cm-meta {
  color: #AA22FF;
}
.cm-s-ipython span.cm-qualifier {
  color: #555;
}
.cm-s-ipython span.cm-builtin {
  color: #008000;
}
.cm-s-ipython span.cm-bracket {
  color: #997;
}
.cm-s-ipython span.cm-tag {
  color: #170;
}
.cm-s-ipython span.cm-attribute {
  color: #00c;
}
.cm-s-ipython span.cm-header {
  color: blue;
}
.cm-s-ipython span.cm-quote {
  color: #090;
}
.cm-s-ipython span.cm-link {
  color: #00c;
}
.cm-s-ipython span.cm-error {
  color: #f00;
}
.cm-s-ipython span.cm-tab {
  background: url(data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAADAAAAAMCAYAAAAkuj5RAAAAAXNSR0IArs4c6QAAAGFJREFUSMft1LsRQFAQheHPowAKoACx3IgEKtaEHujDjORSgWTH/ZOdnZOcM/sgk/kFFWY0qV8foQwS4MKBCS3qR6ixBJvElOobYAtivseIE120FaowJPN75GMu8j/LfMwNjh4HUpwg4LUAAAAASUVORK5CYII=);
  background-position: right;
  background-repeat: no-repeat;
}
div.output_wrapper {
  /* this position must be relative to enable descendents to be absolute within it */
  position: relative;
  /* Old browsers */
  display: -webkit-box;
  -webkit-box-orient: vertical;
  -webkit-box-align: stretch;
  display: -moz-box;
  -moz-box-orient: vertical;
  -moz-box-align: stretch;
  display: box;
  box-orient: vertical;
  box-align: stretch;
  /* Modern browsers */
  display: flex;
  flex-direction: column;
  align-items: stretch;
  z-index: 1;
}
/* class for the output area when it should be height-limited */
div.output_scroll {
  /* ideally, this would be max-height, but FF barfs all over that */
  height: 24em;
  /* FF needs this *and the wrapper* to specify full width, or it will shrinkwrap */
  width: 100%;
  overflow: auto;
  border-radius: 2px;
  -webkit-box-shadow: inset 0 2px 8px rgba(0, 0, 0, 0.8);
  box-shadow: inset 0 2px 8px rgba(0, 0, 0, 0.8);
  display: block;
}
/* output div while it is collapsed */
div.output_collapsed {
  margin: 0px;
  padding: 0px;
  /* Old browsers */
  display: -webkit-box;
  -webkit-box-orient: vertical;
  -webkit-box-align: stretch;
  display: -moz-box;
  -moz-box-orient: vertical;
  -moz-box-align: stretch;
  display: box;
  box-orient: vertical;
  box-align: stretch;
  /* Modern browsers */
  display: flex;
  flex-direction: column;
  align-items: stretch;
}
div.out_prompt_overlay {
  height: 100%;
  padding: 0px 0.4em;
  position: absolute;
  border-radius: 2px;
}
div.out_prompt_overlay:hover {
  /* use inner shadow to get border that is computed the same on WebKit/FF */
  -webkit-box-shadow: inset 0 0 1px #000;
  box-shadow: inset 0 0 1px #000;
  background: rgba(240, 240, 240, 0.5);
}
div.output_prompt {
  color: #D84315;
}
/* This class is the outer container of all output sections. */
div.output_area {
  padding: 0px;
  page-break-inside: avoid;
  /* Old browsers */
  display: -webkit-box;
  -webkit-box-orient: horizontal;
  -webkit-box-align: stretch;
  display: -moz-box;
  -moz-box-orient: horizontal;
  -moz-box-align: stretch;
  display: box;
  box-orient: horizontal;
  box-align: stretch;
  /* Modern browsers */
  display: flex;
  flex-direction: row;
  align-items: stretch;
}
div.output_area .MathJax_Display {
  text-align: left !important;
}
div.output_area .rendered_html table {
  margin-left: 0;
  margin-right: 0;
}
div.output_area .rendered_html img {
  margin-left: 0;
  margin-right: 0;
}
div.output_area img,
div.output_area svg {
  max-width: 100%;
  height: auto;
}
div.output_area img.unconfined,
div.output_area svg.unconfined {
  max-width: none;
}
div.output_area .mglyph > img {
  max-width: none;
}
/* This is needed to protect the pre formating from global settings such
   as that of bootstrap */
.output {
  /* Old browsers */
  display: -webkit-box;
  -webkit-box-orient: vertical;
  -webkit-box-align: stretch;
  display: -moz-box;
  -moz-box-orient: vertical;
  -moz-box-align: stretch;
  display: box;
  box-orient: vertical;
  box-align: stretch;
  /* Modern browsers */
  display: flex;
  flex-direction: column;
  align-items: stretch;
}
@media (max-width: 540px) {
  div.output_area {
    /* Old browsers */
    display: -webkit-box;
    -webkit-box-orient: vertical;
    -webkit-box-align: stretch;
    display: -moz-box;
    -moz-box-orient: vertical;
    -moz-box-align: stretch;
    display: box;
    box-orient: vertical;
    box-align: stretch;
    /* Modern browsers */
    display: flex;
    flex-direction: column;
    align-items: stretch;
  }
}
div.output_area pre {
  margin: 0;
  padding: 1px 0 1px 0;
  border: 0;
  vertical-align: baseline;
  color: black;
  background-color: transparent;
  border-radius: 0;
}
/* This class is for the output subarea inside the output_area and after
   the prompt div. */
div.output_subarea {
  overflow-x: auto;
  padding: 0.4em;
  /* Old browsers */
  -webkit-box-flex: 1;
  -moz-box-flex: 1;
  box-flex: 1;
  /* Modern browsers */
  flex: 1;
  max-width: calc(100% - 14ex);
}
div.output_scroll div.output_subarea {
  overflow-x: visible;
}
/* The rest of the output_* classes are for special styling of the different
   output types */
/* all text output has this class: */
div.output_text {
  text-align: left;
  color: #000;
  /* This has to match that of the the CodeMirror class line-height below */
  line-height: 1.21429em;
}
/* stdout/stderr are 'text' as well as 'stream', but execute_result/error are *not* streams */
div.output_stderr {
  background: #fdd;
  /* very light red background for stderr */
}
div.output_latex {
  text-align: left;
}
/* Empty output_javascript divs should have no height */
div.output_javascript:empty {
  padding: 0;
}
.js-error {
  color: darkred;
}
/* raw_input styles */
div.raw_input_container {
  line-height: 1.21429em;
  padding-top: 5px;
}
pre.raw_input_prompt {
  /* nothing needed here. */
}
input.raw_input {
  font-family: monospace;
  font-size: inherit;
  color: inherit;
  width: auto;
  /* make sure input baseline aligns with prompt */
  vertical-align: baseline;
  /* padding + margin = 0.5em between prompt and cursor */
  padding: 0em 0.25em;
  margin: 0em 0.25em;
}
input.raw_input:focus {
  box-shadow: none;
}
p.p-space {
  margin-bottom: 10px;
}
div.output_unrecognized {
  padding: 5px;
  font-weight: bold;
  color: red;
}
div.output_unrecognized a {
  color: inherit;
  text-decoration: none;
}
div.output_unrecognized a:hover {
  color: inherit;
  text-decoration: none;
}
.rendered_html {
  color: #000;
  /* any extras will just be numbers: */
}
.rendered_html em {
  font-style: italic;
}
.rendered_html strong {
  font-weight: bold;
}
.rendered_html u {
  text-decoration: underline;
}
.rendered_html :link {
  text-decoration: underline;
}
.rendered_html :visited {
  text-decoration: underline;
}
.rendered_html h1 {
  font-size: 185.7%;
  margin: 1.08em 0 0 0;
  font-weight: bold;
  line-height: 1.0;
}
.rendered_html h2 {
  font-size: 157.1%;
  margin: 1.27em 0 0 0;
  font-weight: bold;
  line-height: 1.0;
}
.rendered_html h3 {
  font-size: 128.6%;
  margin: 1.55em 0 0 0;
  font-weight: bold;
  line-height: 1.0;
}
.rendered_html h4 {
  font-size: 100%;
  margin: 2em 0 0 0;
  font-weight: bold;
  line-height: 1.0;
}
.rendered_html h5 {
  font-size: 100%;
  margin: 2em 0 0 0;
  font-weight: bold;
  line-height: 1.0;
  font-style: italic;
}
.rendered_html h6 {
  font-size: 100%;
  margin: 2em 0 0 0;
  font-weight: bold;
  line-height: 1.0;
  font-style: italic;
}
.rendered_html h1:first-child {
  margin-top: 0.538em;
}
.rendered_html h2:first-child {
  margin-top: 0.636em;
}
.rendered_html h3:first-child {
  margin-top: 0.777em;
}
.rendered_html h4:first-child {
  margin-top: 1em;
}
.rendered_html h5:first-child {
  margin-top: 1em;
}
.rendered_html h6:first-child {
  margin-top: 1em;
}
.rendered_html ul:not(.list-inline),
.rendered_html ol:not(.list-inline) {
  padding-left: 2em;
}
.rendered_html ul {
  list-style: disc;
}
.rendered_html ul ul {
  list-style: square;
  margin-top: 0;
}
.rendered_html ul ul ul {
  list-style: circle;
}
.rendered_html ol {
  list-style: decimal;
}
.rendered_html ol ol {
  list-style: upper-alpha;
  margin-top: 0;
}
.rendered_html ol ol ol {
  list-style: lower-alpha;
}
.rendered_html ol ol ol ol {
  list-style: lower-roman;
}
.rendered_html ol ol ol ol ol {
  list-style: decimal;
}
.rendered_html * + ul {
  margin-top: 1em;
}
.rendered_html * + ol {
  margin-top: 1em;
}
.rendered_html hr {
  color: black;
  background-color: black;
}
.rendered_html pre {
  margin: 1em 2em;
  padding: 0px;
  background-color: #fff;
}
.rendered_html code {
  background-color: #eff0f1;
}
.rendered_html p code {
  padding: 1px 5px;
}
.rendered_html pre code {
  background-color: #fff;
}
.rendered_html pre,
.rendered_html code {
  border: 0;
  color: #000;
  font-size: 100%;
}
.rendered_html blockquote {
  margin: 1em 2em;
}
.rendered_html table {
  margin-left: auto;
  margin-right: auto;
  border: none;
  border-collapse: collapse;
  border-spacing: 0;
  color: black;
  font-size: 12px;
  table-layout: fixed;
}
.rendered_html thead {
  border-bottom: 1px solid black;
  vertical-align: bottom;
}
.rendered_html tr,
.rendered_html th,
.rendered_html td {
  text-align: right;
  vertical-align: middle;
  padding: 0.5em 0.5em;
  line-height: normal;
  white-space: normal;
  max-width: none;
  border: none;
}
.rendered_html th {
  font-weight: bold;
}
.rendered_html tbody tr:nth-child(odd) {
  background: #f5f5f5;
}
.rendered_html tbody tr:hover {
  background: rgba(66, 165, 245, 0.2);
}
.rendered_html * + table {
  margin-top: 1em;
}
.rendered_html p {
  text-align: left;
}
.rendered_html * + p {
  margin-top: 1em;
}
.rendered_html img {
  display: block;
  margin-left: auto;
  margin-right: auto;
}
.rendered_html * + img {
  margin-top: 1em;
}
.rendered_html img,
.rendered_html svg {
  max-width: 100%;
  height: auto;
}
.rendered_html img.unconfined,
.rendered_html svg.unconfined {
  max-width: none;
}
.rendered_html .alert {
  margin-bottom: initial;
}
.rendered_html * + .alert {
  margin-top: 1em;
}
[dir="rtl"] .rendered_html p {
  text-align: right;
}
div.text_cell {
  /* Old browsers */
  display: -webkit-box;
  -webkit-box-orient: horizontal;
  -webkit-box-align: stretch;
  display: -moz-box;
  -moz-box-orient: horizontal;
  -moz-box-align: stretch;
  display: box;
  box-orient: horizontal;
  box-align: stretch;
  /* Modern browsers */
  display: flex;
  flex-direction: row;
  align-items: stretch;
}
@media (max-width: 540px) {
  div.text_cell > div.prompt {
    display: none;
  }
}
div.text_cell_render {
  /*font-family: "Helvetica Neue", Arial, Helvetica, Geneva, sans-serif;*/
  outline: none;
  resize: none;
  width: inherit;
  border-style: none;
  padding: 0.5em 0.5em 0.5em 0.4em;
  color: #000;
  box-sizing: border-box;
  -moz-box-sizing: border-box;
  -webkit-box-sizing: border-box;
}
a.anchor-link:link {
  text-decoration: none;
  padding: 0px 20px;
  visibility: hidden;
}
h1:hover .anchor-link,
h2:hover .anchor-link,
h3:hover .anchor-link,
h4:hover .anchor-link,
h5:hover .anchor-link,
h6:hover .anchor-link {
  visibility: visible;
}
.text_cell.rendered .input_area {
  display: none;
}
.text_cell.rendered .rendered_html {
  overflow-x: auto;
  overflow-y: hidden;
}
.text_cell.rendered .rendered_html tr,
.text_cell.rendered .rendered_html th,
.text_cell.rendered .rendered_html td {
  max-width: none;
}
.text_cell.unrendered .text_cell_render {
  display: none;
}
.text_cell .dropzone .input_area {
  border: 2px dashed #bababa;
  margin: -1px;
}
.cm-header-1,
.cm-header-2,
.cm-header-3,
.cm-header-4,
.cm-header-5,
.cm-header-6 {
  font-weight: bold;
  font-family: "Helvetica Neue", Helvetica, Arial, sans-serif;
}
.cm-header-1 {
  font-size: 185.7%;
}
.cm-header-2 {
  font-size: 157.1%;
}
.cm-header-3 {
  font-size: 128.6%;
}
.cm-header-4 {
  font-size: 110%;
}
.cm-header-5 {
  font-size: 100%;
  font-style: italic;
}
.cm-header-6 {
  font-size: 100%;
  font-style: italic;
}
/*!
*
* IPython notebook webapp
*
*/
@media (max-width: 767px) {
  .notebook_app {
    padding-left: 0px;
    padding-right: 0px;
  }
}
#ipython-main-app {
  box-sizing: border-box;
  -moz-box-sizing: border-box;
  -webkit-box-sizing: border-box;
  height: 100%;
}
div#notebook_panel {
  margin: 0px;
  padding: 0px;
  box-sizing: border-box;
  -moz-box-sizing: border-box;
  -webkit-box-sizing: border-box;
  height: 100%;
}
div#notebook {
  font-size: 14px;
  line-height: 20px;
  overflow-y: hidden;
  overflow-x: auto;
  width: 100%;
  /* This spaces the page away from the edge of the notebook area */
  padding-top: 20px;
  margin: 0px;
  outline: none;
  box-sizing: border-box;
  -moz-box-sizing: border-box;
  -webkit-box-sizing: border-box;
  min-height: 100%;
}
@media not print {
  #notebook-container {
    padding: 15px;
    background-color: #fff;
    min-height: 0;
    -webkit-box-shadow: 0px 0px 12px 1px rgba(87, 87, 87, 0.2);
    box-shadow: 0px 0px 12px 1px rgba(87, 87, 87, 0.2);
  }
}
@media print {
  #notebook-container {
    width: 100%;
  }
}
div.ui-widget-content {
  border: 1px solid #ababab;
  outline: none;
}
pre.dialog {
  background-color: #f7f7f7;
  border: 1px solid #ddd;
  border-radius: 2px;
  padding: 0.4em;
  padding-left: 2em;
}
p.dialog {
  padding: 0.2em;
}
/* Word-wrap output correctly.  This is the CSS3 spelling, though Firefox seems
   to not honor it correctly.  Webkit browsers (Chrome, rekonq, Safari) do.
 */
pre,
code,
kbd,
samp {
  white-space: pre-wrap;
}
#fonttest {
  font-family: monospace;
}
p {
  margin-bottom: 0;
}
.end_space {
  min-height: 100px;
  transition: height .2s ease;
}
.notebook_app > #header {
  -webkit-box-shadow: 0px 0px 12px 1px rgba(87, 87, 87, 0.2);
  box-shadow: 0px 0px 12px 1px rgba(87, 87, 87, 0.2);
}
@media not print {
  .notebook_app {
    background-color: #EEE;
  }
}
kbd {
  border-style: solid;
  border-width: 1px;
  box-shadow: none;
  margin: 2px;
  padding-left: 2px;
  padding-right: 2px;
  padding-top: 1px;
  padding-bottom: 1px;
}
.jupyter-keybindings {
  padding: 1px;
  line-height: 24px;
  border-bottom: 1px solid gray;
}
.jupyter-keybindings input {
  margin: 0;
  padding: 0;
  border: none;
}
.jupyter-keybindings i {
  padding: 6px;
}
.well code {
  background-color: #ffffff;
  border-color: #ababab;
  border-width: 1px;
  border-style: solid;
  padding: 2px;
  padding-top: 1px;
  padding-bottom: 1px;
}
/* CSS for the cell toolbar */
.celltoolbar {
  border: thin solid #CFCFCF;
  border-bottom: none;
  background: #EEE;
  border-radius: 2px 2px 0px 0px;
  width: 100%;
  height: 29px;
  padding-right: 4px;
  /* Old browsers */
  display: -webkit-box;
  -webkit-box-orient: horizontal;
  -webkit-box-align: stretch;
  display: -moz-box;
  -moz-box-orient: horizontal;
  -moz-box-align: stretch;
  display: box;
  box-orient: horizontal;
  box-align: stretch;
  /* Modern browsers */
  display: flex;
  flex-direction: row;
  align-items: stretch;
  /* Old browsers */
  -webkit-box-pack: end;
  -moz-box-pack: end;
  box-pack: end;
  /* Modern browsers */
  justify-content: flex-end;
  display: -webkit-flex;
}
@media print {
  .celltoolbar {
    display: none;
  }
}
.ctb_hideshow {
  display: none;
  vertical-align: bottom;
}
/* ctb_show is added to the ctb_hideshow div to show the cell toolbar.
   Cell toolbars are only shown when the ctb_global_show class is also set.
*/
.ctb_global_show .ctb_show.ctb_hideshow {
  display: block;
}
.ctb_global_show .ctb_show + .input_area,
.ctb_global_show .ctb_show + div.text_cell_input,
.ctb_global_show .ctb_show ~ div.text_cell_render {
  border-top-right-radius: 0px;
  border-top-left-radius: 0px;
}
.ctb_global_show .ctb_show ~ div.text_cell_render {
  border: 1px solid #cfcfcf;
}
.celltoolbar {
  font-size: 87%;
  padding-top: 3px;
}
.celltoolbar select {
  display: block;
  width: 100%;
  height: 32px;
  padding: 6px 12px;
  font-size: 13px;
  line-height: 1.42857143;
  color: #555555;
  background-color: #fff;
  background-image: none;
  border: 1px solid #ccc;
  border-radius: 2px;
  -webkit-box-shadow: inset 0 1px 1px rgba(0, 0, 0, 0.075);
  box-shadow: inset 0 1px 1px rgba(0, 0, 0, 0.075);
  -webkit-transition: border-color ease-in-out .15s, box-shadow ease-in-out .15s;
  -o-transition: border-color ease-in-out .15s, box-shadow ease-in-out .15s;
  transition: border-color ease-in-out .15s, box-shadow ease-in-out .15s;
  height: 30px;
  padding: 5px 10px;
  font-size: 12px;
  line-height: 1.5;
  border-radius: 1px;
  width: inherit;
  font-size: inherit;
  height: 22px;
  padding: 0px;
  display: inline-block;
}
.celltoolbar select:focus {
  border-color: #66afe9;
  outline: 0;
  -webkit-box-shadow: inset 0 1px 1px rgba(0,0,0,.075), 0 0 8px rgba(102, 175, 233, 0.6);
  box-shadow: inset 0 1px 1px rgba(0,0,0,.075), 0 0 8px rgba(102, 175, 233, 0.6);
}
.celltoolbar select::-moz-placeholder {
  color: #999;
  opacity: 1;
}
.celltoolbar select:-ms-input-placeholder {
  color: #999;
}
.celltoolbar select::-webkit-input-placeholder {
  color: #999;
}
.celltoolbar select::-ms-expand {
  border: 0;
  background-color: transparent;
}
.celltoolbar select[disabled],
.celltoolbar select[readonly],
fieldset[disabled] .celltoolbar select {
  background-color: #eeeeee;
  opacity: 1;
}
.celltoolbar select[disabled],
fieldset[disabled] .celltoolbar select {
  cursor: not-allowed;
}
textarea.celltoolbar select {
  height: auto;
}
select.celltoolbar select {
  height: 30px;
  line-height: 30px;
}
textarea.celltoolbar select,
select[multiple].celltoolbar select {
  height: auto;
}
.celltoolbar label {
  margin-left: 5px;
  margin-right: 5px;
}
.tags_button_container {
  width: 100%;
  display: flex;
}
.tag-container {
  display: flex;
  flex-direction: row;
  flex-grow: 1;
  overflow: hidden;
  position: relative;
}
.tag-container > * {
  margin: 0 4px;
}
.remove-tag-btn {
  margin-left: 4px;
}
.tags-input {
  display: flex;
}
.cell-tag:last-child:after {
  content: "";
  position: absolute;
  right: 0;
  width: 40px;
  height: 100%;
  /* Fade to background color of cell toolbar */
  background: linear-gradient(to right, rgba(0, 0, 0, 0), #EEE);
}
.tags-input > * {
  margin-left: 4px;
}
.cell-tag,
.tags-input input,
.tags-input button {
  display: block;
  width: 100%;
  height: 32px;
  padding: 6px 12px;
  font-size: 13px;
  line-height: 1.42857143;
  color: #555555;
  background-color: #fff;
  background-image: none;
  border: 1px solid #ccc;
  border-radius: 2px;
  -webkit-box-shadow: inset 0 1px 1px rgba(0, 0, 0, 0.075);
  box-shadow: inset 0 1px 1px rgba(0, 0, 0, 0.075);
  -webkit-transition: border-color ease-in-out .15s, box-shadow ease-in-out .15s;
  -o-transition: border-color ease-in-out .15s, box-shadow ease-in-out .15s;
  transition: border-color ease-in-out .15s, box-shadow ease-in-out .15s;
  height: 30px;
  padding: 5px 10px;
  font-size: 12px;
  line-height: 1.5;
  border-radius: 1px;
  box-shadow: none;
  width: inherit;
  font-size: inherit;
  height: 22px;
  line-height: 22px;
  padding: 0px 4px;
  display: inline-block;
}
.cell-tag:focus,
.tags-input input:focus,
.tags-input button:focus {
  border-color: #66afe9;
  outline: 0;
  -webkit-box-shadow: inset 0 1px 1px rgba(0,0,0,.075), 0 0 8px rgba(102, 175, 233, 0.6);
  box-shadow: inset 0 1px 1px rgba(0,0,0,.075), 0 0 8px rgba(102, 175, 233, 0.6);
}
.cell-tag::-moz-placeholder,
.tags-input input::-moz-placeholder,
.tags-input button::-moz-placeholder {
  color: #999;
  opacity: 1;
}
.cell-tag:-ms-input-placeholder,
.tags-input input:-ms-input-placeholder,
.tags-input button:-ms-input-placeholder {
  color: #999;
}
.cell-tag::-webkit-input-placeholder,
.tags-input input::-webkit-input-placeholder,
.tags-input button::-webkit-input-placeholder {
  color: #999;
}
.cell-tag::-ms-expand,
.tags-input input::-ms-expand,
.tags-input button::-ms-expand {
  border: 0;
  background-color: transparent;
}
.cell-tag[disabled],
.tags-input input[disabled],
.tags-input button[disabled],
.cell-tag[readonly],
.tags-input input[readonly],
.tags-input button[readonly],
fieldset[disabled] .cell-tag,
fieldset[disabled] .tags-input input,
fieldset[disabled] .tags-input button {
  background-color: #eeeeee;
  opacity: 1;
}
.cell-tag[disabled],
.tags-input input[disabled],
.tags-input button[disabled],
fieldset[disabled] .cell-tag,
fieldset[disabled] .tags-input input,
fieldset[disabled] .tags-input button {
  cursor: not-allowed;
}
textarea.cell-tag,
textarea.tags-input input,
textarea.tags-input button {
  height: auto;
}
select.cell-tag,
select.tags-input input,
select.tags-input button {
  height: 30px;
  line-height: 30px;
}
textarea.cell-tag,
textarea.tags-input input,
textarea.tags-input button,
select[multiple].cell-tag,
select[multiple].tags-input input,
select[multiple].tags-input button {
  height: auto;
}
.cell-tag,
.tags-input button {
  padding: 0px 4px;
}
.cell-tag {
  background-color: #fff;
  white-space: nowrap;
}
.tags-input input[type=text]:focus {
  outline: none;
  box-shadow: none;
  border-color: #ccc;
}
.completions {
  position: absolute;
  z-index: 110;
  overflow: hidden;
  border: 1px solid #ababab;
  border-radius: 2px;
  -webkit-box-shadow: 0px 6px 10px -1px #adadad;
  box-shadow: 0px 6px 10px -1px #adadad;
  line-height: 1;
}
.completions select {
  background: white;
  outline: none;
  border: none;
  padding: 0px;
  margin: 0px;
  overflow: auto;
  font-family: monospace;
  font-size: 110%;
  color: #000;
  width: auto;
}
.completions select option.context {
  color: #286090;
}
#kernel_logo_widget .current_kernel_logo {
  display: none;
  margin-top: -1px;
  margin-bottom: -1px;
  width: 32px;
  height: 32px;
}
[dir="rtl"] #kernel_logo_widget {
  float: left !important;
  float: left;
}
.modal .modal-body .move-path {
  display: flex;
  flex-direction: row;
  justify-content: space;
  align-items: center;
}
.modal .modal-body .move-path .server-root {
  padding-right: 20px;
}
.modal .modal-body .move-path .path-input {
  flex: 1;
}
#menubar {
  box-sizing: border-box;
  -moz-box-sizing: border-box;
  -webkit-box-sizing: border-box;
  margin-top: 1px;
}
#menubar .navbar {
  border-top: 1px;
  border-radius: 0px 0px 2px 2px;
  margin-bottom: 0px;
}
#menubar .navbar-toggle {
  float: left;
  padding-top: 7px;
  padding-bottom: 7px;
  border: none;
}
#menubar .navbar-collapse {
  clear: left;
}
[dir="rtl"] #menubar .navbar-toggle {
  float: right;
}
[dir="rtl"] #menubar .navbar-collapse {
  clear: right;
}
[dir="rtl"] #menubar .navbar-nav {
  float: right;
}
[dir="rtl"] #menubar .nav {
  padding-right: 0px;
}
[dir="rtl"] #menubar .navbar-nav > li {
  float: right;
}
[dir="rtl"] #menubar .navbar-right {
  float: left !important;
}
[dir="rtl"] ul.dropdown-menu {
  text-align: right;
  left: auto;
}
[dir="rtl"] ul#new-menu.dropdown-menu {
  right: auto;
  left: 0;
}
.nav-wrapper {
  border-bottom: 1px solid #e7e7e7;
}
i.menu-icon {
  padding-top: 4px;
}
[dir="rtl"] i.menu-icon.pull-right {
  float: left !important;
  float: left;
}
ul#help_menu li a {
  overflow: hidden;
  padding-right: 2.2em;
}
ul#help_menu li a i {
  margin-right: -1.2em;
}
[dir="rtl"] ul#help_menu li a {
  padding-left: 2.2em;
}
[dir="rtl"] ul#help_menu li a i {
  margin-right: 0;
  margin-left: -1.2em;
}
[dir="rtl"] ul#help_menu li a i.pull-right {
  float: left !important;
  float: left;
}
.dropdown-submenu {
  position: relative;
}
.dropdown-submenu > .dropdown-menu {
  top: 0;
  left: 100%;
  margin-top: -6px;
  margin-left: -1px;
}
[dir="rtl"] .dropdown-submenu > .dropdown-menu {
  right: 100%;
  margin-right: -1px;
}
.dropdown-submenu:hover > .dropdown-menu {
  display: block;
}
.dropdown-submenu > a:after {
  display: inline-block;
  font: normal normal normal 14px/1 FontAwesome;
  font-size: inherit;
  text-rendering: auto;
  -webkit-font-smoothing: antialiased;
  -moz-osx-font-smoothing: grayscale;
  display: block;
  content: "\f0da";
  float: right;
  color: #333333;
  margin-top: 2px;
  margin-right: -10px;
}
.dropdown-submenu > a:after.fa-pull-left {
  margin-right: .3em;
}
.dropdown-submenu > a:after.fa-pull-right {
  margin-left: .3em;
}
.dropdown-submenu > a:after.pull-left {
  margin-right: .3em;
}
.dropdown-submenu > a:after.pull-right {
  margin-left: .3em;
}
[dir="rtl"] .dropdown-submenu > a:after {
  float: left;
  content: "\f0d9";
  margin-right: 0;
  margin-left: -10px;
}
.dropdown-submenu:hover > a:after {
  color: #262626;
}
.dropdown-submenu.pull-left {
  float: none;
}
.dropdown-submenu.pull-left > .dropdown-menu {
  left: -100%;
  margin-left: 10px;
}
#notification_area {
  float: right !important;
  float: right;
  z-index: 10;
}
[dir="rtl"] #notification_area {
  float: left !important;
  float: left;
}
.indicator_area {
  float: right !important;
  float: right;
  color: #777;
  margin-left: 5px;
  margin-right: 5px;
  width: 11px;
  z-index: 10;
  text-align: center;
  width: auto;
}
[dir="rtl"] .indicator_area {
  float: left !important;
  float: left;
}
#kernel_indicator {
  float: right !important;
  float: right;
  color: #777;
  margin-left: 5px;
  margin-right: 5px;
  width: 11px;
  z-index: 10;
  text-align: center;
  width: auto;
  border-left: 1px solid;
}
#kernel_indicator .kernel_indicator_name {
  padding-left: 5px;
  padding-right: 5px;
}
[dir="rtl"] #kernel_indicator {
  float: left !important;
  float: left;
  border-left: 0;
  border-right: 1px solid;
}
#modal_indicator {
  float: right !important;
  float: right;
  color: #777;
  margin-left: 5px;
  margin-right: 5px;
  width: 11px;
  z-index: 10;
  text-align: center;
  width: auto;
}
[dir="rtl"] #modal_indicator {
  float: left !important;
  float: left;
}
#readonly-indicator {
  float: right !important;
  float: right;
  color: #777;
  margin-left: 5px;
  margin-right: 5px;
  width: 11px;
  z-index: 10;
  text-align: center;
  width: auto;
  margin-top: 2px;
  margin-bottom: 0px;
  margin-left: 0px;
  margin-right: 0px;
  display: none;
}
.modal_indicator:before {
  width: 1.28571429em;
  text-align: center;
}
.edit_mode .modal_indicator:before {
  display: inline-block;
  font: normal normal normal 14px/1 FontAwesome;
  font-size: inherit;
  text-rendering: auto;
  -webkit-font-smoothing: antialiased;
  -moz-osx-font-smoothing: grayscale;
  content: "\f040";
}
.edit_mode .modal_indicator:before.fa-pull-left {
  margin-right: .3em;
}
.edit_mode .modal_indicator:before.fa-pull-right {
  margin-left: .3em;
}
.edit_mode .modal_indicator:before.pull-left {
  margin-right: .3em;
}
.edit_mode .modal_indicator:before.pull-right {
  margin-left: .3em;
}
.command_mode .modal_indicator:before {
  display: inline-block;
  font: normal normal normal 14px/1 FontAwesome;
  font-size: inherit;
  text-rendering: auto;
  -webkit-font-smoothing: antialiased;
  -moz-osx-font-smoothing: grayscale;
  content: ' ';
}
.command_mode .modal_indicator:before.fa-pull-left {
  margin-right: .3em;
}
.command_mode .modal_indicator:before.fa-pull-right {
  margin-left: .3em;
}
.command_mode .modal_indicator:before.pull-left {
  margin-right: .3em;
}
.command_mode .modal_indicator:before.pull-right {
  margin-left: .3em;
}
.kernel_idle_icon:before {
  display: inline-block;
  font: normal normal normal 14px/1 FontAwesome;
  font-size: inherit;
  text-rendering: auto;
  -webkit-font-smoothing: antialiased;
  -moz-osx-font-smoothing: grayscale;
  content: "\f10c";
}
.kernel_idle_icon:before.fa-pull-left {
  margin-right: .3em;
}
.kernel_idle_icon:before.fa-pull-right {
  margin-left: .3em;
}
.kernel_idle_icon:before.pull-left {
  margin-right: .3em;
}
.kernel_idle_icon:before.pull-right {
  margin-left: .3em;
}
.kernel_busy_icon:before {
  display: inline-block;
  font: normal normal normal 14px/1 FontAwesome;
  font-size: inherit;
  text-rendering: auto;
  -webkit-font-smoothing: antialiased;
  -moz-osx-font-smoothing: grayscale;
  content: "\f111";
}
.kernel_busy_icon:before.fa-pull-left {
  margin-right: .3em;
}
.kernel_busy_icon:before.fa-pull-right {
  margin-left: .3em;
}
.kernel_busy_icon:before.pull-left {
  margin-right: .3em;
}
.kernel_busy_icon:before.pull-right {
  margin-left: .3em;
}
.kernel_dead_icon:before {
  display: inline-block;
  font: normal normal normal 14px/1 FontAwesome;
  font-size: inherit;
  text-rendering: auto;
  -webkit-font-smoothing: antialiased;
  -moz-osx-font-smoothing: grayscale;
  content: "\f1e2";
}
.kernel_dead_icon:before.fa-pull-left {
  margin-right: .3em;
}
.kernel_dead_icon:before.fa-pull-right {
  margin-left: .3em;
}
.kernel_dead_icon:before.pull-left {
  margin-right: .3em;
}
.kernel_dead_icon:before.pull-right {
  margin-left: .3em;
}
.kernel_disconnected_icon:before {
  display: inline-block;
  font: normal normal normal 14px/1 FontAwesome;
  font-size: inherit;
  text-rendering: auto;
  -webkit-font-smoothing: antialiased;
  -moz-osx-font-smoothing: grayscale;
  content: "\f127";
}
.kernel_disconnected_icon:before.fa-pull-left {
  margin-right: .3em;
}
.kernel_disconnected_icon:before.fa-pull-right {
  margin-left: .3em;
}
.kernel_disconnected_icon:before.pull-left {
  margin-right: .3em;
}
.kernel_disconnected_icon:before.pull-right {
  margin-left: .3em;
}
.notification_widget {
  color: #777;
  z-index: 10;
  background: rgba(240, 240, 240, 0.5);
  margin-right: 4px;
  color: #333;
  background-color: #fff;
  border-color: #ccc;
}
.notification_widget:focus,
.notification_widget.focus {
  color: #333;
  background-color: #e6e6e6;
  border-color: #8c8c8c;
}
.notification_widget:hover {
  color: #333;
  background-color: #e6e6e6;
  border-color: #adadad;
}
.notification_widget:active,
.notification_widget.active,
.open > .dropdown-toggle.notification_widget {
  color: #333;
  background-color: #e6e6e6;
  border-color: #adadad;
}
.notification_widget:active:hover,
.notification_widget.active:hover,
.open > .dropdown-toggle.notification_widget:hover,
.notification_widget:active:focus,
.notification_widget.active:focus,
.open > .dropdown-toggle.notification_widget:focus,
.notification_widget:active.focus,
.notification_widget.active.focus,
.open > .dropdown-toggle.notification_widget.focus {
  color: #333;
  background-color: #d4d4d4;
  border-color: #8c8c8c;
}
.notification_widget:active,
.notification_widget.active,
.open > .dropdown-toggle.notification_widget {
  background-image: none;
}
.notification_widget.disabled:hover,
.notification_widget[disabled]:hover,
fieldset[disabled] .notification_widget:hover,
.notification_widget.disabled:focus,
.notification_widget[disabled]:focus,
fieldset[disabled] .notification_widget:focus,
.notification_widget.disabled.focus,
.notification_widget[disabled].focus,
fieldset[disabled] .notification_widget.focus {
  background-color: #fff;
  border-color: #ccc;
}
.notification_widget .badge {
  color: #fff;
  background-color: #333;
}
.notification_widget.warning {
  color: #fff;
  background-color: #f0ad4e;
  border-color: #eea236;
}
.notification_widget.warning:focus,
.notification_widget.warning.focus {
  color: #fff;
  background-color: #ec971f;
  border-color: #985f0d;
}
.notification_widget.warning:hover {
  color: #fff;
  background-color: #ec971f;
  border-color: #d58512;
}
.notification_widget.warning:active,
.notification_widget.warning.active,
.open > .dropdown-toggle.notification_widget.warning {
  color: #fff;
  background-color: #ec971f;
  border-color: #d58512;
}
.notification_widget.warning:active:hover,
.notification_widget.warning.active:hover,
.open > .dropdown-toggle.notification_widget.warning:hover,
.notification_widget.warning:active:focus,
.notification_widget.warning.active:focus,
.open > .dropdown-toggle.notification_widget.warning:focus,
.notification_widget.warning:active.focus,
.notification_widget.warning.active.focus,
.open > .dropdown-toggle.notification_widget.warning.focus {
  color: #fff;
  background-color: #d58512;
  border-color: #985f0d;
}
.notification_widget.warning:active,
.notification_widget.warning.active,
.open > .dropdown-toggle.notification_widget.warning {
  background-image: none;
}
.notification_widget.warning.disabled:hover,
.notification_widget.warning[disabled]:hover,
fieldset[disabled] .notification_widget.warning:hover,
.notification_widget.warning.disabled:focus,
.notification_widget.warning[disabled]:focus,
fieldset[disabled] .notification_widget.warning:focus,
.notification_widget.warning.disabled.focus,
.notification_widget.warning[disabled].focus,
fieldset[disabled] .notification_widget.warning.focus {
  background-color: #f0ad4e;
  border-color: #eea236;
}
.notification_widget.warning .badge {
  color: #f0ad4e;
  background-color: #fff;
}
.notification_widget.success {
  color: #fff;
  background-color: #5cb85c;
  border-color: #4cae4c;
}
.notification_widget.success:focus,
.notification_widget.success.focus {
  color: #fff;
  background-color: #449d44;
  border-color: #255625;
}
.notification_widget.success:hover {
  color: #fff;
  background-color: #449d44;
  border-color: #398439;
}
.notification_widget.success:active,
.notification_widget.success.active,
.open > .dropdown-toggle.notification_widget.success {
  color: #fff;
  background-color: #449d44;
  border-color: #398439;
}
.notification_widget.success:active:hover,
.notification_widget.success.active:hover,
.open > .dropdown-toggle.notification_widget.success:hover,
.notification_widget.success:active:focus,
.notification_widget.success.active:focus,
.open > .dropdown-toggle.notification_widget.success:focus,
.notification_widget.success:active.focus,
.notification_widget.success.active.focus,
.open > .dropdown-toggle.notification_widget.success.focus {
  color: #fff;
  background-color: #398439;
  border-color: #255625;
}
.notification_widget.success:active,
.notification_widget.success.active,
.open > .dropdown-toggle.notification_widget.success {
  background-image: none;
}
.notification_widget.success.disabled:hover,
.notification_widget.success[disabled]:hover,
fieldset[disabled] .notification_widget.success:hover,
.notification_widget.success.disabled:focus,
.notification_widget.success[disabled]:focus,
fieldset[disabled] .notification_widget.success:focus,
.notification_widget.success.disabled.focus,
.notification_widget.success[disabled].focus,
fieldset[disabled] .notification_widget.success.focus {
  background-color: #5cb85c;
  border-color: #4cae4c;
}
.notification_widget.success .badge {
  color: #5cb85c;
  background-color: #fff;
}
.notification_widget.info {
  color: #fff;
  background-color: #5bc0de;
  border-color: #46b8da;
}
.notification_widget.info:focus,
.notification_widget.info.focus {
  color: #fff;
  background-color: #31b0d5;
  border-color: #1b6d85;
}
.notification_widget.info:hover {
  color: #fff;
  background-color: #31b0d5;
  border-color: #269abc;
}
.notification_widget.info:active,
.notification_widget.info.active,
.open > .dropdown-toggle.notification_widget.info {
  color: #fff;
  background-color: #31b0d5;
  border-color: #269abc;
}
.notification_widget.info:active:hover,
.notification_widget.info.active:hover,
.open > .dropdown-toggle.notification_widget.info:hover,
.notification_widget.info:active:focus,
.notification_widget.info.active:focus,
.open > .dropdown-toggle.notification_widget.info:focus,
.notification_widget.info:active.focus,
.notification_widget.info.active.focus,
.open > .dropdown-toggle.notification_widget.info.focus {
  color: #fff;
  background-color: #269abc;
  border-color: #1b6d85;
}
.notification_widget.info:active,
.notification_widget.info.active,
.open > .dropdown-toggle.notification_widget.info {
  background-image: none;
}
.notification_widget.info.disabled:hover,
.notification_widget.info[disabled]:hover,
fieldset[disabled] .notification_widget.info:hover,
.notification_widget.info.disabled:focus,
.notification_widget.info[disabled]:focus,
fieldset[disabled] .notification_widget.info:focus,
.notification_widget.info.disabled.focus,
.notification_widget.info[disabled].focus,
fieldset[disabled] .notification_widget.info.focus {
  background-color: #5bc0de;
  border-color: #46b8da;
}
.notification_widget.info .badge {
  color: #5bc0de;
  background-color: #fff;
}
.notification_widget.danger {
  color: #fff;
  background-color: #d9534f;
  border-color: #d43f3a;
}
.notification_widget.danger:focus,
.notification_widget.danger.focus {
  color: #fff;
  background-color: #c9302c;
  border-color: #761c19;
}
.notification_widget.danger:hover {
  color: #fff;
  background-color: #c9302c;
  border-color: #ac2925;
}
.notification_widget.danger:active,
.notification_widget.danger.active,
.open > .dropdown-toggle.notification_widget.danger {
  color: #fff;
  background-color: #c9302c;
  border-color: #ac2925;
}
.notification_widget.danger:active:hover,
.notification_widget.danger.active:hover,
.open > .dropdown-toggle.notification_widget.danger:hover,
.notification_widget.danger:active:focus,
.notification_widget.danger.active:focus,
.open > .dropdown-toggle.notification_widget.danger:focus,
.notification_widget.danger:active.focus,
.notification_widget.danger.active.focus,
.open > .dropdown-toggle.notification_widget.danger.focus {
  color: #fff;
  background-color: #ac2925;
  border-color: #761c19;
}
.notification_widget.danger:active,
.notification_widget.danger.active,
.open > .dropdown-toggle.notification_widget.danger {
  background-image: none;
}
.notification_widget.danger.disabled:hover,
.notification_widget.danger[disabled]:hover,
fieldset[disabled] .notification_widget.danger:hover,
.notification_widget.danger.disabled:focus,
.notification_widget.danger[disabled]:focus,
fieldset[disabled] .notification_widget.danger:focus,
.notification_widget.danger.disabled.focus,
.notification_widget.danger[disabled].focus,
fieldset[disabled] .notification_widget.danger.focus {
  background-color: #d9534f;
  border-color: #d43f3a;
}
.notification_widget.danger .badge {
  color: #d9534f;
  background-color: #fff;
}
div#pager {
  background-color: #fff;
  font-size: 14px;
  line-height: 20px;
  overflow: hidden;
  display: none;
  position: fixed;
  bottom: 0px;
  width: 100%;
  max-height: 50%;
  padding-top: 8px;
  -webkit-box-shadow: 0px 0px 12px 1px rgba(87, 87, 87, 0.2);
  box-shadow: 0px 0px 12px 1px rgba(87, 87, 87, 0.2);
  /* Display over codemirror */
  z-index: 100;
  /* Hack which prevents jquery ui resizable from changing top. */
  top: auto !important;
}
div#pager pre {
  line-height: 1.21429em;
  color: #000;
  background-color: #f7f7f7;
  padding: 0.4em;
}
div#pager #pager-button-area {
  position: absolute;
  top: 8px;
  right: 20px;
}
div#pager #pager-contents {
  position: relative;
  overflow: auto;
  width: 100%;
  height: 100%;
}
div#pager #pager-contents #pager-container {
  position: relative;
  padding: 15px 0px;
  box-sizing: border-box;
  -moz-box-sizing: border-box;
  -webkit-box-sizing: border-box;
}
div#pager .ui-resizable-handle {
  top: 0px;
  height: 8px;
  background: #f7f7f7;
  border-top: 1px solid #cfcfcf;
  border-bottom: 1px solid #cfcfcf;
  /* This injects handle bars (a short, wide = symbol) for 
        the resize handle. */
}
div#pager .ui-resizable-handle::after {
  content: '';
  top: 2px;
  left: 50%;
  height: 3px;
  width: 30px;
  margin-left: -15px;
  position: absolute;
  border-top: 1px solid #cfcfcf;
}
.quickhelp {
  /* Old browsers */
  display: -webkit-box;
  -webkit-box-orient: horizontal;
  -webkit-box-align: stretch;
  display: -moz-box;
  -moz-box-orient: horizontal;
  -moz-box-align: stretch;
  display: box;
  box-orient: horizontal;
  box-align: stretch;
  /* Modern browsers */
  display: flex;
  flex-direction: row;
  align-items: stretch;
  line-height: 1.8em;
}
.shortcut_key {
  display: inline-block;
  width: 21ex;
  text-align: right;
  font-family: monospace;
}
.shortcut_descr {
  display: inline-block;
  /* Old browsers */
  -webkit-box-flex: 1;
  -moz-box-flex: 1;
  box-flex: 1;
  /* Modern browsers */
  flex: 1;
}
span.save_widget {
  height: 30px;
  margin-top: 4px;
  display: flex;
  justify-content: flex-start;
  align-items: baseline;
  width: 50%;
  flex: 1;
}
span.save_widget span.filename {
  height: 100%;
  line-height: 1em;
  margin-left: 16px;
  border: none;
  font-size: 146.5%;
  text-overflow: ellipsis;
  overflow: hidden;
  white-space: nowrap;
  border-radius: 2px;
}
span.save_widget span.filename:hover {
  background-color: #e6e6e6;
}
[dir="rtl"] span.save_widget.pull-left {
  float: right !important;
  float: right;
}
[dir="rtl"] span.save_widget span.filename {
  margin-left: 0;
  margin-right: 16px;
}
span.checkpoint_status,
span.autosave_status {
  font-size: small;
  white-space: nowrap;
  padding: 0 5px;
}
@media (max-width: 767px) {
  span.save_widget {
    font-size: small;
    padding: 0 0 0 5px;
  }
  span.checkpoint_status,
  span.autosave_status {
    display: none;
  }
}
@media (min-width: 768px) and (max-width: 991px) {
  span.checkpoint_status {
    display: none;
  }
  span.autosave_status {
    font-size: x-small;
  }
}
.toolbar {
  padding: 0px;
  margin-left: -5px;
  margin-top: 2px;
  margin-bottom: 5px;
  box-sizing: border-box;
  -moz-box-sizing: border-box;
  -webkit-box-sizing: border-box;
}
.toolbar select,
.toolbar label {
  width: auto;
  vertical-align: middle;
  margin-right: 2px;
  margin-bottom: 0px;
  display: inline;
  font-size: 92%;
  margin-left: 0.3em;
  margin-right: 0.3em;
  padding: 0px;
  padding-top: 3px;
}
.toolbar .btn {
  padding: 2px 8px;
}
.toolbar .btn-group {
  margin-top: 0px;
  margin-left: 5px;
}
.toolbar-btn-label {
  margin-left: 6px;
}
#maintoolbar {
  margin-bottom: -3px;
  margin-top: -8px;
  border: 0px;
  min-height: 27px;
  margin-left: 0px;
  padding-top: 11px;
  padding-bottom: 3px;
}
#maintoolbar .navbar-text {
  float: none;
  vertical-align: middle;
  text-align: right;
  margin-left: 5px;
  margin-right: 0px;
  margin-top: 0px;
}
.select-xs {
  height: 24px;
}
[dir="rtl"] .btn-group > .btn,
.btn-group-vertical > .btn {
  float: right;
}
.pulse,
.dropdown-menu > li > a.pulse,
li.pulse > a.dropdown-toggle,
li.pulse.open > a.dropdown-toggle {
  background-color: #F37626;
  color: white;
}
/**
 * Primary styles
 *
 * Author: Jupyter Development Team
 */
/** WARNING IF YOU ARE EDITTING THIS FILE, if this is a .css file, It has a lot
 * of chance of beeing generated from the ../less/[samename].less file, you can
 * try to get back the less file by reverting somme commit in history
 **/
/*
 * We'll try to get something pretty, so we
 * have some strange css to have the scroll bar on
 * the left with fix button on the top right of the tooltip
 */
@-moz-keyframes fadeOut {
  from {
    opacity: 1;
  }
  to {
    opacity: 0;
  }
}
@-webkit-keyframes fadeOut {
  from {
    opacity: 1;
  }
  to {
    opacity: 0;
  }
}
@-moz-keyframes fadeIn {
  from {
    opacity: 0;
  }
  to {
    opacity: 1;
  }
}
@-webkit-keyframes fadeIn {
  from {
    opacity: 0;
  }
  to {
    opacity: 1;
  }
}
/*properties of tooltip after "expand"*/
.bigtooltip {
  overflow: auto;
  height: 200px;
  -webkit-transition-property: height;
  -webkit-transition-duration: 500ms;
  -moz-transition-property: height;
  -moz-transition-duration: 500ms;
  transition-property: height;
  transition-duration: 500ms;
}
/*properties of tooltip before "expand"*/
.smalltooltip {
  -webkit-transition-property: height;
  -webkit-transition-duration: 500ms;
  -moz-transition-property: height;
  -moz-transition-duration: 500ms;
  transition-property: height;
  transition-duration: 500ms;
  text-overflow: ellipsis;
  overflow: hidden;
  height: 80px;
}
.tooltipbuttons {
  position: absolute;
  padding-right: 15px;
  top: 0px;
  right: 0px;
}
.tooltiptext {
  /*avoid the button to overlap on some docstring*/
  padding-right: 30px;
}
.ipython_tooltip {
  max-width: 700px;
  /*fade-in animation when inserted*/
  -webkit-animation: fadeOut 400ms;
  -moz-animation: fadeOut 400ms;
  animation: fadeOut 400ms;
  -webkit-animation: fadeIn 400ms;
  -moz-animation: fadeIn 400ms;
  animation: fadeIn 400ms;
  vertical-align: middle;
  background-color: #f7f7f7;
  overflow: visible;
  border: #ababab 1px solid;
  outline: none;
  padding: 3px;
  margin: 0px;
  padding-left: 7px;
  font-family: monospace;
  min-height: 50px;
  -moz-box-shadow: 0px 6px 10px -1px #adadad;
  -webkit-box-shadow: 0px 6px 10px -1px #adadad;
  box-shadow: 0px 6px 10px -1px #adadad;
  border-radius: 2px;
  position: absolute;
  z-index: 1000;
}
.ipython_tooltip a {
  float: right;
}
.ipython_tooltip .tooltiptext pre {
  border: 0;
  border-radius: 0;
  font-size: 100%;
  background-color: #f7f7f7;
}
.pretooltiparrow {
  left: 0px;
  margin: 0px;
  top: -16px;
  width: 40px;
  height: 16px;
  overflow: hidden;
  position: absolute;
}
.pretooltiparrow:before {
  background-color: #f7f7f7;
  border: 1px #ababab solid;
  z-index: 11;
  content: "";
  position: absolute;
  left: 15px;
  top: 10px;
  width: 25px;
  height: 25px;
  -webkit-transform: rotate(45deg);
  -moz-transform: rotate(45deg);
  -ms-transform: rotate(45deg);
  -o-transform: rotate(45deg);
}
ul.typeahead-list i {
  margin-left: -10px;
  width: 18px;
}
[dir="rtl"] ul.typeahead-list i {
  margin-left: 0;
  margin-right: -10px;
}
ul.typeahead-list {
  max-height: 80vh;
  overflow: auto;
}
ul.typeahead-list > li > a {
  /** Firefox bug **/
  /* see https://github.com/jupyter/notebook/issues/559 */
  white-space: normal;
}
ul.typeahead-list  > li > a.pull-right {
  float: left !important;
  float: left;
}
[dir="rtl"] .typeahead-list {
  text-align: right;
}
.cmd-palette .modal-body {
  padding: 7px;
}
.cmd-palette form {
  background: white;
}
.cmd-palette input {
  outline: none;
}
.no-shortcut {
  min-width: 20px;
  color: transparent;
}
[dir="rtl"] .no-shortcut.pull-right {
  float: left !important;
  float: left;
}
[dir="rtl"] .command-shortcut.pull-right {
  float: left !important;
  float: left;
}
.command-shortcut:before {
  content: "(command mode)";
  padding-right: 3px;
  color: #777777;
}
.edit-shortcut:before {
  content: "(edit)";
  padding-right: 3px;
  color: #777777;
}
[dir="rtl"] .edit-shortcut.pull-right {
  float: left !important;
  float: left;
}
#find-and-replace #replace-preview .match,
#find-and-replace #replace-preview .insert {
  background-color: #BBDEFB;
  border-color: #90CAF9;
  border-style: solid;
  border-width: 1px;
  border-radius: 0px;
}
[dir="ltr"] #find-and-replace .input-group-btn + .form-control {
  border-left: none;
}
[dir="rtl"] #find-and-replace .input-group-btn + .form-control {
  border-right: none;
}
#find-and-replace #replace-preview .replace .match {
  background-color: #FFCDD2;
  border-color: #EF9A9A;
  border-radius: 0px;
}
#find-and-replace #replace-preview .replace .insert {
  background-color: #C8E6C9;
  border-color: #A5D6A7;
  border-radius: 0px;
}
#find-and-replace #replace-preview {
  max-height: 60vh;
  overflow: auto;
}
#find-and-replace #replace-preview pre {
  padding: 5px 10px;
}
.terminal-app {
  background: #EEE;
}
.terminal-app #header {
  background: #fff;
  -webkit-box-shadow: 0px 0px 12px 1px rgba(87, 87, 87, 0.2);
  box-shadow: 0px 0px 12px 1px rgba(87, 87, 87, 0.2);
}
.terminal-app .terminal {
  width: 100%;
  float: left;
  font-family: monospace;
  color: white;
  background: black;
  padding: 0.4em;
  border-radius: 2px;
  -webkit-box-shadow: 0px 0px 12px 1px rgba(87, 87, 87, 0.4);
  box-shadow: 0px 0px 12px 1px rgba(87, 87, 87, 0.4);
}
.terminal-app .terminal,
.terminal-app .terminal dummy-screen {
  line-height: 1em;
  font-size: 14px;
}
.terminal-app .terminal .xterm-rows {
  padding: 10px;
}
.terminal-app .terminal-cursor {
  color: black;
  background: white;
}
.terminal-app #terminado-container {
  margin-top: 20px;
}
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.highlight .cp { color: #BC7A00 } /* Comment.Preproc */
.highlight .cpf { color: #408080; font-style: italic } /* Comment.PreprocFile */
.highlight .c1 { color: #408080; font-style: italic } /* Comment.Single */
.highlight .cs { color: #408080; font-style: italic } /* Comment.Special */
.highlight .gd { color: #A00000 } /* Generic.Deleted */
.highlight .ge { font-style: italic } /* Generic.Emph */
.highlight .gr { color: #FF0000 } /* Generic.Error */
.highlight .gh { color: #000080; font-weight: bold } /* Generic.Heading */
.highlight .gi { color: #00A000 } /* Generic.Inserted */
.highlight .go { color: #888888 } /* Generic.Output */
.highlight .gp { color: #000080; font-weight: bold } /* Generic.Prompt */
.highlight .gs { font-weight: bold } /* Generic.Strong */
.highlight .gu { color: #800080; font-weight: bold } /* Generic.Subheading */
.highlight .gt { color: #0044DD } /* Generic.Traceback */
.highlight .kc { color: #008000; font-weight: bold } /* Keyword.Constant */
.highlight .kd { color: #008000; font-weight: bold } /* Keyword.Declaration */
.highlight .kn { color: #008000; font-weight: bold } /* Keyword.Namespace */
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.highlight .nv { color: #19177C } /* Name.Variable */
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<style type="text/css">
/* Overrides of notebook CSS for static HTML export */
body {
  overflow: visible;
  padding: 8px;
}

div#notebook {
  overflow: visible;
  border-top: none;
}@media print {
  div.cell {
    display: block;
    page-break-inside: avoid;
  } 
  div.output_wrapper { 
    display: block;
    page-break-inside: avoid; 
  }
  div.output { 
    display: block;
    page-break-inside: avoid; 
  }
}
</style>

<!-- Custom stylesheet, it must be in the same directory as the html file -->
<link rel="stylesheet" href="custom.css">

<!-- Loading mathjax macro -->
<!-- Load mathjax -->
    <script src="https://cdnjs.cloudflare.com/ajax/libs/mathjax/2.7.5/latest.js?config=TeX-AMS_HTML"></script>
    <!-- MathJax configuration -->
    <script type="text/x-mathjax-config">
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        // Center justify equations in code and markdown cells. Elsewhere
        // we use CSS to left justify single line equations in code cells.
        displayAlign: 'center',
        "HTML-CSS": {
            styles: {'.MathJax_Display': {"margin": 0}},
            linebreaks: { automatic: true }
        }
    });
    </script>
    <!-- End of mathjax configuration --></head>
<body>
  <div tabindex="-1" id="notebook" class="border-box-sizing">
    <div class="container" id="notebook-container">

<div class="cell border-box-sizing text_cell rendered"><div class="prompt input_prompt">
</div><div class="inner_cell">
<div class="text_cell_render border-box-sizing rendered_html">
<h1 id="Format-GWAS-summary-level-data">Format GWAS summary-level data<a class="anchor-link" href="#Format-GWAS-summary-level-data">&#182;</a></h1>
</div>
</div>
</div>
<div class="cell border-box-sizing code_cell rendered">
<div class="input">
<div class="prompt input_prompt">In&nbsp;[6]:</div>
<div class="inner_cell">
    <div class="input_area">
<div class=" highlight hl-r"><pre><span></span><span class="nf">library</span><span class="p">(</span><span class="n">MRAPSS</span><span class="p">)</span>
<span class="nf">library</span><span class="p">(</span><span class="n">readr</span><span class="p">)</span>
</pre></div>

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<div class=" highlight hl-r"><pre><span></span><span class="c1">## 1. AD</span>
<span class="n">AD_raw</span> <span class="o">&lt;-</span> <span class="n">readr</span><span class="o">::</span><span class="nf">read_delim</span><span class="p">(</span><span class="s">&quot;./GWAS_26and5_raw/AD&quot;</span><span class="p">,</span> <span class="s">&quot;\t&quot;</span><span class="p">,</span> <span class="n">escape_double</span> <span class="o">=</span> <span class="kc">FALSE</span><span class="p">,</span> <span class="n">trim_ws</span> <span class="o">=</span> <span class="kc">TRUE</span><span class="p">,</span> <span class="n">progress</span> <span class="o">=</span> <span class="bp">F</span><span class="p">)</span>
<span class="n">AD</span> <span class="o">=</span> <span class="nf">format_data</span><span class="p">(</span><span class="n">AD_raw</span><span class="p">,</span>
                 <span class="n">snp_col</span> <span class="o">=</span> <span class="s">&quot;MarkerName&quot;</span><span class="p">,</span>
                 <span class="n">b_col</span> <span class="o">=</span> <span class="s">&quot;Beta&quot;</span><span class="p">,</span>
                 <span class="n">se_col</span> <span class="o">=</span> <span class="s">&quot;SE&quot;</span><span class="p">,</span>
                 <span class="n">A1_col</span> <span class="o">=</span> <span class="s">&quot;Effect_allele&quot;</span><span class="p">,</span>
                 <span class="n">A2_col</span> <span class="o">=</span> <span class="s">&quot;Non_Effect_allele&quot;</span><span class="p">,</span>
                 <span class="n">p_col</span> <span class="o">=</span> <span class="s">&quot;Pvalue&quot;</span><span class="p">,</span>
                 <span class="n">n</span> <span class="o">=</span> <span class="m">54162</span><span class="p">)</span>

<span class="nf">write.table</span><span class="p">(</span><span class="n">AD</span><span class="p">,</span> <span class="s">&quot;./GWAS_26and5_formatted/AD&quot;</span><span class="p">,</span> <span class="n">sep</span><span class="o">=</span><span class="s">&quot;\t&quot;</span><span class="p">,</span> <span class="n">quote</span> <span class="o">=</span> <span class="bp">F</span><span class="p">,</span> <span class="n">row.names</span> <span class="o">=</span> <span class="bp">F</span><span class="p">,</span> <span class="n">col.names</span> <span class="o">=</span> <span class="bp">T</span><span class="p">)</span>

<span class="nf">rm</span><span class="p">(</span><span class="n">list</span><span class="o">=</span><span class="nf">c</span><span class="p">(</span><span class="s">&quot;AD&quot;</span><span class="p">,</span><span class="s">&quot;AD_raw&quot;</span><span class="p">))</span>
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<pre><span class="ansi-bold">Rows: </span><span class="ansi-blue-fg">7055881</span> <span class="ansi-bold">Columns: </span><span class="ansi-blue-fg">8</span>

<span class="ansi-cyan-fg">──</span> <span class="ansi-bold">Column specification</span> <span class="ansi-cyan-fg">────────────────────────────────────────────────────────────────────────────────────────────────────────</span>
<span class="ansi-bold">Delimiter:</span> &#34;\t&#34;
<span class="ansi-red-fg">chr</span> (3): MarkerName, Effect_allele, Non_Effect_allele
<span class="ansi-green-fg">dbl</span> (5): Chromosome, Position, Beta, SE, Pvalue


<span class="ansi-cyan-fg">ℹ</span> Use <span class="ansi-black-fg ansi-white-bg">`spec()`</span> to retrieve the full column specification for this data.
<span class="ansi-cyan-fg">ℹ</span> Specify the column types or set <span class="ansi-black-fg ansi-white-bg">`show_col_types = FALSE`</span> to quiet this message.

Begin formatting .... 

The raw data set has 7055881 dat lines

Remove ambiguous SNPs ..., remaining 6004428 SNPs.

Remove SNPs in MHC region ..., remaining 5993962 SNPs.

Remove duplicated SNPs ..., remaining 5993414 SNPs.

Merge SNPs with the hapmap3 snplist ..., remaining 1148529 SNPs.

Remove SNPs with alleles not matched with the hapmap3 snplist, remaining 1148507 SNPs.

Generating sample size from specified sample size

Remove SNPs with p-value &lt; 0 or p-value &gt; 1, remaining 1148507 SNPs.

Inferring z score from p value and b ...

Remove missing values, remaining 1148507 SNPs.

Remove SNPs with sample size 5 standard deviations away from the mean, remaining 1148507 SNPs.

Remove SNPs with chi2 &gt; chi2_max ... , remaining 1148476 SNPs.

The formatted data has 1148476 dat lines. 


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<div class=" highlight hl-r"><pre><span></span><span class="c1">## 2. Alcohol</span>
<span class="n">Alcohol_raw</span> <span class="o">&lt;-</span> <span class="n">readr</span><span class="o">::</span><span class="nf">read_delim</span><span class="p">(</span><span class="s">&quot;./GWAS_26and5_raw/Alcohol&quot;</span><span class="p">,</span> <span class="s">&quot;\t&quot;</span><span class="p">,</span> <span class="n">escape_double</span> <span class="o">=</span> <span class="kc">FALSE</span><span class="p">,</span> <span class="n">trim_ws</span> <span class="o">=</span> <span class="kc">TRUE</span><span class="p">,</span> <span class="n">progress</span> <span class="o">=</span> <span class="bp">F</span><span class="p">)</span>

<span class="n">Alcohol</span> <span class="o">=</span> <span class="nf">format_data</span><span class="p">(</span><span class="n">Alcohol_raw</span><span class="p">,</span>
                      <span class="n">snp_col</span> <span class="o">=</span> <span class="s">&quot;MarkerName&quot;</span><span class="p">,</span>
                      <span class="n">b_col</span> <span class="o">=</span> <span class="s">&quot;Beta&quot;</span><span class="p">,</span>
                      <span class="n">se_col</span> <span class="o">=</span> <span class="s">&quot;SE&quot;</span><span class="p">,</span>
                      <span class="n">freq_col</span> <span class="o">=</span> <span class="s">&quot;EAF_A1&quot;</span><span class="p">,</span>
                      <span class="n">A1_col</span> <span class="o">=</span> <span class="s">&quot;A1&quot;</span><span class="p">,</span>
                      <span class="n">A2_col</span> <span class="o">=</span> <span class="s">&quot;A2&quot;</span><span class="p">,</span>
                      <span class="n">p_col</span> <span class="o">=</span> <span class="s">&quot;Pval&quot;</span><span class="p">,</span>
                      <span class="n">n</span> <span class="o">=</span> <span class="m">414343</span><span class="p">)</span>

<span class="nf">write.table</span><span class="p">(</span><span class="n">Alcohol</span><span class="p">,</span> <span class="s">&quot;./GWAS_26and5_formatted/Alcohol&quot;</span><span class="p">,</span> <span class="n">sep</span><span class="o">=</span><span class="s">&quot;\t&quot;</span><span class="p">,</span> <span class="n">quote</span> <span class="o">=</span> <span class="bp">F</span><span class="p">,</span> <span class="n">row.names</span> <span class="o">=</span> <span class="bp">F</span><span class="p">,</span> <span class="n">col.names</span> <span class="o">=</span> <span class="bp">T</span><span class="p">)</span>

<span class="nf">rm</span><span class="p">(</span><span class="n">list</span><span class="o">=</span><span class="nf">c</span><span class="p">(</span><span class="s">&quot;Alcohol_raw&quot;</span><span class="p">,</span><span class="s">&quot;Alcohol&quot;</span><span class="p">))</span>
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<pre><span class="ansi-bold">Rows: </span><span class="ansi-blue-fg">11514936</span> <span class="ansi-bold">Columns: </span><span class="ansi-blue-fg">9</span>

<span class="ansi-cyan-fg">──</span> <span class="ansi-bold">Column specification</span> <span class="ansi-cyan-fg">────────────────────────────────────────────────────────────────────────────────────────────────────────</span>
<span class="ansi-bold">Delimiter:</span> &#34;\t&#34;
<span class="ansi-red-fg">chr</span> (3): MarkerName, A1, A2
<span class="ansi-green-fg">dbl</span> (6): CHR, POS, EAF_A1, Beta, SE, Pval


<span class="ansi-cyan-fg">ℹ</span> Use <span class="ansi-black-fg ansi-white-bg">`spec()`</span> to retrieve the full column specification for this data.
<span class="ansi-cyan-fg">ℹ</span> Specify the column types or set <span class="ansi-black-fg ansi-white-bg">`show_col_types = FALSE`</span> to quiet this message.

Begin formatting .... 

The raw data set has 11514936 dat lines

Remove ambiguous SNPs ..., remaining 9791370 SNPs.

Remove SNPs in MHC region ..., remaining 9742990 SNPs.

Remove duplicated SNPs ..., remaining 9661810 SNPs.

Merge SNPs with the hapmap3 snplist ..., remaining 1198814 SNPs.

Remove SNPs with alleles not matched with the hapmap3 snplist, remaining 1198811 SNPs.

Generating sample size from specified sample size

Remove SNPs with p-value &lt; 0 or p-value &gt; 1, remaining 1084534 SNPs.

Inferring z score from p value and b ...

Remove missing values, remaining 1084534 SNPs.

Remove SNPs with sample size 5 standard deviations away from the mean, remaining 1084534 SNPs.

Remove SNPs with chi2 &gt; chi2_max ... , remaining 1084534 SNPs.

The formatted data has 1084534 dat lines. 


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<div class=" highlight hl-r"><pre><span></span><span class="c1">## 3. Angina</span>
<span class="n">Angina_raw</span> <span class="o">&lt;-</span> <span class="n">readr</span><span class="o">::</span><span class="nf">read_delim</span><span class="p">(</span><span class="s">&quot;./GWAS_26and5_raw/Angina&quot;</span><span class="p">,</span> <span class="s">&quot;\t&quot;</span><span class="p">,</span> <span class="n">escape_double</span> <span class="o">=</span> <span class="kc">FALSE</span><span class="p">,</span> <span class="n">trim_ws</span> <span class="o">=</span> <span class="kc">TRUE</span><span class="p">,</span> <span class="n">progress</span> <span class="o">=</span> <span class="bp">F</span><span class="p">)</span>

<span class="n">Angina</span> <span class="o">=</span> <span class="nf">format_data</span><span class="p">(</span><span class="n">Angina_raw</span><span class="p">,</span>
                     <span class="n">snp_col</span> <span class="o">=</span> <span class="s">&quot;SNPID_UKB&quot;</span><span class="p">,</span>
                     <span class="n">or_col</span> <span class="o">=</span> <span class="s">&quot;OR&quot;</span><span class="p">,</span>
                     <span class="n">se_col</span> <span class="o">=</span> <span class="s">&quot;SE&quot;</span><span class="p">,</span>
                     <span class="n">freq_col</span> <span class="o">=</span> <span class="s">&quot;MAF_UKB&quot;</span><span class="p">,</span>
                     <span class="n">A1_col</span> <span class="o">=</span> <span class="s">&quot;A1&quot;</span><span class="p">,</span>
                     <span class="n">A2_col</span> <span class="o">=</span> <span class="s">&quot;A2&quot;</span><span class="p">,</span>
                     <span class="n">p_col</span> <span class="o">=</span> <span class="s">&quot;P&quot;</span><span class="p">,</span>
                     <span class="n">n_col</span> <span class="o">=</span> <span class="s">&quot;NMISS&quot;</span><span class="p">,</span>
                     <span class="n">info_col</span> <span class="o">=</span> <span class="s">&quot;INFO_UKB&quot;</span><span class="p">)</span>

<span class="nf">write.table</span><span class="p">(</span><span class="n">Angina</span><span class="p">,</span> <span class="s">&quot;./GWAS_26and5_formatted/Angina&quot;</span><span class="p">,</span> <span class="n">sep</span><span class="o">=</span><span class="s">&quot;\t&quot;</span><span class="p">,</span> <span class="n">quote</span> <span class="o">=</span> <span class="bp">F</span><span class="p">,</span> <span class="n">row.names</span> <span class="o">=</span> <span class="bp">F</span><span class="p">,</span> <span class="n">col.names</span> <span class="o">=</span> <span class="bp">T</span><span class="p">)</span>

<span class="nf">rm</span><span class="p">(</span><span class="n">list</span><span class="o">=</span><span class="nf">c</span><span class="p">(</span><span class="s">&quot;Angina_raw&quot;</span><span class="p">,</span><span class="s">&quot;Angina&quot;</span><span class="p">))</span>
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<pre><span class="ansi-bold">Rows: </span><span class="ansi-blue-fg">10321705</span> <span class="ansi-bold">Columns: </span><span class="ansi-blue-fg">20</span>

<span class="ansi-cyan-fg">──</span> <span class="ansi-bold">Column specification</span> <span class="ansi-cyan-fg">────────────────────────────────────────────────────────────────────────────────────────────────────────</span>
<span class="ansi-bold">Delimiter:</span> &#34;\t&#34;
<span class="ansi-red-fg">chr</span>  (7): SNP, A1, TEST, A2, SNPID_UKB, A1_UKB, A2_UKB
<span class="ansi-green-fg">dbl</span> (13): CHR, BP, NMISS, OR, SE, L95, U95, STAT, P, MAF, NCHROBS, INFO_UKB,...


<span class="ansi-cyan-fg">ℹ</span> Use <span class="ansi-black-fg ansi-white-bg">`spec()`</span> to retrieve the full column specification for this data.
<span class="ansi-cyan-fg">ℹ</span> Specify the column types or set <span class="ansi-black-fg ansi-white-bg">`show_col_types = FALSE`</span> to quiet this message.

Begin formatting .... 

The raw data set has 10321705 dat lines

Remove SNPs with imputation info less than 0.9 ..., remaining 10321675 SNPs.

Remove ambiguous SNPs ..., remaining 8761299 SNPs.

Remove SNPs in MHC region ..., remaining 8711402 SNPs.

Remove duplicated SNPs ..., remaining 8711402 SNPs.

Merge SNPs with the hapmap3 snplist ..., remaining 1161107 SNPs.

Remove SNPs with alleles not matched with the hapmap3 snplist, remaining 1160815 SNPs.

infer b column from log(or)...

Remove SNPs with p-value &lt; 0 or p-value &gt; 1, remaining 1037824 SNPs.

Inferring z score from p value and b ...

Remove missing values, remaining 1037824 SNPs.

Remove SNPs with sample size 5 standard deviations away from the mean, remaining 1037824 SNPs.

Remove SNPs with chi2 &gt; chi2_max ... , remaining 1037824 SNPs.

The formatted data has 1037824 dat lines. 


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<div class=" highlight hl-r"><pre><span></span><span class="c1">## 4. Anorexia</span>
<span class="n">Anorexia_raw</span> <span class="o">&lt;-</span> <span class="n">readr</span><span class="o">::</span><span class="nf">read_delim</span><span class="p">(</span><span class="s">&quot;./GWAS_26and5_raw/Anorexia&quot;</span><span class="p">,</span> <span class="s">&quot;\t&quot;</span><span class="p">,</span> <span class="n">escape_double</span> <span class="o">=</span> <span class="kc">FALSE</span><span class="p">,</span> <span class="n">trim_ws</span> <span class="o">=</span> <span class="kc">TRUE</span><span class="p">,</span> <span class="n">progress</span> <span class="o">=</span> <span class="bp">F</span><span class="p">)</span>

<span class="n">Anorexia</span> <span class="o">=</span> <span class="nf">format_data</span><span class="p">(</span><span class="n">Anorexia_raw</span><span class="p">,</span>
                       <span class="n">snp_col</span> <span class="o">=</span> <span class="s">&quot;ID&quot;</span><span class="p">,</span>
                       <span class="n">b_col</span> <span class="o">=</span> <span class="s">&quot;BETA&quot;</span><span class="p">,</span>
                       <span class="n">se_col</span> <span class="o">=</span> <span class="s">&quot;SE&quot;</span><span class="p">,</span>
                       <span class="n">A1_col</span> <span class="o">=</span> <span class="s">&quot;ALT&quot;</span><span class="p">,</span>
                       <span class="n">A2_col</span> <span class="o">=</span> <span class="s">&quot;REF&quot;</span><span class="p">,</span>
                       <span class="n">p_col</span> <span class="o">=</span> <span class="s">&quot;PVAL&quot;</span><span class="p">,</span>
                       <span class="n">ncase_col</span>  <span class="o">=</span> <span class="s">&quot;NCAS&quot;</span><span class="p">,</span>
                       <span class="n">ncontrol_col</span> <span class="o">=</span> <span class="s">&quot;NCON&quot;</span><span class="p">,</span>
                       <span class="n">info_col</span> <span class="o">=</span> <span class="s">&quot;IMPINFO&quot;</span><span class="p">)</span>

<span class="nf">write.table</span><span class="p">(</span><span class="n">Anorexia</span><span class="p">,</span> <span class="s">&quot;./GWAS_26and5_formatted/Anorexia&quot;</span><span class="p">,</span> <span class="n">sep</span> <span class="o">=</span> <span class="s">&quot;\t&quot;</span><span class="p">,</span> <span class="n">quote</span> <span class="o">=</span> <span class="bp">F</span><span class="p">,</span> <span class="n">row.names</span> <span class="o">=</span> <span class="bp">F</span><span class="p">,</span> <span class="n">col.names</span> <span class="o">=</span> <span class="bp">T</span><span class="p">)</span>

<span class="nf">rm</span><span class="p">(</span><span class="n">list</span><span class="o">=</span><span class="nf">c</span><span class="p">(</span><span class="s">&quot;Anorexia_raw&quot;</span><span class="p">,</span><span class="s">&quot;Anorexia&quot;</span><span class="p">))</span>
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<pre><span class="ansi-bold">Rows: </span><span class="ansi-blue-fg">8219102</span> <span class="ansi-bold">Columns: </span><span class="ansi-blue-fg">14</span>

<span class="ansi-cyan-fg">──</span> <span class="ansi-bold">Column specification</span> <span class="ansi-cyan-fg">────────────────────────────────────────────────────────────────────────────────────────────────────────</span>
<span class="ansi-bold">Delimiter:</span> &#34;\t&#34;
<span class="ansi-red-fg">chr</span>  (4): ID, REF, ALT, DIRE
<span class="ansi-green-fg">dbl</span> (10): CHROM, POS, BETA, SE, PVAL, NGT, IMPINFO, NEFFDIV2, NCAS, NCON


<span class="ansi-cyan-fg">ℹ</span> Use <span class="ansi-black-fg ansi-white-bg">`spec()`</span> to retrieve the full column specification for this data.
<span class="ansi-cyan-fg">ℹ</span> Specify the column types or set <span class="ansi-black-fg ansi-white-bg">`show_col_types = FALSE`</span> to quiet this message.

Begin formatting .... 

The raw data set has 8219102 dat lines

Remove SNPs with imputation info less than 0.9 ..., remaining 5880021 SNPs.

effect allele column has some values that are not A/C/T/G. Remove these SNPs..., remaining 5880020 SNPs.

the other allele column has some values that are not A/C/T/G. Remove these SNPs..., remaining 5880019 SNPs.

Remove ambiguous SNPs ..., remaining 5064495 SNPs.

Remove SNPs in MHC region ..., remaining 5033100 SNPs.

Remove duplicated SNPs ..., remaining 4986546 SNPs.

Merge SNPs with the hapmap3 snplist ..., remaining 922421 SNPs.

Remove SNPs with alleles not matched with the hapmap3 snplist, remaining 922420 SNPs.

Generating sample size from ncase and ncontrol

Remove SNPs with p-value &lt; 0 or p-value &gt; 1, remaining 922420 SNPs.

Inferring z score from p value and b ...

Remove missing values, remaining 922420 SNPs.

Remove SNPs with sample size 5 standard deviations away from the mean, remaining 910374 SNPs.

Remove SNPs with chi2 &gt; chi2_max ... , remaining 910374 SNPs.

The formatted data has 910374 dat lines. 


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<div class=" highlight hl-r"><pre><span></span><span class="c1">## 5. ASD</span>
<span class="n">ASD_raw</span> <span class="o">&lt;-</span> <span class="n">readr</span><span class="o">::</span><span class="nf">read_delim</span><span class="p">(</span><span class="s">&quot;./GWAS_26and5_raw/ASD&quot;</span><span class="p">,</span> <span class="s">&quot;\t&quot;</span><span class="p">,</span> <span class="n">escape_double</span> <span class="o">=</span> <span class="kc">FALSE</span><span class="p">,</span> <span class="n">trim_ws</span> <span class="o">=</span> <span class="kc">TRUE</span><span class="p">,</span> <span class="n">progress</span> <span class="o">=</span> <span class="bp">F</span><span class="p">)</span>

<span class="n">ASD</span> <span class="o">=</span> <span class="nf">format_data</span><span class="p">(</span><span class="n">ASD_raw</span><span class="p">,</span>
                  <span class="n">snp_col</span> <span class="o">=</span> <span class="s">&quot;snp&quot;</span><span class="p">,</span>
                  <span class="n">b_col</span> <span class="o">=</span> <span class="s">&quot;b&quot;</span><span class="p">,</span>
                  <span class="n">se_col</span> <span class="o">=</span> <span class="s">&quot;StdErr&quot;</span><span class="p">,</span>
                  <span class="n">freq_col</span> <span class="o">=</span> <span class="s">&quot;freq_A1&quot;</span><span class="p">,</span>
                  <span class="n">A1_col</span> <span class="o">=</span> <span class="s">&quot;A1&quot;</span><span class="p">,</span>
                  <span class="n">A2_col</span> <span class="o">=</span> <span class="s">&quot;A2&quot;</span><span class="p">,</span>
                  <span class="n">p_col</span> <span class="o">=</span> <span class="s">&quot;p&quot;</span><span class="p">,</span>
                  <span class="n">n_col</span> <span class="o">=</span> <span class="s">&quot;N&quot;</span><span class="p">)</span>

<span class="nf">write.table</span><span class="p">(</span><span class="n">ASD</span><span class="p">,</span> <span class="s">&quot;./GWAS_26and5_formatted/ASD&quot;</span><span class="p">,</span> <span class="n">sep</span> <span class="o">=</span> <span class="s">&quot;\t&quot;</span><span class="p">,</span> <span class="n">quote</span> <span class="o">=</span> <span class="bp">F</span><span class="p">,</span> <span class="n">row.names</span> <span class="o">=</span> <span class="bp">F</span><span class="p">,</span> <span class="n">col.names</span> <span class="o">=</span> <span class="bp">T</span><span class="p">)</span>

<span class="nf">rm</span><span class="p">(</span><span class="n">list</span><span class="o">=</span><span class="nf">c</span><span class="p">(</span><span class="s">&quot;ASD_raw&quot;</span><span class="p">,</span><span class="s">&quot;ASD&quot;</span><span class="p">))</span>
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<pre><span class="ansi-bold">Rows: </span><span class="ansi-blue-fg">6517324</span> <span class="ansi-bold">Columns: </span><span class="ansi-blue-fg">15</span>

<span class="ansi-cyan-fg">──</span> <span class="ansi-bold">Column specification</span> <span class="ansi-cyan-fg">────────────────────────────────────────────────────────────────────────────────────────────────────────</span>
<span class="ansi-bold">Delimiter:</span> &#34;\t&#34;
<span class="ansi-red-fg">chr</span>  (4): snp, A1, A2, direction
<span class="ansi-green-fg">dbl</span> (11): chr, bp_hg19, or, tor_l95, or_u95, b, se, p, freq_A1, info, N


<span class="ansi-cyan-fg">ℹ</span> Use <span class="ansi-black-fg ansi-white-bg">`spec()`</span> to retrieve the full column specification for this data.
<span class="ansi-cyan-fg">ℹ</span> Specify the column types or set <span class="ansi-black-fg ansi-white-bg">`show_col_types = FALSE`</span> to quiet this message.

Begin formatting .... 

The raw data set has 6517324 dat lines

effect allele column has some values that are not A/C/T/G. Remove these SNPs..., remaining 6517323 SNPs.

the other allele column has some values that are not A/C/T/G. Remove these SNPs..., remaining 6517322 SNPs.

Remove ambiguous SNPs ..., remaining 5593524 SNPs.

Remove SNPs in MHC region ..., remaining 5585718 SNPs.

Remove duplicated SNPs ..., remaining 5585718 SNPs.

Merge SNPs with the hapmap3 snplist ..., remaining 1093312 SNPs.

Remove SNPs with p-value &lt; 0 or p-value &gt; 1, remaining 1079411 SNPs.

Inferring z score from p value and b ...

Remove missing values, remaining 1079411 SNPs.

Remove SNPs with sample size 5 standard deviations away from the mean, remaining 1076873 SNPs.

Remove SNPs with chi2 &gt; chi2_max ... , remaining 1076873 SNPs.

The formatted data has 1076873 dat lines. 


</pre>
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<div class=" highlight hl-r"><pre><span></span><span class="c1">## 6. BMI</span>
<span class="n">BMI_raw</span> <span class="o">&lt;-</span> <span class="n">readr</span><span class="o">::</span><span class="nf">read_delim</span><span class="p">(</span><span class="s">&quot;./GWAS_26and5_raw/BMI&quot;</span><span class="p">,</span> <span class="s">&quot;\t&quot;</span><span class="p">,</span> <span class="n">escape_double</span> <span class="o">=</span> <span class="kc">FALSE</span><span class="p">,</span> <span class="n">trim_ws</span> <span class="o">=</span> <span class="kc">TRUE</span><span class="p">,</span> <span class="n">progress</span> <span class="o">=</span> <span class="bp">F</span><span class="p">)</span>

<span class="n">BMI</span> <span class="o">=</span> <span class="nf">format_data</span><span class="p">(</span><span class="n">BMI_raw</span><span class="p">,</span>
                  <span class="n">snp_col</span> <span class="o">=</span> <span class="s">&quot;SNPID_UKB&quot;</span><span class="p">,</span>
                  <span class="n">b_col</span> <span class="o">=</span> <span class="s">&quot;BETA&quot;</span><span class="p">,</span>
                  <span class="n">se_col</span> <span class="o">=</span> <span class="s">&quot;SE&quot;</span><span class="p">,</span>
                  <span class="n">freq_col</span> <span class="o">=</span> <span class="s">&quot;MAF_UKB&quot;</span><span class="p">,</span>
                  <span class="n">A1_col</span> <span class="o">=</span> <span class="s">&quot;A1&quot;</span><span class="p">,</span>
                  <span class="n">A2_col</span> <span class="o">=</span> <span class="s">&quot;A2&quot;</span><span class="p">,</span>
                  <span class="n">p_col</span> <span class="o">=</span> <span class="s">&quot;P&quot;</span><span class="p">,</span>
                  <span class="n">n_col</span> <span class="o">=</span> <span class="s">&quot;NMISS&quot;</span><span class="p">,</span>
                  <span class="n">info_col</span> <span class="o">=</span> <span class="s">&quot;INFO_UKB&quot;</span><span class="p">)</span>

<span class="nf">write.table</span><span class="p">(</span><span class="n">BMI</span><span class="p">,</span> <span class="s">&quot;./GWAS_26and5_formatted/BMI&quot;</span><span class="p">,</span> <span class="n">sep</span> <span class="o">=</span> <span class="s">&quot;\t&quot;</span><span class="p">,</span> <span class="n">quote</span> <span class="o">=</span> <span class="bp">F</span><span class="p">,</span> <span class="n">row.names</span> <span class="o">=</span> <span class="bp">F</span><span class="p">,</span> <span class="n">col.names</span> <span class="o">=</span> <span class="bp">T</span><span class="p">)</span>

<span class="nf">rm</span><span class="p">(</span><span class="n">list</span><span class="o">=</span><span class="nf">c</span><span class="p">(</span><span class="s">&quot;BMI_raw&quot;</span><span class="p">,</span><span class="s">&quot;BMI&quot;</span><span class="p">))</span>
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<pre><span class="ansi-bold">Rows: </span><span class="ansi-blue-fg">10599054</span> <span class="ansi-bold">Columns: </span><span class="ansi-blue-fg">20</span>

<span class="ansi-cyan-fg">──</span> <span class="ansi-bold">Column specification</span> <span class="ansi-cyan-fg">────────────────────────────────────────────────────────────────────────────────────────────────────────</span>
<span class="ansi-bold">Delimiter:</span> &#34;\t&#34;
<span class="ansi-red-fg">chr</span>  (7): SNP, A1, TEST, A2, SNPID_UKB, A1_UKB, A2_UKB
<span class="ansi-green-fg">dbl</span> (13): CHR, BP, NMISS, BETA, SE, L95, U95, STAT, P, MAF, NCHROBS, INFO_UK...


<span class="ansi-cyan-fg">ℹ</span> Use <span class="ansi-black-fg ansi-white-bg">`spec()`</span> to retrieve the full column specification for this data.
<span class="ansi-cyan-fg">ℹ</span> Specify the column types or set <span class="ansi-black-fg ansi-white-bg">`show_col_types = FALSE`</span> to quiet this message.

Begin formatting .... 

The raw data set has 10599054 dat lines

Remove SNPs with imputation info less than 0.9 ..., remaining 10599018 SNPs.

Remove ambiguous SNPs ..., remaining 8995068 SNPs.

Remove SNPs in MHC region ..., remaining 8944044 SNPs.

Remove duplicated SNPs ..., remaining 8944044 SNPs.

Merge SNPs with the hapmap3 snplist ..., remaining 1161501 SNPs.

Remove SNPs with alleles not matched with the hapmap3 snplist, remaining 1161195 SNPs.

Remove SNPs with p-value &lt; 0 or p-value &gt; 1, remaining 1037824 SNPs.

Inferring z score from p value and b ...

Remove missing values, remaining 1037824 SNPs.

Remove SNPs with sample size 5 standard deviations away from the mean, remaining 1037824 SNPs.

Remove SNPs with chi2 &gt; chi2_max ... , remaining 1037799 SNPs.

The formatted data has 1037799 dat lines. 


</pre>
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<div class=" highlight hl-r"><pre><span></span><span class="c1">## 7. CAD</span>
<span class="n">CAD_raw</span> <span class="o">&lt;-</span> <span class="n">readr</span><span class="o">::</span><span class="nf">read_delim</span><span class="p">(</span><span class="s">&quot;./GWAS_26and5_raw/CAD&quot;</span><span class="p">,</span> <span class="s">&quot;\t&quot;</span><span class="p">,</span> <span class="n">escape_double</span> <span class="o">=</span> <span class="kc">FALSE</span><span class="p">,</span> <span class="n">trim_ws</span> <span class="o">=</span> <span class="kc">TRUE</span><span class="p">,</span> <span class="n">progress</span> <span class="o">=</span> <span class="bp">F</span><span class="p">)</span>

<span class="n">CAD</span> <span class="o">=</span> <span class="nf">format_data</span><span class="p">(</span><span class="n">CAD_raw</span><span class="p">,</span>
                  <span class="n">snp_col</span> <span class="o">=</span> <span class="s">&quot;markername&quot;</span><span class="p">,</span>
                  <span class="n">b_col</span> <span class="o">=</span> <span class="s">&quot;beta&quot;</span><span class="p">,</span>
                  <span class="n">se_col</span> <span class="o">=</span> <span class="s">&quot;se&quot;</span><span class="p">,</span>
                  <span class="n">freq_col</span> <span class="o">=</span> <span class="s">&quot;effect_allele_freq&quot;</span><span class="p">,</span>
                  <span class="n">A1_col</span> <span class="o">=</span> <span class="s">&quot;effect_allele&quot;</span><span class="p">,</span>
                  <span class="n">A2_col</span> <span class="o">=</span> <span class="s">&quot;noneffect_allele&quot;</span><span class="p">,</span>
                  <span class="n">p_col</span> <span class="o">=</span> <span class="s">&quot;p_dgc&quot;</span><span class="p">,</span>
                  <span class="n">n</span> <span class="o">=</span> <span class="m">184305</span><span class="p">)</span>

<span class="nf">write.table</span><span class="p">(</span><span class="n">CAD</span><span class="p">,</span> <span class="s">&quot;./GWAS_26and5_formatted/CAD&quot;</span><span class="p">,</span> <span class="n">sep</span> <span class="o">=</span> <span class="s">&quot;\t&quot;</span><span class="p">,</span> <span class="n">quote</span> <span class="o">=</span> <span class="bp">F</span><span class="p">,</span> <span class="n">row.names</span> <span class="o">=</span> <span class="bp">F</span><span class="p">,</span> <span class="n">col.names</span> <span class="o">=</span> <span class="bp">T</span><span class="p">)</span>

<span class="nf">rm</span><span class="p">(</span><span class="n">list</span><span class="o">=</span><span class="nf">c</span><span class="p">(</span><span class="s">&quot;CAD_raw&quot;</span><span class="p">,</span><span class="s">&quot;CAD&quot;</span><span class="p">))</span>
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<pre><span class="ansi-bold">Rows: </span><span class="ansi-blue-fg">9455778</span> <span class="ansi-bold">Columns: </span><span class="ansi-blue-fg">13</span>

<span class="ansi-cyan-fg">──</span> <span class="ansi-bold">Column specification</span> <span class="ansi-cyan-fg">────────────────────────────────────────────────────────────────────────────────────────────────────────</span>
<span class="ansi-bold">Delimiter:</span> &#34;\t&#34;
<span class="ansi-red-fg">chr</span> (4): markername, effect_allele, noneffect_allele, model
<span class="ansi-green-fg">dbl</span> (9): chr, bp_hg19, effect_allele_freq, median_info, beta, se_dgc, p_dgc,...


<span class="ansi-cyan-fg">ℹ</span> Use <span class="ansi-black-fg ansi-white-bg">`spec()`</span> to retrieve the full column specification for this data.
<span class="ansi-cyan-fg">ℹ</span> Specify the column types or set <span class="ansi-black-fg ansi-white-bg">`show_col_types = FALSE`</span> to quiet this message.

Begin formatting .... 

The raw data set has 9455778 dat lines

effect allele column has some values that are not A/C/T/G. Remove these SNPs..., remaining 9455777 SNPs.

the other allele column has some values that are not A/C/T/G. Remove these SNPs..., remaining 9455776 SNPs.

Remove ambiguous SNPs ..., remaining 8123051 SNPs.

Remove SNPs in MHC region ..., remaining 8109390 SNPs.

Remove duplicated SNPs ..., remaining 8109390 SNPs.

Merge SNPs with the hapmap3 snplist ..., remaining 1192337 SNPs.

Generating sample size from specified sample size

Remove SNPs with p-value &lt; 0 or p-value &gt; 1, remaining 1112984 SNPs.

Inferring z score from p value and b ...

Remove missing values, remaining 1112984 SNPs.

Remove SNPs with sample size 5 standard deviations away from the mean, remaining 1112984 SNPs.

Remove SNPs with chi2 &gt; chi2_max ... , remaining 1112977 SNPs.

The formatted data has 1112977 dat lines. 


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<div class=" highlight hl-r"><pre><span></span><span class="c1">## 8. CD (Crohn Disease)</span>
<span class="c1"># CD_rsid: CD annotated with rs-number and freq</span>

<span class="n">CD_raw</span> <span class="o">&lt;-</span> <span class="n">readr</span><span class="o">::</span><span class="nf">read_delim</span><span class="p">(</span><span class="s">&quot;./GWAS_26and5_raw/CD_rsid&quot;</span><span class="p">,</span> <span class="s">&quot;\t&quot;</span><span class="p">,</span> <span class="n">escape_double</span> <span class="o">=</span> <span class="kc">FALSE</span><span class="p">,</span> <span class="n">trim_ws</span> <span class="o">=</span> <span class="kc">TRUE</span><span class="p">,</span> <span class="n">progress</span> <span class="o">=</span> <span class="bp">F</span><span class="p">)</span>

<span class="n">CD</span> <span class="o">=</span> <span class="nf">format_data</span><span class="p">(</span><span class="n">CD_raw</span><span class="p">,</span>
                 <span class="n">snp_col</span> <span class="o">=</span> <span class="s">&quot;rsid&quot;</span><span class="p">,</span>
                 <span class="n">b_col</span> <span class="o">=</span> <span class="s">&quot;Effect&quot;</span><span class="p">,</span>
                 <span class="n">se_col</span> <span class="o">=</span> <span class="s">&quot;StdErr&quot;</span><span class="p">,</span>
                 <span class="n">freq_col</span> <span class="o">=</span> <span class="s">&quot;freq&quot;</span><span class="p">,</span>
                 <span class="n">A1_col</span> <span class="o">=</span> <span class="s">&quot;Allele1&quot;</span><span class="p">,</span>
                 <span class="n">A2_col</span> <span class="o">=</span> <span class="s">&quot;Allele2&quot;</span><span class="p">,</span>
                 <span class="n">p_col</span> <span class="o">=</span> <span class="s">&quot;P.value&quot;</span><span class="p">,</span>
                 <span class="n">n</span> <span class="o">=</span> <span class="m">40266</span><span class="p">)</span>

<span class="nf">write.table</span><span class="p">(</span><span class="n">CD</span><span class="p">,</span> <span class="s">&quot;./GWAS_26and5_formatted/CD&quot;</span><span class="p">,</span> <span class="n">sep</span> <span class="o">=</span> <span class="s">&quot;\t&quot;</span><span class="p">,</span> <span class="n">quote</span> <span class="o">=</span> <span class="bp">F</span><span class="p">,</span> <span class="n">row.names</span> <span class="o">=</span> <span class="bp">F</span><span class="p">,</span> <span class="n">col.names</span> <span class="o">=</span> <span class="bp">T</span><span class="p">)</span>

<span class="nf">rm</span><span class="p">(</span><span class="n">list</span><span class="o">=</span><span class="nf">c</span><span class="p">(</span><span class="s">&quot;CD_raw&quot;</span><span class="p">,</span><span class="s">&quot;CD&quot;</span><span class="p">))</span>
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<pre><span class="ansi-bold">Rows: </span><span class="ansi-blue-fg">7055380</span> <span class="ansi-bold">Columns: </span><span class="ansi-blue-fg">7</span>

<span class="ansi-cyan-fg">──</span> <span class="ansi-bold">Column specification</span> <span class="ansi-cyan-fg">────────────────────────────────────────────────────────────────────────────────────────────────────────</span>
<span class="ansi-bold">Delimiter:</span> &#34;\t&#34;
<span class="ansi-red-fg">chr</span> (3): rsid, Allele1, Allele2
<span class="ansi-green-fg">dbl</span> (4): freq, Effect, StdErr, P.value


<span class="ansi-cyan-fg">ℹ</span> Use <span class="ansi-black-fg ansi-white-bg">`spec()`</span> to retrieve the full column specification for this data.
<span class="ansi-cyan-fg">ℹ</span> Specify the column types or set <span class="ansi-black-fg ansi-white-bg">`show_col_types = FALSE`</span> to quiet this message.

Begin formatting .... 

The raw data set has 7055380 dat lines

Remove ambiguous SNPs ..., remaining 6012676 SNPs.

Remove SNPs in MHC region ..., remaining 5983174 SNPs.

Remove duplicated SNPs ..., remaining 5979640 SNPs.

Merge SNPs with the hapmap3 snplist ..., remaining 1108128 SNPs.

Remove SNPs with alleles not matched with the hapmap3 snplist, remaining 1108106 SNPs.

Generating sample size from specified sample size

Remove SNPs with p-value &lt; 0 or p-value &gt; 1, remaining 1004931 SNPs.

Inferring z score from p value and b ...

Remove missing values, remaining 1004931 SNPs.

Remove SNPs with sample size 5 standard deviations away from the mean, remaining 1004931 SNPs.

Remove SNPs with chi2 &gt; chi2_max ... , remaining 1004565 SNPs.

The formatted data has 1004565 dat lines. 


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<div class=" highlight hl-r"><pre><span></span><span class="c1">## 9. DaytimeSleepiness</span>
<span class="n">dat_raw</span> <span class="o">&lt;-</span> <span class="n">readr</span><span class="o">::</span><span class="nf">read_delim</span><span class="p">(</span><span class="s">&quot;./GWAS_26and5_raw/DaytimeSleepiness&quot;</span><span class="p">,</span> <span class="s">&quot;\t&quot;</span><span class="p">,</span> <span class="n">escape_double</span> <span class="o">=</span> <span class="kc">FALSE</span><span class="p">,</span> <span class="n">trim_ws</span> <span class="o">=</span> <span class="kc">TRUE</span><span class="p">,</span> <span class="n">progress</span> <span class="o">=</span> <span class="bp">F</span><span class="p">)</span>

<span class="n">dat</span> <span class="o">=</span> <span class="nf">format_data</span><span class="p">(</span><span class="n">dat_raw</span><span class="p">,</span>
                  <span class="n">snp_col</span> <span class="o">=</span> <span class="s">&quot;SNP&quot;</span><span class="p">,</span>
                  <span class="n">b_col</span> <span class="o">=</span> <span class="s">&quot;BETA&quot;</span><span class="p">,</span>
                  <span class="n">se_col</span> <span class="o">=</span> <span class="s">&quot;SE&quot;</span><span class="p">,</span>
                  <span class="n">freq_col</span> <span class="o">=</span> <span class="s">&quot;A1FREQ&quot;</span><span class="p">,</span>
                  <span class="n">A1_col</span> <span class="o">=</span> <span class="s">&quot;ALLELE1&quot;</span><span class="p">,</span>
                  <span class="n">A2_col</span> <span class="o">=</span> <span class="s">&quot;ALLELE0&quot;</span><span class="p">,</span>
                  <span class="n">info_col</span> <span class="o">=</span> <span class="s">&quot;INFO&quot;</span><span class="p">,</span>
                  <span class="n">p_col</span> <span class="o">=</span> <span class="s">&quot;P&quot;</span><span class="p">,</span>
                  <span class="n">n</span> <span class="o">=</span> <span class="m">452071</span><span class="p">)</span>

<span class="nf">write.table</span><span class="p">(</span><span class="n">dat</span><span class="p">,</span> <span class="s">&quot;./GWAS_26and5_formatted/Daytime_Sleepiness&quot;</span><span class="p">,</span>  <span class="n">sep</span><span class="o">=</span><span class="s">&quot;\t&quot;</span><span class="p">,</span> <span class="n">quote</span> <span class="o">=</span> <span class="bp">F</span><span class="p">,</span> <span class="n">row.names</span> <span class="o">=</span> <span class="bp">F</span><span class="p">,</span> <span class="n">col.names</span> <span class="o">=</span> <span class="bp">T</span><span class="p">)</span>

<span class="nf">rm</span><span class="p">(</span><span class="n">list</span><span class="o">=</span><span class="nf">c</span><span class="p">(</span><span class="s">&quot;dat_raw&quot;</span><span class="p">,</span><span class="s">&quot;dat&quot;</span><span class="p">))</span>
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<pre><span class="ansi-bold">Rows: </span><span class="ansi-blue-fg">14661601</span> <span class="ansi-bold">Columns: </span><span class="ansi-blue-fg">10</span>

<span class="ansi-cyan-fg">──</span> <span class="ansi-bold">Column specification</span> <span class="ansi-cyan-fg">────────────────────────────────────────────────────────────────────────────────────────────────────────</span>
<span class="ansi-bold">Delimiter:</span> &#34;\t&#34;
<span class="ansi-red-fg">chr</span> (3): SNP, ALLELE1, ALLELE0
<span class="ansi-green-fg">dbl</span> (7): CHR, BP, A1FREQ, INFO, BETA, SE, P


<span class="ansi-cyan-fg">ℹ</span> Use <span class="ansi-black-fg ansi-white-bg">`spec()`</span> to retrieve the full column specification for this data.
<span class="ansi-cyan-fg">ℹ</span> Specify the column types or set <span class="ansi-black-fg ansi-white-bg">`show_col_types = FALSE`</span> to quiet this message.

Begin formatting .... 

The raw data set has 14661601 dat lines

Remove SNPs with imputation info less than 0.9 ..., remaining 10903657 SNPs.

Remove ambiguous SNPs ..., remaining 9250294 SNPs.

Remove SNPs in MHC region ..., remaining 9202639 SNPs.

Remove duplicated SNPs ..., remaining 9196675 SNPs.

Merge SNPs with the hapmap3 snplist ..., remaining 1198480 SNPs.

Remove SNPs with alleles not matched with the hapmap3 snplist, remaining 1198465 SNPs.

Generating sample size from specified sample size

Remove SNPs with p-value &lt; 0 or p-value &gt; 1, remaining 1065141 SNPs.

Inferring z score from p value and b ...

Remove missing values, remaining 1065141 SNPs.

Remove SNPs with sample size 5 standard deviations away from the mean, remaining 1065141 SNPs.

Remove SNPs with chi2 &gt; chi2_max ... , remaining 1065141 SNPs.

The formatted data has 1065141 dat lines. 


</pre>
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<div class="prompt input_prompt">In&nbsp;[13]:</div>
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<div class=" highlight hl-r"><pre><span></span><span class="c1">## 10. Depression</span>
<span class="n">dat_raw</span> <span class="o">&lt;-</span> <span class="n">readr</span><span class="o">::</span><span class="nf">read_delim</span><span class="p">(</span><span class="s">&quot;./GWAS_26and5_raw/Depression&quot;</span><span class="p">,</span> <span class="s">&quot;\t&quot;</span><span class="p">,</span> <span class="n">escape_double</span> <span class="o">=</span> <span class="kc">FALSE</span><span class="p">,</span> <span class="n">trim_ws</span> <span class="o">=</span> <span class="kc">TRUE</span><span class="p">,</span> <span class="n">progress</span> <span class="o">=</span> <span class="bp">F</span><span class="p">)</span>

<span class="n">dat</span> <span class="o">=</span> <span class="n">MRAPSS</span><span class="o">::</span><span class="nf">format_data</span><span class="p">(</span><span class="n">dat_raw</span><span class="p">,</span>
                          <span class="n">snp_col</span> <span class="o">=</span> <span class="s">&quot;RSID&quot;</span><span class="p">,</span>
                          <span class="n">z_col</span> <span class="o">=</span> <span class="s">&quot;Z&quot;</span><span class="p">,</span>
                          <span class="n">freq_col</span> <span class="o">=</span> <span class="s">&quot;MAF_UKB&quot;</span><span class="p">,</span>
                          <span class="n">A1_col</span> <span class="o">=</span> <span class="s">&quot;A1&quot;</span><span class="p">,</span>
                          <span class="n">A2_col</span> <span class="o">=</span> <span class="s">&quot;A2&quot;</span><span class="p">,</span>
                          <span class="n">p_col</span> <span class="o">=</span> <span class="s">&quot;P&quot;</span><span class="p">,</span>
                          <span class="n">n_col</span> <span class="o">=</span> <span class="s">&quot;N&quot;</span><span class="p">,</span>
                          <span class="n">info_col</span> <span class="o">=</span> <span class="s">&quot;INFO_UKB&quot;</span><span class="p">)</span>

<span class="nf">write.table</span><span class="p">(</span><span class="n">dat</span><span class="p">,</span> <span class="s">&quot;./GWAS_26and5_formatted/Depression&quot;</span><span class="p">,</span> <span class="n">sep</span> <span class="o">=</span> <span class="s">&quot;\t&quot;</span><span class="p">,</span> <span class="n">quote</span> <span class="o">=</span> <span class="bp">F</span><span class="p">,</span> <span class="n">row.names</span> <span class="o">=</span> <span class="bp">F</span><span class="p">,</span> <span class="n">col.names</span> <span class="o">=</span> <span class="bp">T</span><span class="p">)</span>

<span class="nf">rm</span><span class="p">(</span><span class="n">list</span><span class="o">=</span><span class="nf">c</span><span class="p">(</span><span class="s">&quot;dat_raw&quot;</span><span class="p">,</span><span class="s">&quot;dat&quot;</span><span class="p">))</span>
</pre></div>

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<pre><span class="ansi-bold">Rows: </span><span class="ansi-blue-fg">10886529</span> <span class="ansi-bold">Columns: </span><span class="ansi-blue-fg">12</span>

<span class="ansi-cyan-fg">──</span> <span class="ansi-bold">Column specification</span> <span class="ansi-cyan-fg">────────────────────────────────────────────────────────────────────────────────────────────────────────</span>
<span class="ansi-bold">Delimiter:</span> &#34;\t&#34;
<span class="ansi-red-fg">chr</span> (4): RSID, SNP, A1, A2
<span class="ansi-green-fg">dbl</span> (8): CHR, POS, EAF_UKB, MAF_UKB, Z, P, N, INFO_UKB


<span class="ansi-cyan-fg">ℹ</span> Use <span class="ansi-black-fg ansi-white-bg">`spec()`</span> to retrieve the full column specification for this data.
<span class="ansi-cyan-fg">ℹ</span> Specify the column types or set <span class="ansi-black-fg ansi-white-bg">`show_col_types = FALSE`</span> to quiet this message.

Begin formatting .... 

The raw data set has 10886529 dat lines

Remove SNPs with imputation info less than 0.9 ..., remaining 10847393 SNPs.

Remove ambiguous SNPs ..., remaining 9204753 SNPs.

Remove SNPs in MHC region ..., remaining 9152908 SNPs.

Remove duplicated SNPs ..., remaining 9152468 SNPs.

Merge SNPs with the hapmap3 snplist ..., remaining 1161303 SNPs.

Remove SNPs with alleles not matched with the hapmap3 snplist, remaining 1161185 SNPs.

Remove SNPs with p-value &lt; 0 or p-value &gt; 1, remaining 1026902 SNPs.

Remove missing values, remaining 1026902 SNPs.

Remove SNPs with sample size 5 standard deviations away from the mean, remaining 1026744 SNPs.

Remove SNPs with chi2 &gt; chi2_max ... , remaining 1026744 SNPs.

The formatted data has 1026744 dat lines. 


</pre>
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<div class="cell border-box-sizing code_cell rendered">
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<div class="prompt input_prompt">In&nbsp;[14]:</div>
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<div class=" highlight hl-r"><pre><span></span><span class="c1">## 11-14. Hair_Black, Hair_Blonde, Hair_Dark_Brown, Hair_Light_Brown</span>
<span class="nf">for </span><span class="p">(</span><span class="n">trait</span> <span class="n">in</span> <span class="nf">c</span><span class="p">(</span><span class="s">&quot;Hair_Black&quot;</span><span class="p">,</span> <span class="s">&quot;Hair_Blonde&quot;</span><span class="p">,</span> <span class="s">&quot;Hair_Dark_Brown&quot;</span><span class="p">,</span> <span class="s">&quot;Hair_Light_Brown&quot;</span><span class="p">)){</span>
  
  <span class="n">dat_raw</span> <span class="o">&lt;-</span> <span class="n">readr</span><span class="o">::</span><span class="nf">read_delim</span><span class="p">(</span><span class="nf">paste0</span><span class="p">(</span><span class="s">&quot;./GWAS_26and5_raw/&quot;</span><span class="p">,</span> <span class="n">trait</span><span class="p">),</span> <span class="n">delim</span> <span class="o">=</span> <span class="s">&quot;\t&quot;</span><span class="p">,</span> <span class="n">escape_double</span> <span class="o">=</span> <span class="kc">FALSE</span><span class="p">,</span> <span class="n">trim_ws</span> <span class="o">=</span> <span class="kc">TRUE</span><span class="p">,</span> <span class="n">progress</span> <span class="o">=</span> <span class="bp">F</span><span class="p">)</span>
  
  <span class="n">dat</span> <span class="o">=</span> <span class="nf">format_data</span><span class="p">(</span><span class="n">dat_raw</span><span class="p">,</span>
                    <span class="n">snp_col</span> <span class="o">=</span> <span class="s">&quot;SNPID_UKB&quot;</span><span class="p">,</span>
                    <span class="n">or_col</span> <span class="o">=</span> <span class="s">&quot;OR&quot;</span><span class="p">,</span>
                    <span class="n">se_col</span> <span class="o">=</span> <span class="s">&quot;SE&quot;</span><span class="p">,</span>
                    <span class="n">freq_col</span> <span class="o">=</span> <span class="s">&quot;MAF_UKB&quot;</span><span class="p">,</span>
                    <span class="n">A1_col</span> <span class="o">=</span> <span class="s">&quot;A1&quot;</span><span class="p">,</span>
                    <span class="n">A2_col</span> <span class="o">=</span> <span class="s">&quot;A2&quot;</span><span class="p">,</span>
                    <span class="n">p_col</span> <span class="o">=</span> <span class="s">&quot;P&quot;</span><span class="p">,</span>
                    <span class="n">n_col</span> <span class="o">=</span> <span class="s">&quot;NMISS&quot;</span><span class="p">,</span>
                    <span class="n">info_col</span> <span class="o">=</span> <span class="s">&quot;INFO_UKB&quot;</span><span class="p">)</span>
  
  <span class="nf">write.table</span><span class="p">(</span><span class="n">dat</span><span class="p">,</span> <span class="nf">paste0</span><span class="p">(</span><span class="s">&quot;./GWAS_26and5_formatted/&quot;</span><span class="p">,</span> <span class="n">trait</span><span class="p">),</span> <span class="n">sep</span><span class="o">=</span><span class="s">&quot;\t&quot;</span><span class="p">,</span> <span class="n">quote</span> <span class="o">=</span> <span class="bp">F</span><span class="p">,</span> <span class="n">row.names</span> <span class="o">=</span> <span class="bp">F</span><span class="p">,</span> <span class="n">col.names</span> <span class="o">=</span> <span class="bp">T</span><span class="p">)</span>
  
  <span class="nf">rm</span><span class="p">(</span><span class="n">list</span><span class="o">=</span><span class="nf">c</span><span class="p">(</span><span class="s">&quot;dat_raw&quot;</span><span class="p">,</span> <span class="s">&quot;dat&quot;</span><span class="p">))</span>
  
<span class="p">}</span>
</pre></div>

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<div class="output">


<div class="output_area">

    <div class="prompt"></div>


<div class="output_subarea output_stream output_stderr output_text">
<pre><span class="ansi-bold">Rows: </span><span class="ansi-blue-fg">10599054</span> <span class="ansi-bold">Columns: </span><span class="ansi-blue-fg">20</span>

<span class="ansi-cyan-fg">──</span> <span class="ansi-bold">Column specification</span> <span class="ansi-cyan-fg">────────────────────────────────────────────────────────────────────────────────────────────────────────</span>
<span class="ansi-bold">Delimiter:</span> &#34;\t&#34;
<span class="ansi-red-fg">chr</span>  (7): SNP, A1, TEST, A2, SNPID_UKB, A1_UKB, A2_UKB
<span class="ansi-green-fg">dbl</span> (13): CHR, BP, NMISS, OR, SE, L95, U95, STAT, P, MAF, NCHROBS, INFO_UKB,...


<span class="ansi-cyan-fg">ℹ</span> Use <span class="ansi-black-fg ansi-white-bg">`spec()`</span> to retrieve the full column specification for this data.
<span class="ansi-cyan-fg">ℹ</span> Specify the column types or set <span class="ansi-black-fg ansi-white-bg">`show_col_types = FALSE`</span> to quiet this message.

Begin formatting .... 

The raw data set has 10599054 dat lines

Remove SNPs with imputation info less than 0.9 ..., remaining 10599018 SNPs.

Remove ambiguous SNPs ..., remaining 8995068 SNPs.

Remove SNPs in MHC region ..., remaining 8944044 SNPs.

Remove duplicated SNPs ..., remaining 8944044 SNPs.

Merge SNPs with the hapmap3 snplist ..., remaining 1161501 SNPs.

Remove SNPs with alleles not matched with the hapmap3 snplist, remaining 1161195 SNPs.

infer b column from log(or)...

Remove SNPs with p-value &lt; 0 or p-value &gt; 1, remaining 1037824 SNPs.

Inferring z score from p value and b ...

Remove missing values, remaining 1037824 SNPs.

Remove SNPs with sample size 5 standard deviations away from the mean, remaining 1037824 SNPs.

Remove SNPs with chi2 &gt; chi2_max ... , remaining 1037702 SNPs.

The formatted data has 1037702 dat lines. 


<span class="ansi-bold">Rows: </span><span class="ansi-blue-fg">10599054</span> <span class="ansi-bold">Columns: </span><span class="ansi-blue-fg">20</span>

<span class="ansi-cyan-fg">──</span> <span class="ansi-bold">Column specification</span> <span class="ansi-cyan-fg">────────────────────────────────────────────────────────────────────────────────────────────────────────</span>
<span class="ansi-bold">Delimiter:</span> &#34;\t&#34;
<span class="ansi-red-fg">chr</span>  (7): SNP, A1, TEST, A2, SNPID_UKB, A1_UKB, A2_UKB
<span class="ansi-green-fg">dbl</span> (13): CHR, BP, NMISS, OR, SE, L95, U95, STAT, P, MAF, NCHROBS, INFO_UKB,...


<span class="ansi-cyan-fg">ℹ</span> Use <span class="ansi-black-fg ansi-white-bg">`spec()`</span> to retrieve the full column specification for this data.
<span class="ansi-cyan-fg">ℹ</span> Specify the column types or set <span class="ansi-black-fg ansi-white-bg">`show_col_types = FALSE`</span> to quiet this message.

Begin formatting .... 

The raw data set has 10599054 dat lines

Remove SNPs with imputation info less than 0.9 ..., remaining 10599018 SNPs.

Remove ambiguous SNPs ..., remaining 8995068 SNPs.

Remove SNPs in MHC region ..., remaining 8944044 SNPs.

Remove duplicated SNPs ..., remaining 8944044 SNPs.

Merge SNPs with the hapmap3 snplist ..., remaining 1161501 SNPs.

Remove SNPs with alleles not matched with the hapmap3 snplist, remaining 1161195 SNPs.

infer b column from log(or)...

Remove SNPs with p-value &lt; 0 or p-value &gt; 1, remaining 1037824 SNPs.

Inferring z score from p value and b ...

Remove missing values, remaining 1037824 SNPs.

Remove SNPs with sample size 5 standard deviations away from the mean, remaining 1037824 SNPs.

Remove SNPs with chi2 &gt; chi2_max ... , remaining 1037533 SNPs.

The formatted data has 1037533 dat lines. 


<span class="ansi-bold">Rows: </span><span class="ansi-blue-fg">10599054</span> <span class="ansi-bold">Columns: </span><span class="ansi-blue-fg">20</span>

<span class="ansi-cyan-fg">──</span> <span class="ansi-bold">Column specification</span> <span class="ansi-cyan-fg">────────────────────────────────────────────────────────────────────────────────────────────────────────</span>
<span class="ansi-bold">Delimiter:</span> &#34;\t&#34;
<span class="ansi-red-fg">chr</span>  (7): SNP, A1, TEST, A2, SNPID_UKB, A1_UKB, A2_UKB
<span class="ansi-green-fg">dbl</span> (13): CHR, BP, NMISS, OR, SE, L95, U95, STAT, P, MAF, NCHROBS, INFO_UKB,...


<span class="ansi-cyan-fg">ℹ</span> Use <span class="ansi-black-fg ansi-white-bg">`spec()`</span> to retrieve the full column specification for this data.
<span class="ansi-cyan-fg">ℹ</span> Specify the column types or set <span class="ansi-black-fg ansi-white-bg">`show_col_types = FALSE`</span> to quiet this message.

Begin formatting .... 

The raw data set has 10599054 dat lines

Remove SNPs with imputation info less than 0.9 ..., remaining 10599018 SNPs.

Remove ambiguous SNPs ..., remaining 8995068 SNPs.

Remove SNPs in MHC region ..., remaining 8944044 SNPs.

Remove duplicated SNPs ..., remaining 8944044 SNPs.

Merge SNPs with the hapmap3 snplist ..., remaining 1161501 SNPs.

Remove SNPs with alleles not matched with the hapmap3 snplist, remaining 1161195 SNPs.

infer b column from log(or)...

Remove SNPs with p-value &lt; 0 or p-value &gt; 1, remaining 1037824 SNPs.

Inferring z score from p value and b ...

Remove missing values, remaining 1037824 SNPs.

Remove SNPs with sample size 5 standard deviations away from the mean, remaining 1037824 SNPs.

Remove SNPs with chi2 &gt; chi2_max ... , remaining 1037381 SNPs.

The formatted data has 1037381 dat lines. 


<span class="ansi-bold">Rows: </span><span class="ansi-blue-fg">10599054</span> <span class="ansi-bold">Columns: </span><span class="ansi-blue-fg">20</span>

<span class="ansi-cyan-fg">──</span> <span class="ansi-bold">Column specification</span> <span class="ansi-cyan-fg">────────────────────────────────────────────────────────────────────────────────────────────────────────</span>
<span class="ansi-bold">Delimiter:</span> &#34;\t&#34;
<span class="ansi-red-fg">chr</span>  (7): SNP, A1, TEST, A2, SNPID_UKB, A1_UKB, A2_UKB
<span class="ansi-green-fg">dbl</span> (13): CHR, BP, NMISS, OR, SE, L95, U95, STAT, P, MAF, NCHROBS, INFO_UKB,...


<span class="ansi-cyan-fg">ℹ</span> Use <span class="ansi-black-fg ansi-white-bg">`spec()`</span> to retrieve the full column specification for this data.
<span class="ansi-cyan-fg">ℹ</span> Specify the column types or set <span class="ansi-black-fg ansi-white-bg">`show_col_types = FALSE`</span> to quiet this message.

Begin formatting .... 

The raw data set has 10599054 dat lines

Remove SNPs with imputation info less than 0.9 ..., remaining 10599018 SNPs.

Remove ambiguous SNPs ..., remaining 8995068 SNPs.

Remove SNPs in MHC region ..., remaining 8944044 SNPs.

Remove duplicated SNPs ..., remaining 8944044 SNPs.

Merge SNPs with the hapmap3 snplist ..., remaining 1161501 SNPs.

Remove SNPs with alleles not matched with the hapmap3 snplist, remaining 1161195 SNPs.

infer b column from log(or)...

Remove SNPs with p-value &lt; 0 or p-value &gt; 1, remaining 1037824 SNPs.

Inferring z score from p value and b ...

Remove missing values, remaining 1037824 SNPs.

Remove SNPs with sample size 5 standard deviations away from the mean, remaining 1037824 SNPs.

Remove SNPs with chi2 &gt; chi2_max ... , remaining 1037742 SNPs.

The formatted data has 1037742 dat lines. 


</pre>
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<div class="cell border-box-sizing code_cell rendered">
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<div class="prompt input_prompt">In&nbsp;[15]:</div>
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<div class=" highlight hl-r"><pre><span></span><span class="c1">## 15. HBP (High Blood Pressure)</span>

<span class="n">HBP_raw</span> <span class="o">&lt;-</span> <span class="n">readr</span><span class="o">::</span><span class="nf">read_delim</span><span class="p">(</span><span class="s">&quot;./GWAS_26and5_raw/HBP&quot;</span><span class="p">,</span> <span class="s">&quot;\t&quot;</span><span class="p">,</span> <span class="n">escape_double</span> <span class="o">=</span> <span class="kc">FALSE</span><span class="p">,</span> <span class="n">trim_ws</span> <span class="o">=</span> <span class="kc">TRUE</span><span class="p">,</span> <span class="n">progress</span> <span class="o">=</span> <span class="bp">F</span><span class="p">)</span>

<span class="n">HBP</span> <span class="o">=</span> <span class="n">MRAPSS</span><span class="o">::</span><span class="nf">format_data</span><span class="p">(</span><span class="n">HBP_raw</span><span class="p">,</span>
                          <span class="n">snp_col</span> <span class="o">=</span> <span class="s">&quot;SNPID_UKB&quot;</span><span class="p">,</span>
                          <span class="n">or_col</span> <span class="o">=</span> <span class="s">&quot;OR&quot;</span><span class="p">,</span>
                          <span class="n">se_col</span> <span class="o">=</span> <span class="s">&quot;SE&quot;</span><span class="p">,</span>
                          <span class="n">freq_col</span> <span class="o">=</span> <span class="s">&quot;MAF_UKB&quot;</span><span class="p">,</span>
                          <span class="n">A1_col</span> <span class="o">=</span> <span class="s">&quot;A1&quot;</span><span class="p">,</span>
                          <span class="n">A2_col</span> <span class="o">=</span> <span class="s">&quot;A2&quot;</span><span class="p">,</span>
                          <span class="n">p_col</span> <span class="o">=</span> <span class="s">&quot;P&quot;</span><span class="p">,</span>
                          <span class="n">n_col</span> <span class="o">=</span> <span class="s">&quot;NMISS&quot;</span><span class="p">,</span>
                          <span class="n">info_col</span> <span class="o">=</span> <span class="s">&quot;INFO_UKB&quot;</span><span class="p">)</span>

<span class="nf">write.table</span><span class="p">(</span><span class="n">HBP</span><span class="p">,</span> <span class="s">&quot;./GWAS_26and5_formatted/HBP&quot;</span><span class="p">,</span> <span class="n">sep</span><span class="o">=</span><span class="s">&quot;\t&quot;</span><span class="p">,</span> <span class="n">quote</span> <span class="o">=</span> <span class="bp">F</span><span class="p">,</span> <span class="n">row.names</span> <span class="o">=</span> <span class="bp">F</span><span class="p">,</span> <span class="n">col.names</span> <span class="o">=</span> <span class="bp">T</span><span class="p">)</span>

<span class="nf">rm</span><span class="p">(</span><span class="n">list</span><span class="o">=</span><span class="nf">c</span><span class="p">(</span><span class="s">&quot;HBP_raw&quot;</span><span class="p">,</span> <span class="s">&quot;HBP&quot;</span><span class="p">))</span>
</pre></div>

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<div class="output">


<div class="output_area">

    <div class="prompt"></div>


<div class="output_subarea output_stream output_stderr output_text">
<pre><span class="ansi-bold">Rows: </span><span class="ansi-blue-fg">10599054</span> <span class="ansi-bold">Columns: </span><span class="ansi-blue-fg">20</span>

<span class="ansi-cyan-fg">──</span> <span class="ansi-bold">Column specification</span> <span class="ansi-cyan-fg">────────────────────────────────────────────────────────────────────────────────────────────────────────</span>
<span class="ansi-bold">Delimiter:</span> &#34;\t&#34;
<span class="ansi-red-fg">chr</span>  (7): SNP, A1, TEST, A2, SNPID_UKB, A1_UKB, A2_UKB
<span class="ansi-green-fg">dbl</span> (13): CHR, BP, NMISS, OR, SE, L95, U95, STAT, P, MAF, NCHROBS, INFO_UKB,...


<span class="ansi-cyan-fg">ℹ</span> Use <span class="ansi-black-fg ansi-white-bg">`spec()`</span> to retrieve the full column specification for this data.
<span class="ansi-cyan-fg">ℹ</span> Specify the column types or set <span class="ansi-black-fg ansi-white-bg">`show_col_types = FALSE`</span> to quiet this message.

Begin formatting .... 

The raw data set has 10599054 dat lines

Remove SNPs with imputation info less than 0.9 ..., remaining 10599018 SNPs.

Remove ambiguous SNPs ..., remaining 8995068 SNPs.

Remove SNPs in MHC region ..., remaining 8944044 SNPs.

Remove duplicated SNPs ..., remaining 8944044 SNPs.

Merge SNPs with the hapmap3 snplist ..., remaining 1161501 SNPs.

Remove SNPs with alleles not matched with the hapmap3 snplist, remaining 1161195 SNPs.

infer b column from log(or)...

Remove SNPs with p-value &lt; 0 or p-value &gt; 1, remaining 1037824 SNPs.

Inferring z score from p value and b ...

Remove missing values, remaining 1037824 SNPs.

Remove SNPs with sample size 5 standard deviations away from the mean, remaining 1037824 SNPs.

Remove SNPs with chi2 &gt; chi2_max ... , remaining 1037824 SNPs.

The formatted data has 1037824 dat lines. 


</pre>
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<div class=" highlight hl-r"><pre><span></span><span class="c1">## 16. Height (GIANT)</span>

<span class="n">Height_raw</span> <span class="o">&lt;-</span> <span class="n">readr</span><span class="o">::</span><span class="nf">read_delim</span><span class="p">(</span><span class="s">&quot;./GWAS_26and5_raw/Height_GIANT&quot;</span><span class="p">,</span> <span class="s">&quot;\t&quot;</span><span class="p">,</span> <span class="n">escape_double</span> <span class="o">=</span> <span class="kc">FALSE</span><span class="p">,</span> <span class="n">trim_ws</span> <span class="o">=</span> <span class="kc">TRUE</span><span class="p">,</span> <span class="n">progress</span> <span class="o">=</span> <span class="bp">F</span><span class="p">)</span>
<span class="n">Height_raw</span> <span class="o">=</span> <span class="n">Height_raw[</span><span class="o">!</span><span class="nf">is.na</span><span class="p">(</span><span class="n">Height_raw</span><span class="o">$</span><span class="n">Freq.Allele1.HapMapCEU</span><span class="p">),</span> <span class="n">]</span>
<span class="n">Height</span> <span class="o">=</span> <span class="nf">format_data</span><span class="p">(</span><span class="n">Height_raw</span><span class="p">,</span>
                     <span class="n">snp_col</span> <span class="o">=</span> <span class="s">&quot;MarkerName&quot;</span><span class="p">,</span>
                     <span class="n">b_col</span> <span class="o">=</span> <span class="s">&quot;b&quot;</span><span class="p">,</span>
                     <span class="n">se_col</span> <span class="o">=</span> <span class="s">&quot;SE&quot;</span><span class="p">,</span>
                     <span class="n">freq_col</span> <span class="o">=</span> <span class="s">&quot;Freq.Allele1.HapMapCEU&quot;</span><span class="p">,</span>
                     <span class="n">A1_col</span> <span class="o">=</span> <span class="s">&quot;Allele1&quot;</span><span class="p">,</span>
                     <span class="n">A2_col</span> <span class="o">=</span> <span class="s">&quot;Allele2&quot;</span><span class="p">,</span>
                     <span class="n">p_col</span> <span class="o">=</span> <span class="s">&quot;p&quot;</span><span class="p">,</span>
                     <span class="n">n_col</span> <span class="o">=</span> <span class="s">&quot;N&quot;</span><span class="p">)</span>

<span class="nf">write.table</span><span class="p">(</span><span class="n">Height</span><span class="p">,</span> <span class="s">&quot;./GWAS_26and5_formatted/Height_GIANT&quot;</span><span class="p">,</span> <span class="n">sep</span><span class="o">=</span><span class="s">&quot;\t&quot;</span><span class="p">,</span> <span class="n">quote</span> <span class="o">=</span> <span class="bp">F</span><span class="p">,</span> <span class="n">row.names</span> <span class="o">=</span> <span class="bp">F</span><span class="p">,</span> <span class="n">col.names</span> <span class="o">=</span> <span class="bp">T</span><span class="p">)</span>

<span class="nf">rm</span><span class="p">(</span><span class="n">list</span><span class="o">=</span><span class="nf">c</span><span class="p">(</span><span class="s">&quot;Height_raw&quot;</span><span class="p">,</span><span class="s">&quot;Height&quot;</span><span class="p">))</span>
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<pre><span class="ansi-bold">Rows: </span><span class="ansi-blue-fg">2550858</span> <span class="ansi-bold">Columns: </span><span class="ansi-blue-fg">8</span>

<span class="ansi-cyan-fg">──</span> <span class="ansi-bold">Column specification</span> <span class="ansi-cyan-fg">────────────────────────────────────────────────────────────────────────────────────────────────────────</span>
<span class="ansi-bold">Delimiter:</span> &#34;\t&#34;
<span class="ansi-red-fg">chr</span> (3): MarkerName, Allele1, Allele2
<span class="ansi-green-fg">dbl</span> (5): Freq.Allele1.HapMapCEU, b, SE, p, N


<span class="ansi-cyan-fg">ℹ</span> Use <span class="ansi-black-fg ansi-white-bg">`spec()`</span> to retrieve the full column specification for this data.
<span class="ansi-cyan-fg">ℹ</span> Specify the column types or set <span class="ansi-black-fg ansi-white-bg">`show_col_types = FALSE`</span> to quiet this message.

Begin formatting .... 

The raw data set has 2547281 dat lines

Remove ambiguous SNPs ..., remaining 2154206 SNPs.

Remove SNPs in MHC region ..., remaining 2143731 SNPs.

Remove duplicated SNPs ..., remaining 2143731 SNPs.

Merge SNPs with the hapmap3 snplist ..., remaining 1091189 SNPs.

Remove SNPs with alleles not matched with the hapmap3 snplist, remaining 1091150 SNPs.

Remove SNPs with p-value &lt; 0 or p-value &gt; 1, remaining 975042 SNPs.

Inferring z score from p value and b ...

Remove missing values, remaining 975042 SNPs.

Remove SNPs with sample size 5 standard deviations away from the mean, remaining 961175 SNPs.

Remove SNPs with chi2 &gt; chi2_max ... , remaining 961042 SNPs.

The formatted data has 961042 dat lines. 


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<div class=" highlight hl-r"><pre><span></span><span class="c1">## 17. Height (UKBB)</span>

<span class="n">Height_UKB_raw</span> <span class="o">&lt;-</span> <span class="n">readr</span><span class="o">::</span><span class="nf">read_delim</span><span class="p">(</span><span class="s">&quot;./GWAS_26and5_raw/Height_UKB&quot;</span><span class="p">,</span> <span class="s">&quot;\t&quot;</span><span class="p">,</span> <span class="n">escape_double</span> <span class="o">=</span> <span class="kc">FALSE</span><span class="p">,</span>
                                    <span class="n">trim_ws</span> <span class="o">=</span> <span class="kc">TRUE</span><span class="p">,</span> <span class="n">progress</span> <span class="o">=</span> <span class="bp">F</span><span class="p">)</span>

<span class="n">Height_UKB</span> <span class="o">=</span> <span class="nf">format_data</span><span class="p">(</span><span class="n">Height_UKB_raw</span><span class="p">,</span>
                         <span class="n">snp_col</span> <span class="o">=</span> <span class="s">&quot;SNPID_UKB&quot;</span><span class="p">,</span>
                         <span class="n">b_col</span> <span class="o">=</span> <span class="s">&quot;BETA&quot;</span><span class="p">,</span>
                         <span class="n">se_col</span> <span class="o">=</span> <span class="s">&quot;SE&quot;</span><span class="p">,</span>
                         <span class="n">freq_col</span> <span class="o">=</span> <span class="s">&quot;MAF_UKB&quot;</span><span class="p">,</span>
                         <span class="n">A1_col</span> <span class="o">=</span> <span class="s">&quot;A1&quot;</span><span class="p">,</span>
                         <span class="n">A2_col</span> <span class="o">=</span> <span class="s">&quot;A2&quot;</span><span class="p">,</span>
                         <span class="n">p_col</span> <span class="o">=</span> <span class="s">&quot;P&quot;</span><span class="p">,</span>
                         <span class="n">n_col</span> <span class="o">=</span> <span class="s">&quot;NMISS&quot;</span><span class="p">,</span>
                         <span class="n">info_col</span> <span class="o">=</span> <span class="s">&quot;INFO_UKB&quot;</span><span class="p">)</span>

<span class="nf">write.table</span><span class="p">(</span><span class="n">Height_UKB</span><span class="p">,</span> <span class="s">&quot;./GWAS_26and5_formatted/Height_UKB&quot;</span><span class="p">,</span> <span class="n">sep</span> <span class="o">=</span> <span class="s">&quot;\t&quot;</span><span class="p">,</span> <span class="n">quote</span> <span class="o">=</span> <span class="bp">F</span><span class="p">,</span> <span class="n">row.names</span> <span class="o">=</span> <span class="bp">F</span><span class="p">,</span> <span class="n">col.names</span> <span class="o">=</span> <span class="bp">T</span><span class="p">)</span>

<span class="nf">rm</span><span class="p">(</span><span class="n">list</span><span class="o">=</span><span class="nf">c</span><span class="p">(</span><span class="s">&quot;Height_UKB_raw&quot;</span><span class="p">,</span><span class="s">&quot;Height_UKB&quot;</span><span class="p">))</span>
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<pre><span class="ansi-bold">Rows: </span><span class="ansi-blue-fg">10599054</span> <span class="ansi-bold">Columns: </span><span class="ansi-blue-fg">20</span>

<span class="ansi-cyan-fg">──</span> <span class="ansi-bold">Column specification</span> <span class="ansi-cyan-fg">────────────────────────────────────────────────────────────────────────────────────────────────────────</span>
<span class="ansi-bold">Delimiter:</span> &#34;\t&#34;
<span class="ansi-red-fg">chr</span>  (7): SNP, A1, TEST, A2, SNPID_UKB, A1_UKB, A2_UKB
<span class="ansi-green-fg">dbl</span> (13): CHR, BP, NMISS, BETA, SE, L95, U95, STAT, P, MAF, NCHROBS, INFO_UK...


<span class="ansi-cyan-fg">ℹ</span> Use <span class="ansi-black-fg ansi-white-bg">`spec()`</span> to retrieve the full column specification for this data.
<span class="ansi-cyan-fg">ℹ</span> Specify the column types or set <span class="ansi-black-fg ansi-white-bg">`show_col_types = FALSE`</span> to quiet this message.

Begin formatting .... 

The raw data set has 10599054 dat lines

Remove SNPs with imputation info less than 0.9 ..., remaining 10599018 SNPs.

Remove ambiguous SNPs ..., remaining 8995068 SNPs.

Remove SNPs in MHC region ..., remaining 8944044 SNPs.

Remove duplicated SNPs ..., remaining 8944044 SNPs.

Merge SNPs with the hapmap3 snplist ..., remaining 1161501 SNPs.

Remove SNPs with alleles not matched with the hapmap3 snplist, remaining 1161195 SNPs.

Remove SNPs with p-value &lt; 0 or p-value &gt; 1, remaining 1037824 SNPs.

Inferring z score from p value and b ...

Remove missing values, remaining 1037824 SNPs.

Remove SNPs with sample size 5 standard deviations away from the mean, remaining 1037824 SNPs.

Remove SNPs with chi2 &gt; chi2_max ... , remaining 1037320 SNPs.

The formatted data has 1037320 dat lines. 


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<div class=" highlight hl-r"><pre><span></span><span class="c1"># 18. IBD (Inflammatory Bowel Disease)</span>

<span class="n">IBD_raw</span> <span class="o">&lt;-</span> <span class="n">readr</span><span class="o">::</span><span class="nf">read_delim</span><span class="p">(</span><span class="s">&quot;./GWAS_26and5_raw/IBD_rsid&quot;</span><span class="p">,</span> <span class="s">&quot;\t&quot;</span><span class="p">,</span> <span class="n">escape_double</span> <span class="o">=</span> <span class="kc">FALSE</span><span class="p">,</span> <span class="n">trim_ws</span> <span class="o">=</span> <span class="kc">TRUE</span><span class="p">,</span> <span class="n">progress</span> <span class="o">=</span> <span class="bp">F</span><span class="p">)</span>

<span class="n">IBD</span> <span class="o">=</span> <span class="nf">format_data</span><span class="p">(</span><span class="n">IBD_raw</span><span class="p">,</span>
                  <span class="n">snp_col</span> <span class="o">=</span> <span class="s">&quot;rsid&quot;</span><span class="p">,</span>
                  <span class="n">b_col</span> <span class="o">=</span> <span class="s">&quot;Effect&quot;</span><span class="p">,</span>
                  <span class="n">se_col</span> <span class="o">=</span> <span class="s">&quot;StdErr&quot;</span><span class="p">,</span>
                  <span class="n">freq_col</span> <span class="o">=</span> <span class="s">&quot;freq&quot;</span><span class="p">,</span>
                  <span class="n">A1_col</span> <span class="o">=</span> <span class="s">&quot;Allele1&quot;</span><span class="p">,</span>
                  <span class="n">A2_col</span> <span class="o">=</span> <span class="s">&quot;Allele2&quot;</span><span class="p">,</span>
                  <span class="n">p_col</span> <span class="o">=</span> <span class="s">&quot;P.value&quot;</span><span class="p">,</span>
                  <span class="n">n</span> <span class="o">=</span> <span class="m">59957</span><span class="p">)</span>

<span class="nf">write.table</span><span class="p">(</span><span class="n">IBD</span><span class="p">,</span> <span class="s">&quot;./GWAS_26and5_formatted/IBD&quot;</span><span class="p">,</span> <span class="n">sep</span><span class="o">=</span><span class="s">&quot;\t&quot;</span><span class="p">,</span> <span class="n">quote</span> <span class="o">=</span> <span class="bp">F</span><span class="p">,</span> <span class="n">row.names</span> <span class="o">=</span> <span class="bp">F</span><span class="p">,</span> <span class="n">col.names</span> <span class="o">=</span> <span class="bp">T</span><span class="p">)</span>

<span class="nf">rm</span><span class="p">(</span><span class="n">list</span><span class="o">=</span><span class="nf">c</span><span class="p">(</span><span class="s">&quot;IBD_raw&quot;</span><span class="p">,</span><span class="s">&quot;IBD&quot;</span><span class="p">))</span>
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<pre><span class="ansi-bold">Rows: </span><span class="ansi-blue-fg">7059162</span> <span class="ansi-bold">Columns: </span><span class="ansi-blue-fg">7</span>

<span class="ansi-cyan-fg">──</span> <span class="ansi-bold">Column specification</span> <span class="ansi-cyan-fg">────────────────────────────────────────────────────────────────────────────────────────────────────────</span>
<span class="ansi-bold">Delimiter:</span> &#34;\t&#34;
<span class="ansi-red-fg">chr</span> (3): rsid, Allele1, Allele2
<span class="ansi-green-fg">dbl</span> (4): freq, Effect, StdErr, P.value


<span class="ansi-cyan-fg">ℹ</span> Use <span class="ansi-black-fg ansi-white-bg">`spec()`</span> to retrieve the full column specification for this data.
<span class="ansi-cyan-fg">ℹ</span> Specify the column types or set <span class="ansi-black-fg ansi-white-bg">`show_col_types = FALSE`</span> to quiet this message.

Begin formatting .... 

The raw data set has 7059162 dat lines

Remove ambiguous SNPs ..., remaining 6015921 SNPs.

Remove SNPs in MHC region ..., remaining 5986496 SNPs.

Remove duplicated SNPs ..., remaining 5982838 SNPs.

Merge SNPs with the hapmap3 snplist ..., remaining 1108191 SNPs.

Remove SNPs with alleles not matched with the hapmap3 snplist, remaining 1108169 SNPs.

Generating sample size from specified sample size

Remove SNPs with p-value &lt; 0 or p-value &gt; 1, remaining 1004923 SNPs.

Inferring z score from p value and b ...

Remove missing values, remaining 1004923 SNPs.

Remove SNPs with sample size 5 standard deviations away from the mean, remaining 1004923 SNPs.

Remove SNPs with chi2 &gt; chi2_max ... , remaining 1004597 SNPs.

The formatted data has 1004597 dat lines. 


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<div class="prompt input_prompt">In&nbsp;[19]:</div>
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<div class=" highlight hl-r"><pre><span></span><span class="c1">## 19. Income</span>

<span class="n">Income_raw</span> <span class="o">&lt;-</span> <span class="n">readr</span><span class="o">::</span><span class="nf">read_delim</span><span class="p">(</span><span class="s">&quot;./GWAS_26and5_raw/Income&quot;</span><span class="p">,</span> <span class="s">&quot; &quot;</span><span class="p">,</span> <span class="n">escape_double</span> <span class="o">=</span> <span class="kc">FALSE</span><span class="p">,</span> <span class="n">trim_ws</span> <span class="o">=</span> <span class="kc">TRUE</span><span class="p">,</span> <span class="n">progress</span> <span class="o">=</span> <span class="bp">F</span><span class="p">)</span>

<span class="n">Income</span> <span class="o">=</span> <span class="nf">format_data</span><span class="p">(</span><span class="n">Income_raw</span><span class="p">,</span>
                     <span class="n">snp_col</span> <span class="o">=</span> <span class="s">&quot;SNP&quot;</span><span class="p">,</span>
                     <span class="n">b_col</span> <span class="o">=</span> <span class="s">&quot;Beta&quot;</span><span class="p">,</span>
                     <span class="n">se_col</span> <span class="o">=</span> <span class="s">&quot;Standard_Error_of_Beta&quot;</span><span class="p">,</span>
                     <span class="n">A1_col</span> <span class="o">=</span> <span class="s">&quot;Effect_Allele&quot;</span><span class="p">,</span>
                     <span class="n">A2_col</span> <span class="o">=</span> <span class="s">&quot;Non_effect_Allele&quot;</span><span class="p">,</span>
                     <span class="n">p_col</span> <span class="o">=</span> <span class="s">&quot;P&quot;</span><span class="p">,</span>
                     <span class="n">n</span><span class="o">=</span><span class="m">286301</span><span class="p">)</span>

<span class="nf">write.table</span><span class="p">(</span><span class="n">Income</span><span class="p">,</span> <span class="s">&quot;./GWAS_26and5_formatted/Income&quot;</span><span class="p">,</span> <span class="n">sep</span> <span class="o">=</span> <span class="s">&quot;\t&quot;</span><span class="p">,</span> <span class="n">quote</span> <span class="o">=</span> <span class="bp">F</span><span class="p">,</span> <span class="n">row.names</span> <span class="o">=</span> <span class="bp">F</span><span class="p">,</span> <span class="n">col.names</span> <span class="o">=</span> <span class="bp">T</span><span class="p">)</span>

<span class="nf">rm</span><span class="p">(</span><span class="n">list</span><span class="o">=</span><span class="nf">c</span><span class="p">(</span><span class="s">&quot;Income_raw&quot;</span><span class="p">,</span><span class="s">&quot;Income&quot;</span><span class="p">))</span>
</pre></div>

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<pre><span class="ansi-bold">Rows: </span><span class="ansi-blue-fg">18485882</span> <span class="ansi-bold">Columns: </span><span class="ansi-blue-fg">8</span>

<span class="ansi-cyan-fg">──</span> <span class="ansi-bold">Column specification</span> <span class="ansi-cyan-fg">────────────────────────────────────────────────────────────────────────────────────────────────────────</span>
<span class="ansi-bold">Delimiter:</span> &#34; &#34;
<span class="ansi-red-fg">chr</span> (3): SNP, Non_effect_Allele, Effect_Allele
<span class="ansi-green-fg">dbl</span> (5): Chr, BPos, Beta, Standard_Error_of_Beta, P


<span class="ansi-cyan-fg">ℹ</span> Use <span class="ansi-black-fg ansi-white-bg">`spec()`</span> to retrieve the full column specification for this data.
<span class="ansi-cyan-fg">ℹ</span> Specify the column types or set <span class="ansi-black-fg ansi-white-bg">`show_col_types = FALSE`</span> to quiet this message.

Begin formatting .... 

The raw data set has 18485882 dat lines

Remove ambiguous SNPs ..., remaining 15709024 SNPs.

Remove SNPs in MHC region ..., remaining 15648261 SNPs.

Remove duplicated SNPs ..., remaining 15648261 SNPs.

Merge SNPs with the hapmap3 snplist ..., remaining 1208817 SNPs.

Remove SNPs with alleles not matched with the hapmap3 snplist, remaining 1208814 SNPs.

Generating sample size from specified sample size

Remove SNPs with p-value &lt; 0 or p-value &gt; 1, remaining 1208814 SNPs.

Inferring z score from p value and b ...

Remove missing values, remaining 1208814 SNPs.

Remove SNPs with sample size 5 standard deviations away from the mean, remaining 1208814 SNPs.

Remove SNPs with chi2 &gt; chi2_max ... , remaining 1208814 SNPs.

The formatted data has 1208814 dat lines. 


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<div class=" highlight hl-r"><pre><span></span><span class="c1">## 20. Insomnia</span>

<span class="n">Insomnia_raw</span> <span class="o">&lt;-</span> <span class="n">readr</span><span class="o">::</span><span class="nf">read_delim</span><span class="p">(</span><span class="s">&quot;./GWAS_26and5_raw/Insomnia&quot;</span><span class="p">,</span> <span class="s">&quot; &quot;</span><span class="p">,</span> <span class="n">escape_double</span> <span class="o">=</span> <span class="kc">FALSE</span><span class="p">,</span> <span class="n">trim_ws</span> <span class="o">=</span> <span class="kc">TRUE</span><span class="p">,</span> <span class="n">progress</span> <span class="o">=</span> <span class="bp">F</span><span class="p">)</span>

<span class="n">Insomnia</span> <span class="o">=</span> <span class="nf">format_data</span><span class="p">(</span><span class="n">Insomnia_raw</span><span class="p">,</span>
                       <span class="n">snp_col</span> <span class="o">=</span> <span class="s">&quot;SNP&quot;</span><span class="p">,</span>
                       <span class="n">b_col</span> <span class="o">=</span> <span class="s">&quot;BETA_INSOMNIA&quot;</span><span class="p">,</span>
                       <span class="n">se_col</span> <span class="o">=</span> <span class="s">&quot;SE_INSOMNIA&quot;</span><span class="p">,</span>
                       <span class="n">freq_col</span> <span class="o">=</span> <span class="s">&quot;A1FREQ&quot;</span><span class="p">,</span>
                       <span class="n">A1_col</span> <span class="o">=</span> <span class="s">&quot;ALLELE1&quot;</span><span class="p">,</span>
                       <span class="n">A2_col</span> <span class="o">=</span> <span class="s">&quot;ALLELE0&quot;</span><span class="p">,</span>
                       <span class="n">info_col</span> <span class="o">=</span> <span class="s">&quot;INFO&quot;</span><span class="p">,</span>
                       <span class="n">p_col</span> <span class="o">=</span> <span class="s">&quot;P_INSOMNIA&quot;</span><span class="p">,</span>
                       <span class="n">n</span> <span class="o">=</span> <span class="m">453379</span><span class="p">)</span>

<span class="nf">write.table</span><span class="p">(</span><span class="n">Insomnia</span><span class="p">,</span> <span class="s">&quot;./GWAS_26and5_formatted/Insomnia&quot;</span><span class="p">,</span> <span class="n">sep</span> <span class="o">=</span> <span class="s">&quot;\t&quot;</span><span class="p">,</span> <span class="n">quote</span> <span class="o">=</span> <span class="bp">F</span><span class="p">,</span> <span class="n">row.names</span> <span class="o">=</span> <span class="bp">F</span><span class="p">,</span> <span class="n">col.names</span> <span class="o">=</span> <span class="bp">T</span><span class="p">)</span>

<span class="nf">rm</span><span class="p">(</span><span class="n">list</span><span class="o">=</span><span class="nf">c</span><span class="p">(</span><span class="s">&quot;Insomnia_raw&quot;</span><span class="p">,</span><span class="s">&quot;Insomnia&quot;</span><span class="p">))</span>
</pre></div>

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<pre><span class="ansi-bold">Rows: </span><span class="ansi-blue-fg">14661601</span> <span class="ansi-bold">Columns: </span><span class="ansi-blue-fg">10</span>

<span class="ansi-cyan-fg">──</span> <span class="ansi-bold">Column specification</span> <span class="ansi-cyan-fg">────────────────────────────────────────────────────────────────────────────────────────────────────────</span>
<span class="ansi-bold">Delimiter:</span> &#34; &#34;
<span class="ansi-red-fg">chr</span> (3): SNP, ALLELE1, ALLELE0
<span class="ansi-green-fg">dbl</span> (7): CHR, BP, A1FREQ, INFO, BETA_INSOMNIA, SE_INSOMNIA, P_INSOMNIA


<span class="ansi-cyan-fg">ℹ</span> Use <span class="ansi-black-fg ansi-white-bg">`spec()`</span> to retrieve the full column specification for this data.
<span class="ansi-cyan-fg">ℹ</span> Specify the column types or set <span class="ansi-black-fg ansi-white-bg">`show_col_types = FALSE`</span> to quiet this message.

Begin formatting .... 

The raw data set has 14661601 dat lines

Remove SNPs with imputation info less than 0.9 ..., remaining 10903657 SNPs.

Remove ambiguous SNPs ..., remaining 9250294 SNPs.

Remove SNPs in MHC region ..., remaining 9202639 SNPs.

Remove duplicated SNPs ..., remaining 9196675 SNPs.

Merge SNPs with the hapmap3 snplist ..., remaining 1198480 SNPs.

Remove SNPs with alleles not matched with the hapmap3 snplist, remaining 1198465 SNPs.

Generating sample size from specified sample size

Remove SNPs with p-value &lt; 0 or p-value &gt; 1, remaining 1065149 SNPs.

Inferring z score from p value and b ...

Remove missing values, remaining 1065149 SNPs.

Remove SNPs with sample size 5 standard deviations away from the mean, remaining 1065149 SNPs.

Remove SNPs with chi2 &gt; chi2_max ... , remaining 1065149 SNPs.

The formatted data has 1065149 dat lines. 


</pre>
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<div class=" highlight hl-r"><pre><span></span><span class="c1">## 21. Intelligence</span>

<span class="n">Intelligence_raw</span> <span class="o">&lt;-</span> <span class="n">readr</span><span class="o">::</span><span class="nf">read_delim</span><span class="p">(</span><span class="s">&quot;./GWAS_26and5_raw/Intelligence&quot;</span><span class="p">,</span> <span class="s">&quot;\t&quot;</span><span class="p">,</span> <span class="n">escape_double</span> <span class="o">=</span> <span class="kc">FALSE</span><span class="p">,</span> <span class="n">trim_ws</span> <span class="o">=</span> <span class="kc">TRUE</span><span class="p">,</span> <span class="n">progress</span> <span class="o">=</span> <span class="bp">F</span><span class="p">)</span>

<span class="n">Intelligence</span> <span class="o">=</span> <span class="nf">format_data</span><span class="p">(</span><span class="n">Intelligence_raw</span><span class="p">,</span>
                           <span class="n">snp_col</span> <span class="o">=</span> <span class="s">&quot;SNPID_UKB&quot;</span><span class="p">,</span>
                           <span class="n">b_col</span> <span class="o">=</span> <span class="s">&quot;BETA&quot;</span><span class="p">,</span>
                           <span class="n">se_col</span> <span class="o">=</span> <span class="s">&quot;SE&quot;</span><span class="p">,</span>
                           <span class="n">freq_col</span> <span class="o">=</span> <span class="s">&quot;MAF_UKB&quot;</span><span class="p">,</span>
                           <span class="n">A1_col</span> <span class="o">=</span> <span class="s">&quot;A1&quot;</span><span class="p">,</span>
                           <span class="n">A2_col</span> <span class="o">=</span> <span class="s">&quot;A2&quot;</span><span class="p">,</span>
                           <span class="n">p_col</span> <span class="o">=</span> <span class="s">&quot;P&quot;</span><span class="p">,</span>
                           <span class="n">n_col</span> <span class="o">=</span> <span class="s">&quot;NMISS&quot;</span><span class="p">,</span>
                           <span class="n">info_col</span> <span class="o">=</span> <span class="s">&quot;INFO_UKB&quot;</span><span class="p">)</span>

<span class="nf">write.table</span><span class="p">(</span><span class="n">Intelligence</span><span class="p">,</span> <span class="s">&quot;./GWAS_26and5_formatted/Intelligence&quot;</span><span class="p">,</span> <span class="n">sep</span> <span class="o">=</span> <span class="s">&quot;\t&quot;</span><span class="p">,</span> <span class="n">quote</span> <span class="o">=</span> <span class="bp">F</span><span class="p">,</span> <span class="n">row.names</span> <span class="o">=</span> <span class="bp">F</span><span class="p">,</span> <span class="n">col.names</span> <span class="o">=</span> <span class="bp">T</span><span class="p">)</span>

<span class="nf">rm</span><span class="p">(</span><span class="n">list</span><span class="o">=</span><span class="nf">c</span><span class="p">(</span><span class="s">&quot;Intelligence_raw&quot;</span><span class="p">,</span><span class="s">&quot;Intelligence&quot;</span><span class="p">))</span>
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<pre><span class="ansi-bold">Rows: </span><span class="ansi-blue-fg">9561902</span> <span class="ansi-bold">Columns: </span><span class="ansi-blue-fg">20</span>

<span class="ansi-cyan-fg">──</span> <span class="ansi-bold">Column specification</span> <span class="ansi-cyan-fg">────────────────────────────────────────────────────────────────────────────────────────────────────────</span>
<span class="ansi-bold">Delimiter:</span> &#34;\t&#34;
<span class="ansi-red-fg">chr</span>  (7): SNP, A1, TEST, A2, SNPID_UKB, A1_UKB, A2_UKB
<span class="ansi-green-fg">dbl</span> (13): CHR, BP, NMISS, BETA, SE, L95, U95, STAT, P, MAF, NCHROBS, INFO_UK...


<span class="ansi-cyan-fg">ℹ</span> Use <span class="ansi-black-fg ansi-white-bg">`spec()`</span> to retrieve the full column specification for this data.
<span class="ansi-cyan-fg">ℹ</span> Specify the column types or set <span class="ansi-black-fg ansi-white-bg">`show_col_types = FALSE`</span> to quiet this message.

Begin formatting .... 

The raw data set has 9561902 dat lines

Remove SNPs with imputation info less than 0.9 ..., remaining 9561873 SNPs.

Remove ambiguous SNPs ..., remaining 8119324 SNPs.

Remove SNPs in MHC region ..., remaining 8072530 SNPs.

Remove duplicated SNPs ..., remaining 8072530 SNPs.

Merge SNPs with the hapmap3 snplist ..., remaining 1159117 SNPs.

Remove SNPs with alleles not matched with the hapmap3 snplist, remaining 1158862 SNPs.

Remove SNPs with p-value &lt; 0 or p-value &gt; 1, remaining 1037824 SNPs.

Inferring z score from p value and b ...

Remove missing values, remaining 1037824 SNPs.

Remove SNPs with sample size 5 standard deviations away from the mean, remaining 1037824 SNPs.

Remove SNPs with chi2 &gt; chi2_max ... , remaining 1037824 SNPs.

The formatted data has 1037824 dat lines. 


</pre>
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<div class=" highlight hl-r"><pre><span></span><span class="c1">## 22. MDD</span>
<span class="n">MDD_raw</span> <span class="o">&lt;-</span> <span class="n">readr</span><span class="o">::</span><span class="nf">read_delim</span><span class="p">(</span><span class="s">&quot;./GWAS_26and5_raw/MDD&quot;</span><span class="p">,</span> <span class="s">&quot;\t&quot;</span><span class="p">,</span> <span class="n">escape_double</span> <span class="o">=</span> <span class="kc">FALSE</span><span class="p">,</span> <span class="n">trim_ws</span> <span class="o">=</span> <span class="kc">TRUE</span><span class="p">,</span> <span class="n">progress</span> <span class="o">=</span> <span class="bp">F</span><span class="p">)</span>

<span class="n">MDD</span> <span class="o">=</span> <span class="n">MRAPSS</span><span class="o">::</span><span class="nf">format_data</span><span class="p">(</span><span class="n">MDD_raw</span><span class="p">,</span>
                          <span class="n">snp_col</span> <span class="o">=</span> <span class="s">&quot;SNPID_UKB&quot;</span><span class="p">,</span>
                          <span class="n">or_col</span> <span class="o">=</span> <span class="s">&quot;OR&quot;</span><span class="p">,</span>
                          <span class="n">se_col</span> <span class="o">=</span> <span class="s">&quot;SE&quot;</span><span class="p">,</span>
                          <span class="n">freq_col</span> <span class="o">=</span> <span class="s">&quot;MAF_UKB&quot;</span><span class="p">,</span>
                          <span class="n">A1_col</span> <span class="o">=</span> <span class="s">&quot;A1&quot;</span><span class="p">,</span>
                          <span class="n">A2_col</span> <span class="o">=</span> <span class="s">&quot;A2&quot;</span><span class="p">,</span>
                          <span class="n">p_col</span> <span class="o">=</span> <span class="s">&quot;P&quot;</span><span class="p">,</span>
                          <span class="n">n_col</span> <span class="o">=</span> <span class="s">&quot;NMISS&quot;</span><span class="p">,</span>
                          <span class="n">info_col</span> <span class="o">=</span> <span class="s">&quot;INFO_UKB&quot;</span><span class="p">)</span>

<span class="nf">write.table</span><span class="p">(</span><span class="n">MDD</span><span class="p">,</span> <span class="s">&quot;./GWAS_26and5_formatted/MDD&quot;</span><span class="p">,</span> <span class="n">sep</span> <span class="o">=</span> <span class="s">&quot;\t&quot;</span><span class="p">,</span> <span class="n">quote</span> <span class="o">=</span> <span class="bp">F</span><span class="p">,</span> <span class="n">row.names</span> <span class="o">=</span> <span class="bp">F</span><span class="p">,</span> <span class="n">col.names</span> <span class="o">=</span> <span class="bp">T</span><span class="p">)</span>

<span class="nf">rm</span><span class="p">(</span><span class="n">list</span><span class="o">=</span><span class="nf">c</span><span class="p">(</span><span class="s">&quot;MDD_raw&quot;</span><span class="p">,</span><span class="s">&quot;MDD&quot;</span><span class="p">))</span>
</pre></div>

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<pre><span class="ansi-bold">Rows: </span><span class="ansi-blue-fg">10154467</span> <span class="ansi-bold">Columns: </span><span class="ansi-blue-fg">20</span>

<span class="ansi-cyan-fg">──</span> <span class="ansi-bold">Column specification</span> <span class="ansi-cyan-fg">────────────────────────────────────────────────────────────────────────────────────────────────────────</span>
<span class="ansi-bold">Delimiter:</span> &#34;\t&#34;
<span class="ansi-red-fg">chr</span>  (7): SNP, A1, TEST, A2, SNPID_UKB, A1_UKB, A2_UKB
<span class="ansi-green-fg">dbl</span> (13): CHR, BP, NMISS, OR, SE, L95, U95, STAT, P, MAF, NCHROBS, INFO_UKB,...


<span class="ansi-cyan-fg">ℹ</span> Use <span class="ansi-black-fg ansi-white-bg">`spec()`</span> to retrieve the full column specification for this data.
<span class="ansi-cyan-fg">ℹ</span> Specify the column types or set <span class="ansi-black-fg ansi-white-bg">`show_col_types = FALSE`</span> to quiet this message.

Begin formatting .... 

The raw data set has 10154467 dat lines

Remove SNPs with imputation info less than 0.9 ..., remaining 10154437 SNPs.

Remove ambiguous SNPs ..., remaining 8620374 SNPs.

Remove SNPs in MHC region ..., remaining 8571258 SNPs.

Remove duplicated SNPs ..., remaining 8571258 SNPs.

Merge SNPs with the hapmap3 snplist ..., remaining 1160811 SNPs.

Remove SNPs with alleles not matched with the hapmap3 snplist, remaining 1160529 SNPs.

infer b column from log(or)...

Remove SNPs with p-value &lt; 0 or p-value &gt; 1, remaining 1037824 SNPs.

Inferring z score from p value and b ...

Remove missing values, remaining 1037824 SNPs.

Remove SNPs with sample size 5 standard deviations away from the mean, remaining 1037824 SNPs.

Remove SNPs with chi2 &gt; chi2_max ... , remaining 1037824 SNPs.

The formatted data has 1037824 dat lines. 


</pre>
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<div class=" highlight hl-r"><pre><span></span><span class="c1">## 23. NEB</span>
<span class="n">NEB_raw</span> <span class="o">&lt;-</span> <span class="n">readr</span><span class="o">::</span><span class="nf">read_delim</span><span class="p">(</span><span class="s">&quot;./GWAS_26and5_raw/NEB&quot;</span><span class="p">,</span> <span class="s">&quot;\t&quot;</span><span class="p">,</span> <span class="n">escape_double</span> <span class="o">=</span> <span class="kc">FALSE</span><span class="p">,</span> <span class="n">trim_ws</span> <span class="o">=</span> <span class="kc">TRUE</span><span class="p">,</span> <span class="n">progress</span> <span class="o">=</span> <span class="bp">F</span><span class="p">)</span>

<span class="n">NEB</span> <span class="o">=</span> <span class="n">MRAPSS</span><span class="o">::</span><span class="nf">format_data</span><span class="p">(</span><span class="n">NEB_raw</span><span class="p">,</span>
                          <span class="n">snp_col</span> <span class="o">=</span> <span class="s">&quot;SNPID&quot;</span><span class="p">,</span>
                          <span class="n">freq_col</span> <span class="o">=</span> <span class="s">&quot;Freq_HapMap&quot;</span><span class="p">,</span>
                          <span class="n">A1_col</span> <span class="o">=</span> <span class="s">&quot;A1&quot;</span><span class="p">,</span>
                          <span class="n">A2_col</span> <span class="o">=</span> <span class="s">&quot;A2&quot;</span><span class="p">,</span>
                          <span class="n">z_col</span> <span class="o">=</span> <span class="s">&quot;Zscore&quot;</span><span class="p">,</span>
                          <span class="n">p_col</span> <span class="o">=</span> <span class="s">&quot;Pvalue&quot;</span><span class="p">,</span>
                          <span class="n">n</span> <span class="o">=</span> <span class="m">343072</span><span class="p">)</span>

<span class="nf">write.table</span><span class="p">(</span><span class="n">NEB</span><span class="p">,</span> <span class="n">file</span> <span class="o">=</span> <span class="s">&quot;./GWAS_26and5_formatted/NEB&quot;</span><span class="p">,</span> <span class="n">sep</span> <span class="o">=</span> <span class="s">&quot;\t&quot;</span><span class="p">,</span> <span class="n">quote</span> <span class="o">=</span> <span class="bp">F</span><span class="p">,</span> <span class="n">row.names</span> <span class="o">=</span> <span class="bp">F</span><span class="p">,</span> <span class="n">col.names</span> <span class="o">=</span> <span class="bp">T</span><span class="p">)</span>

<span class="nf">rm</span><span class="p">(</span><span class="n">list</span><span class="o">=</span><span class="nf">c</span><span class="p">(</span><span class="s">&quot;NEB_raw&quot;</span><span class="p">,</span><span class="s">&quot;NEB&quot;</span><span class="p">))</span>
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<pre><span class="ansi-bold">Rows: </span><span class="ansi-blue-fg">2474037</span> <span class="ansi-bold">Columns: </span><span class="ansi-blue-fg">8</span>

<span class="ansi-cyan-fg">──</span> <span class="ansi-bold">Column specification</span> <span class="ansi-cyan-fg">────────────────────────────────────────────────────────────────────────────────────────────────────────</span>
<span class="ansi-bold">Delimiter:</span> &#34;\t&#34;
<span class="ansi-red-fg">chr</span> (3): SNPID, A1, A2
<span class="ansi-green-fg">dbl</span> (5): CHR, POS, Freq_HapMap, Zscore, Pvalue


<span class="ansi-cyan-fg">ℹ</span> Use <span class="ansi-black-fg ansi-white-bg">`spec()`</span> to retrieve the full column specification for this data.
<span class="ansi-cyan-fg">ℹ</span> Specify the column types or set <span class="ansi-black-fg ansi-white-bg">`show_col_types = FALSE`</span> to quiet this message.

Begin formatting .... 

The raw data set has 2474037 dat lines

Remove ambiguous SNPs ..., remaining 2092463 SNPs.

Remove SNPs in MHC region ..., remaining 2089374 SNPs.

Remove duplicated SNPs ..., remaining 2089374 SNPs.

Merge SNPs with the hapmap3 snplist ..., remaining 1078165 SNPs.

Generating sample size from specified sample size

Remove SNPs with p-value &lt; 0 or p-value &gt; 1, remaining 984184 SNPs.

Remove missing values, remaining 984184 SNPs.

Remove SNPs with sample size 5 standard deviations away from the mean, remaining 984184 SNPs.

Remove SNPs with chi2 &gt; chi2_max ... , remaining 984184 SNPs.

The formatted data has 984184 dat lines. 


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<div class=" highlight hl-r"><pre><span></span><span class="c1">## 24. Neuroticism</span>
<span class="n">dat_raw</span> <span class="o">&lt;-</span> <span class="n">readr</span><span class="o">::</span><span class="nf">read_delim</span><span class="p">(</span><span class="s">&quot;./GWAS_26and5_raw/Neuroticism&quot;</span><span class="p">,</span> <span class="s">&quot;\t&quot;</span><span class="p">,</span> <span class="n">escape_double</span> <span class="o">=</span> <span class="kc">FALSE</span><span class="p">,</span> <span class="n">trim_ws</span> <span class="o">=</span> <span class="kc">TRUE</span><span class="p">,</span> <span class="n">progress</span> <span class="o">=</span> <span class="bp">F</span><span class="p">)</span>

<span class="n">dat</span> <span class="o">=</span> <span class="n">MRAPSS</span><span class="o">::</span><span class="nf">format_data</span><span class="p">(</span><span class="n">dat_raw</span><span class="p">,</span>
                          <span class="n">snp_col</span> <span class="o">=</span> <span class="s">&quot;SNPID_UKB&quot;</span><span class="p">,</span>
                          <span class="n">b_col</span> <span class="o">=</span> <span class="s">&quot;BETA&quot;</span><span class="p">,</span>
                          <span class="n">se_col</span> <span class="o">=</span> <span class="s">&quot;SE&quot;</span><span class="p">,</span>
                          <span class="n">freq_col</span> <span class="o">=</span> <span class="s">&quot;MAF_UKB&quot;</span><span class="p">,</span>
                          <span class="n">A1_col</span> <span class="o">=</span> <span class="s">&quot;A1&quot;</span><span class="p">,</span>
                          <span class="n">A2_col</span> <span class="o">=</span> <span class="s">&quot;A2&quot;</span><span class="p">,</span>
                          <span class="n">p_col</span> <span class="o">=</span> <span class="s">&quot;P&quot;</span><span class="p">,</span>
                          <span class="n">n_col</span> <span class="o">=</span> <span class="s">&quot;NMISS&quot;</span><span class="p">,</span>
                          <span class="n">info_col</span> <span class="o">=</span> <span class="s">&quot;INFO_UKB&quot;</span><span class="p">)</span>

<span class="nf">write.table</span><span class="p">(</span><span class="n">dat</span><span class="p">,</span> <span class="s">&quot;./GWAS_26and5_formatted/Neuroticism&quot;</span><span class="p">,</span> <span class="n">sep</span> <span class="o">=</span> <span class="s">&quot;\t&quot;</span><span class="p">,</span> <span class="n">quote</span> <span class="o">=</span> <span class="bp">F</span><span class="p">,</span> <span class="n">row.names</span> <span class="o">=</span> <span class="bp">F</span><span class="p">,</span> <span class="n">col.names</span> <span class="o">=</span> <span class="bp">T</span><span class="p">)</span>

<span class="nf">rm</span><span class="p">(</span><span class="n">list</span><span class="o">=</span><span class="nf">c</span><span class="p">(</span><span class="s">&quot;dat_raw&quot;</span><span class="p">,</span><span class="s">&quot;dat&quot;</span><span class="p">))</span>
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<pre><span class="ansi-bold">Rows: </span><span class="ansi-blue-fg">10399545</span> <span class="ansi-bold">Columns: </span><span class="ansi-blue-fg">20</span>

<span class="ansi-cyan-fg">──</span> <span class="ansi-bold">Column specification</span> <span class="ansi-cyan-fg">────────────────────────────────────────────────────────────────────────────────────────────────────────</span>
<span class="ansi-bold">Delimiter:</span> &#34;\t&#34;
<span class="ansi-red-fg">chr</span>  (7): SNP, A1, TEST, A2, SNPID_UKB, A1_UKB, A2_UKB
<span class="ansi-green-fg">dbl</span> (13): CHR, BP, NMISS, BETA, SE, L95, U95, STAT, P, MAF, NCHROBS, INFO_UK...


<span class="ansi-cyan-fg">ℹ</span> Use <span class="ansi-black-fg ansi-white-bg">`spec()`</span> to retrieve the full column specification for this data.
<span class="ansi-cyan-fg">ℹ</span> Specify the column types or set <span class="ansi-black-fg ansi-white-bg">`show_col_types = FALSE`</span> to quiet this message.

Begin formatting .... 

The raw data set has 10399545 dat lines

Remove SNPs with imputation info less than 0.9 ..., remaining 10399514 SNPs.

Remove ambiguous SNPs ..., remaining 8826898 SNPs.

Remove SNPs in MHC region ..., remaining 8776612 SNPs.

Remove duplicated SNPs ..., remaining 8776612 SNPs.

Merge SNPs with the hapmap3 snplist ..., remaining 1161220 SNPs.

Remove SNPs with alleles not matched with the hapmap3 snplist, remaining 1160924 SNPs.

Remove SNPs with p-value &lt; 0 or p-value &gt; 1, remaining 1037824 SNPs.

Inferring z score from p value and b ...

Remove missing values, remaining 1037824 SNPs.

Remove SNPs with sample size 5 standard deviations away from the mean, remaining 1037824 SNPs.

Remove SNPs with chi2 &gt; chi2_max ... , remaining 1037824 SNPs.

The formatted data has 1037824 dat lines. 


</pre>
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<div class=" highlight hl-r"><pre><span></span><span class="c1">## 25. RA</span>
<span class="c1"># RA_freq: RA annotated with a column of freq</span>
<span class="c1"># Note that the freq_col is not a required column. If freq_col is not available, it will skip the step of QC with freq.</span>

<span class="n">RA_raw</span> <span class="o">&lt;-</span> <span class="n">readr</span><span class="o">::</span><span class="nf">read_delim</span><span class="p">(</span><span class="s">&quot;./GWAS_26and5_raw/RA_freq&quot;</span><span class="p">,</span> <span class="s">&quot;\t&quot;</span><span class="p">,</span> <span class="n">escape_double</span> <span class="o">=</span> <span class="kc">FALSE</span><span class="p">,</span> <span class="n">trim_ws</span> <span class="o">=</span> <span class="kc">TRUE</span><span class="p">,</span> <span class="n">progress</span> <span class="o">=</span> <span class="bp">F</span><span class="p">)</span>

<span class="n">RA</span> <span class="o">=</span> <span class="nf">format_data</span><span class="p">(</span><span class="n">RA_raw</span><span class="p">,</span>
                  <span class="n">snp_col</span> <span class="o">=</span> <span class="s">&quot;SNPID&quot;</span><span class="p">,</span>
                  <span class="n">or_col</span> <span class="o">=</span> <span class="s">&quot;OR(A1)&quot;</span><span class="p">,</span>
                  <span class="n">A1_col</span> <span class="o">=</span> <span class="s">&quot;A1&quot;</span><span class="p">,</span>
                  <span class="n">A2_col</span> <span class="o">=</span> <span class="s">&quot;A2&quot;</span><span class="p">,</span>
                  <span class="n">freq_col</span> <span class="o">=</span> <span class="s">&quot;freq&quot;</span><span class="p">,</span>
                  <span class="n">p_col</span> <span class="o">=</span> <span class="s">&quot;P-val&quot;</span><span class="p">,</span>
                  <span class="n">n</span> <span class="o">=</span> <span class="m">58284</span><span class="p">)</span>

<span class="nf">write.table</span><span class="p">(</span><span class="n">RA</span><span class="p">,</span> <span class="s">&quot;./GWAS_26and5_formatted/RA&quot;</span><span class="p">,</span> <span class="n">sep</span> <span class="o">=</span> <span class="s">&quot;\t&quot;</span><span class="p">,</span> <span class="n">quote</span> <span class="o">=</span> <span class="bp">F</span><span class="p">,</span> <span class="n">row.names</span> <span class="o">=</span> <span class="bp">F</span><span class="p">,</span> <span class="n">col.names</span> <span class="o">=</span> <span class="bp">T</span><span class="p">)</span>

<span class="nf">rm</span><span class="p">(</span><span class="n">list</span><span class="o">=</span><span class="nf">c</span><span class="p">(</span><span class="s">&quot;RA_raw&quot;</span><span class="p">,</span><span class="s">&quot;RA&quot;</span><span class="p">))</span>
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<pre><span class="ansi-bold">Rows: </span><span class="ansi-blue-fg">7022577</span> <span class="ansi-bold">Columns: </span><span class="ansi-blue-fg">10</span>

<span class="ansi-cyan-fg">──</span> <span class="ansi-bold">Column specification</span> <span class="ansi-cyan-fg">────────────────────────────────────────────────────────────────────────────────────────────────────────</span>
<span class="ansi-bold">Delimiter:</span> &#34;\t&#34;
<span class="ansi-red-fg">chr</span> (3): SNPID, A1, A2
<span class="ansi-green-fg">dbl</span> (7): freq, Chr, Position(hg19), OR(A1), OR_95%CIlow, OR_95%CIup, P-val


<span class="ansi-cyan-fg">ℹ</span> Use <span class="ansi-black-fg ansi-white-bg">`spec()`</span> to retrieve the full column specification for this data.
<span class="ansi-cyan-fg">ℹ</span> Specify the column types or set <span class="ansi-black-fg ansi-white-bg">`show_col_types = FALSE`</span> to quiet this message.

Begin formatting .... 

The raw data set has 7022577 dat lines

Remove ambiguous SNPs ..., remaining 5963060 SNPs.

Remove SNPs in MHC region ..., remaining 5935712 SNPs.

Remove duplicated SNPs ..., remaining 5935712 SNPs.

Merge SNPs with the hapmap3 snplist ..., remaining 1131678 SNPs.

infer b column from log(or)...

Generating sample size from specified sample size

Remove SNPs with p-value &lt; 0 or p-value &gt; 1, remaining 1030014 SNPs.

Inferring z score from p value and b ...

Remove missing values, remaining 1030014 SNPs.

Remove SNPs with sample size 5 standard deviations away from the mean, remaining 1030014 SNPs.

Remove SNPs with chi2 &gt; chi2_max ... , remaining 1029912 SNPs.

The formatted data has 1029912 dat lines. 


</pre>
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<div class="prompt input_prompt">In&nbsp;[26]:</div>
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<div class=" highlight hl-r"><pre><span></span><span class="c1">## 26. SCZ</span>

<span class="n">SCZ_raw</span> <span class="o">&lt;-</span> <span class="n">readr</span><span class="o">::</span><span class="nf">read_delim</span><span class="p">(</span><span class="s">&quot;./GWAS_26and5_raw/SCZ_rsid&quot;</span><span class="p">,</span> <span class="s">&quot;\t&quot;</span><span class="p">,</span> <span class="n">escape_double</span> <span class="o">=</span> <span class="kc">FALSE</span><span class="p">,</span> <span class="n">trim_ws</span> <span class="o">=</span> <span class="kc">TRUE</span><span class="p">,</span> <span class="n">progress</span> <span class="o">=</span> <span class="bp">F</span><span class="p">)</span>

<span class="n">SCZ</span> <span class="o">=</span> <span class="nf">format_data</span><span class="p">(</span><span class="n">SCZ_raw</span><span class="p">,</span>
                  <span class="n">snp_col</span> <span class="o">=</span> <span class="s">&quot;rsid&quot;</span><span class="p">,</span>
                  <span class="n">or_col</span> <span class="o">=</span> <span class="s">&quot;OR&quot;</span><span class="p">,</span>
                  <span class="n">se_col</span> <span class="o">=</span> <span class="s">&quot;SE&quot;</span><span class="p">,</span>
                  <span class="n">freq_col</span> <span class="o">=</span> <span class="s">&quot;Freq.A1&quot;</span><span class="p">,</span>
                  <span class="n">A1_col</span> <span class="o">=</span> <span class="s">&quot;A1&quot;</span><span class="p">,</span>
                  <span class="n">A2_col</span> <span class="o">=</span> <span class="s">&quot;A2&quot;</span><span class="p">,</span>
                  <span class="n">p_col</span> <span class="o">=</span> <span class="s">&quot;P&quot;</span><span class="p">,</span>
                  <span class="n">n</span><span class="o">=</span><span class="m">105318</span><span class="p">)</span>

<span class="nf">write.table</span><span class="p">(</span><span class="n">SCZ</span><span class="p">,</span> <span class="s">&quot;./GWAS_26and5_formatted/SCZ&quot;</span><span class="p">,</span> <span class="n">sep</span> <span class="o">=</span> <span class="s">&quot;\t&quot;</span><span class="p">,</span> <span class="n">quote</span> <span class="o">=</span> <span class="bp">F</span><span class="p">,</span> <span class="n">row.names</span> <span class="o">=</span> <span class="bp">F</span><span class="p">,</span> <span class="n">col.names</span> <span class="o">=</span> <span class="bp">T</span><span class="p">)</span>

<span class="nf">rm</span><span class="p">(</span><span class="n">list</span><span class="o">=</span><span class="nf">c</span><span class="p">(</span><span class="s">&quot;SCZ_raw&quot;</span><span class="p">,</span><span class="s">&quot;SCZ&quot;</span><span class="p">))</span>
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<pre><span class="ansi-bold">Rows: </span><span class="ansi-blue-fg">7480977</span> <span class="ansi-bold">Columns: </span><span class="ansi-blue-fg">10</span>

<span class="ansi-cyan-fg">──</span> <span class="ansi-bold">Column specification</span> <span class="ansi-cyan-fg">────────────────────────────────────────────────────────────────────────────────────────────────────────</span>
<span class="ansi-bold">Delimiter:</span> &#34;\t&#34;
<span class="ansi-red-fg">chr</span> (4): rsid, SNP, A1, A2
<span class="ansi-green-fg">dbl</span> (6): Freq.A1, CHR, BP, OR, SE, P


<span class="ansi-cyan-fg">ℹ</span> Use <span class="ansi-black-fg ansi-white-bg">`spec()`</span> to retrieve the full column specification for this data.
<span class="ansi-cyan-fg">ℹ</span> Specify the column types or set <span class="ansi-black-fg ansi-white-bg">`show_col_types = FALSE`</span> to quiet this message.

Begin formatting .... 

The raw data set has 7480977 dat lines

Remove ambiguous SNPs ..., remaining 6341312 SNPs.

Remove SNPs in MHC region ..., remaining 6315985 SNPs.

Remove duplicated SNPs ..., remaining 6315867 SNPs.

Merge SNPs with the hapmap3 snplist ..., remaining 1145148 SNPs.

infer b column from log(or)...

Generating sample size from specified sample size

Remove SNPs with p-value &lt; 0 or p-value &gt; 1, remaining 1047566 SNPs.

Inferring z score from p value and b ...

Remove missing values, remaining 1047566 SNPs.

Remove SNPs with sample size 5 standard deviations away from the mean, remaining 1047566 SNPs.

Remove SNPs with chi2 &gt; chi2_max ... , remaining 1047564 SNPs.

The formatted data has 1047564 dat lines. 


</pre>
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<div class=" highlight hl-r"><pre><span></span><span class="c1">## 27. Smoking</span>
<span class="n">Smoking_raw</span> <span class="o">&lt;-</span> <span class="n">readr</span><span class="o">::</span><span class="nf">read_delim</span><span class="p">(</span><span class="s">&quot;./GWAS_26and5_raw/Smoking&quot;</span><span class="p">,</span> <span class="s">&quot;\t&quot;</span><span class="p">,</span> <span class="n">escape_double</span> <span class="o">=</span> <span class="kc">FALSE</span><span class="p">,</span> <span class="n">trim_ws</span> <span class="o">=</span> <span class="kc">TRUE</span><span class="p">,</span> <span class="n">progress</span> <span class="o">=</span> <span class="bp">F</span><span class="p">)</span>
<span class="n">Smoking_raw</span> <span class="o">=</span> <span class="n">Smoking_raw[</span><span class="o">!</span><span class="nf">is.na</span><span class="p">(</span><span class="n">Smoking_raw</span><span class="o">$</span><span class="n">AF</span><span class="p">),</span> <span class="n">]</span>
<span class="n">Smoking</span> <span class="o">=</span> <span class="nf">format_data</span><span class="p">(</span><span class="n">Smoking_raw</span><span class="p">,</span>
                      <span class="n">snp_col</span> <span class="o">=</span> <span class="s">&quot;RSID&quot;</span><span class="p">,</span>
                      <span class="n">b_col</span> <span class="o">=</span> <span class="s">&quot;BETA&quot;</span><span class="p">,</span>
                      <span class="n">se_col</span> <span class="o">=</span> <span class="s">&quot;SE&quot;</span><span class="p">,</span>
                      <span class="n">freq_col</span> <span class="o">=</span> <span class="s">&quot;AF&quot;</span><span class="p">,</span>
                      <span class="n">A1_col</span> <span class="o">=</span> <span class="s">&quot;ALT&quot;</span><span class="p">,</span>
                      <span class="n">A2_col</span> <span class="o">=</span> <span class="s">&quot;REF&quot;</span><span class="p">,</span>
                      <span class="n">p_col</span> <span class="o">=</span> <span class="s">&quot;PVALUE&quot;</span><span class="p">,</span>
                      <span class="n">n_col</span> <span class="o">=</span> <span class="s">&quot;N&quot;</span><span class="p">)</span>

<span class="nf">write.table</span><span class="p">(</span><span class="n">Smoking</span> <span class="p">,</span> <span class="s">&quot;./GWAS_26and5_formatted/Smoking&quot;</span><span class="p">,</span> <span class="n">sep</span> <span class="o">=</span> <span class="s">&quot;\t&quot;</span><span class="p">,</span> <span class="n">quote</span> <span class="o">=</span> <span class="bp">F</span><span class="p">,</span> <span class="n">row.names</span> <span class="o">=</span> <span class="bp">F</span><span class="p">,</span> <span class="n">col.names</span> <span class="o">=</span> <span class="bp">T</span><span class="p">)</span>

<span class="nf">rm</span><span class="p">(</span><span class="n">list</span><span class="o">=</span><span class="nf">c</span><span class="p">(</span><span class="s">&quot;Smoking_raw&quot;</span><span class="p">,</span><span class="s">&quot;Smoking&quot;</span><span class="p">))</span>
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<pre><span class="ansi-bold">Rows: </span><span class="ansi-blue-fg">13933175</span> <span class="ansi-bold">Columns: </span><span class="ansi-blue-fg">13</span>

<span class="ansi-cyan-fg">──</span> <span class="ansi-bold">Column specification</span> <span class="ansi-cyan-fg">────────────────────────────────────────────────────────────────────────────────────────────────────────</span>
<span class="ansi-bold">Delimiter:</span> &#34;\t&#34;
<span class="ansi-red-fg">chr</span>  (3): RSID, REF, ALT
<span class="ansi-green-fg">dbl</span> (10): CHROM, POS, AF, STAT, PVALUE, BETA, SE, N, EFFECTIVE_N, Number_of_...


<span class="ansi-cyan-fg">ℹ</span> Use <span class="ansi-black-fg ansi-white-bg">`spec()`</span> to retrieve the full column specification for this data.
<span class="ansi-cyan-fg">ℹ</span> Specify the column types or set <span class="ansi-black-fg ansi-white-bg">`show_col_types = FALSE`</span> to quiet this message.

Begin formatting .... 

The raw data set has 12168248 dat lines

Remove ambiguous SNPs ..., remaining 10357018 SNPs.

Remove SNPs in MHC region ..., remaining 10306304 SNPs.

Remove duplicated SNPs ..., remaining 10298519 SNPs.

Merge SNPs with the hapmap3 snplist ..., remaining 1189942 SNPs.

Remove SNPs with p-value &lt; 0 or p-value &gt; 1, remaining 1073202 SNPs.

Inferring z score from p value and b ...

Remove missing values, remaining 1073202 SNPs.

Remove SNPs with sample size 5 standard deviations away from the mean, remaining 1043420 SNPs.

Remove SNPs with chi2 &gt; chi2_max ... , remaining 1043420 SNPs.

The formatted data has 1043420 dat lines. 


</pre>
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<div class=" highlight hl-r"><pre><span></span><span class="c1">## 28. SWB</span>

<span class="n">SWB_raw</span> <span class="o">&lt;-</span> <span class="n">readr</span><span class="o">::</span><span class="nf">read_delim</span><span class="p">(</span><span class="s">&quot;./GWAS_26and5_raw/SWB&quot;</span><span class="p">,</span> <span class="s">&quot;\t&quot;</span><span class="p">,</span> <span class="n">escape_double</span> <span class="o">=</span> <span class="kc">FALSE</span><span class="p">,</span> <span class="n">trim_ws</span> <span class="o">=</span> <span class="kc">TRUE</span><span class="p">,</span> <span class="n">progress</span> <span class="o">=</span> <span class="bp">F</span><span class="p">)</span>

<span class="n">SWB</span> <span class="o">=</span> <span class="n">MRAPSS</span><span class="o">::</span><span class="nf">format_data</span><span class="p">(</span><span class="n">SWB_raw</span><span class="p">,</span>
                          <span class="n">snp_col</span> <span class="o">=</span> <span class="s">&quot;MarkerName&quot;</span><span class="p">,</span>
                          <span class="n">freq_col</span> <span class="o">=</span> <span class="s">&quot;EAF&quot;</span><span class="p">,</span>
                          <span class="n">A1_col</span> <span class="o">=</span> <span class="s">&quot;A1&quot;</span><span class="p">,</span>
                          <span class="n">A2_col</span> <span class="o">=</span> <span class="s">&quot;A2&quot;</span><span class="p">,</span>
                          <span class="n">b_col</span> <span class="o">=</span> <span class="s">&quot;Beta&quot;</span><span class="p">,</span>
                          <span class="n">se_col</span> <span class="o">=</span> <span class="s">&quot;SE&quot;</span><span class="p">,</span>
                          <span class="n">p_col</span> <span class="o">=</span> <span class="s">&quot;Pval&quot;</span><span class="p">,</span>
                          <span class="n">n</span> <span class="o">=</span> <span class="m">298420</span><span class="p">)</span>

<span class="nf">write.table</span><span class="p">(</span><span class="n">SWB</span><span class="p">,</span> <span class="n">file</span> <span class="o">=</span> <span class="s">&quot;./GWAS_26and5_formatted/SWB&quot;</span><span class="p">,</span> <span class="n">sep</span> <span class="o">=</span> <span class="s">&quot;\t&quot;</span><span class="p">,</span> <span class="n">quote</span> <span class="o">=</span> <span class="bp">F</span><span class="p">,</span> <span class="n">row.names</span> <span class="o">=</span> <span class="bp">F</span><span class="p">,</span> <span class="n">col.names</span> <span class="o">=</span> <span class="bp">T</span><span class="p">)</span>

<span class="nf">rm</span><span class="p">(</span><span class="n">list</span><span class="o">=</span><span class="nf">c</span><span class="p">(</span><span class="s">&quot;SWB_raw&quot;</span><span class="p">,</span><span class="s">&quot;SWB&quot;</span><span class="p">))</span>
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<pre><span class="ansi-bold">Rows: </span><span class="ansi-blue-fg">2268674</span> <span class="ansi-bold">Columns: </span><span class="ansi-blue-fg">9</span>

<span class="ansi-cyan-fg">──</span> <span class="ansi-bold">Column specification</span> <span class="ansi-cyan-fg">────────────────────────────────────────────────────────────────────────────────────────────────────────</span>
<span class="ansi-bold">Delimiter:</span> &#34;\t&#34;
<span class="ansi-red-fg">chr</span> (3): MarkerName, A1, A2
<span class="ansi-green-fg">dbl</span> (6): CHR, POS, EAF, Beta, SE, Pval


<span class="ansi-cyan-fg">ℹ</span> Use <span class="ansi-black-fg ansi-white-bg">`spec()`</span> to retrieve the full column specification for this data.
<span class="ansi-cyan-fg">ℹ</span> Specify the column types or set <span class="ansi-black-fg ansi-white-bg">`show_col_types = FALSE`</span> to quiet this message.

Begin formatting .... 

The raw data set has 2268674 dat lines

Remove ambiguous SNPs ..., remaining 1918560 SNPs.

Remove SNPs in MHC region ..., remaining 1915787 SNPs.

Remove duplicated SNPs ..., remaining 1915787 SNPs.

Merge SNPs with the hapmap3 snplist ..., remaining 1018811 SNPs.

Generating sample size from specified sample size

Remove SNPs with p-value &lt; 0 or p-value &gt; 1, remaining 975109 SNPs.

Inferring z score from p value and b ...

Remove missing values, remaining 975109 SNPs.

Remove SNPs with sample size 5 standard deviations away from the mean, remaining 975109 SNPs.

Remove SNPs with chi2 &gt; chi2_max ... , remaining 975109 SNPs.

The formatted data has 975109 dat lines. 


</pre>
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<div class="prompt input_prompt">In&nbsp;[29]:</div>
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<div class=" highlight hl-r"><pre><span></span><span class="c1">## 29. T2D</span>

<span class="n">T2D_raw</span> <span class="o">&lt;-</span> <span class="n">readr</span><span class="o">::</span><span class="nf">read_delim</span><span class="p">(</span><span class="s">&quot;./GWAS_26and5_raw/T2D_rsid&quot;</span><span class="p">,</span> <span class="s">&quot;\t&quot;</span><span class="p">,</span> <span class="n">escape_double</span> <span class="o">=</span> <span class="kc">FALSE</span><span class="p">,</span> <span class="n">trim_ws</span> <span class="o">=</span> <span class="kc">TRUE</span><span class="p">,</span> <span class="n">progress</span> <span class="o">=</span> <span class="bp">F</span><span class="p">)</span>

<span class="n">T2D</span> <span class="o">=</span> <span class="n">MRAPSS</span><span class="o">::</span><span class="nf">format_data</span><span class="p">(</span><span class="n">T2D_raw</span><span class="p">,</span>
                          <span class="n">snp_col</span> <span class="o">=</span> <span class="s">&quot;rsid&quot;</span><span class="p">,</span>
                          <span class="n">b_col</span> <span class="o">=</span> <span class="s">&quot;Beta&quot;</span><span class="p">,</span>
                          <span class="n">se_col</span> <span class="o">=</span> <span class="s">&quot;SE&quot;</span><span class="p">,</span>
                          <span class="n">freq_col</span> <span class="o">=</span> <span class="s">&quot;EAF&quot;</span><span class="p">,</span>
                          <span class="n">A1_col</span> <span class="o">=</span> <span class="s">&quot;EA&quot;</span><span class="p">,</span>
                          <span class="n">A2_col</span> <span class="o">=</span> <span class="s">&quot;NEA&quot;</span><span class="p">,</span>
                          <span class="n">p_col</span> <span class="o">=</span> <span class="s">&quot;Pvalue&quot;</span><span class="p">,</span>
                          <span class="n">n_col</span> <span class="o">=</span> <span class="s">&quot;Neff&quot;</span><span class="p">)</span>

<span class="nf">write.table</span><span class="p">(</span><span class="n">T2D</span><span class="p">,</span> <span class="s">&quot;./GWAS_26and5_formatted/T2D&quot;</span><span class="p">,</span> <span class="n">sep</span> <span class="o">=</span> <span class="s">&quot;\t&quot;</span><span class="p">,</span> <span class="n">quote</span> <span class="o">=</span> <span class="bp">F</span><span class="p">,</span> <span class="n">row.names</span> <span class="o">=</span> <span class="bp">F</span><span class="p">,</span> <span class="n">col.names</span> <span class="o">=</span> <span class="bp">T</span><span class="p">)</span>

<span class="nf">rm</span><span class="p">(</span><span class="n">list</span><span class="o">=</span><span class="nf">c</span><span class="p">(</span><span class="s">&quot;T2D_raw&quot;</span><span class="p">,</span><span class="s">&quot;T2D&quot;</span><span class="p">))</span>
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<pre><span class="ansi-bold">Rows: </span><span class="ansi-blue-fg">9073559</span> <span class="ansi-bold">Columns: </span><span class="ansi-blue-fg">11</span>

<span class="ansi-cyan-fg">──</span> <span class="ansi-bold">Column specification</span> <span class="ansi-cyan-fg">────────────────────────────────────────────────────────────────────────────────────────────────────────</span>
<span class="ansi-bold">Delimiter:</span> &#34;\t&#34;
<span class="ansi-red-fg">chr</span>  (3): rsid, EA, NEA
<span class="ansi-green-fg">dbl</span>  (7): Chr, Pos, EAF, Beta, SE, Pvalue, Neff
<span class="ansi-blue-fg">time</span> (1): SNP


<span class="ansi-cyan-fg">ℹ</span> Use <span class="ansi-black-fg ansi-white-bg">`spec()`</span> to retrieve the full column specification for this data.
<span class="ansi-cyan-fg">ℹ</span> Specify the column types or set <span class="ansi-black-fg ansi-white-bg">`show_col_types = FALSE`</span> to quiet this message.

Begin formatting .... 

The raw data set has 9073559 dat lines

Remove ambiguous SNPs ..., remaining 7713357 SNPs.

Remove SNPs in MHC region ..., remaining 7671570 SNPs.

Remove duplicated SNPs ..., remaining 7663228 SNPs.

Merge SNPs with the hapmap3 snplist ..., remaining 1186472 SNPs.

Remove SNPs with p-value &lt; 0 or p-value &gt; 1, remaining 1058930 SNPs.

Inferring z score from p value and b ...

Remove missing values, remaining 1058930 SNPs.

Remove SNPs with sample size 5 standard deviations away from the mean, remaining 1048396 SNPs.

Remove SNPs with chi2 &gt; chi2_max ... , remaining 1048310 SNPs.

The formatted data has 1048310 dat lines. 


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<div class=" highlight hl-r"><pre><span></span><span class="c1">## 30. Tanning</span>

<span class="n">dat_raw</span> <span class="o">&lt;-</span> <span class="n">readr</span><span class="o">::</span><span class="nf">read_delim</span><span class="p">(</span><span class="s">&quot;./GWAS_26and5_raw/Tanning&quot;</span><span class="p">,</span> <span class="n">delim</span> <span class="o">=</span> <span class="s">&quot;\t&quot;</span><span class="p">,</span> <span class="n">escape_double</span> <span class="o">=</span> <span class="kc">FALSE</span><span class="p">,</span> <span class="n">trim_ws</span> <span class="o">=</span> <span class="kc">TRUE</span><span class="p">,</span> <span class="n">progress</span> <span class="o">=</span> <span class="bp">F</span><span class="p">)</span>

<span class="n">dat</span> <span class="o">=</span> <span class="n">MRAPSS</span><span class="o">::</span><span class="nf">format_data</span><span class="p">(</span><span class="n">dat_raw</span><span class="p">,</span>
                          <span class="n">snp_col</span> <span class="o">=</span> <span class="s">&quot;SNPID_UKB&quot;</span><span class="p">,</span>
                          <span class="n">b_col</span> <span class="o">=</span> <span class="s">&quot;BETA&quot;</span><span class="p">,</span>
                          <span class="n">se_col</span> <span class="o">=</span> <span class="s">&quot;SE&quot;</span><span class="p">,</span>
                          <span class="n">freq_col</span> <span class="o">=</span> <span class="s">&quot;MAF_UKB&quot;</span><span class="p">,</span>
                          <span class="n">A1_col</span> <span class="o">=</span> <span class="s">&quot;A1&quot;</span><span class="p">,</span>
                          <span class="n">A2_col</span> <span class="o">=</span> <span class="s">&quot;A2&quot;</span><span class="p">,</span>
                          <span class="n">p_col</span> <span class="o">=</span> <span class="s">&quot;P&quot;</span><span class="p">,</span>
                          <span class="n">n_col</span> <span class="o">=</span> <span class="s">&quot;NMISS&quot;</span><span class="p">,</span>
                          <span class="n">info_col</span> <span class="o">=</span> <span class="s">&quot;INFO_UKB&quot;</span><span class="p">)</span>

<span class="nf">write.table</span><span class="p">(</span><span class="n">dat</span><span class="p">,</span> <span class="s">&quot;./GWAS_26and5_formatted/Tanning&quot;</span><span class="p">,</span> <span class="n">sep</span> <span class="o">=</span> <span class="s">&quot;\t&quot;</span><span class="p">,</span> <span class="n">quote</span> <span class="o">=</span> <span class="bp">F</span><span class="p">,</span> <span class="n">row.names</span> <span class="o">=</span> <span class="bp">F</span><span class="p">,</span> <span class="n">col.names</span> <span class="o">=</span> <span class="bp">T</span><span class="p">)</span>

<span class="nf">rm</span><span class="p">(</span><span class="n">list</span><span class="o">=</span><span class="nf">c</span><span class="p">(</span><span class="s">&quot;dat_raw&quot;</span><span class="p">,</span> <span class="s">&quot;dat&quot;</span><span class="p">))</span>
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<pre><span class="ansi-bold">Rows: </span><span class="ansi-blue-fg">10579925</span> <span class="ansi-bold">Columns: </span><span class="ansi-blue-fg">20</span>

<span class="ansi-cyan-fg">──</span> <span class="ansi-bold">Column specification</span> <span class="ansi-cyan-fg">────────────────────────────────────────────────────────────────────────────────────────────────────────</span>
<span class="ansi-bold">Delimiter:</span> &#34;\t&#34;
<span class="ansi-red-fg">chr</span>  (7): SNP, A1, TEST, A2, SNPID_UKB, A1_UKB, A2_UKB
<span class="ansi-green-fg">dbl</span> (13): CHR, BP, NMISS, BETA, SE, L95, U95, STAT, P, MAF, NCHROBS, INFO_UK...


<span class="ansi-cyan-fg">ℹ</span> Use <span class="ansi-black-fg ansi-white-bg">`spec()`</span> to retrieve the full column specification for this data.
<span class="ansi-cyan-fg">ℹ</span> Specify the column types or set <span class="ansi-black-fg ansi-white-bg">`show_col_types = FALSE`</span> to quiet this message.

Begin formatting .... 

The raw data set has 10579925 dat lines

Remove SNPs with imputation info less than 0.9 ..., remaining 10579890 SNPs.

Remove ambiguous SNPs ..., remaining 8978911 SNPs.

Remove SNPs in MHC region ..., remaining 8927942 SNPs.

Remove duplicated SNPs ..., remaining 8927942 SNPs.

Merge SNPs with the hapmap3 snplist ..., remaining 1161467 SNPs.

Remove SNPs with alleles not matched with the hapmap3 snplist, remaining 1161162 SNPs.

Remove SNPs with p-value &lt; 0 or p-value &gt; 1, remaining 1037824 SNPs.

Inferring z score from p value and b ...

Remove missing values, remaining 1037824 SNPs.

Remove SNPs with sample size 5 standard deviations away from the mean, remaining 1037824 SNPs.

Remove SNPs with chi2 &gt; chi2_max ... , remaining 1037026 SNPs.

The formatted data has 1037026 dat lines. 


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<div class=" highlight hl-r"><pre><span></span><span class="c1">## 31. Urate</span>

<span class="n">Urate_raw</span> <span class="o">&lt;-</span> <span class="n">readr</span><span class="o">::</span><span class="nf">read_delim</span><span class="p">(</span><span class="s">&quot;./GWAS_26and5_raw/Urate&quot;</span><span class="p">,</span> <span class="s">&quot;,&quot;</span><span class="p">,</span> <span class="n">escape_double</span> <span class="o">=</span> <span class="kc">FALSE</span><span class="p">,</span> <span class="n">trim_ws</span> <span class="o">=</span> <span class="kc">TRUE</span><span class="p">,</span> <span class="n">progress</span> <span class="o">=</span> <span class="bp">F</span><span class="p">)</span>

<span class="n">Urate</span> <span class="o">=</span> <span class="nf">format_data</span><span class="p">(</span><span class="n">Urate_raw</span><span class="p">,</span>
                    <span class="n">snp_col</span> <span class="o">=</span> <span class="s">&quot;MarkerName&quot;</span><span class="p">,</span>
                    <span class="n">b_col</span> <span class="o">=</span> <span class="s">&quot;beta&quot;</span><span class="p">,</span>
                    <span class="n">se_col</span> <span class="o">=</span> <span class="s">&quot;se&quot;</span><span class="p">,</span>
                    <span class="n">A1_col</span> <span class="o">=</span> <span class="s">&quot;A1&quot;</span><span class="p">,</span>
                    <span class="n">A2_col</span> <span class="o">=</span> <span class="s">&quot;A2&quot;</span><span class="p">,</span>
                    <span class="n">p_col</span> <span class="o">=</span> <span class="s">&quot;p_gc&quot;</span><span class="p">,</span>
                    <span class="n">n_col</span> <span class="o">=</span> <span class="s">&quot;n_total&quot;</span><span class="p">)</span>

<span class="nf">write.table</span><span class="p">(</span><span class="n">Urate</span><span class="p">,</span> <span class="s">&quot;./GWAS_26and5_formatted/Urate&quot;</span><span class="p">,</span> <span class="n">sep</span> <span class="o">=</span> <span class="s">&quot;\t&quot;</span><span class="p">,</span> <span class="n">quote</span> <span class="o">=</span> <span class="bp">F</span><span class="p">,</span> <span class="n">row.names</span> <span class="o">=</span> <span class="bp">F</span><span class="p">,</span> <span class="n">col.names</span> <span class="o">=</span> <span class="bp">T</span><span class="p">)</span>

<span class="nf">rm</span><span class="p">(</span><span class="n">list</span><span class="o">=</span><span class="nf">c</span><span class="p">(</span><span class="s">&quot;Urate_raw&quot;</span><span class="p">,</span><span class="s">&quot;Urate&quot;</span><span class="p">))</span>
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<pre><span class="ansi-bold">Rows: </span><span class="ansi-blue-fg">2450547</span> <span class="ansi-bold">Columns: </span><span class="ansi-blue-fg">7</span>

<span class="ansi-cyan-fg">──</span> <span class="ansi-bold">Column specification</span> <span class="ansi-cyan-fg">────────────────────────────────────────────────────────────────────────────────────────────────────────</span>
<span class="ansi-bold">Delimiter:</span> &#34;,&#34;
<span class="ansi-red-fg">chr</span> (3): MarkerName, A1, A2
<span class="ansi-green-fg">dbl</span> (4): n_total, beta, se, p_gc


<span class="ansi-cyan-fg">ℹ</span> Use <span class="ansi-black-fg ansi-white-bg">`spec()`</span> to retrieve the full column specification for this data.
<span class="ansi-cyan-fg">ℹ</span> Specify the column types or set <span class="ansi-black-fg ansi-white-bg">`show_col_types = FALSE`</span> to quiet this message.

Begin formatting .... 

The raw data set has 2450547 dat lines

Remove ambiguous SNPs ..., remaining 2072342 SNPs.

Remove SNPs in MHC region ..., remaining 2062309 SNPs.

Remove duplicated SNPs ..., remaining 2062309 SNPs.

Merge SNPs with the hapmap3 snplist ..., remaining 1064399 SNPs.

Remove SNPs with alleles not matched with the hapmap3 snplist, remaining 1064363 SNPs.

Remove SNPs with p-value &lt; 0 or p-value &gt; 1, remaining 1064363 SNPs.

Inferring z score from p value and b ...

Remove missing values, remaining 1064363 SNPs.

Remove SNPs with sample size 5 standard deviations away from the mean, remaining 1060694 SNPs.

Remove SNPs with chi2 &gt; chi2_max ... , remaining 1060305 SNPs.

The formatted data has 1060305 dat lines. 


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