GPR curation for Carnitine shuttle (4)

[JHL-452b]

Current behavior:

23 genes are discovered to be uncorrelated with their corresponding reactions in Carnitine shuttle.

Gene	UniProtID	Reaction	GPR	Correlation	Manually check
ENSG00000197119	Q8N8R3	MAR02772: (13Z,16Z)-docosadienoylcarnitine + L-carnitine <=> (13Z,16Z)-docosadienoylcarnitine + L-carnitine	ENSG00000149742 or ENSG00000175003 or ENSG00000178537 or ENSG00000197119 or ENSG00000197208	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation. The gene ENSG00000197119 encodes a mitochondrial transporter involved in the transport of basic amino acids such as arginine, lysine, homoarginine, methylarginine, ornithine, and histidine. It does not transport carnitine or acylcarnitines. The provided reaction involves docosadienoylcarnitine and L-carnitine, which are not substrates of the gene's transporter function. Therefore, there is no relation between the gene and the reaction provided.	No
ENSG00000197119	Q8N8R3	MAR02775: 10,13,16-docosatrienoylcarnitine + L-carnitine <=> 10,13,16-docosatrienoylcarnitine + L-carnitine	ENSG00000149742 or ENSG00000175003 or ENSG00000178537 or ENSG00000197119 or ENSG00000197208	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation. The gene ENSG00000197119 encodes a mitochondrial transporter that specifically facilitates the transport of certain amino acids such as arginine, lysine, and histidine, among others. The gene function involves the transport and exchange of these amino acids across the mitochondrial membrane. In contrast, the provided reaction involves 10,13,16-docosatrienoylcarnitine and L-carnitine, which are not substrates transported by the gene product, as it does not transport carnitine or acylcarnitines. Therefore, the gene is not related to the reaction cited.	No
ENSG00000175003	O15245	MAR02606: L-carnitine + tridecanoylcarnitine <=> L-carnitine + tridecanoylcarnitine	ENSG00000149742 or ENSG00000175003 or ENSG00000178537 or ENSG00000197119 or ENSG00000197208	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation. Based on the annotation of the gene ENSG00000175003, the gene encodes for an electrogenic voltage-dependent transporter involved in the transport of various organic cations such as endogenous bioactive amines, cationic drugs, and xenobiotics. The catalytic activities specified for this gene involve the transport of compounds like 1-methylnicotinamide, dopamine, serotonin, adrenaline, histamine, guanidine, acetylcholine, thiamine, agmatine, putrescine, spermidine, L-histidyl-L-proline diketopiperazine, salsolinol, prostaglandin E2, and prostaglandin F2-alpha. However, the provided reaction involving "L-carnitine + tridecanoylcarnitine <=> L-carnitine + tridecanoylcarnitine" does not align with any of the substrates or functions annotated for this gene. Therefore, the gene ENSG00000175003 is not relevant to the reaction provided.	No
ENSG00000149742	Q8IVM8	MAR02612: L-carnitine + tetradecenoylcarnitine(5) <=> L-carnitine + tetradecenoylcarnitine(5)	ENSG00000149742 or ENSG00000175003 or ENSG00000178537 or ENSG00000197119 or ENSG00000197208	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation: The gene ENSG00000149742 encodes a sodium-independent organic anion transporter that is involved in the transport of sulfated conjugates of xenobiotics and steroid hormones, as well as specific short-chain fatty acids. The catalytic activities detailed for this gene involve the exchange of compounds such as estrone 3-sulfate and dehydroepiandrosterone sulfate with butanoate, propanoate, or pentanoate. However, the reaction provided involves the interchange of L-carnitine and tetradecenoylcarnitine, which is unrelated to the gene¡¯s function and catalytic activities. Therefore, the gene ENSG00000149742 does not have any relevance to the provided reaction involving L-carnitine and tetradecenoylcarnitine.	No
ENSG00000149742	Q8IVM8	MAR02629: L-carnitine + L-palmitoylcarnitine <=> L-carnitine + L-palmitoylcarnitine	ENSG00000149742 or ENSG00000175003 or ENSG00000178537 or ENSG00000197119 or ENSG00000197208	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation: The gene ENSG00000149742 encodes a sodium-independent organic anion transporter responsible for transporting sulfated conjugates of xenobiotics and steroid hormones, such as estrone 3-sulfate and dehydroepiandrosterone sulfate, and is specifically activated by short-chain fatty acids. However, the provided reaction involves the exchange between L-carnitine and L-palmitoylcarnitine, which is unrelated to the functions and substrates handled by the gene product. Therefore, the gene is not connected to the given reaction.	No
ENSG00000149742	Q8IVM8	MAR02664: L-carnitine + L-oleoylcarnitine <=> L-carnitine + L-oleoylcarnitine	ENSG00000149742 or ENSG00000175003 or ENSG00000178537 or ENSG00000197119 or ENSG00000197208	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation: The gene ENSG00000149742 encodes a sodium-independent organic anion transporter involved in the transport of sulfated conjugates of xenobiotics and steroid hormones like estrone 3-sulfate and dehydroepiandrosterone sulfate. The provided reaction, which involves the exchange of L-carnitine and L-oleoylcarnitine, is not related to the described function of the gene, as there is no mention of L-carnitine or L-oleoylcarnitine transport in the gene's function or catalytic activities.	No
ENSG00000149742	Q8IVM8	MAR02667: (9E)-octadecenoylcarnitine + L-carnitine <=> (9E)-octadecenoylcarnitine + L-carnitine	ENSG00000149742 or ENSG00000175003 or ENSG00000178537 or ENSG00000197119 or ENSG00000197208	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation: The gene ENSG00000149742 encodes a sodium-independent organic anion transporter that primarily facilitates the exchange of sulfated conjugates of various xenobiotics and steroid hormones, such as estrone 3-sulfate and dehydroepiandrosterone sulfate, against short-chain fatty acids. The reactions it catalyzes specifically involve compounds like butanoate, propanoate, and pentanoate. The provided reaction involving (9E)-octadecenoylcarnitine and L-carnitine does not involve any sulfated conjugates or short-chain fatty acids, nor does it match any of the documented catalytic activities of the gene product, indicating no relevance.	No
ENSG00000175003	O15245	MAR02676: L-carnitine + nonadecanoylcarnitine <=> L-carnitine + nonadecanoylcarnitine	ENSG00000149742 or ENSG00000175003 or ENSG00000178537 or ENSG00000197119 or ENSG00000197208	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation. Based on the provided annotation, the gene ENSG00000175003 is involved in the transport of various organic cations such as endogenous bioactive amines, cationic drugs, and xenobiotics. This gene mediates the bidirectional transport of substances like dopamine, serotonin, adrenaline, histamine, guanidine, acetylcholine, thiamine, and others across cellular membranes. However, the reaction provided "L-carnitine + nonadecanoylcarnitine <=> L-carnitine + nonadecanoylcarnitine" does not involve the transport of such cations but pertains to a different biochemical process involving L-carnitine and nonadecanoylcarnitine. Hence, the gene and the reaction are not related.	No
ENSG00000149742	Q8IVM8	MAR02679: eicosanoylcarnitine + L-carnitine <=> eicosanoylcarnitine + L-carnitine	ENSG00000149742 or ENSG00000175003 or ENSG00000178537 or ENSG00000197119 or ENSG00000197208	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation: The gene ENSG00000149742 encodes for a sodium-independent organic anion transporter that specifically transports sulfated conjugates of xenobiotics and steroid hormones, such as estrone 3-sulfate (E1S) and dehydroepiandrosterone sulfate (DHEAS). It also facilitates the exchange of sulfated organic compounds against short-chain fatty acids like butanoate, propanoate, and pentanoate, with distinct catalytic activities described. However, the reaction provided involves the exchange of eicosanoylcarnitine and L-carnitine, which are not substrates or products mentioned related to the gene's function. Therefore, the gene and the reaction are not related.	No
ENSG00000149742	Q8IVM8	MAR02740: 10,13,16,19-docosatetraenoylcarnitine + L-carnitine <=> 10,13,16,19-docosatetraenoylcarnitine + L-carnitine	ENSG00000149742 or ENSG00000175003 or ENSG00000178537 or ENSG00000197119 or ENSG00000197208	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation: The gene ENSG00000149742 encodes a sodium-independent organic anion transporter that exhibits high specificity for sulfated conjugates of xenobiotics and steroid hormones such as estrone 3-sulfate and dehydroepiandrosterone sulfate. It is also involved in transporting substances such as pravastatin and short-chain fatty acids. The catalytic activities described involve exchanges of sulfated organic compounds against short-chain fatty acids. The reaction provided, however, involves 10,13,16,19-docosatetraenoylcarnitine and L-carnitine, which are not related to the substrates or activities associated with the gene's encoded transporter.	No
ENSG00000175003	O15245	MAR02748: gamma-linolenoylcarnitine + L-carnitine <=> gamma-linolenoylcarnitine + L-carnitine	ENSG00000149742 or ENSG00000175003 or ENSG00000178537 or ENSG00000197119 or ENSG00000197208	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation: The gene ENSG00000175003 functions as an electrogenic voltage-dependent transporter mediating the transport of various organic cations, such as endogenous bioactive amines, cationic drugs, and xenobiotics. Its catalytic activities include transport of substances like 1-methylnicotinamide, dopamine, serotonin, adrenaline, histamine, guanidine, acetylcholine, thiamine, agmatine, putrescine, spermidine, L-histidyl-L-proline diketopiperazine, (R)-salsolinol, prostaglandin F2alpha, and prostaglandin E2. However, the reaction involving gamma-linolenoylcarnitine and L-carnitine is not within the scope of substrates transported by this gene, indicating no relevance between the gene's function and the provided reaction.	No
ENSG00000197119	Q8N8R3	MAR02757: arachidonyl-carnitine + L-carnitine <=> arachidonyl-carnitine + L-carnitine	ENSG00000149742 or ENSG00000175003 or ENSG00000178537 or ENSG00000197119 or ENSG00000197208	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation: The gene ENSG00000197119 encodes a mitochondrial transporter that specifically transports basic amino acids such as arginine, lysine, homoarginine, methylarginine, ornithine, and histidine. It does not transport carnitine or acylcarnitines, as supported by the provided annotations. The reaction described involves arachidonyl-carnitine and L-carnitine, which are not substrates for the mitochondrial transporter encoded by this gene. Therefore, the gene is not relevant to the reaction provided.	No
ENSG00000175003	O15245	MAR02760: L-carnitine + ocosatetraenoylcarnitine <=> L-carnitine + ocosatetraenoylcarnitine	ENSG00000149742 or ENSG00000175003 or ENSG00000178537 or ENSG00000197119 or ENSG00000197208	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation. The provided reaction involves L-carnitine and ocosatetraenoylcarnitine, however, the gene ENSG00000175003 is involved in the transport of various organic cations, such as bioactive amines, cationic drugs, and xenobiotics, but there is no mention of its involvement in the transport or reaction of L-carnitine or ocosatetraenoylcarnitine.	No
ENSG00000175003	O15245	MAR02603: dodecanoylcarnitine + L-carnitine <=> dodecanoylcarnitine + L-carnitine	ENSG00000149742 or ENSG00000175003 or ENSG00000178537 or ENSG00000197119 or ENSG00000197208	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation: The gene ENSG00000175003 encodes for a transporter that mediates the transport of a variety of organic cations, such as endogenous bioactive amines, cationic drugs, and xenobiotics. The outlined catalytic activities involve the transport of various compounds, including neurotransmitters, natural polyamines, prostaglandins, and other organic cations across cellular membranes. However, the provided reaction involves the exchange of dodecanoylcarnitine and L-carnitine, which are not listed among the substrates that the gene-encoded transporter is known to mediate. Thus, the gene does not correspond to the reaction involving dodecanoylcarnitine and L-carnitine.	No
ENSG00000149742	Q8IVM8	MAR02649: heptadecenoylcarnitine(7) + L-carnitine <=> heptadecenoylcarnitine(7) + L-carnitine	ENSG00000149742 or ENSG00000175003 or ENSG00000178537 or ENSG00000197119 or ENSG00000197208	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation: The gene ENSG00000149742 encodes a sodium-independent organic anion transporter involved in the transport of sulfated conjugates like estrone 3-sulfate and dehydroepiandrosterone sulfate, and is activated by short-chain fatty acids. None of the listed catalytic activities involve heptadecenoylcarnitine or L-carnitine, which are the reactants in the provided reaction. Therefore, the gene and the reaction are unrelated.	No
ENSG00000149742	Q8IVM8	MAR02652: heptadecenoylcarnitine(8) + L-carnitine <=> heptadecenoylcarnitine(8) + L-carnitine	ENSG00000149742 or ENSG00000175003 or ENSG00000178537 or ENSG00000197119 or ENSG00000197208	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation: The gene ENSG00000149742 encodes a sodium-independent organic anion transporter that specifically mediates the transport of sulfated conjugates of xenobiotics and steroid hormones such as estrone 3-sulfate and dehydroepiandrosterone sulfate. The catalytic activities described involve the exchange of these sulfated substances against short-chain fatty acids such as butanoate, propanoate, and pentanoate. However, the reaction provided involves heptadecenoylcarnitine and L-carnitine, which are not substrates or products listed in the known catalytic activities of the transporter encoded by this gene. Therefore, based on the annotated functions and catalytic activities, the gene and the reaction are not related.	No
ENSG00000197208	Q9H015	MAR02655: L-carnitine + stearoylcarnitine <=> L-carnitine + stearoylcarnitine	ENSG00000149742 or ENSG00000175003 or ENSG00000178537 or ENSG00000197119 or ENSG00000197208	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation. The gene ENSG00000197208 encodes a transporter protein that mediates the transport of various organic cations and zwitterions, including ergothioneine, acetylcholine, (R)-carnitine, and glycine betaine, either in a Na(+)-dependent or pH-dependent manner. None of the catalytic activities described for this gene involve the reaction between L-carnitine and stearoylcarnitine. Therefore, the annotated function of this gene does not match the reaction provided.	No
ENSG00000149742	Q8IVM8	MAR02670: L-carnitine + octadecenoylcarnitine(11) <=> L-carnitine + octadecenoylcarnitine(11)	ENSG00000149742 or ENSG00000175003 or ENSG00000178537 or ENSG00000197119 or ENSG00000197208	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation: The gene ENSG00000149742 encodes a sodium-independent organic anion transporter that is involved in the transport of sulfated conjugates of xenobiotics and steroid hormones. It facilitates the transport of estrone 3-sulfate and dehydroepiandrosterone sulfate, as well as their exchange with short-chain fatty acids such as propanoate, butanoate, and pentanoate. However, the reaction involving L-carnitine and octadecenoylcarnitine(11) does not involve sulfated conjugates or short-chain fatty acids, and thus is unrelated to the annotated functions and catalytic activities of the gene product.	No
ENSG00000149742	Q8IVM8	MAR02682: eicosenoylcarnitine(7) + L-carnitine <=> eicosenoylcarnitine(7) + L-carnitine	ENSG00000149742 or ENSG00000175003 or ENSG00000178537 or ENSG00000197119 or ENSG00000197208	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation: The gene ENSG00000149742 encodes a sodium-independent organic anion transporter that specifically transports sulfated conjugates of xenobiotics and steroid hormones, such as estrone 3-sulfate and dehydroepiandrosterone sulfate, against short-chain fatty acids like butanoate, propanoate, and pentanoate. The provided reaction involves the exchange between eicosenoylcarnitine and L-carnitine, which is not related to the substrates or the function described for the gene ENSG00000149742. Thus, the gene and the reaction are not related.	No
ENSG00000149742	Q8IVM8	MAR02722: (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoylcarnitine + L-carnitine <=> (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoylcarnitine + L-carnitine	ENSG00000149742 or ENSG00000175003 or ENSG00000178537 or ENSG00000197119 or ENSG00000197208	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation: The gene ENSG00000149742 encodes for a sodium-independent organic anion transporter that is specific for sulfated conjugates of xenobiotics and steroid hormones such as estrone 3-sulfate and dehydroepiandrosterone sulfate. Its catalytic activities include the transport of these conjugates against short-chain fatty acids like propanoate, butanoate, and pentanoate. However, the reaction provided involves (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoylcarnitine and L-carnitine, which are not mentioned as substrates or products of the gene¡¯s transporter activity. Therefore, there is no connection between the gene's function and the specified reaction.	No
ENSG00000149742	Q8IVM8	MAR02764: (4Z,7Z,10Z,13Z,16Z)-docosapentaenoylcarnitine + L-carnitine <=> (4Z,7Z,10Z,13Z,16Z)-docosapentaenoylcarnitine + L-carnitine	ENSG00000149742 or ENSG00000175003 or ENSG00000178537 or ENSG00000197119 or ENSG00000197208	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation. The gene ENSG00000149742 encodes a sodium-independent organic anion transporter that specifically transports sulfated conjugates of xenobiotics and steroid hormones, such as estrone 3-sulfate and dehydroepiandrosterone sulfate, in exchange for short-chain fatty acids like propionate, butyrate, and valerate. The specified reaction involves (4Z,7Z,10Z,13Z,16Z)-docosapentaenoylcarnitine and L-carnitine, which are not substrates or products that the transporter gene handles according to the given annotations. Therefore, there is no relationship between the gene's function and the described reaction.	No
ENSG00000197119	Q8N8R3	MAR03033: L-carnitine + L-octanoylcarnitine <=> L-carnitine + L-octanoylcarnitine	ENSG00000178537 or ENSG00000197119	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation: The gene ENSG00000197119 encodes for a mitochondrial transporter responsible for the transport of specific basic amino acids such as arginine, lysine, homoarginine, methylarginine, ornithine, and histidine. It does not transport carnitine or acylcarnitines, as evidenced by PubMed references. The provided reaction involves L-carnitine and L-octanoylcarnitine, which are not substrates transported by the gene's product. Therefore, the gene is not relevant to the reaction involving L-carnitine and L-octanoylcarnitine.	No
ENSG00000197119	Q8N8R3	MAR03035: L-carnitine + O-propanoylcarnitine <=> L-carnitine + O-propanoylcarnitine	ENSG00000178537 or ENSG00000197119	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation: The gene ENSG00000197119 encodes a mitochondrial transporter involved in the transport of specific amino acids, including arginine, lysine, homoarginine, methylarginine, ornithine, and histidine, as detailed in the provided catalytic activities. However, the reaction described involves the exchange of L-carnitine and O-propanoylcarnitine, which the gene explicitly does not transport, based on the annotation indicating that it does not transport carnitine nor acylcarnitines. Therefore, the gene and the reaction are not related.	No