GPR curation for Leukotriene metabolism (3)

[JHL-452b]

Current behavior:

22 genes are discovered to be uncorrelated with their corresponding reactions in Leukotriene metabolism.

Gene	UniProtID	Reaction	GPR	Correlation	Manually check
ENSG00000196616	P00325	MAR01288: 20-hydroxy-LTE4 + NAD+ --> 20-oxo-LTE4 + H+ + NADH	ENSG00000147576 or ENSG00000172955 or ENSG00000187758 or ENSG00000196344 or ENSG00000196616 or ENSG00000197894 or ENSG00000198099 or ENSG00000248144	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation. The gene ENSG00000196616 catalyzes the NAD-dependent oxidation and reduction of all-trans-retinol and its derivatives, such as all-trans-4-hydroxyretinol and all-trans-4-oxoretinal, involving retinoid metabolism. However, the reaction provided involves the oxidation of 20-hydroxy-LTE4 to 20-oxo-LTE4, which is not related to the substrates and catalytic activities associated with this gene.	No
ENSG00000141096	Q9H4B8	MAR01085: H2O + LTD4 --> glycine + leukotriene E4	ENSG00000015413 or ENSG00000141096 or ENSG00000167261	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation: The gene ENSG00000141096 lacks dipeptidase activity and cannot hydrolyze the specified substrates, including leukotriene D4, as detailed in its function annotation. The catalytic activity section specifies "nan," indicating no known catalytic activity, further supporting its irrelevance to the reaction converting LTD4 to leukotriene E4 and glycine.	No
ENSG00000023041	Q9H6R6	MAR01088: CoA + H+ + N-acetyl-LTE4 <=> acetyl-CoA + leukotriene E4	ENSG00000023041 or ENSG00000054392 or ENSG00000087253 or ENSG00000090971 or ENSG00000097033 or ENSG00000099904 or ENSG00000100344 or ENSG00000102030 or ENSG00000102312 or ENSG00000102383 or ENSG00000103066 or ENSG00000104219 or ENSG00000106636 or ENSG00000109065 or ENSG00000110583 or ENSG00000111684 or ENSG00000121579 or ENSG00000122390 or ENSG00000123684 or ENSG00000125505 or ENSG00000133328 or ENSG00000135372 or ENSG00000136247 or ENSG00000141446 or ENSG00000143797 or ENSG00000144035 or ENSG00000153395 or ENSG00000153786 or ENSG00000156599 or ENSG00000159714 or ENSG00000160446 or ENSG00000163812 or ENSG00000163958 or ENSG00000167011 or ENSG00000171307 or ENSG00000171320 or ENSG00000172197 or ENSG00000172954 or ENSG00000173418 or ENSG00000174165 or ENSG00000175048 or ENSG00000175893 or ENSG00000176454 or ENSG00000177054 or ENSG00000177108 or ENSG00000177669 or ENSG00000180776 or ENSG00000184210 or ENSG00000184307 or ENSG00000184788 or ENSG00000186908 or ENSG00000188706 or ENSG00000188818 or ENSG00000203972 or ENSG00000204160 or ENSG00000206077 or ENSG00000243477	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation: The gene ENSG00000023041 encodes for an endoplasmic reticulum palmitoyl acyltransferase involved in the palmitoylation and stearoylation of specific proteins. The reactions catalyzed by this enzyme involve the transfer of fatty acid groups (hexadecanoyl-CoA and octadecanoyl-CoA) to cysteine residues on proteins. However, the reaction provided involves the conversion of N-acetyl-LTE4 to leukotriene E4, which does not involve the palmitoylation or stearoylation activities described for this gene. Hence, the gene is not related to the given reaction.	No
ENSG00000184307	Q8IYP9	MAR01088: CoA + H+ + N-acetyl-LTE4 <=> acetyl-CoA + leukotriene E4	ENSG00000023041 or ENSG00000054392 or ENSG00000087253 or ENSG00000090971 or ENSG00000097033 or ENSG00000099904 or ENSG00000100344 or ENSG00000102030 or ENSG00000102312 or ENSG00000102383 or ENSG00000103066 or ENSG00000104219 or ENSG00000106636 or ENSG00000109065 or ENSG00000110583 or ENSG00000111684 or ENSG00000121579 or ENSG00000122390 or ENSG00000123684 or ENSG00000125505 or ENSG00000133328 or ENSG00000135372 or ENSG00000136247 or ENSG00000141446 or ENSG00000143797 or ENSG00000144035 or ENSG00000153395 or ENSG00000153786 or ENSG00000156599 or ENSG00000159714 or ENSG00000160446 or ENSG00000163812 or ENSG00000163958 or ENSG00000167011 or ENSG00000171307 or ENSG00000171320 or ENSG00000172197 or ENSG00000172954 or ENSG00000173418 or ENSG00000174165 or ENSG00000175048 or ENSG00000175893 or ENSG00000176454 or ENSG00000177054 or ENSG00000177108 or ENSG00000177669 or ENSG00000180776 or ENSG00000184210 or ENSG00000184307 or ENSG00000184788 or ENSG00000186908 or ENSG00000188706 or ENSG00000188818 or ENSG00000203972 or ENSG00000204160 or ENSG00000206077 or ENSG00000243477	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation: The gene ENSG00000184307 encodes a palmitoyltransferase enzyme that catalyzes the addition of palmitate onto protein substrates, specifically facilitating the palmitoylation of KCNMA1 and possibly involving NOS1 regulation. The described catalytic activity involves hexadecanoyl-CoA and L-cysteinyl-[protein]. However, the reaction provided (CoA + H+ + N-acetyl-LTE4 <=> acetyl-CoA + leukotriene E4) does not involve these substrates or processes associated with palmitoylation, indicating no relevance between the gene and the provided reaction.	No
ENSG00000121579	Q9GZZ1	MAR01088: CoA + H+ + N-acetyl-LTE4 <=> acetyl-CoA + leukotriene E4	ENSG00000023041 or ENSG00000054392 or ENSG00000087253 or ENSG00000090971 or ENSG00000097033 or ENSG00000099904 or ENSG00000100344 or ENSG00000102030 or ENSG00000102312 or ENSG00000102383 or ENSG00000103066 or ENSG00000104219 or ENSG00000106636 or ENSG00000109065 or ENSG00000110583 or ENSG00000111684 or ENSG00000121579 or ENSG00000122390 or ENSG00000123684 or ENSG00000125505 or ENSG00000133328 or ENSG00000135372 or ENSG00000136247 or ENSG00000141446 or ENSG00000143797 or ENSG00000144035 or ENSG00000153395 or ENSG00000153786 or ENSG00000156599 or ENSG00000159714 or ENSG00000160446 or ENSG00000163812 or ENSG00000163958 or ENSG00000167011 or ENSG00000171307 or ENSG00000171320 or ENSG00000172197 or ENSG00000172954 or ENSG00000173418 or ENSG00000174165 or ENSG00000175048 or ENSG00000175893 or ENSG00000176454 or ENSG00000177054 or ENSG00000177108 or ENSG00000177669 or ENSG00000180776 or ENSG00000184210 or ENSG00000184307 or ENSG00000184788 or ENSG00000186908 or ENSG00000188706 or ENSG00000188818 or ENSG00000203972 or ENSG00000204160 or ENSG00000206077 or ENSG00000243477	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation: The gene ENSG00000121579 encodes for an N-alpha-acetyltransferase involved in acetylating the N-terminus of proteins that retain their initiating methionine. It has broad substrate specificity for acetylating the initiator methionine of various peptides and also displays N-epsilon-acetyltransferase activity. The catalytic activities listed for this gene pertain to acetylation reactions involving acetyl-CoA and N-terminal methionyl peptides. In contrast, the reaction provided involves the conversion of N-acetyl-LTE4 and CoA to acetyl-CoA and leukotriene E4, which is not related to the protein acetylation functions of the gene. Therefore, the gene and the reaction are not related.	No
ENSG00000103066	Q8NCC3	MAR01088: CoA + H+ + N-acetyl-LTE4 <=> acetyl-CoA + leukotriene E4	ENSG00000023041 or ENSG00000054392 or ENSG00000087253 or ENSG00000090971 or ENSG00000097033 or ENSG00000099904 or ENSG00000100344 or ENSG00000102030 or ENSG00000102312 or ENSG00000102383 or ENSG00000103066 or ENSG00000104219 or ENSG00000106636 or ENSG00000109065 or ENSG00000110583 or ENSG00000111684 or ENSG00000121579 or ENSG00000122390 or ENSG00000123684 or ENSG00000125505 or ENSG00000133328 or ENSG00000135372 or ENSG00000136247 or ENSG00000141446 or ENSG00000143797 or ENSG00000144035 or ENSG00000153395 or ENSG00000153786 or ENSG00000156599 or ENSG00000159714 or ENSG00000160446 or ENSG00000163812 or ENSG00000163958 or ENSG00000167011 or ENSG00000171307 or ENSG00000171320 or ENSG00000172197 or ENSG00000172954 or ENSG00000173418 or ENSG00000174165 or ENSG00000175048 or ENSG00000175893 or ENSG00000176454 or ENSG00000177054 or ENSG00000177108 or ENSG00000177669 or ENSG00000180776 or ENSG00000184210 or ENSG00000184307 or ENSG00000184788 or ENSG00000186908 or ENSG00000188706 or ENSG00000188818 or ENSG00000203972 or ENSG00000204160 or ENSG00000206077 or ENSG00000243477	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation: The gene ENSG00000103066 encodes a protein with dual calcium-independent phospholipase and O-acyltransferase activities, which are involved in the hydrolysis and transfer of fatty acyl groups in phospholipids and lipophilic alcohols. The provided reaction involves the conversion of CoA, H+, and N-acetyl-LTE4 to acetyl-CoA and leukotriene E4, which does not align with the enzyme activities related to phospholipid metabolism stated in the gene's annotation. Therefore, the gene and the reaction are not related.	No
ENSG00000144035	Q9UHE5	MAR01088: CoA + H+ + N-acetyl-LTE4 <=> acetyl-CoA + leukotriene E4	ENSG00000023041 or ENSG00000054392 or ENSG00000087253 or ENSG00000090971 or ENSG00000097033 or ENSG00000099904 or ENSG00000100344 or ENSG00000102030 or ENSG00000102312 or ENSG00000102383 or ENSG00000103066 or ENSG00000104219 or ENSG00000106636 or ENSG00000109065 or ENSG00000110583 or ENSG00000111684 or ENSG00000121579 or ENSG00000122390 or ENSG00000123684 or ENSG00000125505 or ENSG00000133328 or ENSG00000135372 or ENSG00000136247 or ENSG00000141446 or ENSG00000143797 or ENSG00000144035 or ENSG00000153395 or ENSG00000153786 or ENSG00000156599 or ENSG00000159714 or ENSG00000160446 or ENSG00000163812 or ENSG00000163958 or ENSG00000167011 or ENSG00000171307 or ENSG00000171320 or ENSG00000172197 or ENSG00000172954 or ENSG00000173418 or ENSG00000174165 or ENSG00000175048 or ENSG00000175893 or ENSG00000176454 or ENSG00000177054 or ENSG00000177108 or ENSG00000177669 or ENSG00000180776 or ENSG00000184210 or ENSG00000184307 or ENSG00000184788 or ENSG00000186908 or ENSG00000188706 or ENSG00000188818 or ENSG00000203972 or ENSG00000204160 or ENSG00000206077 or ENSG00000243477	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation. The gene ENSG00000144035 encodes an enzyme that acetylates the free alpha-amino group of cysteine S-conjugates to form mercapturic acids, which is a detoxification route involving glutathione S-conjugates. However, the reaction mentioned involves the interconversion of CoA, H+, N-acetyl-LTE4, acetyl-CoA, and leukotriene E4, which is different from the described function and catalytic activity of the gene product. Therefore, the gene and the reaction are not related.	No
ENSG00000054392	Q5VTY9	MAR01088: CoA + H+ + N-acetyl-LTE4 <=> acetyl-CoA + leukotriene E4	ENSG00000023041 or ENSG00000054392 or ENSG00000087253 or ENSG00000090971 or ENSG00000097033 or ENSG00000099904 or ENSG00000100344 or ENSG00000102030 or ENSG00000102312 or ENSG00000102383 or ENSG00000103066 or ENSG00000104219 or ENSG00000106636 or ENSG00000109065 or ENSG00000110583 or ENSG00000111684 or ENSG00000121579 or ENSG00000122390 or ENSG00000123684 or ENSG00000125505 or ENSG00000133328 or ENSG00000135372 or ENSG00000136247 or ENSG00000141446 or ENSG00000143797 or ENSG00000144035 or ENSG00000153395 or ENSG00000153786 or ENSG00000156599 or ENSG00000159714 or ENSG00000160446 or ENSG00000163812 or ENSG00000163958 or ENSG00000167011 or ENSG00000171307 or ENSG00000171320 or ENSG00000172197 or ENSG00000172954 or ENSG00000173418 or ENSG00000174165 or ENSG00000175048 or ENSG00000175893 or ENSG00000176454 or ENSG00000177054 or ENSG00000177108 or ENSG00000177669 or ENSG00000180776 or ENSG00000184210 or ENSG00000184307 or ENSG00000184788 or ENSG00000186908 or ENSG00000188706 or ENSG00000188818 or ENSG00000203972 or ENSG00000204160 or ENSG00000206077 or ENSG00000243477	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation: The gene ENSG00000054392 encodes a palmitoyl acyltransferase that catalyzes N-terminal palmitoylation of SHH and DHH, which is essential for SHH signaling and proper embryonic development. The provided reaction, CoA + H+ + N-acetyl-LTE4 <=> acetyl-CoA + leukotriene E4, involves acetyl-CoA and leukotriene E4, indicating a different biochemical pathway unrelated to the palmitoylation activities of the gene product.	No
ENSG00000156599	Q9C0B5	MAR01091: CoA + H+ + N-acetyl-LTE4 <=> acetyl-CoA + leukotriene E4	ENSG00000023041 or ENSG00000054392 or ENSG00000087253 or ENSG00000090971 or ENSG00000097033 or ENSG00000099904 or ENSG00000100344 or ENSG00000102030 or ENSG00000102312 or ENSG00000102383 or ENSG00000103066 or ENSG00000104219 or ENSG00000106636 or ENSG00000109065 or ENSG00000110583 or ENSG00000111684 or ENSG00000121579 or ENSG00000122390 or ENSG00000123684 or ENSG00000125505 or ENSG00000133328 or ENSG00000135372 or ENSG00000136247 or ENSG00000141446 or ENSG00000143797 or ENSG00000144035 or ENSG00000153395 or ENSG00000153786 or ENSG00000156599 or ENSG00000159714 or ENSG00000160446 or ENSG00000163812 or ENSG00000163958 or ENSG00000167011 or ENSG00000171307 or ENSG00000171320 or ENSG00000172197 or ENSG00000172954 or ENSG00000173418 or ENSG00000174165 or ENSG00000175048 or ENSG00000175893 or ENSG00000176454 or ENSG00000177054 or ENSG00000177108 or ENSG00000177669 or ENSG00000180776 or ENSG00000184210 or ENSG00000184307 or ENSG00000184788 or ENSG00000186908 or ENSG00000188706 or ENSG00000188818 or ENSG00000203972 or ENSG00000204160 or ENSG00000206077 or ENSG00000243477	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation. The gene ENSG00000156599 encodes a palmitoyltransferase enzyme that catalyzes the addition of palmitate to specific protein substrates, playing roles in processes such as cell adhesion, fatty acid uptake, bacterial sensing, and synapse efficacy. The catalytic activity involves reactions with hexadecanoyl-CoA and protein substrates. However, the provided reaction describes the conversion of CoA, H+, and N-acetyl-LTE4 to acetyl-CoA and leukotriene E4, which does not involve palmitoylation or any substrates or products related to the function of the gene ENSG00000156599.	No
ENSG00000136247	Q9NPG8	MAR01091: CoA + H+ + N-acetyl-LTE4 <=> acetyl-CoA + leukotriene E4	ENSG00000023041 or ENSG00000054392 or ENSG00000087253 or ENSG00000090971 or ENSG00000097033 or ENSG00000099904 or ENSG00000100344 or ENSG00000102030 or ENSG00000102312 or ENSG00000102383 or ENSG00000103066 or ENSG00000104219 or ENSG00000106636 or ENSG00000109065 or ENSG00000110583 or ENSG00000111684 or ENSG00000121579 or ENSG00000122390 or ENSG00000123684 or ENSG00000125505 or ENSG00000133328 or ENSG00000135372 or ENSG00000136247 or ENSG00000141446 or ENSG00000143797 or ENSG00000144035 or ENSG00000153395 or ENSG00000153786 or ENSG00000156599 or ENSG00000159714 or ENSG00000160446 or ENSG00000163812 or ENSG00000163958 or ENSG00000167011 or ENSG00000171307 or ENSG00000171320 or ENSG00000172197 or ENSG00000172954 or ENSG00000173418 or ENSG00000174165 or ENSG00000175048 or ENSG00000175893 or ENSG00000176454 or ENSG00000177054 or ENSG00000177108 or ENSG00000177669 or ENSG00000180776 or ENSG00000184210 or ENSG00000184307 or ENSG00000184788 or ENSG00000186908 or ENSG00000188706 or ENSG00000188818 or ENSG00000203972 or ENSG00000204160 or ENSG00000206077 or ENSG00000243477	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation: The gene ENSG00000136247 encodes a palmitoyltransferase enzyme that catalyzes the addition of palmitate onto protein substrates, specifically in a reaction involving hexadecanoyl-CoA and L-cysteinyl-[protein]. However, the reaction provided involves CoA, H+, N-acetyl-LTE4, acetyl-CoA, and leukotriene E4, which is unrelated to the palmitoylation activity described for the gene.	No
ENSG00000171320	Q56NI9	MAR01091: CoA + H+ + N-acetyl-LTE4 <=> acetyl-CoA + leukotriene E4	ENSG00000023041 or ENSG00000054392 or ENSG00000087253 or ENSG00000090971 or ENSG00000097033 or ENSG00000099904 or ENSG00000100344 or ENSG00000102030 or ENSG00000102312 or ENSG00000102383 or ENSG00000103066 or ENSG00000104219 or ENSG00000106636 or ENSG00000109065 or ENSG00000110583 or ENSG00000111684 or ENSG00000121579 or ENSG00000122390 or ENSG00000123684 or ENSG00000125505 or ENSG00000133328 or ENSG00000135372 or ENSG00000136247 or ENSG00000141446 or ENSG00000143797 or ENSG00000144035 or ENSG00000153395 or ENSG00000153786 or ENSG00000156599 or ENSG00000159714 or ENSG00000160446 or ENSG00000163812 or ENSG00000163958 or ENSG00000167011 or ENSG00000171307 or ENSG00000171320 or ENSG00000172197 or ENSG00000172954 or ENSG00000173418 or ENSG00000174165 or ENSG00000175048 or ENSG00000175893 or ENSG00000176454 or ENSG00000177054 or ENSG00000177108 or ENSG00000177669 or ENSG00000180776 or ENSG00000184210 or ENSG00000184307 or ENSG00000184788 or ENSG00000186908 or ENSG00000188706 or ENSG00000188818 or ENSG00000203972 or ENSG00000204160 or ENSG00000206077 or ENSG00000243477	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation. The gene ENSG00000171320 encodes an acetyltransferase involved in sister chromatid cohesion and primarily functions during the S phase of the cell cycle by acetylating cohesin component SMC3. The catalytic activity of the gene involves the acetylation of lysine residues on protein substrates using acetyl-CoA. The reaction provided involves CoA, H+, N-acetyl-LTE4, acetyl-CoA, and leukotriene E4, which is clearly not related to the function of an acetyltransferase working on chromatid cohesion. Therefore, the gene's function does not align with the described reaction.	No
ENSG00000160446	Q96GR4	MAR01091: CoA + H+ + N-acetyl-LTE4 <=> acetyl-CoA + leukotriene E4	ENSG00000023041 or ENSG00000054392 or ENSG00000087253 or ENSG00000090971 or ENSG00000097033 or ENSG00000099904 or ENSG00000100344 or ENSG00000102030 or ENSG00000102312 or ENSG00000102383 or ENSG00000103066 or ENSG00000104219 or ENSG00000106636 or ENSG00000109065 or ENSG00000110583 or ENSG00000111684 or ENSG00000121579 or ENSG00000122390 or ENSG00000123684 or ENSG00000125505 or ENSG00000133328 or ENSG00000135372 or ENSG00000136247 or ENSG00000141446 or ENSG00000143797 or ENSG00000144035 or ENSG00000153395 or ENSG00000153786 or ENSG00000156599 or ENSG00000159714 or ENSG00000160446 or ENSG00000163812 or ENSG00000163958 or ENSG00000167011 or ENSG00000171307 or ENSG00000171320 or ENSG00000172197 or ENSG00000172954 or ENSG00000173418 or ENSG00000174165 or ENSG00000175048 or ENSG00000175893 or ENSG00000176454 or ENSG00000177054 or ENSG00000177108 or ENSG00000177669 or ENSG00000180776 or ENSG00000184210 or ENSG00000184307 or ENSG00000184788 or ENSG00000186908 or ENSG00000188706 or ENSG00000188818 or ENSG00000203972 or ENSG00000204160 or ENSG00000206077 or ENSG00000243477	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation: The gene ENSG00000160446 encodes for a palmitoyltransferase that primarily catalyzes the addition of palmitate onto various protein substrates. The catalytic activity involves the conversion of hexadecanoyl-CoA and L-cysteinyl-[protein] to CoA and S-hexadecanoyl-L-cysteinyl-[protein]. In contrast, the reaction in question involves the conversion of CoA, H+, and N-acetyl-LTE4 to acetyl-CoA and leukotriene E4, which does not involve palmitoylation or the substrates specified by the gene's function. Hence, the gene's function and the reaction are not related.	No
ENSG00000054392	Q5VTY9	MAR01091: CoA + H+ + N-acetyl-LTE4 <=> acetyl-CoA + leukotriene E4	ENSG00000023041 or ENSG00000054392 or ENSG00000087253 or ENSG00000090971 or ENSG00000097033 or ENSG00000099904 or ENSG00000100344 or ENSG00000102030 or ENSG00000102312 or ENSG00000102383 or ENSG00000103066 or ENSG00000104219 or ENSG00000106636 or ENSG00000109065 or ENSG00000110583 or ENSG00000111684 or ENSG00000121579 or ENSG00000122390 or ENSG00000123684 or ENSG00000125505 or ENSG00000133328 or ENSG00000135372 or ENSG00000136247 or ENSG00000141446 or ENSG00000143797 or ENSG00000144035 or ENSG00000153395 or ENSG00000153786 or ENSG00000156599 or ENSG00000159714 or ENSG00000160446 or ENSG00000163812 or ENSG00000163958 or ENSG00000167011 or ENSG00000171307 or ENSG00000171320 or ENSG00000172197 or ENSG00000172954 or ENSG00000173418 or ENSG00000174165 or ENSG00000175048 or ENSG00000175893 or ENSG00000176454 or ENSG00000177054 or ENSG00000177108 or ENSG00000177669 or ENSG00000180776 or ENSG00000184210 or ENSG00000184307 or ENSG00000184788 or ENSG00000186908 or ENSG00000188706 or ENSG00000188818 or ENSG00000203972 or ENSG00000204160 or ENSG00000206077 or ENSG00000243477	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation. Based on the annotation, the gene ENSG00000054392 functions as a palmitoyl acyltransferase responsible for the N-terminal palmitoylation of SHH and DHH, crucial for SHH signaling and embryonic development. The catalytic activity involves hexadecanoyl-CoA and N-terminal L-cysteinyl-[protein], but the provided reaction involves CoA, H+, and N-acetyl-LTE4 converting to acetyl-CoA and leukotriene E4, which does not align with the gene's known activities or functions.	No
ENSG00000196616	P00325	MAR01131: 20-OH-LTB4 + NAD+ <=> 20-oxo-LTB4 + H+ + NADH	ENSG00000147576 or ENSG00000172955 or ENSG00000187758 or ENSG00000196344 or ENSG00000196616 or ENSG00000197894 or ENSG00000198099 or ENSG00000248144	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation: According to the annotation, the gene ENSG00000196616 encodes an enzyme that catalyzes the NAD-dependent oxidation of all-trans-retinol and its derivatives, such as all-trans-4-hydroxyretinol, and the reduction of all-trans-retinal and its derivatives. The reactions involved are specific to retinoid metabolism, focusing on all-trans-retinol, all-trans-4-hydroxyretinol, and their related compounds. However, the provided reaction, "20-OH-LTB4 + NAD+ <=> 20-oxo-LTB4 + H+ + NADH," involves the oxidation of 20-OH-LTB4 to 20-oxo-LTB4, which is a distinct process from the metabolic functions detailed for the gene product of ENSG00000196616. Thus, the reaction does not align with the enzymatic activities attributed to the gene, indicating they are not related.	No
ENSG00000186526	P98187	MAR01149: 5-oxo-6-trans-LTB4 + H+ + NADPH <=> 6,7-dihydro-5-oxo-LTB4 + NADP+	ENSG00000021461 or ENSG00000100197 or ENSG00000106258 or ENSG00000108242 or ENSG00000130649 or ENSG00000134716 or ENSG00000137869 or ENSG00000138061 or ENSG00000138109 or ENSG00000138115 or ENSG00000140465 or ENSG00000140505 or ENSG00000142973 or ENSG00000155016 or ENSG00000160868 or ENSG00000160870 or ENSG00000167600 or ENSG00000171903 or ENSG00000186160 or ENSG00000186204 or ENSG00000186377 or ENSG00000186526 or ENSG00000197408 or ENSG00000197446 or ENSG00000197838 or ENSG00000198077 or ENSG00000255974	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation. The gene ENSG00000186526 encodes a cytochrome P450 monooxygenase involved in the metabolism of endogenous polyunsaturated fatty acids (PUFAs) and their oxygenated derivatives (oxylipins). It catalyzes the hydroxylation of carbon hydrogen bonds and the epoxidation of double bonds of PUFAs using molecular oxygen and NADPH. The specific reactions provided in the gene annotation include the hydroxylation and epoxidation of various fatty acids and prostaglandins, which are different from the reaction involving 5-oxo-6-trans-LTB4 and NADPH to form 6,7-dihydro-5-oxo-LTB4 and NADP+. Therefore, the gene's annotated functions do not involve or match the provided reaction.	No
ENSG00000186160	Q86W10	MAR01153: 6,7-dihydro-5-oxo-LTB4 + H+ + NADPH <=> 6,7-dihydro-LTB4 + NADP+	ENSG00000021461 or ENSG00000100197 or ENSG00000106258 or ENSG00000108242 or ENSG00000130649 or ENSG00000134716 or ENSG00000137869 or ENSG00000138061 or ENSG00000138109 or ENSG00000138115 or ENSG00000140465 or ENSG00000140505 or ENSG00000142973 or ENSG00000155016 or ENSG00000160868 or ENSG00000160870 or ENSG00000165841 or ENSG00000167600 or ENSG00000171903 or ENSG00000186160 or ENSG00000186204 or ENSG00000186377 or ENSG00000186526 or ENSG00000197408 or ENSG00000197446 or ENSG00000197838 or ENSG00000198077 or ENSG00000255974	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation. The gene ENSG00000186160 encodes a cytochrome P450 monooxygenase, which catalyzes the in-chain oxidation of fatty acids and the epoxidation of double bonds of polyunsaturated fatty acids (PUFA). The specific reactions catalyzed by this enzyme involve the oxidation of lauric and myristic acids as well as the epoxidation of arachidonic acid, using molecular oxygen and NADPH. However, the provided reaction involves the conversion of 6,7-dihydro-5-oxo-LTB4 to 6,7-dihydro-LTB4 using NADPH, which is not one of the reactions catalyzed by the enzyme encoded by ENSG00000186160. Therefore, based on the function and catalytic activities of the gene product, there is no relevance to the provided reaction.	No
ENSG00000137869	P11511	MAR01153: 6,7-dihydro-5-oxo-LTB4 + H+ + NADPH <=> 6,7-dihydro-LTB4 + NADP+	ENSG00000021461 or ENSG00000100197 or ENSG00000106258 or ENSG00000108242 or ENSG00000130649 or ENSG00000134716 or ENSG00000137869 or ENSG00000138061 or ENSG00000138109 or ENSG00000138115 or ENSG00000140465 or ENSG00000140505 or ENSG00000142973 or ENSG00000155016 or ENSG00000160868 or ENSG00000160870 or ENSG00000165841 or ENSG00000167600 or ENSG00000171903 or ENSG00000186160 or ENSG00000186204 or ENSG00000186377 or ENSG00000186526 or ENSG00000197408 or ENSG00000197446 or ENSG00000197838 or ENSG00000198077 or ENSG00000255974	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation: The gene ENSG00000137869 encodes for a cytochrome P450 monooxygenase involved in the oxidation of C19 androgens to C18 estrogens, using molecular oxygen and NADPH. The described catalytic activities primarily include conversions of androgens like testosterone and androst-4-ene-3,17-dione to estrogens like estrone and estradiol. However, the provided reaction involves the conversion of 6,7-dihydro-5-oxo-LTB4 to 6,7-dihydro-LTB4 using NADPH, which is a different biochemical process unrelated to the enzyme's androgen and estrogen conversion functions. Thus, the gene does not relate to this particular reaction.	No
ENSG00000137869	P11511	MAR01155: 6,7-dihydro-5-oxo-LTB4 + H+ + NADPH <=> 6,7-dihydro-LTB4 + NADP+	ENSG00000021461 or ENSG00000100197 or ENSG00000106258 or ENSG00000108242 or ENSG00000130649 or ENSG00000134716 or ENSG00000137869 or ENSG00000138061 or ENSG00000138109 or ENSG00000138115 or ENSG00000140465 or ENSG00000140505 or ENSG00000142973 or ENSG00000155016 or ENSG00000160868 or ENSG00000160870 or ENSG00000165841 or ENSG00000167600 or ENSG00000171903 or ENSG00000186160 or ENSG00000186204 or ENSG00000186377 or ENSG00000186526 or ENSG00000197408 or ENSG00000197446 or ENSG00000197838 or ENSG00000198077 or ENSG00000255974	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation. The gene ENSG00000137869 encodes a cytochrome P450 monooxygenase involved in the conversion of C19 androgens to C18 estrogens and exhibits various specific catalytic activities related to steroid metabolism. In contrast, the reaction provided concerns the conversion of 6,7-dihydro-5-oxo-LTB4 to 6,7-dihydro-LTB4, involving NADPH and NADP+, which is not related to the steroidogenic functions of the cytochrome P450 enzyme encoded by ENSG00000137869. Hence, the gene is not relevant to the specified reaction.	No
ENSG00000137869	P11511	MAR01193: 5-oxo-(6E)-12-epi-LTB4 + H+ + NADPH <=> 6,7-dihydro-5-oxo-12-epi-LTB4 + NADP+	ENSG00000021461 or ENSG00000100197 or ENSG00000106258 or ENSG00000108242 or ENSG00000130649 or ENSG00000134716 or ENSG00000137869 or ENSG00000138061 or ENSG00000138109 or ENSG00000138115 or ENSG00000140465 or ENSG00000140505 or ENSG00000142973 or ENSG00000155016 or ENSG00000160868 or ENSG00000160870 or ENSG00000165841 or ENSG00000167600 or ENSG00000171903 or ENSG00000186160 or ENSG00000186204 or ENSG00000186377 or ENSG00000186526 or ENSG00000197408 or ENSG00000197446 or ENSG00000197838 or ENSG00000198077 or ENSG00000255974	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation: The gene ENSG00000137869 encodes a cytochrome P450 monooxygenase that primarily catalyzes the conversion of C19 androgens like androstenedione and testosterone to C18 estrogens such as estrone and estradiol, and exhibits several other specific oxidations involving androgens and estrogens. However, it does not involve or participate in the conversion of 5-oxo-(6E)-12-epi-LTB4 to 6,7-dihydro-5-oxo-12-epi-LTB4 as described in the reaction provided. This reaction is related to leukotriene metabolism rather than the steroid metabolism pathways catalyzed by the gene's enzyme.	No
ENSG00000108242	P33260	MAR01194: 5-oxo-(6E)-12-epi-LTB4 + H+ + NADPH <=> 6,7-dihydro-5-oxo-12-epi-LTB4 + NADP+	ENSG00000021461 or ENSG00000100197 or ENSG00000106258 or ENSG00000108242 or ENSG00000130649 or ENSG00000134716 or ENSG00000137869 or ENSG00000138061 or ENSG00000138109 or ENSG00000138115 or ENSG00000140465 or ENSG00000140505 or ENSG00000142973 or ENSG00000155016 or ENSG00000160868 or ENSG00000160870 or ENSG00000165841 or ENSG00000167600 or ENSG00000171903 or ENSG00000186160 or ENSG00000186204 or ENSG00000186377 or ENSG00000186526 or ENSG00000197408 or ENSG00000197446 or ENSG00000197838 or ENSG00000198077 or ENSG00000255974	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation: The gene ENSG00000108242 encodes a cytochrome P450 monooxygenase involved in retinoid metabolism, specifically hydroxylating all-trans-retinoic acid (atRA) to 4-hydroxyretinoate. This enzymatic activity involves the use of molecular oxygen and NADPH to facilitate the hydroxylation process. However, the provided reaction involves the reduction of 5-oxo-(6E)-12-epi-LTB4 to 6,7-dihydro-5-oxo-12-epi-LTB4 using NADPH, which is unrelated to the metabolic functions or catalytic activities described for the gene ENSG00000108242. Hence, there is no connection between the gene¡¯s function and the reaction provided.	No
ENSG00000184210	Q6ZPD8	MAR01088: CoA + H+ + N-acetyl-LTE4 <=> acetyl-CoA + leukotriene E4	ENSG00000023041 or ENSG00000054392 or ENSG00000087253 or ENSG00000090971 or ENSG00000097033 or ENSG00000099904 or ENSG00000100344 or ENSG00000102030 or ENSG00000102312 or ENSG00000102383 or ENSG00000103066 or ENSG00000104219 or ENSG00000106636 or ENSG00000109065 or ENSG00000110583 or ENSG00000111684 or ENSG00000121579 or ENSG00000122390 or ENSG00000123684 or ENSG00000125505 or ENSG00000133328 or ENSG00000135372 or ENSG00000136247 or ENSG00000141446 or ENSG00000143797 or ENSG00000144035 or ENSG00000153395 or ENSG00000153786 or ENSG00000156599 or ENSG00000159714 or ENSG00000160446 or ENSG00000163812 or ENSG00000163958 or ENSG00000167011 or ENSG00000171307 or ENSG00000171320 or ENSG00000172197 or ENSG00000172954 or ENSG00000173418 or ENSG00000174165 or ENSG00000175048 or ENSG00000175893 or ENSG00000176454 or ENSG00000177054 or ENSG00000177108 or ENSG00000177669 or ENSG00000180776 or ENSG00000184210 or ENSG00000184307 or ENSG00000184788 or ENSG00000186908 or ENSG00000188706 or ENSG00000188818 or ENSG00000203972 or ENSG00000204160 or ENSG00000206077 or ENSG00000243477	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation: The gene ENSG00000184210 encodes for a diglyceride acyltransferase, which is involved in the synthesis of triglycerides and monoalkyl-monoacylglycerol using fatty acyl-CoA as a substrate. In contrast, the reaction provided involves the conversion of N-acetyl-LTE4 to leukotriene E4 with the involvement of acetyl-CoA and CoA, which falls under leukotriene metabolism, not related to lipid or triglyceride synthesis. Thus, the gene and the provided reaction are not related.	No
ENSG00000177108	Q8N966	MAR01088: CoA + H+ + N-acetyl-LTE4 <=> acetyl-CoA + leukotriene E4	ENSG00000023041 or ENSG00000054392 or ENSG00000087253 or ENSG00000090971 or ENSG00000097033 or ENSG00000099904 or ENSG00000100344 or ENSG00000102030 or ENSG00000102312 or ENSG00000102383 or ENSG00000103066 or ENSG00000104219 or ENSG00000106636 or ENSG00000109065 or ENSG00000110583 or ENSG00000111684 or ENSG00000121579 or ENSG00000122390 or ENSG00000123684 or ENSG00000125505 or ENSG00000133328 or ENSG00000135372 or ENSG00000136247 or ENSG00000141446 or ENSG00000143797 or ENSG00000144035 or ENSG00000153395 or ENSG00000153786 or ENSG00000156599 or ENSG00000159714 or ENSG00000160446 or ENSG00000163812 or ENSG00000163958 or ENSG00000167011 or ENSG00000171307 or ENSG00000171320 or ENSG00000172197 or ENSG00000172954 or ENSG00000173418 or ENSG00000174165 or ENSG00000175048 or ENSG00000175893 or ENSG00000176454 or ENSG00000177054 or ENSG00000177108 or ENSG00000177669 or ENSG00000180776 or ENSG00000184210 or ENSG00000184307 or ENSG00000184788 or ENSG00000186908 or ENSG00000188706 or ENSG00000188818 or ENSG00000203972 or ENSG00000204160 or ENSG00000206077 or ENSG00000243477	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation. The gene ENSG00000177108 encodes a palmitoyltransferase that catalyzes the addition of palmitate onto various protein substrates. The specific catalytic activity involves hexadecanoyl-CoA and L-cysteinyl-[protein] substrates. However, the reaction described involves CoA, H+, N-acetyl-LTE4, and leukotriene E4, which do not align with the substrates or products associated with the gene's palmitoyltransferase function. Therefore, the gene and the reaction are not related.	No