GPR curation for Sphingolipid metabolism

[JHL-452b]

Current behavior:

23 genes are discovered to be uncorrelated with their corresponding reactions in Sphingolipid metabolism

Gene	UniProtID	Reaction	GPR	Correlation	Manually check
ENSG00000101577	Q92539	MAR00746: H2O + sphinganine-1-phosphate --> Pi + sphinganine	ENSG00000067113 or ENSG00000101577 or ENSG00000132793 or ENSG00000134324 or ENSG00000141934 or ENSG00000162407	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation: The gene ENSG00000101577 encodes an enzyme that catalyzes the conversion of phosphatidic acid to diacylglycerol and is involved in fatty acid metabolism and lipid biosynthesis. The specific reaction it catalyzes, involving a 1,2-diacyl-sn-glycero-3-phosphate and water, does not match the provided reaction where sphinganine-1-phosphate is converted to sphinganine and phosphate. Therefore, the functions and catalytic activities of the gene do not align with the provided reaction.	No
ENSG00000132793	Q9BQK8	MAR00746: H2O + sphinganine-1-phosphate --> Pi + sphinganine	ENSG00000067113 or ENSG00000101577 or ENSG00000132793 or ENSG00000134324 or ENSG00000141934 or ENSG00000162407	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation. The gene ENSG00000132793 encodes a magnesium-dependent phosphatidate phosphatase enzyme that catalyzes the conversion of phosphatidic acid to diacylglycerol, which is involved in triglyceride, phosphatidylcholine, and phosphatidylethanolamine biosynthesis. The provided reaction illustrates the conversion of sphinganine-1-phosphate to sphinganine and phosphate, which is unrelated to the activities of the enzyme encoded by ENSG00000132793.	No
ENSG00000102595	Q9NYU1	MAR00765: glucosylceramide pool + UDP-galactose --> H+ + LacCer pool + UDP	ENSG00000016864 or ENSG00000027847 or ENSG00000060642 or ENSG00000069943 or ENSG00000085998 or ENSG00000086062 or ENSG00000102595 or ENSG00000109586 or ENSG00000117411 or ENSG00000118017 or ENSG00000118276 or ENSG00000119227 or ENSG00000120820 or ENSG00000121578 or ENSG00000124091 or ENSG00000134910 or ENSG00000136731 or ENSG00000139044 or ENSG00000143315 or ENSG00000147162 or ENSG00000148288 or ENSG00000156966 or ENSG00000158470 or ENSG00000158850 or ENSG00000162630 or ENSG00000162885 or ENSG00000163527 or ENSG00000167080 or ENSG00000167889 or ENSG00000170340 or ENSG00000172318 or ENSG00000172461 or ENSG00000172728 or ENSG00000175711 or ENSG00000176383 or ENSG00000176597 or ENSG00000177191 or ENSG00000179913 or ENSG00000180549 or ENSG00000182272 or ENSG00000183778 or ENSG00000187676 or ENSG00000196371 or ENSG00000196968 or ENSG00000198488 or ENSG00000204007 or ENSG00000237172 or ENSG00000251287	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation. The gene ENSG00000102595 encodes a protein that functions in recognizing glycoproteins with minor folding defects and reglucosylates N-glycans, which plays a role in protein quality control in the endoplasmic reticulum. The annotated catalytic activity of the gene involves the reaction of N-glycan mannose isomer forms and UDP-alpha-D-glucose, resulting in the production of reglucosylated N-glycan mannose and UDP. However, the provided reaction involves glucosylceramide and UDP-galactose, which produces LacCer and UDP, indicating entirely different substrates and products than the gene's activity. Thus, the gene's role and the given reaction are unrelated. No
ENSG00000175711	Q67FW5	MAR00765: glucosylceramide pool + UDP-galactose --> H+ + LacCer pool + UDP	ENSG00000016864 or ENSG00000027847 or ENSG00000060642 or ENSG00000069943 or ENSG00000085998 or ENSG00000086062 or ENSG00000102595 or ENSG00000109586 or ENSG00000117411 or ENSG00000118017 or ENSG00000118276 or ENSG00000119227 or ENSG00000120820 or ENSG00000121578 or ENSG00000124091 or ENSG00000134910 or ENSG00000136731 or ENSG00000139044 or ENSG00000143315 or ENSG00000147162 or ENSG00000148288 or ENSG00000156966 or ENSG00000158470 or ENSG00000158850 or ENSG00000162630 or ENSG00000162885 or ENSG00000163527 or ENSG00000167080 or ENSG00000167889 or ENSG00000170340 or ENSG00000172318 or ENSG00000172461 or ENSG00000172728 or ENSG00000175711 or ENSG00000176383 or ENSG00000176597 or ENSG00000177191 or ENSG00000179913 or ENSG00000180549 or ENSG00000182272 or ENSG00000183778 or ENSG00000187676 or ENSG00000196371 or ENSG00000196968 or ENSG00000198488 or ENSG00000204007 or ENSG00000237172 or ENSG00000251287	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation: The gene ENSG00000175711 encodes a glycosyltransferase that catalyzes the transfer of a galactose moiety specifically to queuosine at position 34 in tRNA(Tyr) to form galactosyl-queuosine(34). This activity is distinct from the reaction provided, where glucosylceramide is converted to lactosylceramide using UDP-galactose. The provided reaction does not involve tRNA or queuosine, which are key substrates for the gene's function, thereby making the gene irrelevant to the reaction in question.	No
ENSG00000147162	O15294	MAR00765: glucosylceramide pool + UDP-galactose --> H+ + LacCer pool + UDP	ENSG00000016864 or ENSG00000027847 or ENSG00000060642 or ENSG00000069943 or ENSG00000085998 or ENSG00000086062 or ENSG00000102595 or ENSG00000109586 or ENSG00000117411 or ENSG00000118017 or ENSG00000118276 or ENSG00000119227 or ENSG00000120820 or ENSG00000121578 or ENSG00000124091 or ENSG00000134910 or ENSG00000136731 or ENSG00000139044 or ENSG00000143315 or ENSG00000147162 or ENSG00000148288 or ENSG00000156966 or ENSG00000158470 or ENSG00000158850 or ENSG00000162630 or ENSG00000162885 or ENSG00000163527 or ENSG00000167080 or ENSG00000167889 or ENSG00000170340 or ENSG00000172318 or ENSG00000172461 or ENSG00000172728 or ENSG00000175711 or ENSG00000176383 or ENSG00000176597 or ENSG00000177191 or ENSG00000179913 or ENSG00000180549 or ENSG00000182272 or ENSG00000183778 or ENSG00000187676 or ENSG00000196371 or ENSG00000196968 or ENSG00000198488 or ENSG00000204007 or ENSG00000237172 or ENSG00000251287	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation. The gene ENSG00000147162 encodes a protein that catalyzes the transfer of N-acetylglucosamine to serine or threonine residues in proteins, specifically performing O-GlcNAcylation. However, the reaction described involves the conversion of glucosylceramide and UDP-galactose to LacCer and UDP. This reaction is related to glycolipid metabolism, which is a different biological process from the O-GlcNAcylation mediated by the gene ENSG00000147162. Therefore, the gene's function and the provided reaction are not related.	No
ENSG00000180549	Q11130	MAR00765: glucosylceramide pool + UDP-galactose --> H+ + LacCer pool + UDP	ENSG00000016864 or ENSG00000027847 or ENSG00000060642 or ENSG00000069943 or ENSG00000085998 or ENSG00000086062 or ENSG00000102595 or ENSG00000109586 or ENSG00000117411 or ENSG00000118017 or ENSG00000118276 or ENSG00000119227 or ENSG00000120820 or ENSG00000121578 or ENSG00000124091 or ENSG00000134910 or ENSG00000136731 or ENSG00000139044 or ENSG00000143315 or ENSG00000147162 or ENSG00000148288 or ENSG00000156966 or ENSG00000158470 or ENSG00000158850 or ENSG00000162630 or ENSG00000162885 or ENSG00000163527 or ENSG00000167080 or ENSG00000167889 or ENSG00000170340 or ENSG00000172318 or ENSG00000172461 or ENSG00000172728 or ENSG00000175711 or ENSG00000176383 or ENSG00000176597 or ENSG00000177191 or ENSG00000179913 or ENSG00000180549 or ENSG00000182272 or ENSG00000183778 or ENSG00000187676 or ENSG00000196371 or ENSG00000196968 or ENSG00000198488 or ENSG00000204007 or ENSG00000237172 or ENSG00000251287	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation: The gene ENSG00000180549 encodes an enzyme that catalyzes the transfer of L-fucose from GDP-beta-L-fucose to a variety of glycosylated substrates, contributing to the biosynthesis of sialyl Lewis X and other fucosylated structures. However, the provided reaction involves the conversion of glucosylceramide and UDP-galactose to LacCer and UDP, a process that does not involve L-fucose or the substrates specific to the enzyme encoded by ENSG00000180549. Therefore, the gene's function is not related to this reaction.	No
ENSG00000101577	Q92539	MAR00767: ceramide-1P pool + H2O --> ceramide pool + Pi	ENSG00000067113 or ENSG00000101577 or ENSG00000105520 or ENSG00000117600 or ENSG00000129951 or ENSG00000132793 or ENSG00000134324 or ENSG00000141934 or ENSG00000147535 or ENSG00000162407 or ENSG00000203805	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation: The gene ENSG00000101577 encodes a protein that acts as a magnesium-dependent phosphatidate phosphatase enzyme, which catalyzes the conversion of phosphatidic acid to diacylglycerol. This process is involved in triglyceride, phosphatidylcholine, and phosphatidylethanolamine biosynthesis and occurs in the endoplasmic reticulum membrane. However, the provided reaction involves the hydrolysis of ceramide-1-phosphate to ceramide and phosphate, which is a different biochemical process not associated with the function of the gene ENSG00000101577. Therefore, the gene and the reaction are not related.	No
ENSG00000134324	Q14693	MAR00775: H2O + sphingosine-1-phosphate --> Pi + sphingosine	ENSG00000067113 or ENSG00000101577 or ENSG00000132793 or ENSG00000134324 or ENSG00000141934 or ENSG00000162407	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation: The gene ENSG00000134324 encodes an enzyme that functions as a magnesium-dependent phosphatidate phosphatase, catalyzing the conversion of phosphatidic acid to diacylglycerol, which is essential in the biosynthesis of triglycerides, phosphatidylcholine, and phosphatidylethanolamine. This enzyme's specific catalytic activities involve various forms of phosphatidic acid substrates, consistently converting them into diacylglycerol and phosphate. However, the provided reaction involves the conversion of sphingosine-1-phosphate to sphingosine and phosphate, which is a completely different substrate and reaction mechanism that does not align with the enzymatic activities described for the gene ENSG00000134324. Therefore, the gene is not relevant to the reaction involving sphingosine-1-phosphate.	No
ENSG00000179913	Q9Y2A9	MAR08152: glcnac-gal-globoside + UDP-galactose --> gal-glcnac-gal-globoside + H+ + UDP	ENSG00000179913	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation: The gene ENSG00000179913 encodes for a Beta-1,3-N-acetylglucosaminyltransferase, which is involved in the synthesis of poly-N-acetyllactosamine and forms specific glycan structures like the 6-sulfo sialyl Lewis x on extended core1 O-glycans. The catalytic activities described for this gene involve the addition of N-acetylglucosamine (GlcNAc) residues to various oligosaccharide substrates. However, the reaction provided involves the transformation of glcnac-gal-globoside with UDP-galactose, leading to the production of gal-glcnac-gal-globoside, which is a different substrate and product and does not match the enzymatic activities associated with the gene in question. Thus, the gene does not participate in the specified reaction.	No
ENSG00000179913	Q9Y2A9	MAR08173: GM2alpha + UDP-galactose --> GM1alpha + H+ + UDP	ENSG00000179913	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation. The gene ENSG00000179913 encodes for Beta-1,3-N-acetylglucosaminyltransferase, which is involved in the synthesis of poly-N-acetyllactosamine and has catalytic activity for specific glycosylation reactions involving UDP-N-acetyl-alpha-D-glucosamine (EC 2.4.1.146 and EC 2.4.1.149). However, the provided reaction involves the conversion of GM2alpha to GM1alpha using UDP-galactose, which is a different biochemical process. Therefore, the gene and the reaction are not related.	No
ENSG00000168350	Q6QHC5	MAR08219: dihydroceramide pool + NADP+ --> ceramide pool + H+ + NADPH	ENSG00000143753 or ENSG00000168350	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation. The gene ENSG00000168350 is associated with sphingolipid metabolism, acting as a bifunctional enzyme with activities like sphingolipid delta(4)-desaturase and sphingolipid C4-monooxygenase. The annotated catalytic activities involve conversions such as dihydroceramide to phytoceramide and N-acylsphinganine to N-acylsphing-4-enine, which require Fe(II)-[cytochrome b5] and involve reactions with molecular oxygen. However, the reaction provided that involves dihydroceramide pool and NADP+ converting to ceramide pool, H+, and NADPH does not align with these described activities and does not match the enzymatic reactions or cofactors (Fe(II)-[cytochrome b5] and O2) specified for this gene. Hence, the gene and the reaction are not related.	No
ENSG00000069943	Q92521	MAR00765: glucosylceramide pool + UDP-galactose --> H+ + LacCer pool + UDP	ENSG00000016864 or ENSG00000027847 or ENSG00000060642 or ENSG00000069943 or ENSG00000085998 or ENSG00000086062 or ENSG00000102595 or ENSG00000109586 or ENSG00000117411 or ENSG00000118017 or ENSG00000118276 or ENSG00000119227 or ENSG00000120820 or ENSG00000121578 or ENSG00000124091 or ENSG00000134910 or ENSG00000136731 or ENSG00000139044 or ENSG00000143315 or ENSG00000147162 or ENSG00000148288 or ENSG00000156966 or ENSG00000158470 or ENSG00000158850 or ENSG00000162630 or ENSG00000162885 or ENSG00000163527 or ENSG00000167080 or ENSG00000167889 or ENSG00000170340 or ENSG00000172318 or ENSG00000172461 or ENSG00000172728 or ENSG00000175711 or ENSG00000176383 or ENSG00000176597 or ENSG00000177191 or ENSG00000179913 or ENSG00000180549 or ENSG00000182272 or ENSG00000183778 or ENSG00000187676 or ENSG00000196371 or ENSG00000196968 or ENSG00000198488 or ENSG00000204007 or ENSG00000237172 or ENSG00000251287	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation. The gene ENSG00000069943 encodes a mannosyltransferase involved in glycosylphosphatidylinositol-anchor biosynthesis, specifically transferring alpha-1,2-mannose to Man2-GlcN-acyl-PI during GPI precursor assembly. However, the given reaction involves glucosylceramide and UDP-galactose, producing H+, LacCer, and UDP, which is unrelated to GPI-anchor biosynthesis and does not involve mannosyltransferase activity.	No
ENSG00000172461	Q9Y231	MAR00765: glucosylceramide pool + UDP-galactose --> H+ + LacCer pool + UDP	ENSG00000016864 or ENSG00000027847 or ENSG00000060642 or ENSG00000069943 or ENSG00000085998 or ENSG00000086062 or ENSG00000102595 or ENSG00000109586 or ENSG00000117411 or ENSG00000118017 or ENSG00000118276 or ENSG00000119227 or ENSG00000120820 or ENSG00000121578 or ENSG00000124091 or ENSG00000134910 or ENSG00000136731 or ENSG00000139044 or ENSG00000143315 or ENSG00000147162 or ENSG00000148288 or ENSG00000156966 or ENSG00000158470 or ENSG00000158850 or ENSG00000162630 or ENSG00000162885 or ENSG00000163527 or ENSG00000167080 or ENSG00000167889 or ENSG00000170340 or ENSG00000172318 or ENSG00000172461 or ENSG00000172728 or ENSG00000175711 or ENSG00000176383 or ENSG00000176597 or ENSG00000177191 or ENSG00000179913 or ENSG00000180549 or ENSG00000182272 or ENSG00000183778 or ENSG00000187676 or ENSG00000196371 or ENSG00000196968 or ENSG00000198488 or ENSG00000204007 or ENSG00000237172 or ENSG00000251287	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation. The gene ENSG00000172461 encodes an enzyme that catalyzes the transfer of a fucosyl moiety from GDP-beta-L-fucose to N-acetylglucosamine within type 2 lactosamine glycan structures, forming structures like Lewis x (Lex) and Lewis y (Ley) epitopes. However, the provided reaction involves the conversion of glucosylceramide and UDP-galactose to lactosylceramide (LacCer) and UDP, which is a glycosylation reaction not involving fucose or the specific function of the gene. Therefore, the gene's specific activity does not align with the provided reaction mechanism.	No
ENSG00000198488	Q6ZMB0	MAR00765: glucosylceramide pool + UDP-galactose --> H+ + LacCer pool + UDP	ENSG00000016864 or ENSG00000027847 or ENSG00000060642 or ENSG00000069943 or ENSG00000085998 or ENSG00000086062 or ENSG00000102595 or ENSG00000109586 or ENSG00000117411 or ENSG00000118017 or ENSG00000118276 or ENSG00000119227 or ENSG00000120820 or ENSG00000121578 or ENSG00000124091 or ENSG00000134910 or ENSG00000136731 or ENSG00000139044 or ENSG00000143315 or ENSG00000147162 or ENSG00000148288 or ENSG00000156966 or ENSG00000158470 or ENSG00000158850 or ENSG00000162630 or ENSG00000162885 or ENSG00000163527 or ENSG00000167080 or ENSG00000167889 or ENSG00000170340 or ENSG00000172318 or ENSG00000172461 or ENSG00000172728 or ENSG00000175711 or ENSG00000176383 or ENSG00000176597 or ENSG00000177191 or ENSG00000179913 or ENSG00000180549 or ENSG00000182272 or ENSG00000183778 or ENSG00000187676 or ENSG00000196371 or ENSG00000196968 or ENSG00000198488 or ENSG00000204007 or ENSG00000237172 or ENSG00000251287	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation: The gene ENSG00000198488 encodes for an enzyme involved in the biosynthesis of mucin-type glycoproteins, specifically characterized by its function as a Beta-1,3-N-acetylglucosaminyltransferase. This enzyme catalyzes reactions involving the transfer of N-acetylglucosamine to form O-glycans on proteins. In contrast, the reaction provided involves the conversion of glucosylceramide to lactosylceramide using UDP-galactose, a different metabolic pathway not related to mucin-type glycoprotein biosynthesis. Hence, the gene is not relevant to the reaction provided.	No
ENSG00000179913	Q9Y2A9	MAR08249: globotriaosylceramide + UDP-galactose --> galthcrm heparan sulfate + H+ + UDP	ENSG00000179913	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation: The gene ENSG00000179913 encodes an enzyme involved in the synthesis of poly-N-acetyllactosamine and various O-glycans, specifically catalyzing the transfer of N-acetylglucosamine in different biochemical contexts as indicated by the provided catalytic activities. However, the reaction described, which involves globotriaosylceramide and UDP-galactose to produce heparan sulfate and UDP, does not align with the enzyme's specified functions or catalytic activities such as those involving N-acetylglucosamine transfer. Therefore, the gene and the reaction are not related.	No
ENSG00000134324	Q14693	MAR00746: H2O + sphinganine-1-phosphate --> Pi + sphinganine	ENSG00000067113 or ENSG00000101577 or ENSG00000132793 or ENSG00000134324 or ENSG00000141934 or ENSG00000162407	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation. The gene ENSG00000134324 encodes a magnesium-dependent phosphatidate phosphatase enzyme that catalyzes the conversion of phosphatidic acid to diacylglycerol, with various substrate specificities, as evidenced by multiple catalytic activities listed. However, the reaction provided involves the hydrolysis of sphinganine-1-phosphate to sphinganine and phosphate, which does not involve phosphatidate substrates or the formation of diacylglycerol, indicating the irrelevance of the gene to the reaction.	No
ENSG00000170340	Q9NY97	MAR00765: glucosylceramide pool + UDP-galactose --> H+ + LacCer pool + UDP	ENSG00000016864 or ENSG00000027847 or ENSG00000060642 or ENSG00000069943 or ENSG00000085998 or ENSG00000086062 or ENSG00000102595 or ENSG00000109586 or ENSG00000117411 or ENSG00000118017 or ENSG00000118276 or ENSG00000119227 or ENSG00000120820 or ENSG00000121578 or ENSG00000124091 or ENSG00000134910 or ENSG00000136731 or ENSG00000139044 or ENSG00000143315 or ENSG00000147162 or ENSG00000148288 or ENSG00000156966 or ENSG00000158470 or ENSG00000158850 or ENSG00000162630 or ENSG00000162885 or ENSG00000163527 or ENSG00000167080 or ENSG00000167889 or ENSG00000170340 or ENSG00000172318 or ENSG00000172461 or ENSG00000172728 or ENSG00000175711 or ENSG00000176383 or ENSG00000176597 or ENSG00000177191 or ENSG00000179913 or ENSG00000180549 or ENSG00000182272 or ENSG00000183778 or ENSG00000187676 or ENSG00000196371 or ENSG00000196968 or ENSG00000198488 or ENSG00000204007 or ENSG00000237172 or ENSG00000251287	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation: The gene ENSG00000170340 encodes a protein that functions as a Beta-1,3-N-acetylglucosaminyltransferase involved in the synthesis of poly-N-acetyllactosamine chains, specifically catalyzing reactions involving Gal(beta1-4)Glc(NAc)-based acceptors. However, the reaction provided involves the conversion of a glucosylceramide pool and UDP-galactose to LacCer pool and UDP, which is not related to the synthesis or elongation of poly-N-acetyllactosamine chains. Therefore, the gene's annotated function and the provided reaction do not match.	No
ENSG00000196371	P22083	MAR00765: glucosylceramide pool + UDP-galactose --> H+ + LacCer pool + UDP	ENSG00000016864 or ENSG00000027847 or ENSG00000060642 or ENSG00000069943 or ENSG00000085998 or ENSG00000086062 or ENSG00000102595 or ENSG00000109586 or ENSG00000117411 or ENSG00000118017 or ENSG00000118276 or ENSG00000119227 or ENSG00000120820 or ENSG00000121578 or ENSG00000124091 or ENSG00000134910 or ENSG00000136731 or ENSG00000139044 or ENSG00000143315 or ENSG00000147162 or ENSG00000148288 or ENSG00000156966 or ENSG00000158470 or ENSG00000158850 or ENSG00000162630 or ENSG00000162885 or ENSG00000163527 or ENSG00000167080 or ENSG00000167889 or ENSG00000170340 or ENSG00000172318 or ENSG00000172461 or ENSG00000172728 or ENSG00000175711 or ENSG00000176383 or ENSG00000176597 or ENSG00000177191 or ENSG00000179913 or ENSG00000180549 or ENSG00000182272 or ENSG00000183778 or ENSG00000187676 or ENSG00000196371 or ENSG00000196968 or ENSG00000198488 or ENSG00000204007 or ENSG00000237172 or ENSG00000251287	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation. The gene ENSG00000196371 encodes an enzyme that catalyzes the transfer of a fucosyl moiety from GDP-beta-L-fucose to N-acetyl glucosamine (GlcNAc) within type 2 lactosamine glycan attached to N- or O-linked glycoproteins, with several specific reactions detailed in the gene annotation. However, the provided reaction involves the conversion of glucosylceramide with UDP-galactose to produce LacCer and UDP, which does not involve fucosylation or GlcNAc substrates. Therefore, the gene's described functions and catalytic activities do not align with the provided reaction.	No
ENSG00000136731	Q9NYU2	MAR00765: glucosylceramide pool + UDP-galactose --> H+ + LacCer pool + UDP	ENSG00000016864 or ENSG00000027847 or ENSG00000060642 or ENSG00000069943 or ENSG00000085998 or ENSG00000086062 or ENSG00000102595 or ENSG00000109586 or ENSG00000117411 or ENSG00000118017 or ENSG00000118276 or ENSG00000119227 or ENSG00000120820 or ENSG00000121578 or ENSG00000124091 or ENSG00000134910 or ENSG00000136731 or ENSG00000139044 or ENSG00000143315 or ENSG00000147162 or ENSG00000148288 or ENSG00000156966 or ENSG00000158470 or ENSG00000158850 or ENSG00000162630 or ENSG00000162885 or ENSG00000163527 or ENSG00000167080 or ENSG00000167889 or ENSG00000170340 or ENSG00000172318 or ENSG00000172461 or ENSG00000172728 or ENSG00000175711 or ENSG00000176383 or ENSG00000176597 or ENSG00000177191 or ENSG00000179913 or ENSG00000180549 or ENSG00000182272 or ENSG00000183778 or ENSG00000187676 or ENSG00000196371 or ENSG00000196968 or ENSG00000198488 or ENSG00000204007 or ENSG00000237172 or ENSG00000251287	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation: The gene ENSG00000136731 encodes for a protein that recognizes glycoproteins with minor folding defects and reglucosylates single N-glycans near the misfolded part of the protein as part of a quality control process in the endoplasmic reticulum. Its catalytic activity involves reglucosylation of N-glycans using UDP-alpha-D-glucose, which is catalyzed through a specific and well-defined process related to protein folding and degradation. On the other hand, the reaction provided involves the conversion of glucosylceramide pool and UDP-galactose to LacCer pool, H+ and UDP, which is unrelated to the function and catalytic activity of the gene ENSG00000136731. Therefore, the gene and the reaction are not related.	No
ENSG00000172728	Q6P4F1	MAR00765: glucosylceramide pool + UDP-galactose --> H+ + LacCer pool + UDP	ENSG00000016864 or ENSG00000027847 or ENSG00000060642 or ENSG00000069943 or ENSG00000085998 or ENSG00000086062 or ENSG00000102595 or ENSG00000109586 or ENSG00000117411 or ENSG00000118017 or ENSG00000118276 or ENSG00000119227 or ENSG00000120820 or ENSG00000121578 or ENSG00000124091 or ENSG00000134910 or ENSG00000136731 or ENSG00000139044 or ENSG00000143315 or ENSG00000147162 or ENSG00000148288 or ENSG00000156966 or ENSG00000158470 or ENSG00000158850 or ENSG00000162630 or ENSG00000162885 or ENSG00000163527 or ENSG00000167080 or ENSG00000167889 or ENSG00000170340 or ENSG00000172318 or ENSG00000172461 or ENSG00000172728 or ENSG00000175711 or ENSG00000176383 or ENSG00000176597 or ENSG00000177191 or ENSG00000179913 or ENSG00000180549 or ENSG00000182272 or ENSG00000183778 or ENSG00000187676 or ENSG00000196371 or ENSG00000196968 or ENSG00000198488 or ENSG00000204007 or ENSG00000237172 or ENSG00000251287	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation. The gene ENSG00000172728 encodes an enzyme that primarily catalyzes the transfer of a fucosyl moiety from GDP-beta-L-fucose to the innermost GlcNAc residue in biantennary N-glycan acceptors. However, the provided reaction involves the conversion of glucosylceramide and UDP-galactose to LacCer, H+, and UDP, which requires a different enzymatic activity, specifically a galactosyltransferase, not a fucosyltransferase. Therefore, the gene's function does not match the reaction's requirements.	No
ENSG00000085998	Q8WZA1	MAR00765: glucosylceramide pool + UDP-galactose --> H+ + LacCer pool + UDP	ENSG00000016864 or ENSG00000027847 or ENSG00000060642 or ENSG00000069943 or ENSG00000085998 or ENSG00000086062 or ENSG00000102595 or ENSG00000109586 or ENSG00000117411 or ENSG00000118017 or ENSG00000118276 or ENSG00000119227 or ENSG00000120820 or ENSG00000121578 or ENSG00000124091 or ENSG00000134910 or ENSG00000136731 or ENSG00000139044 or ENSG00000143315 or ENSG00000147162 or ENSG00000148288 or ENSG00000156966 or ENSG00000158470 or ENSG00000158850 or ENSG00000162630 or ENSG00000162885 or ENSG00000163527 or ENSG00000167080 or ENSG00000167889 or ENSG00000170340 or ENSG00000172318 or ENSG00000172461 or ENSG00000172728 or ENSG00000175711 or ENSG00000176383 or ENSG00000176597 or ENSG00000177191 or ENSG00000179913 or ENSG00000180549 or ENSG00000182272 or ENSG00000183778 or ENSG00000187676 or ENSG00000196371 or ENSG00000196968 or ENSG00000198488 or ENSG00000204007 or ENSG00000237172 or ENSG00000251287	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation. The gene ENSG00000085998 is involved in the O-mannosyl glycosylation pathway, specifically catalyzing the addition of N-acetylglucosamine to O-linked mannose on glycoproteins. In contrast, the provided reaction describes the conversion of glucosylceramide pool and UDP-galactose to H+, LacCer pool, and UDP, which is unrelated to the function and catalytic activity of the gene. The gene does not participate in reactions involving glucosylceramide or UDP-galactose.	No
ENSG00000167889	Q3V5L5	MAR00765: glucosylceramide pool + UDP-galactose --> H+ + LacCer pool + UDP	ENSG00000016864 or ENSG00000027847 or ENSG00000060642 or ENSG00000069943 or ENSG00000085998 or ENSG00000086062 or ENSG00000102595 or ENSG00000109586 or ENSG00000117411 or ENSG00000118017 or ENSG00000118276 or ENSG00000119227 or ENSG00000120820 or ENSG00000121578 or ENSG00000124091 or ENSG00000134910 or ENSG00000136731 or ENSG00000139044 or ENSG00000143315 or ENSG00000147162 or ENSG00000148288 or ENSG00000156966 or ENSG00000158470 or ENSG00000158850 or ENSG00000162630 or ENSG00000162885 or ENSG00000163527 or ENSG00000167080 or ENSG00000167889 or ENSG00000170340 or ENSG00000172318 or ENSG00000172461 or ENSG00000172728 or ENSG00000175711 or ENSG00000176383 or ENSG00000176597 or ENSG00000177191 or ENSG00000179913 or ENSG00000180549 or ENSG00000182272 or ENSG00000183778 or ENSG00000187676 or ENSG00000196371 or ENSG00000196968 or ENSG00000198488 or ENSG00000204007 or ENSG00000237172 or ENSG00000251287	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation. The gene ENSG00000167889 encodes a glycosyltransferase that specifically acts on alpha-linked mannose of N-glycans and O-mannosyl glycans, catalyzing the transfer of N-acetylglucosamine to mannose residues. It does not show any involvement with glucosylceramide or UDP-galactose, which are the substrates in the provided reaction. Therefore, the gene's function does not correspond to the reaction involving glucosylceramide and UDP-galactose.	No
ENSG00000147535	Q8NEB5	MAR00767: ceramide-1P pool + H2O --> ceramide pool + Pi	ENSG00000067113 or ENSG00000101577 or ENSG00000105520 or ENSG00000117600 or ENSG00000129951 or ENSG00000132793 or ENSG00000134324 or ENSG00000141934 or ENSG00000147535 or ENSG00000162407 or ENSG00000203805	Pending No, the gene is not relevant to the reaction provided. Analysis and explanation: The gene ENSG00000147535 encodes a magnesium-independent phospholipid phosphatase that primarily catalyzes reactions involving diacylglycerol pyrophosphate, phosphatidate, and lysophosphatidate. The reaction provided involves the conversion of ceramide-1P to ceramide and inorganic phosphate (Pi), which is not among the substrates mentioned in the gene's annotated catalytic activities. Therefore, the gene and the reaction are not related.	No