Read the results #284
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The The other methods ( |
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Thank you Sam for the clarification.
*Salem Werdyani,PhD.*
*Human Genetics.*
…On Tue, Apr 23, 2024 at 4:38 AM Sam Lambert ***@***.***> wrote:
The SUM is always the PGS (weighted sum of allele dosages) calculated on
the matched variants. The SUM may change when you run with/without
ancestry adjustment because the variants overlapping your genotypes and the
reference panel might not be identical.
The other methods (Z_MostSimilarPop, percentile_MostSimilarPop, Z_norm1,
or Z_norm2) are different ways for reporting a PGS with respect to
genetic ancestry, you can see more information here:
https://pgsc-calc.readthedocs.io/en/latest/explanation/geneticancestry.html
.
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The
SUMis always the PGS (weighted sum of allele dosages) calculated on the matched variants. TheSUMmay change when you run with/without ancestry adjustment because the variants overlapping your genotypes and the reference panel might not be identical.The other methods (
Z_MostSimilarPop,percentile_MostSimilarPop,Z_norm1, orZ_norm2) are different ways for reporting a PGS with respect to genetic ancestry, you can see more information here: https://pgsc-calc.readthedocs.io/en/latest/explanation/geneticancestry.html.