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Create mtype taxonomy for placement from KG mtype resources #20

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eleftherioszisis opened this issue Jun 27, 2024 · 1 comment
Open

Create mtype taxonomy for placement from KG mtype resources #20

eleftherioszisis opened this issue Jun 27, 2024 · 1 comment

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@eleftherioszisis
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eleftherioszisis commented Jun 27, 2024 •
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The mtype taxonomy is currently hard-coded here:

blue-cwl/src/blue_cwl/recipes.py

Lines 48 to 75 in 383b4fd

tokens = {
"DAC": ("INT", "INH"),
"HAC": ("INT", "INH"),
"LAC": ("INT", "INH"),
"NGC-DA": ("INT", "INH"),
"NGC-SA": ("INT", "INH"),
"SAC": ("INT", "INH"),
"BP": ("INT", "INH"),
"BTC": ("INT", "INH"),
"ChC": ("INT", "INH"),
"DBC": ("INT", "INH"),
"LBC": ("INT", "INH"),
"MC": ("INT", "INH"),
"NBC": ("INT", "INH"),
"NGC": ("INT", "INH"),
"SBC": ("INT", "INH"),
"GIN_mtype": ("INT", "INH"),
"TPC": ("PYR", "EXC"),
"TPC:A": ("PYR", "EXC"),
"TPC:B": ("PYR", "EXC"),
"TPC:C": ("PYR", "EXC"),
"UPC": ("PYR", "EXC"),
"BPC": ("PYR", "EXC"),
"IPC": ("PYR", "EXC"),
"SSC": ("INT", "EXC"),
"HPC": ("PYR", "EXC"),
"GEN_mtype": ("PYR", "EXC"),
}

However, with new mtypes, a dynamic way must be added to fetch that information from nexus.

There are two properties needed to be retrieved from mtype resources:

  1. If the mtype is excitatory or inhibitory (EXC/INH)
  2. If the mtype is pyramidal cell or an interneuron (PYR/INT)

These two properties can be found in the documentation as morph_class and synapse_class respectively:
https://sonata-extension.readthedocs.io/en/latest/sonata_tech.html#fields-for-biophysically-detailed-neurons-model-type-biophysical

Current mtype composition from the latest atlas:

        mtype                                                             mtype_url
0   GEN_mtype  https://bbp.epfl.ch/ontologies/core/bmo/GenericExcitatoryNeuronMType
1   GIN_mtype  https://bbp.epfl.ch/ontologies/core/bmo/GenericInhibitoryNeuronMType
2      L1_DAC                              http://uri.interlex.org/base/ilx_0383192
3      L1_HAC                              http://uri.interlex.org/base/ilx_0383193
4      L1_LAC                              http://uri.interlex.org/base/ilx_0383194
5   L1_NGC-DA                              http://uri.interlex.org/base/ilx_0383195
6   L1_NGC-SA                              http://uri.interlex.org/base/ilx_0383196
7      L1_SAC                              http://uri.interlex.org/base/ilx_0383197
8      L23_BP                              http://uri.interlex.org/base/ilx_0383198
9     L23_BTC                              http://uri.interlex.org/base/ilx_0383199
10    L23_ChC                              http://uri.interlex.org/base/ilx_0383200
11    L23_DBC                              http://uri.interlex.org/base/ilx_0383201
12    L23_LBC                              http://uri.interlex.org/base/ilx_0383202
13     L23_MC                              http://uri.interlex.org/base/ilx_0383203
14    L23_NBC                              http://uri.interlex.org/base/ilx_0383204
15    L23_NGC                              http://uri.interlex.org/base/ilx_0383205
16    L23_SBC                              http://uri.interlex.org/base/ilx_0383206
17     L2_IPC                              http://uri.interlex.org/base/ilx_0383207
18   L2_TPC:A                              http://uri.interlex.org/base/ilx_0383208
19   L2_TPC:B                              http://uri.interlex.org/base/ilx_0381367
20   L3_TPC:A                              http://uri.interlex.org/base/ilx_0381366
21   L3_TPC:C       http://bbp.epfl.ch/neurosciencegraph/ontologies/mtypes/L3_TPC_C
22      L4_BP                              http://uri.interlex.org/base/ilx_0383209
23     L4_BTC                              http://uri.interlex.org/base/ilx_0383210
24     L4_ChC                              http://uri.interlex.org/base/ilx_0383211
25     L4_DBC                              http://uri.interlex.org/base/ilx_0383212
26     L4_LBC                              http://uri.interlex.org/base/ilx_0383213
27      L4_MC                              http://uri.interlex.org/base/ilx_0383214
28     L4_NBC                              http://uri.interlex.org/base/ilx_0383215
29     L4_NGC                              http://uri.interlex.org/base/ilx_0383216
30     L4_SBC                              http://uri.interlex.org/base/ilx_0383217
31     L4_SSC                              http://uri.interlex.org/base/ilx_0383218
32     L4_TPC                              http://uri.interlex.org/base/ilx_0383219
33     L4_UPC                              http://uri.interlex.org/base/ilx_0383220
34      L5_BP                              http://uri.interlex.org/base/ilx_0383221
35     L5_BTC                              http://uri.interlex.org/base/ilx_0383222
36     L5_ChC                              http://uri.interlex.org/base/ilx_0383223
37     L5_DBC                              http://uri.interlex.org/base/ilx_0383224
38     L5_LBC                              http://uri.interlex.org/base/ilx_0383225
39      L5_MC                              http://uri.interlex.org/base/ilx_0381369
40     L5_NBC                              http://uri.interlex.org/base/ilx_0383226
41     L5_NGC                              http://uri.interlex.org/base/ilx_0383239
42     L5_SBC                              http://uri.interlex.org/base/ilx_0383227
43   L5_TPC:A                              http://uri.interlex.org/base/ilx_0381365
44   L5_TPC:B                              http://uri.interlex.org/base/ilx_0381364
45   L5_TPC:C                              http://uri.interlex.org/base/ilx_0381370
46     L5_UPC                              http://uri.interlex.org/base/ilx_0381371
47      L6_BP                              http://uri.interlex.org/base/ilx_0383240
48     L6_BPC                              http://uri.interlex.org/base/ilx_0383228
49     L6_BTC                              http://uri.interlex.org/base/ilx_0383229
50     L6_ChC                              http://uri.interlex.org/base/ilx_0383230
51     L6_DBC                              http://uri.interlex.org/base/ilx_0383231
52     L6_HPC                              http://uri.interlex.org/base/ilx_0383232
53     L6_IPC                              http://uri.interlex.org/base/ilx_0381373
54     L6_LBC                              http://uri.interlex.org/base/ilx_0383233
55      L6_MC                              http://uri.interlex.org/base/ilx_0381374
56     L6_NBC                              http://uri.interlex.org/base/ilx_0383234
57     L6_NGC                              http://uri.interlex.org/base/ilx_0383235
58     L6_SBC                              http://uri.interlex.org/base/ilx_0383236
59   L6_TPC:A                              http://uri.interlex.org/base/ilx_0381375
60   L6_TPC:C                              http://uri.interlex.org/base/ilx_0381376
61     L6_UPC                              http://uri.interlex.org/base/ilx_0381377
62      Rt_RC                              http://uri.interlex.org/base/ilx_0738229
63     VPL_IN                              http://uri.interlex.org/base/ilx_0738235
@eleftherioszisis
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The property 'hasNeurotransmitterType' may be of use for the synapse class, however it is not defined for all mtypes:

        mtype                                type
0   GEN_mtype  bmo:ExcitatoryNeurotransmitterType
1   GIN_mtype  bmo:InhibitoryNeurotransmitterType
2      L1_DAC  bmo:InhibitoryNeurotransmitterType
3      L1_HAC  bmo:InhibitoryNeurotransmitterType
4      L1_LAC  bmo:InhibitoryNeurotransmitterType
5   L1_NGC-DA  bmo:InhibitoryNeurotransmitterType
6   L1_NGC-SA  bmo:InhibitoryNeurotransmitterType
7      L1_SAC  bmo:InhibitoryNeurotransmitterType
8      L23_BP  bmo:InhibitoryNeurotransmitterType
9     L23_BTC  bmo:InhibitoryNeurotransmitterType
10    L23_ChC  bmo:InhibitoryNeurotransmitterType
11    L23_DBC  bmo:InhibitoryNeurotransmitterType
12    L23_LBC  bmo:InhibitoryNeurotransmitterType
13     L23_MC  bmo:InhibitoryNeurotransmitterType
14    L23_NBC  bmo:InhibitoryNeurotransmitterType
15    L23_NGC  bmo:InhibitoryNeurotransmitterType
16    L23_SBC  bmo:InhibitoryNeurotransmitterType
17     L2_IPC  bmo:ExcitatoryNeurotransmitterType
18   L2_TPC:A  bmo:ExcitatoryNeurotransmitterType
19   L2_TPC:B  bmo:ExcitatoryNeurotransmitterType
20   L3_TPC:A  bmo:ExcitatoryNeurotransmitterType
21   L3_TPC:C                                None
22      L4_BP  bmo:InhibitoryNeurotransmitterType
23     L4_BTC  bmo:InhibitoryNeurotransmitterType
24     L4_ChC  bmo:InhibitoryNeurotransmitterType
25     L4_DBC  bmo:InhibitoryNeurotransmitterType
26     L4_LBC  bmo:InhibitoryNeurotransmitterType
27      L4_MC  bmo:InhibitoryNeurotransmitterType
28     L4_NBC  bmo:InhibitoryNeurotransmitterType
29     L4_NGC  bmo:InhibitoryNeurotransmitterType
30     L4_SBC  bmo:InhibitoryNeurotransmitterType
31     L4_SSC  bmo:ExcitatoryNeurotransmitterType
32     L4_TPC  bmo:ExcitatoryNeurotransmitterType
33     L4_UPC  bmo:ExcitatoryNeurotransmitterType
34      L5_BP  bmo:InhibitoryNeurotransmitterType
35     L5_BTC  bmo:InhibitoryNeurotransmitterType
36     L5_ChC  bmo:InhibitoryNeurotransmitterType
37     L5_DBC  bmo:InhibitoryNeurotransmitterType
38     L5_LBC  bmo:InhibitoryNeurotransmitterType
39      L5_MC  bmo:InhibitoryNeurotransmitterType
40     L5_NBC  bmo:InhibitoryNeurotransmitterType
41     L5_NGC  bmo:InhibitoryNeurotransmitterType
42     L5_SBC  bmo:InhibitoryNeurotransmitterType
43   L5_TPC:A  bmo:ExcitatoryNeurotransmitterType
44   L5_TPC:B  bmo:ExcitatoryNeurotransmitterType
45   L5_TPC:C  bmo:ExcitatoryNeurotransmitterType
46     L5_UPC  bmo:ExcitatoryNeurotransmitterType
47      L6_BP  bmo:InhibitoryNeurotransmitterType
48     L6_BPC  bmo:ExcitatoryNeurotransmitterType
49     L6_BTC  bmo:InhibitoryNeurotransmitterType
50     L6_ChC  bmo:InhibitoryNeurotransmitterType
51     L6_DBC  bmo:InhibitoryNeurotransmitterType
52     L6_HPC  bmo:ExcitatoryNeurotransmitterType
53     L6_IPC  bmo:ExcitatoryNeurotransmitterType
54     L6_LBC  bmo:InhibitoryNeurotransmitterType
55      L6_MC  bmo:InhibitoryNeurotransmitterType
56     L6_NBC  bmo:InhibitoryNeurotransmitterType
57     L6_NGC  bmo:InhibitoryNeurotransmitterType
58     L6_SBC  bmo:InhibitoryNeurotransmitterType
59   L6_TPC:A  bmo:ExcitatoryNeurotransmitterType
60   L6_TPC:C  bmo:ExcitatoryNeurotransmitterType
61     L6_UPC  bmo:ExcitatoryNeurotransmitterType
62      Rt_RC  bmo:InhibitoryNeurotransmitterType
63     VPL_IN  bmo:InhibitoryNeurotransmitterType

@eleftherioszisis eleftherioszisis changed the title Create mtype taxonomy for placement from KG mtype data Create mtype taxonomy for placement from KG mtype resources Jun 27, 2024
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